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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 573-580页

作者： Shyamapada Mandal Manisha Deb Mandal Nishith kumar pal Department of Zoology Gurudas CollegeNarkeldangaKolkata-700 054India Department of Physiology and Biophysics KPC Medical College and Hospital1F Raja S C Mallick RoadJadavpurKolkata-700032India Department of Microbiology Institute of Post Graduate Medical Education and Research244B A J C Bose RoadKolkata-700 020India

Cholera,caused by the infection of toxigenic Vibrio cholerae(***) to humans,is a life threatening diarrheal disease with epidemic and pandemic *** ***,both 01 and 0139 serogroups,produce a potent enterotoxin(cholera toxin) responsible for the lethal symptoms of the *** O1 serogroup has two biotypes(phenotypes),classical and El Tor;each of which has two major serotypes(based on antigenic responses),Ogawa and Inaba and the extremely rare *** O1 strains interconvert and switch between the Ogawa and Inaba *** and electrolyte replacement is the mainstay of treatment of cholera patients;the severe cases require antibiotic treatment to reduce the duration of illness and replacement of fluid *** antibiotic therapy cunenlly has faced difficulties due to the rapid emergence and spread o(multidrug resistant *** causing several outbreaks in the ***,cholera has been becoming endemic in an increasing number of geographical areas,reflecting a failure in implementation of control ***,the current safe oral vaccines lower the number of resistant infections and could thus represent an effective intervention measure to control antibiotic resistance in ***,the priorities for cholera control remain public health interventions through improved drinking water,sanitation, surveillance and access to health care facilities,and lurther development of safe,effective and appropriate ***,this review describes the facts and phenomena related to the disease cholera,which is still a great threat mainly to the developing countries,and hence a grave global concern too.

关键词： Cholera Toxigenic Vibrio cholerae Pandemics-epidemics-outbreaks Cholera vaccine Multidrug resistance

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Recent advances in assessment of soil erosion vulnerability in a watershed

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International Soil and Water Conservation Research 2021年第3期9卷 305-318页

作者： Shachi Pandey Parmanand kumar Miodrag Zlatic Raman Nautiyal Vijender pal Panwar Forest Ecology and Climate Change Division Forest Research InstituteDehradunIndia Faculty of Forestry Belgrade UniversityBelgradeSerbia Indian Council of Forestry Research and Education India

Soil erosion is one of the most critical hazards adversely affecting both environment and *** of the annual soil erosion rate provides information on soil erosion risk zones indicating the areas with high,severe and low *** and prediction of soil erosion has a long history of more than seven *** becomes imperative to be familiar with the quantum of studies conducted and methods employed across the world to assess vulnerability of ecosystems to soil erosion to plan strategies for their *** are several methods based on various factors like land use,soil quality,topography *** to assess the susceptibility of a region to soil *** time the gap in understanding of such models and their use around the world has *** models for assessing soil erosion exist but there is a lack of knowledge on spatial distribution of the methods being *** papers related to assessment of soil erosion vulnerability published during the past three decades(1991—2019)were *** 160 studies were reviewed to understand advances in the methods used to assess soil erosion vulnerability worldwide,identification of the most popular methods and proportion of studies conducted in the fragile region of *** results show that 18 different methods have mainly been used to assess soil erosion risk in different *** methods include statistical,physical,process based and empirical *** use of few physical methods like ANSWERS and SHE has decreased with time while that of physical and process methods like RUSLE,SWAT,WEPP and PESERA has increased with *** review highlighted that various models being used worldwide are based on their suitability to the *** also brings to attention that few models like PESERA,EUROSEM and WEPP are mostly being used concentrated in a particular *** like PESERA and EPM are mostly used in European region and may be encouraged to estimate soil er

关键词： Soil erosion vulnerability RUSLE MCDM

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Multi-response optimization of process parameters in friction stir welded AM20 magnesium alloy by Taguchi grey relational analysis

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Journal of Magnesium and Alloys 2015年第1期3卷 36-46页

作者： Prakash kumar Sahu Sukhomay pal Department of Mechanical Engineering Indian Institute of Technology Guwahati781039 AssamIndia

The purpose of this paper is to optimize the process parameter to get the better mechanical properties of friction stir welded AM20 magnesium alloy using Taguchi Grey relational analysis(GRA).The considered process parameters are welding speed,tool rotation speed,shoulder diameter and plunging *** experiments were carried out by using Taguchi's L18 factorial design of *** processes parameters were optimized and ranked the parameters based on the *** percentage influence of each process parameter on the weld quality was also quantified.A validation experimental run was conducted using optimal process condition,which was obtained from the analysis,to show the improvement in mechanical properties of the *** study also shows the feasibility of the GRA with Taguchi technique for improvement in welding quality of magnesium alloy.

