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Single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-yuan Xiao Qing Zhang fei Huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei Xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen Yang bin Yang Lu-Sheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

多功能分子SLPI调节肾缺血再灌注损伤和修复的作用及机制

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生理学报 2024年第3期76卷 475-486页

作者：陈飞吴圆圆杨斌南通-莱斯特联合肾脏病学研究所南通大学附属医院肾内科南通大学医学院南通226001 南通大学医学院病理系南通226001 莱斯特大学生命科学院心血管科学系肾脏研究组莱斯特LE19HN英国

分泌性白细胞蛋白酶抑制因子(secretory leukocyte protease inhibitor,SLPI)主要由免疫细胞及多种上皮细胞产生,受多种细胞因子调节,如转化生长因子β1、白介素1β和肿瘤坏死因子α等。除公认的抗蛋白酶活性外,近年来发现SLPI还具备抗... 详细信息

分泌性白细胞蛋白酶抑制因子(secretory leukocyte protease inhibitor,SLPI)主要由免疫细胞及多种上皮细胞产生,受多种细胞因子调节,如转化生长因子β1、白介素1β和肿瘤坏死因子α等。除公认的抗蛋白酶活性外,近年来发现SLPI还具备抗细胞凋亡、调节细胞周期、促进细胞分化和增殖及抑制炎症反应等多种特性。SLPI亦可增强细胞吞噬功能和免疫系统对病原体/损伤细胞的清除,从而改善组织损伤及启动修复。另外,新近研究表明,血清SLPI水平变化对心血管术后急性肾损伤的发生具有较高的诊断价值,提示SLPI参与肾脏缺血再灌注损伤相关的免疫反应。本文中我们综述了SLPI在不同器官损伤模型中的表达、调控、信号通路机制以及相关生物学事件,并探讨和评价其在缺血再灌注所致急性肾损伤中发挥保护作用及作为生物学标志物的潜力。

关键词：分泌性白细胞蛋白酶抑制因子急性肾损伤缺血再灌注损伤生物标志物

Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

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World Journal of Gastroenterology 2024年第13期30卷 1911-1925页

作者： fei-Lin Ge Yan Yang Lan-Lan Si yuan-Hua Li Meng-Zhen Cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Department of Chinese Medicine State Key Laboratory of Antiviral DrugsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina The Fifth Medical Center of Chinese PLA General Hospital Beijing 100039China College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China Department of Infectious Diseases State Key Laboratory of Antiviral Drugsthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Liuweiwuling Tablet(LWWL)is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus(HBV)*** studies have indicated an anti-HBV effect of LWWL,specifically in terms of antigen inhibition,but the underlying mechanism remains *** To investigate the potential mechanism of action of LWWL against *** In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell *** in vivo experiment involved a hydrodynamic injectionmediated mouse model with HBV *** and metabolomics were used to investigate the underlying mechanisms of action of *** In HepG2.1403F cells,LWWL(0.8 mg/mL)exhibited inhibitory effects on HBV DNA,hepatitis B surface antigen and pregenomic RNA(pgRNA)at rates of 51.36%,24.74%and 50.74%,*** inhibition rates of LWWL(0.8mg/mL)on pgRNA/covalently closed circular DNA in HepG2.1403F,HepG2.2.15 and HepG2.A64 cells were 47.78%,39.51%and 46.74%,*** of transcriptomics and metabolomics showed that the anti-HBV effect of LWWL was primarily linked to pathways related to apoptosis(PI3K-AKT,CASP8-CASP3 and P53 pathways).Apoptosis flow analysis revealed that the apoptosis rate in the LWWL-treated group was significantly higher than in the control group(CG)among HBV-replicating cell lines,including HepG2.2.15(2.92%±1.01%vs 6.68%±2.04%,P0.05),L02 cells(5.49%±0.80%vs 5.48%±1.01%,P>0.05)and LX2 cells(6.29%±1.54%vs 6.29%±0.88%,P>0.05).TUNEL staining revealed a significantly higher apoptosis rate in the LWWL-treated group than in the CG in the HBVreplicating mouse model,while no noticeable difference in apoptosis rates between the two groups

关键词： Hepatitis B virus Chinese patent medicine Antiviral activity Antiviral mechanism Selective apoptosis

Ultrafast pulse-dilation framing camera and its application for time-resolved X-ray diagnostic

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Nuclear Science and Techniques 2024年第7期35卷 101-114页

作者： Hou-Zhi Cai Qiu-Yan Luo Kai-Xuan Lin Xuan Deng Jun-Kai Liu Kai-Zhi Yang Dong Wang Jia-Jie Chen Jia-Heng Wang Jing-Hua Long Li-Hong Niu Yun-fei Lei Jin-yuan Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen Key Laboratory of Photonics and BiophotonicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were *** camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic *** spatial resolution characteristics of the camera were studied both theoretically and *** results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the ***,the camera was used to detect the X-rays produced by the laser-targeting *** diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.

