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Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity

World Journal of Gastroenterology 2022年第25期28卷 2802-2822页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma manojit bhattacharya Kuldeep Dhama Sang-Soo Lee School of Life Science and Biotechnology Adamas UniversityKolkata 700126India Institute for Skeletal Aging&Orthopaedic Surgery Hallym UniversityChuncheon-si 24252South Korea Department of Zoology Fakir Mohan UniversityBalasore 756020India Division of Pathology Indian Council of Agricultural Research(ICAR)-Indian Veterinary Research Institute(IVRI)Bareilly 243122Uttar PradeshIndia Institute for Skeletal Aging&Orthopedic Surgery Hallym UniversityChuncheon-si 24252South Korea

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune *** alterations include decreased levels of beneficial bacteria and augmentation of opportunistic ***,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)*** include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung ***,we have illustrated the hypoxia state in COVID-19 associated gut microbiota *** role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 ***,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe *** clinical trials to understand the role of probiotics in COVID-19 patients are listed in this *** inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease ***,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment.

关键词： COVID-19 Inflammation Gut microbiota Therapeutic

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PPARγLBD and its ligand specificity reveal a selection of potential partial agonist:Molecular dynamics based T2D drug discovery initiative

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BIOCELL 2021年第4期45卷 953-961页

作者： BIDYUT MALLICK ASHISH RANJAN SHARMA manojit bhattacharya SANG-SOO LEE CHIRANJIB CHAKRABORTY Department of Applied Science Galgotias College of Engineering and TechnologyKnowledge Park-IIGreater Noida201306India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityVyasa ViharBalasore756020India Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityKolkata700126India

PPARγis a peroxisome proliferator-activated receptor(PPAR)family protein and is a target for type 2 diabetes(T2D).In this paper,we have performed a molecular docking analysis between ligand molecules(CID9816265,CID11608015,CID20251380,CID20251343,CID20556263,CID624491,CID42609928,and CID86287562)and PPARγto determine the ligand *** also helps to understand the ligand-binding domain(LBD)activity of PPARγduring the binding of the ***,a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ*** ligand specificity informed us about the potentiality of selecting a partial *** study also shows the binding conformation of Ceramicine B having hydrogen bonding affinity with a tricyclic polar head and stabilized theβ-sheet *** the other hand,the tricyclic polar head of nimbolide also formed hydrogen bonding(Ser342),but it shows a lesser degree of stabilization in theβ-sheet *** shows the binding conformation of partial agonist(PPARγ)in the Pocket-II of PPARγLBD,which has a significant role in stabilizing theβ-sheet *** might help to regulate ERK/Cdk5 mediated phosphorylation of *** study helps us understand the valid pose of a set of ligands confirmation and target protein conformation using docking and molecular dynamics *** in silico study will also help to initiate a drug discovery process of T2D.

关键词： PPARγ Partial agonist Molecular simulation T2D Drug discovery

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The 2019 novel coronavirus disease(COVID-19) pandemic: A zoonotic prospective

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Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 242-246页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma manojit bhattacharya Garima Sharma Sang-Soo Lee Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityBarasat-Barrackpore RdKolkataWest Bengal 700126India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Gangwon-doRepublic of Korea Neuropsychopharmacology and Toxicology Program College of PharmacyKangwon National UniversityRepublic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),a novel coronavirus(CoV),has recently emerged as a significant pathogen for humans and the cause for the recent outbreak of the 2019 novel coronavirus disease(COVID-19)throughout the *** developing any preventive measure,an understanding of the zoonotic pattern for this virus is a *** should have a clear knowledge of its reservoir host,its distribution pattern and spreading *** about zoonotic reservoirs and its transmission among them can help to understand the COVID-19 *** this article,we discuss about the bats as the zoonotic reservoir of several CoV strains,co-existence of bats and CoV/viruses,the sequence similarity of SARS-CoV-2 with bat SARS-like CoV,the probable source of the origin of SARS-CoV-2 strain and COVID-19 outbreak,intermediate host of CoVs and SARS-CoV-2,human to human transmission and the possibility to maintain the zoonotic *** knowledge about the zoonotic reservoir of SARS-CoV-2 and its transmission ability may help develop the preventive measures and control for the future outbreak of CoV.

关键词： SARS-CoV-2 COVID-19 Coronavirus Zoonotic reservoir

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The bacteriophage mu lysis system–A new mechanism of host lysis?