关键词： Friction stir welding Magnesium alloy Tensile strength Bending strength Micro-hardness Optimization Taguchi Grey relational analysis

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Enhancing chloramphenicol and trimethoprim in vitro activity by Ocimum sanctum Linn.(Lamiaceae) leaf extract against Salmonella enterica serovar Typhi

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 220-224页

作者： Shyamapada Mandal Manisha Deb Mandal Nishith kumar pal Department of Microbiology Bacteriology and Serology UnitCalcutta School of Tropical MedicineC.R.AvenueKolkata-700073India Department of Physiology and Biophysics KPC Medical College and HospitalJadavpurKolkata-700032India

Objective:To evaluate the antibacterial activity of Ocimum sanctum(***) leaf extract, alone,and in combination with chloramphenicol(C) and trimethoprim(Tm) against Salmonella enterica serovar Typhi(***).Methods:The antibacterial activity of ethanolic extract of tulsi, ***,leaf(TLE:500μg) for 23 *** isolates was determined following agar diffusion. The C(30μg) and Tm(5μg) activity alone and in combination with TLE(250μg) was determined by disk *** zone diameter of inhibition(ZDI) for the agents was recorded, and growth inhibitory indices(Glls) were ***:The *** isolates(n=23),which were resistant to both C(ZDI 6 mm) and Tm(ZDI 6 mm),had TLE(500μg) ZDIs 16-24 *** ZDIs of C and Tm were increased up to 15-21 mm and 17-23 mm,respectively,when TLE(250μg) was added to the C and Tm *** Glls ranged 0.789-1.235 and 0.894-1.352,due to combined activity against *** isolates,of C and TLE and Tm and ***:The data suggest that TLE,in combination with C and Tm,had synergistic activity for *** isolates, and hence *** is potential in combating *** drug resistance,as well promising in the development of non-antibiotic drug for *** infection.

关键词： Antibacterial activity Ocimum sanctum Chloramphenicol Trimethoprim Growth inhibitory index Synergy Salmonella enterica serovar Typhi

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Recent advances on pathogenesis,diagnosis,prevention,immunological aspects,and vectors of dengue:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 325-338页

作者： Mahesh Chandra Sahu Rakesh kumar Samantaray Aditi pal Sanghamitra Pati Division of Medical Entomology ICMR-Regional Medical Research CentreChandrasekharpurBhubaneswar-751023OdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023OdishaIndia

Dengue is a vector-borne disease caused by the dengue virus(DENV)of family *** fever is common in both developed and developing ***,approximately 400 million cases of dengue fever are reported annually,resulting in approximately 22000 *** cases in India have progressively increased in the last *** recent years,substantial progress has been made in understanding various aspects of dengue,including its pathogenesis,diagnosis,prevention strategies,immunological responses,and the role of vectors in its *** transmission of a positive RNA virus occurs through Aedes mosquitoes,specifically Aedes aegypti and Aedes *** virus is associated with a wide spectrum of symptoms,ranging from mild undifferentiated fever to severe hemorrhagic fever and shock,posing a potential threat to human *** are 4 types of antigenically distinct dengue serotypes(DENV-1 to DENV-4)and among them,DENV-2 is more lethal and extremely *** overcome the severity of dengue,Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue *** diagnosis of dengue is carried out by ELISA-based non-structural protein(NS1)and immunoglobulin ***,there are no specific biomarkers to identify severe disease *** factors and temperature play an important role in complex interaction among host,vector,and virus to manifest the severity of *** is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of *** mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans.

关键词： Dengue Aedes mosquitoes Insecticide NS1 Immunoglobulin

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COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

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Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny kumar Malini Basu Pratyasha Ghosh Uttam pal Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

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Synergistic anti - Staphylococcus aureus activity of amoxicillin in combination with Emblica officinalis and Nymphae odorata extracts

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 711-714页

作者： Shyamapada Mandal Manisha DebMandal Nishith kumar pal Krishnendu Saha Department of Microbiology Bacteriology and Serology UnitCalcutta School of Tropical MedicineC.R.AvenueKolkata-700 073India Department of Physiology and Biophysics KPC Medical College and Hospital1F Raja S C Mallick RoadJadavpurKolkata-700 032India

Objective:To evaluate the antibacterial activity of Emblica officinalis Gaertn(***: Family:Euphorbiaceae) seed and Nymphae odorala Aiton(***:Family:Nymphaeaceae) stamen extracts,alone and in combination,and in combination with amoxicillin(Ax) against Staphylococcus aureus(***).Methods:Antibacterial activity of ethanolic extracts of amla,***,seed(AMS:500μg) and sapla,***,stamen(SAP:500 p g) for 12 methicillin-resistant ***(MRSA) isolates was determined following agar diffusion:in order to assess the combined antibacterial activity,AMS(250μg) plus SAP(250μg) were *** Ax(10μg) activity alone and in combination with AMS(250μg),and SAP(250μg) was determined by disk *** zone diameters of inhibition(ZDIs) for the agents were recorded,and growth inhibitory indices(GIIs) were ***:The MRSA isolates (n=12) had AMS(500μg) and SAP(500μg) ZDIs of 12-19 mm and 21-24 mm,*** ZDIs(range 24-27 mm) increased by 3-4 mm due to combined action of AMS(250μg) and SAP(250μg) indicating synergy between extracts for MRSA(GII 0.634-0.742).The MRSA isolates were resistant to Ax(ZDI:8-11 mm),which in combination with AMS and SAP had synergistic effect,both due to increased ZDI[mean±SD=(3.5±0.577) mm]and GII(0.631-0.894).Conclusions:The data suggest that the plants,*** and *** alone or in combination,are promising in the development of phytomedicines,which may be used,alone or in combination with the antibiotic. Ax,against MRSA infection.

