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A 5′tRNA-Ala-derived small RNA regulates anti-fungal defense in plants

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Science China(Life Sciences) 2022年第1期65卷 1-15页

作者： Hanqing Gu bi lian Yuxiang Yuan Ci Kong Yan Li Chang Liu Yijun Qi Center for Plant biology School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua University-Peking University Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China

Apart from their primordial role in protein synthesis,t RNAs can be cleaved to produce t RNA-derived small RNAs(ts RNAs).The biological functions of ts RNAs in plants remain largely *** this study,we developed Rtc B ligation-based small RNA(s RNA)sequencing,a method that captures and distinguishes between 3′-2′,3′-cyclic-phosphate(c P)/phosphate(P)-terminated s RNAs and 3′-OH-terminated s RNAs,and profiled 5′ts RNAs and 5′t RNA halves in Arabidopsis *** found that Arabidopsis 5′ts RNAs and 5′t RNA halves predominantly contain a c P at the 3′end and require S-like RNase 1(RNS1)and RNS3 for their *** of the most abundant 5′ts RNAs,5′ts R-Ala,by associating with AGO1,negatively regulates Cytochrome P45071 A13(CYP71 A13)expression and camalexin biosynthesis to repress anti-fungal ***,5′ts R-Ala is downregulated upon fungal *** study provides a global view of 5′ts RNAs and 5′t RNA halves in Arabidopsis and unravels an important role of a 5′ts RNA in regulating anti-fungal defense.

关键词： tRNA-derived small RNAs small RNA sequencing RNase T2 CYP71A13 disease resistance

A Highly Efficient Luminescent Metal-Organic Framework with Strong Conjugate Unit for Sensing Small Molecules

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Chinese Journal of Chemistry 2022年第11期40卷 1305-1312页

作者： bi-lian Chai Hui Xu Teng-Fei Zheng Jing-Lin Chen Sui-Jun Liu Mei-Hui Yu He-Rui Wen School of Chemistry and Chemical Engineering Jiangxi Provincial Key Laboratory of Functional Molecular Materials ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi 341000China School of Materials Science and Engineering TKL of Metal-and Molecule-Based Material Chemistry and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300350China

Luminescent metal-organic frameworks(LMOFs)have become a promising class of fluorescence sensing materials,however,the multi-responsive LMOF sensors for organic compounds are rather ***,a water stable and highly efficient luminescent MOF with the formula of{[Zn(BBZB)(2,6-NDC)]-solvents}n(JXUST-10,BBZB=4,7-bis(1H-benzimidazole-1-yl)-2,1,3-benzothiadiazole and 2,6-NDC=2,6-naphthalenedicarboxylate)was constructed by the incorporation of Zn2+and two organic ligands(BBZB and 2,6-NDC)featuring the conjugate ***-10 is a three-dimensional two-fold interpenetrated framework with good fluorescent *** on the luminescent characteristic,JXUST-10 can be used as a multi-responsive sensor for detection of three different ana-lytes including tetracycline,benzaldehyde and uric acid via different luminescent change ***,fluorescence test paper and LED light devices are used to detect analytes through the visual change of luminescence colour of JXUST-10 from blue greenish to yellow greenish under ultraviolet light(365 nm)***,the probable sensing mechanisms for three target analytes were also discussed.

关键词： Metal-organic frameworks Sensors Luminescence Red-shift emission Turn-on effect

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煤炭筛分最佳入料条件探索试验研究

煤炭加工与综合利用 2024年第1期 55-59页

作者：陈昌艳王李丹李宏伟余姣周青刘碧连六盘水师范学院矿业与机械工程学院贵州六盘水553000

为了探索煤炭入料量、水分以及粒度组成对筛分效果的影响,先采用多因素逐项试验寻找各因素较优水平,进而利用正交试验探索各因素的主次顺序、最佳水平组合。结果表明:各因素的主次顺序为:小于3 mm占比>水分>入料量。最佳水平组合为入料... 详细信息

为了探索煤炭入料量、水分以及粒度组成对筛分效果的影响,先采用多因素逐项试验寻找各因素较优水平,进而利用正交试验探索各因素的主次顺序、最佳水平组合。结果表明:各因素的主次顺序为:小于3 mm占比>水分>入料量。最佳水平组合为入料量15 kg、水分2.55%、小于3 mm占比25%,筛分效率最高达85.28%。

关键词：筛分筛分效率多因素逐项试验正交试验

基于加速康复外科理念的清单式护理在踝关节骨折患者中的应用效果

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安徽医专学报 2024年第1期23卷 60-62页

作者：闭丽连陆彩玲刘彩颜赖颖雪黄璇黄芮黄海燕广西贵港市人民医院广西贵港537100

目的:探讨基于加速康复外科理念的清单式护理在踝关节骨折患者围手术期中的应用效果。方法:选取在医院住院接受手术的156例踝关节骨折患者,按随机数表法分为两组,实验组患者(80例)采用基于加速康复外科理念的清单式护理,对照组患者(76例... 详细信息