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BIOCELL 2021年第5期45卷 1175-1186页

作者： SAIKAT SAMANTA ASHISH RANJAN SHARMA ABINIT SAHA MANOJ KUMAR SINGH ARPITA DAS manojit bhattacharya RUDRA PRASAD SAHA SANG-SOO LEE CHIRANJIB CHAKRABORTY Department of Biotechnology School of Life Science&BiotechnologyAdamas UniversityKolkata700126India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityBalasore56020India

Bacteriophages are viruses that infect bacteria and can choose any one of the two alternative pathways for infection,i.e.,lysis or *** lysis is one of the conventional biological processes required to spread infection from one bacterium to *** analysis suggests that in the paradigm bacteriophage Mu,six proteins might be involved in host cell *** has a broad host range,and Mu-like phages were found in both Gram-negative and Gram-positive *** analysis of the genomes of Mu and Mu-like phages could be useful in elucidating the lysis mechanism in this group of phages.A detailed review of the various mechanisms of phage lysis and different proteins associated with the process will help researchers understand the phage biology and their life cycle in different *** recent increase in the number of multidrug-resistant(MDR)strains of bacteria and the usual long-term nature of new drug development has encouraged scientists to look for alternative strategies like phage therapy and the discovery of new lysis *** the lysis mechanism in the Mu-like phages could be exploited to develop alternative therapeutics to kill drug-resistant pathogenic *** this review article,we have analyzed the phage Mu-mediated host lysis system,which is unknown till now,and our analysis indicates a possibility of the existence of a new lysis mechanism operating in Mu.

关键词： Bacteriophage Mu Host cell lysis Endolysin Holin Spanin

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Human health implications of emerging diseases and the current situation in India's vaccine industry

Science in One Health

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Science in One Health 2023年第1期2卷 100046页

作者： Behera, Jiban Kumar Mishra, Pabitra Jena, Anway Kumar Behera, Bhaskar bhattacharya, manojit Department of Zoology Fakir Mohan University Vyasa Vihar Odisha Balasore 756020 India Department of Biosciences and Biotechnology Fakir Mohan University Vyasa Vihar Odisha Balasore 756020 India

Emerging diseases are infectious diseases that pose significant threat to human health, causing millions of deaths and disabilities in the upcoming days. Periodic epidemics of new infections and old reinfections increase the global burden of disease prevalence. They can be caused by new pathogens or evolving ones, which change human behavior and environmental factors. Researchers have studied the dynamic connections between microbes, hosts, and the environment, but new infectious diseases like coronavirus disease 2019 (COVID-19), re-emerging diseases, and deliberately disseminated diseases persist despite earlier hopes of elimination. With heavy privatesector investments, Indian pharmacology now provides core Expanded Programme on Immunization vaccines to United Nations International Children's Emergency Fund, producing previously unattainable vaccines for diseases like meningitis, hepatitis B, pneumococcal conjugate, rotavirus, influenza A (H1N1), and COVID-19. India's vaccine sector has emerged, among the oriented leaders of the Bharat Biotech, Serum Institute of India, Panacea Biotech and Biological E. Specifically, the technology transferred from Western countries has benefited the sector, which produces 1.3 billion doses annually. The Serum Institute is the world's largest manufacturer of vaccines, providing measles and diphtheria-tetanus-pertussis vaccines to United Nations. The Serum Institute has developed several vaccines, including Nasovac, MenAfriVac, Pentavac, and an inactivated polio vaccine. India's success in vaccinations can be attributed to attractive investment conditions, government assistance, international alliances, and rising domestic technical talent. Despite its booming economy and technical advances, India's disproportionate share of the world's child mortality rate remains unchanged. However, the growing production and distribution of vaccinations in developing nations has initiated a new era, leading to a worldwide decline in childhood de

关键词： Emerging diseases Human health India Pharmacology Vaccine

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pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

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Nano Research 2019年第1期12卷 49-55页

作者： Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu manojit Pramanik Bengang Xing Division of Chemistry and Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637459Singapore School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable ***,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and ***,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(*** pH5)in mice with higher signal-to-noise *** CTN is biodegradable under physiological conditions(*** 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in *** results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.

