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SYMPLICITY HTN-3：射频消融去肾交感神经术不能有效降低难治性高血压患者的血压

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中华高血压杂志 2014年第5期22卷 487-488页

作者： bhatt dl Kandzari DE O'Neill WW 张刘锋叶鹏机构不详

编者按:自从Schlaich博士等首次报道了一例经皮经导管射频消融去肾交感神经术(RDN)治疗使患者血压从161/107降至127/81mm Hg的病例后,医学界开始对RDN趋之若鹜。SYMPLICITY HTN-1和HTN-2研究结果表明,RDN治疗可以显著降压,似乎证明了该... 详细信息

编者按:自从Schlaich博士等首次报道了一例经皮经导管射频消融去肾交感神经术(RDN)治疗使患者血压从161/107降至127/81mm Hg的病例后,医学界开始对RDN趋之若鹜。SYMPLICITY HTN-1和HTN-2研究结果表明,RDN治疗可以显著降压,似乎证明了该手术的安全有效性。但最近SYMPLICITY HTN-3研究结果的发表使得这股热浪"戛然而止"。SYMPLICITY HTN-3是一项前瞻性、双盲、随机、假手术对照试验,研究结果显示,术后6月,RDN组与假手术组的诊室收缩压和动态收缩压变化值差异均无统计学意义。这一结论与大多数已发表的关于RDN的研究结论相反。可见RDN作为难治性高血压的一种治疗方法,仍有许多问题悬而未决,有必要进行深入研究。

关键词：经导管射频消融高血压患者难治性高血压经术交感治疗方法肾安全有效性

Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

Evaluation of Human Impacts on Bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. bhatt Amede Rubio Ganesh B. Malla Cristobal Lopez Virginia Morales Erick Vazquez Cano David Marquez Orlando Berumen Alvarez Alfred Addo-Mensah Department of Biology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within Bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

醛固酮合酶抑制剂baxdrostat治疗难治性高血压的2期试验

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中华高血压杂志 2023年第7期31卷 699-699页

作者：刘青(译) 练桂丽(审) 不详

醛固酮合酶控制醛固酮的合成,几十年来一直是治疗高血压的药物靶点。选择性抑制醛固酮合酶是必要的,但很难实现,因为皮质醇的合成是由另一种与醛固酮合酶具有93%序列相似性的酶催化的。在临床前和1期研究中,baxdrostat对酶抑制的选择性... 详细信息

醛固酮合酶控制醛固酮的合成,几十年来一直是治疗高血压的药物靶点。选择性抑制醛固酮合酶是必要的,但很难实现,因为皮质醇的合成是由另一种与醛固酮合酶具有93%序列相似性的酶催化的。在临床前和1期研究中,baxdrostat对酶抑制的选择性为100:1,在几个剂量水平下,baxdrostat降低血浆醛固酮水平,但未降低皮质醇水平。

关键词：醛固酮合酶难治性高血压剂量水平皮质醇水平选择性抑制药物靶点治疗高血压酶抑制

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妊娠期高血压疾病对远期心血管病的影响

中华高血压杂志 2020年第2期28卷 123-123页

作者：周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D bhatt dl Scott NS Peloso GM Natarajan P 不详

对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年... 详细信息

对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。

关键词：妊娠期高血压疾病动脉硬度心血管病活产无创性无症状 pregnancy 纳入标准

Immunotherapy for recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第15期29卷 2261-2271页

作者： Ahan bhatt Jennifer Wu Division of Hematology and Oncology Perlmutter Cancer Center of NYU Langone HealthNYU School of MedicineNew YorkNY 10016United States

Hepatocellular carcinoma(HCC)is presented frequently in late stages that are not amenable for curative *** for patients who can undergo resection for curative treatment of HCC,up to 50%*** patients who were not exposed to systemic therapy prior to recurrence,recurrence frequently cannot be subjected to curative therapy or local *** patients have several options of immunotherapy(IO).This includes programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte associated protein 4 treatment,combination of PD-1 and vascular endothelial growth factor inhibitor or single agent PD-1 therapy when all other options are deemed *** are also investigational therapies in this area that explore either PD-1 and tyrosine kinase inhibitors or a novel agent in addition to PD-1 with vascular endothelial growth factor *** minireview explored IO options for patients with recurrent HCC who were not exposed to systemic therapy at the initial *** also discussed potential IO options for patients with recurrent HCC who were exposed to first-line therapy with curative intent at diagnosis.

关键词： Liver neoplasms Immune checkpoint blockade Combination drug therapy PD-1-PD-L1 blockade CTLA-4 inhibitor

CHARISMA试验:阿司匹林与氯吡格雷联合阿司匹林预防动脉粥样硬化事件的对照研究

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中国现代神经疾病杂志 2009年第1期9卷 102-102页

作者： bhatt dl Fox KA Hacke W 王蔚不详南京医科大学第一附属医院神经内科 210029

CHARISMA（Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events）试验旨在比较阿司匹林单药治疗与阿司匹林和氯吡格雷联合治疗预防动脉粥样硬化事件的疗效。有26个国家参与了该项研究，共纳... 详细信息

CHARISMA（Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events）试验旨在比较阿司匹林单药治疗与阿司匹林和氯吡格雷联合治疗预防动脉粥样硬化事件的疗效。有26个国家参与了该项研究，共纳入15603例≥45岁受试者，均符合下列条件：具有动脉粥样硬化多种危险因素，或具有明确的冠心病、脑血管疾病及症状性外周动脉疾病。

关键词：动脉粥样硬化阿司匹林氯吡格雷预防试验 Prevention Aspirin 外周动脉疾病

溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响

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中华高血压杂志 2017年第4期25卷 328-328页

作者：刘莉叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD bhatt dl Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE

尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂（阿替普酶）溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。

关键词：脑卒中治疗溶栓时间阿替普酶美国心脏协会溶栓适应证时间延迟颅内出血

非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系

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中华高血压杂志 2018年第2期26卷 118-118页

作者：刘青叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF bhatt dl Peterson ED Fonarow GC

尽管非维生素K拮抗口服抗凝剂（non-vitamin K antagonist oral anticoagulants, NOACs）越来越多地应用于预防血栓栓塞性疾病，但关于NOACs相关性脑出血的数据仍然有限。

关键词：脑出血患者口服抗凝剂维生素K 住院死亡拮抗血栓栓塞性疾病相关性