关键词： Antibacterial activity Plant extract Amoxicillin Emblica officinalis Nimphae odorata Synergy MRSA

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Enhanced electrical conductivity in Zr-Doped(La_(0.7)Ba_(0.3))(Mn_(0.5)Fe_(0.5))O_(3)solid solutions

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Journal of Advanced Dielectrics 2020年第6期10卷 61-68页

作者： Yogesh kumar Jaswinder pal Parambir Singh Malhi Rakesh kumar CT University Sidhwan Khurd LudhianaPunjab 142024India Department of Physics Baba Farid College(Affiliated to Punjabi UniversityPatiala)BathindaPunjab 151001India Department of Chemistry Guru Nanak Dev University AmritsarPunjab 143005India Ludhiana Group of Colleges Chokimann LudhianaPunjab 142001India

The perovskite(La_(0.7)Ba_(0.3))(Mn_(0.5)Fe_(0.5))_(1−x)Zr_(x)O_(3),where x=0.1,0.2 and 0.3,ceramics were synthesized by solid-state reaction *** introductory structural studies were followed through by X-ray diffraction technique and the results have disclosed that all the samples were crystallized into an isolated *** Zr substitution in the resulting solid solutions increases the electrical conductivity and the maximum value of ac conductivity has been found to be~118.8 ***^(−1)for x=0.3 at 200°C(at 1 MHz).The frequency dependence of ac conductivity data follows Jonscher’s power *** variation of the exponent n versus temperature follows the nonoverlapping small polaron tunneling(NSPT)*** dielectric relaxation has been observed to be of non-Debye nature for all measuring temperatures(50-200°C).The impedance spectroscopy reveals that all the samples exhibit negative temperature coefficient of resistance(NTCR)*** prepared samples(for x>1)are supposed to be suitable for cathode materials in SOFCs.

关键词： SOFC perovskite X-Ray Diffraction(XRD) ac conductivity dielectric

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Antibacterial activity of honey against clinical isolates of Escherichia coli,Pseudomonas aeruginosa and Salmonella enterica serovar Typhi

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 961-964页

Objective:To ascertain the potential antibacterial activity of honey against clinical isolates of Escherichia coli(***),Pseudomonas aeruginosa(***) and Salmonella enterica serovar Typhi(*** serovar Typhi) by in vitro ***:The partial inhibitory concentration(PIC),minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC) values of the autoclaved honey(extracted from Apis indica hive by indigenous method) were determined for *** serovar Typhi(n=8:from blood cultute), ***(n=5:from urine culture) and ***(n=5:from pus culture) isolates by in vitro ***:The PICs of the honey tested for the isolates ranged 0.50%-1.25%(v/v) for S. enterica serovar Typhi,0.75%-1.50%(v/v) for *** and 1.00%-1.25%(v/v) for ***, while the MICs ranged 1.75%-3.00%(v/v),3.00%-3.50%(v/v) and 3.50%(v/v),*** *** and *** isolates had MBC value of 4.00%(v/v):the *** serovar Typhi showed MBCs in between 3.00%and 3.50%(v/v).The bactericidal activity of honey was achieved at concentration 3.00%(v/v) for *** serovar Typhi and ***,and at 3.50%(v/v) for P. ***:The excellent antibacterial activity of honey against clinical bacterial isolates indicates the usefulness of honey in clinical practice against bacterial infection.

关键词： Partial inhibitory concentration Minimum inhibitory concentration Minimum bactericidal concentration Honey Clinical bacteria

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Separation Behaviour of Iron Ore Fines in Kelsey Centrifugal Jig

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Journal of Minerals and Materials Characterization and Engineering 2013年第3期1卷 85-89页

作者： Nirlipta P. Nayak bhatu K. pal Department of Mining Engineering National Institute of Technology Rourkela India

Kelsey Centrifugal Jig was found to be promising for the beneficiation of fine iron particles. The present study was carried out to have a better understanding of the separation process of Kelsey Jig through detailed experimentation. Beneficiation of fine iron ore fines was studied in Kelsey Jig. A constant pulp density (25% solids) of the feed slurry was maintained in the study. The feed rate was also kept constant at 60 kg/hr (dry solids basis). Magnetite of size -0.853+0.6 mmwas used as ragging material to avoid the pegging of internal screen having an opening of 425 μm. The rotational speed was found to have significant effect on the depth of the ragging bed and its porosity. Pulsation was identified as the key factor in stratifying the iron bed and defining the misplacement as well as ragging bed porosity, influencing the mass yield and quality of product.

关键词： EGS Ragging Material Beneficiation

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