A sustained-release microcarrier effectively prolongs and enhances the antibacterial activity of lysozyme

作     者：Mei Du Jingzhang Liu Fengbang Wang Lei Bi Chunyan Ma Maoyong Song Guibin Jiang Mei Du;Jingzhang Liu;Fengbang Wang;Lei Bi;Chunyan Ma;Maoyong Song;Guibin Jiang

作者机构：State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing 100085China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第129卷第7期

页      面：128-138页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：This work was supported by the National Key R&D Program of China(No.2021YFA0910300) the National Natural Science Foundation of China(Nos.22125606 and 21976198) the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDPB2005) 

主　　题：Bacterial infection Lysozyme Temperature-responsive Inverse opal particle Wound healing 

摘      要：Bacterial infections have become a great threat to public health in recent years.A primary lysozyme is a natural antimicrobial protein;however,its widespread application is limited by its ***,we present a poly(N-isopropylacrylamide)hydrogel inverse opal particle(PHIOP)as a microcarrier of lysozyme to prolong and enhance the efficiency against *** PHIOP-based lysozyme(PHIOP-Lys)formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 *** shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus,which is even higher than that of free lysozyme in solution at the same ***-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat *** study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.