关键词： Inertial confinement fusion Plasma diagnostics Framing camera Combined lenses Pulse-dilation

Burden of gastrointestinal cancers among working-age population over past thirty years in China

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3955-3979页

作者： Yu Dong Zhuan-Zhuan Fan Wen-Ting Li Jian Kang Yan Zhang Yue Guan Hui-Qing Xu Jie yuan fei Xu Department of Gastroenterology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Primary Healthcare Management Nanjing Municipal Center for Disease Control and PreventionNanjing 210003Jiangsu ProvinceChina Department of Emergency The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Epidemiology Nanjing Medical University School of Public HealthNanjing 211116Jiangsu ProvinceChina

BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age *** To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to *** Data were extracted from the Global Burden of Disease Study *** burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs *** in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression *** For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age ***,an increasing trend was observed in the ASIR for overall GI cancers from *** number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older ***,sex disparity in the GI cancers burden was also examined over 30 *** The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to *** in the GI cancers burden existed between sexes,age groups,and cancer ***-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.

关键词： Gastrointestinal cancer Working-age population Disease burden Disability-adjusted life-years Chinese

基于网络中心性及凝聚子群分析法的基金经理社会网络研究

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数学的实践与认识 2024年第8期54卷 38-59页

作者：王良王元菲李璧肖西安理工大学经济管理学院陕西西西安710048

基于图论、中心性分析、凝聚子群分析等方法,将基金经理的社会网络解构为校友关系网络和同事关系网络,从性别、学历、区域三个不同视角对我国证券投资基金经理个体、局域及整体网络进行了测度与分析.研究发现:1)男性基金经理社会网络整... 详细信息

基于图论、中心性分析、凝聚子群分析等方法,将基金经理的社会网络解构为校友关系网络和同事关系网络,从性别、学历、区域三个不同视角对我国证券投资基金经理个体、局域及整体网络进行了测度与分析.研究发现:1)男性基金经理社会网络整体规模显著大于女性的,且前者的网络广度、结构复杂度均远超后者,而后者的孤立个体数多于前者;2)上海、北京基金经理社会网络的核心子群围绕着度数中心性较高的核心个体展开,但深圳基金经理社会网络中的核心个体多为子群间的“中介人”;3)我国证券投资基金经理社会网络的整体结构极其复杂,群体间的网络复杂度和个体间的联系紧密度均较高,且基金经理的中心化程度呈纺锤形分布,极端个体数量较少.

关键词：社会网络基金经理中心性分析凝聚子群分析

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Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang fei-Fan Xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan Wang Chun-Mei Lu Meng-Meng Ge Li-yuan Hu yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

Role of micro-Ca/In alloying in tailoring the microstructural characteristics and discharge performance of dilute Mg-bi-Sn-based alloys as anodes for Mg-air batteries

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Journal of Magnesium and Alloys 2024年第1期12卷 251-266页

作者： fei-er Shangguan Wei-li Cheng Yu-hang Chen Ze-qin Cui Hui Yu Hong-xia Wang Li-fei Wang Hang Li Hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are *** grain size and texture intensity of the Mg-bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing *** that,in addition to nanoscale Mg_(3)bi_(2)phase,a new microscale Mg_(2)bi_(2)Ca phase forms in the Ca-containing *** electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical *** In to alloy the Mg-bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca *** micro-alloying of Ca/In to Mg-bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly *** In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.

关键词： Mg-air batteries Mg-bi-Sn based alloys Electrochemical behaviors Discharge properties

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新型射孔动态仿真模拟及适用性评价

煤田地质与勘探 2024年第5期52卷 67-76页

作者：毕刚元沛杰韩斐付帅帅吴捷敏马颖西安石油大学石油工程学院陕西西安710065 陕西省油气井及储层渗流与岩石力学重点实验室陕西西安710065

射孔完井技术的发展与完善对油气田的高效测试和开采具有重要的现实意义和实用价值。但低渗透储层(如低渗煤层)采用常规聚能射孔完井时,存在压实损坏带,导致渗流阻力大、产能降低等问题。为改善低渗透储层的开发效果,提出了自清洁、后... 详细信息

射孔完井技术的发展与完善对油气田的高效测试和开采具有重要的现实意义和实用价值。但低渗透储层(如低渗煤层)采用常规聚能射孔完井时,存在压实损坏带,导致渗流阻力大、产能降低等问题。为改善低渗透储层的开发效果,提出了自清洁、后效体等新型射孔技术,但其射孔效果、适用性等问题尚不明确。基于LS-DYNA的显示时间积分算法及流固耦合机理,形成地层-水泥环-套管-射孔弹动态射孔有限元模型建立方法,制定了不同射孔技术条件下动态射孔数值模拟方案,建立了不同射孔技术的有限元模型,并开展了不同射孔技术动态射孔仿真模拟研究,基于数值模拟研究结果,对2种射孔技术的适用性进行了分析研究。结果表明:自清洁和后效体射孔较常规射孔孔深有所下降,但孔径较常规射孔扩大15%左右。孔深和孔径与抗压强度、弹性模量、围压成反比,与孔隙率成正比,负压对单一射孔效果的影响较小。针对中孔低渗、低孔低渗油气藏,自清洁、后效体射孔技术孔道容积较常规分别增大9.55%、12.23%左右,射孔效果突出。上述研究结果可为自清洁与后效体射孔技术的设计与应用提供理论支撑,对两种射孔技术的发展及其对低渗储层(如低渗煤层)油气井的增产有着重要的意义。

关键词：自清洁射孔后效体射孔动态仿真 LS-DYNA 适用性分析