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A review of ecological risk assessment and associated health risks with heavy metals in sediment from India

International Journal of Sediment Research 2020年第5期35卷 516-526页

作者： Vinod Kumar Anket Sharma Shevita Pandita renu bhardwaj Ashwani Kumar Thukral Artemi Cerda Department of Botany Government Degree College Ramban State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture & Forest University Department of Botany University of Jammu Department of Botanical and Environmental Sciences Guru Nanak Dev University Soil Erosion and Degradation Research Group Department of GeographyUniversity of Valencia

Heavy metal(HM) pollution in sediment is a serious concern particularly in developing nations,warranting an extensive survey to understand the current situation and propose possible remedial *** paper compiles the data of HMs cadmium(Cd),iron(Fe),cobalt(Co),manganese(Mn),arsenic(As),lead(Pb),chromium(Cr),copper(Cu),zinc(Zn) and nickel(Ni) in aquatic sediment from India from 1979 to *** was found that mean values of Cu,Co,Zn,Pb,As,and Cr in Indian sediment were high in comparison to the Australian Interim Sediment Quality Guidelines,World Surface Rock Average,and the Threshold Effect Level for freshwater *** activities,lithogenic factors,and sand intrusion are the main factors associated with HM pollution as observed using cluster analysis and principal component *** results of contamination indices indicate that HM contamination ranged from average to high,in the *** ecological risk assessment results showed that 11%HMs present very high *** cancer risk,due to the high contents of Cd,As,and Cr the ingestion pathway,showed high risk of cancer through food/water contaminated with *** source reduction of HMs in industrial effluents by effluent treatment plants,and plantation of phytoremediating rooted macrophytes in sediment may help in HM mitigation of the sediment.

关键词： Sediments Heavy metal pollution Ecological risk assessment Cancer risk Health risk

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Thermo-Protective Role of 28-Homobrassinolide in <i>Brassica juncea</i>Plants

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American Journal of Plant Sciences 2014年第15期5卷 2431-2439页

作者： Sirhindi Geetika Kaur Harpreet bhardwaj renu Kaur Nirmal Spal Sharma Poonam Department of Botanical and Environmental Sciences GNDU Amritsar India Department of Botany Punjabi University Patiala India

The present work was undertaken to study the effects of 28-homobrassinolide on growth, stress markers, antioxidative enzyme [superoxide dismutase (EC 1.***.1.1), guaiacol peroxidase (EC 1.***.1.7), catalase (EC 1.***.1.6) ] activities and protein content in 10 days old seedlings of Brassica juncea L. treated with different degrees (4°C, 44°C) of temperature. 28-homobrassinolide at 10-9 M concentration lowered temperature stress. Different degrees of temperature treatment alone decreased the enzyme activities and protein concentration of seedlings. However, pre-sowing treatments of 28-homobrassinolide lowered the temperature stress and enhanced the contents of MDA and proline, activities of enzymes and protein concentration of seedlings.

关键词： Antioxidative Enzymes 28-Homobrassinolide Brassinosteroids Temperature Stress Lipid Peroxidation Guaiacol Peroxidase Catalase

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Inhibition of H2O2-induced DNA damage in single cell gel electrophoresis assay (comet assay) by castasterone isolated from leaves of centella asiatica

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Health 2010年第6期2卷 595-602页

作者： Nishi Sondhi renu bhardwaj Satwinderjeet Kaur Madhu Chandel Neeraj Kumar Bikram Singh 不详

Brassinosteroids (BRs) are a large group of polyhydroxy steroids, which regulate numerous aspects of plant growth and development, including stem elongation, leaf bending, tracheary element differentiation, stress protection and photomorphogenesis. Recent studies indicate antigenotoxic and anticancerous activities of these compounds. The role of natural BRs in H2O2 (hydrogen peroxide) -induced DNA damage in human lymphocytes is still unknown. The present study reports the presence of Castasterone from leaves of Centella asiatica, an important medicinal herb commonly used as a memory enhancer and immunomodulator. CA50 fraction isolated from Centella asiatica was characterized as Castasterone by electrospray ionization mass spectral data with standard Castasterone. An attempt has been made to study antigenotoxic activity of the isolated Castasterone against H2O2 -induced DNA damage in human blood lymphocytes using Single cell gel electrophoresis assay (Comet Assay). Castasterone at 10–9 M concentration proved to be effective in diminishing the DNA damage by 89.42 %.

关键词： Brassinosteroids Castasterone Comet Assay Hydrogen Peroxide

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Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy

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Nano Research 2023年第5期16卷 7085-7094页

作者： Yue Yu Guoxin Zhang Zhongping Li Jia Wang Yang Liu Rahul bhardwaj renu Wadhwa Yuki Nagao Mototada Shichiri Ran Gao Biomedical Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Osaka 563-8577Japan AIST-INDIA DAILAB DBT-AIST International Center for Translational&Environmental Research(DAICENTER)AISTTsukubaIbaraki 305-8565Japan Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases NHC Key Laboratory of Human Disease Comparative MedicineNational Human Diseases Animal Model Resource CenterInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollageBeijing 100021China School of Materials Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1211Japan Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 120-749Republic of Korea Flexible 3D System Integration Laboratory SANKENOsaka UniversityOsaka 567-0047Japan

Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer *** targeting has been considered as an effective technique for tumor *** this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer *** biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell *** biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer *** analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A *** together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in *** simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.

关键词： covalent organic framework active targeting folate receptor drug delivery cancer therapy

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