目的:探讨基于加速康复外科理念的清单式护理在踝关节骨折患者围手术期中的应用效果。方法:选取在医院住院接受手术的156例踝关节骨折患者,按随机数表法分为两组,实验组患者(80例)采用基于加速康复外科理念的清单式护理,对照组患者(76例)采用加速康复外科的一般护理。比较两组患者术后总住院天数、功能康复训练效果和护理满意度。结果:实验组患者总住院天数明显短于对照组(P<0.05);实验组患者出院时、术后1个月及术后3个月踝关节功能评分优于对照组(P<0.05);实验组患者的满意度优于对照组(P<0.05)。结论:基于加速康复外科理念的清单式护理能明显提高ERAS效率,促进踝关节骨折患者的功能的康复,提高护理质量和护理满意度。

关键词：加速康复外科清单式护理踝关节骨折围手术期

Diagnosis and treatment of primary seminoma of the prostate:A case report and review of literature

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World Journal of Clinical Cases 2023年第10期11卷 2267-2275页

作者： Zhi-Lie Cao bi-Jun lian Wei-Ying Chen Xu-Dong Fang Hang-Yang Jin Ke Zhang Xiao-Ping Qi Department of Urology The 903^(rd)PLA HospitalHangzhou Medical CollegeHangzhou 310004Zhejiang ProvinceChina Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityEnze HospitalTaizhou Enze Medical Center(Group)Taizhou 318050Zhejiang ProvinceChina Center for Radiation Oncology Affiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou 310002Zhejiang ProvinceChina

BACKGROUND Primary seminoma of the prostate(PSP)is a rare type of extragonadal germ cell tumour that is easily misdiagnosed,owing to the lack of specific clinical *** is therefore necessary for clinicians to work toward improving the accuracy of PSP *** SUMMARY A 59-year-old male patient presenting with acute urinary retention was admitted to a local hospital.A misdiagnosis of benign prostatic hyperplasia led to an improper *** revealed PSP invading the bladder neck and bilateral seminal *** radiotherapy treatment for the local lesion was performed,and the patient had a disease-free survival period of 96 *** case was analysed along with 13 other cases of PSP identified from the *** four of the cases(28.6%)were initially confirmed by prostate *** these cases,imaging examinations showed an enlarged prostate(range 6-11 cm)involving the bladder neck(13/14).Of the 14 total cases,11(78.6%)presented typical pure seminoma cell features,staining strongly positive for placental alkaline phosphatase,CD117,and *** median age at diagnosis was 51(range 27-59)years,and patients had a median progression-free survival time of 48(range 6-156)mo after treatment by cisplatin-based chemotherapy combined with surgery or *** remaining three were cases of mixed embryonal tumours with focal seminoma,which had clinical features similar to those of pure PSP,in addition that they also had elevated serum alpha fetoprotein,beta-human chorionic gonadotropin,and lactose *** PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder *** prostate biopsies may aid in proper PSP ***-based chemotherapy is still the main primary therapy for PSP.

关键词： Prostatic neoplasms Seminoma Germ cell and embryonic neoplasms Diagnosis Case report

Plasma microRNA-15a/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma

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Liver Research 2024年第2期8卷 105-117页

作者： Huan Wei Songhao Luo Yanhua bi Chunhong Liao Yifan lian Jiajun Zhang Yuehua Huang Guangdong Provincial Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina School of Mathematics Sun Yat-sen UniversityGuangzhouChina School of Public Health Sun Yat-sen UniversityGuangzhouChina Guangdong Province Key Laboratory of Computational Science Sun Yat-sen UniversityGuangzhouChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively *** aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/16)as a biomarker of hepatitis B virus-related HCC(HBV-HCC)using the machine learning *** study was the first large-scale investigation of these two miRNAs in HCC plasma ***:Using quantitative polymerase chain reaction,we measured the plasma miR-15a/16 levels in a total of 766 participants,including 74 healthy controls,335 with chronic hepatitis B(CHB),47 with compensated liver cirrhosis,and 310 with *** diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein(AFP).Lastly,to validate the diagnostic efficiency of miR-15a/16,we performed pseudotemporal sorting of the samples to simulate progression from CHB to ***:Plasma miR-15a/16 was significantly decreased in HCC than in all control groups(Pbining miR-15a/16 with AFP increased the AUC to 0.86(sensitivity 85.9%)and the AP to 0.85 and was significantly superior to the other markers in this study(Pbited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.