关键词： charge-transfer nanocomplex second near-infrared window photoacoustic imaging pH-sensitive biodegradable tumor acidic microenvironment

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Polyester-tethered near-infrared fluorophores confined in colloidal nanoparticles:Tunable and thermoresponsive aggregation and biomedical applications

Aggregate

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Aggregate 2023年第2期4卷 193-205页

作者： Cangjie Yang Wei Zhang Xin Pang Fan Xiao Sandeep Kumar Kalva Yipeng Zhang manojit Pramanik Leilei Tian Gang Liu Mingfeng Wang School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingaporeSingapore School of Science and Engineering The Chinese University of Hong KongShenzhenChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamenChina School of Materials Science and Engineering South University of Science and TechnologyShenzhenChina Institute of Pharmacology and Toxicology and Institute of Biomedical Engineering Faculty of MedicineUniversity of ZurichZurich CH-8057Switzerland

Intricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light-harvesting complexes of the photosynthetic systems in ***,it remains a challenge to achieve such structural complexity and functionality in synthetic polymer-chromophore ***,we report a series of polyester-tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water,which show tunable J-or H-aggregation excitonic coupling and near-infrared fluorescence by precise control of the polymer chain lengths,composition,and ***,the optimal fluorescence or photothermal effect of the Jaggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy.

关键词： bioimaging colloids fluorescence polymers self-assembly

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In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

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Science China Materials 2016年第11期59卷 892-900页

作者： Malathi Mathiyazhakan Paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani Praveen Kumar Vemula 邹培超浦侃裔杨诚 manojit Pramanik 徐臣杰 School of Chemical&Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore Institute for Stem Cell Biology and Regenerative Medicine(inStem) GKVK-CampusBellary RoadBangaloreIndia Ramalingaswami Re-Entry Fellow Department of BiotechnologyNew Delhi 110003India Division of Energy&Environment Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China NTU-Northwestern Institute for Nanomedicine Nanyang Technological University50 Nanyang AvenueSingapore

This report describes the design and synthesis of gold nanostars(AuNSs) containing liposomes by the in situ reduction of gold precursor,HAuCU(pre-encapsulated within the liposomes) through HEPES diffusion and *** with the conventional process that encapsulates the pre-synthesized gold nanoparticles into liposomes during the thin-film hydration step,this facile and convenient method allows the formation and simultaneous encapsulation of AuNSs within *** absorption spectra of AuNSs can be tuned between visible and near infra-red(NIR) regions by controlling the size and morphology of AuNSs through varying the concentrations of HAuCU and *** a proof of concept,we demonstrate the synthesis of AuNSs with a maximum absorbance at 803 nm within the temperature-sensitive *** liposomes can produce stronger photoacoustic signals(1.5 fold) in the NIR region than ***,when there are drugs(i.e.,doxorubicin) within these liposomes,the irradiation with the NIR pulse laser will disrupt the liposomes and trigger the 100%release of these pre-encapsulated drugs within 10 *** comparison,there is neglectable contrast enhancement or minor release(10%) of drugs for the pure liposomes under the same ***,cell experiment shows the potential therapeutic application of this system.

关键词： gold nanostars light sensitive liposomes controlled drug release photoacoustic imaging

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用钯催化含双亚乙基的环状化合物合成2—苯并[C]呋喃酮的方法

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河南大学学报（医学版） 1995年第1期20卷 66-68页

作者： Nitya G.kundu manojit Pal 王保真

含有2—苯并[C]呋喃环的化合物是许多已知的天然物质的成分。2—苯并[C]呋喃还可以作为合成具有复杂结构的几种天然产品的中间体。我们已经掌握了合成含有2—苯并[C]呋喃结构的化合物的许多方法,最近,用钯催化碳环和杂环化合物的反应已... 详细信息

含有2—苯并[C]呋喃环的化合物是许多已知的天然物质的成分。2—苯并[C]呋喃还可以作为合成具有复杂结构的几种天然产品的中间体。我们已经掌握了合成含有2—苯并[C]呋喃结构的化合物的许多方法,最近,用钯催化碳环和杂环化合物的反应已经引起了世界范围的兴趣。然而,以含双亚乙基的杂环化合物为中间体,通过钯试剂催化合成含2—苯并[C]呋喃结构的化合物的合成法,还尚未有报道。由于我们的兴趣在有可能具有抗癌和抗病毒作用的试剂,所以,我们关心的是正在发展中的合成杂环的几种方法。在钯催化的反应中。

关键词：钯催化环状化合物亚乙基呋喃酮杂环化合物催化剂二聚作用苯并乙基胺中间体

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