关键词： Hepatitis B virus-related hepatocellular carcinoma(HBV-HCC) microRNA-15a microRNA-16-1 biomarker Machine learning Pseudotemporal ordering

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塑造纪念的时间:全球思想史视野下的帝国日

华东师范大学学报（哲学社会科学版） 2022年第4期54卷 59-68,176页

作者：朱联璧复旦大学历史学系上海200433

20世纪80年代之后出现的针对纪念日的研究,大多采取民族国家的视角,而非全球史的视角。对纪念日的研究可以也应该被纳入到全球思想史的研究范围内,这是因为纪念日从创设到实践,都会呈现不同群体对特定观念(如民族和帝国)的理解,呈现不... 详细信息

20世纪80年代之后出现的针对纪念日的研究,大多采取民族国家的视角,而非全球史的视角。对纪念日的研究可以也应该被纳入到全球思想史的研究范围内,这是因为纪念日从创设到实践,都会呈现不同群体对特定观念(如民族和帝国)的理解,呈现不同观念之间的影响。本讨论采用以“时间”为核心的分析工具,扩充现有全球史对时间问题的分析视角,以前人研究相对匮乏的帝国日作为研究对象。通过比较和分析帝国日的不同变体及其在时间上的选择,可以厘清这一组纪念日所试图传递的理念是否产生效果以及如何发挥影响,并将此作为全球思想史研究视域下的一种尝试。

关键词：帝国日全球思想史时间

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Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-like Cells Induced by Math5

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Chemical Research in Chinese Universities 2012年第6期28卷 1041-1046页

作者： WANG Hai-yan KE bi-lian SU Guan-fang XU Xun Department of Ophthalmology Shanghai First People's Hospital Affiliate of Shanghai Jiaotong University Shanghai 200080 P. R. China Department of Ophthalmology The Second Hospital of Jilin University Changehun 130041 P. R. China

We explored the appropriate inducing conditions needed to facilitate the differentiation of bone marrow mesenchymal stem cells（BMSCs） into retinal ganglion cells（RGCs）.Math5,a pro-neural basic helixloop-helix（bHLH） gene,was constructed in an adenoviral vector and then infected into the 3rd passage *** inverted fluorescence microscope was used to observe the morphological changes of the infected *** expressions of Math5,the neuromarkers neuron-specific enolase（NSE）,neurofilament（NF）,Thy1.1,and the RGC-related genes GAP-43 and Brn3b were examined by Western blot and reverse transcription-polymerase chain reaction（RT-PCR）.The results show that cells infected with Math5 adenoviral vector were able to stably express Math5 and presented with a typical morphology of ***,these cells expressed NSE,NF,Thy1.1,and *** the synergistic induction conditions of retinal conditioned differentiation medium in combination with epidermal growth factor（EGF） and basic fibroblast growth factor（BFGF）,BMSCs infected with Math5 adenoviral vector had a more typical morphology of RGCs,with a greater number of longer axons that connected with each other and formed a *** addition,the number of NF positive cells was higher,the expression of Brn3b was detected,and the expressions of NSE,NF,and GAP-43 were significantly up-regulated compared to those of them in the *** results indicate that BMSCs infected with Math5 are able to differentiate into retinal ganglion-like ***,Math5 is a stronger activator of the downstream gene Brn3b than the cytokine,which suggests that it is possible to regulate the survival and axon path determination of these differentiated cells.

关键词： Bone marrow mesenchymal stem cells Math5 Brn3b Retinal ganglion cell

Size Effects for the Adsorption of Alkali Metal Atoms on the Si(001) Surface

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Chinese Journal of Structural Chemistry 2015年第6期34卷 837-852页

作者： NI bi-lian HU Jian-Ming ZHAO Yong-Gang LI Yi Department of Basic Chemistry College of PharmacyFujian Medical University College of Chemistry Fuzhou University Command Academy of Fuzhou the Chinese People's Armed Police Force

The adsorptions of a series of alkali metal （AM） atoms, Li, Na, K, Rb and Cs, on a Si（001）-2 × 2 surface at 0.25 monolayer coverage have been investigated systematically by means of density functional theory calculations. The effects of the size of AM atoms on the Si（001） surface are focused in the present work by examining the most stable adsorption site, diffusion path, band structure, charge transfer, and the change of work function for different adsorbates. Our results suggest that, when the interactions among AM atoms are neglectable, these AM atoms can be divided into three classes. For Li and Na atoms, they show unique site preferences, and correspond to the strongest and weakest AM-Si interactions, respectively. In particular, the band structure calculation indicates that the nature of Li-Si interaction differs significantly from others. For the adsorptions of other AM atoms with larger size （namely, K, Rb and Cs）, the similarities in the atomic and electronic structures are observed, implying that the atom size has little influence on the adsorption behavior for these large AM atoms on the Si（001） surface.

关键词： size effects adsorption alkali metal atoms Si(001) surface