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Effects of crude thymus gland extract on some physiological and biochemical parameters in local rabbits

Clinical Research Communications 2021年第3期4卷 9-13页

作者： Ghorbat Saleh Ali Amad MSaleh Jubrail Zeliha Selamoglu betul ozdemir Malika Kassem Najeeb Collage of Science University of DuhokDuhokIraq Department of Medical Biology Faculty of MedicineNigdeomer Halisdemir UniversityNigdeTurkey Department of Cardiology Faculty of MedicineNigdeomer Halisdemir UniversityCampusNigdeTurkey

In the present study,36 local rabbits of different ages were divided into two groups:18 infants and 18 adult rabbits of both sexes were *** group of rabbits were subdivided randomly into two subgroups(control and treated).Treated groups,received intraperitoneally calf thymus extract obtained from abattoir and homogenized with 0.15M NaCl,centrifuged and the supernatant was Millipore filtrated and stored at-20ºC and used in a dose of 0.25 mL/kg body weight daily for two *** groups received similar doses of normal saline *** obtained from each treated group were compared to those of the control *** days after the last injection,animals were anesthetized and blood samples were collected for biochemical,hematological *** treated with crude thymus extract showed significant decreases in RBC,Hb and *** indices(MCV and MCHC)also showed significant decreases in treated *** count and the percentage of lymphocytes showed highly significant decrease in both treated groups,crude extract seems to induce immunosup-pressive action through anti proliferative *** parameters showed high significant decrease of serum albumin level in the treated adult group but no changes were observed in the infant group,while total protein markedly decreased only in treated adult,which could be explained on the base of decreased negative acute protein and increased catabolism of proteins in the *** in the lipid profile showed significant increase in triglyceride,VLDL,and LDL level,while HDL level was decreased in both treated *** in the HDL composition which is expected and decrease of antioxidant lead to increase in free radicals which induced LDL and VLDL oxidation and initiation of *** all treated groups highly significant increase of AST,ALT and ALP activation were obvious as a result of liver cell damages.

关键词： Blood Rabbit Serum Thymus extract

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Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1662-1668页

作者： betul Tugcu Senay Asik Nacaroglu Asuman Gedikbasi Mehmet Uhri Nur Acar Hakan ozdemir Department of Ophthalmology Faculty of Medicine Bezmialem University Istanbu134093 Turkey Department of Ophthalmology Bagcilar Training and Research Hospital Istanbu134200 Turkey Department of Biochemistry Bakirkoy Dr. Sadi Konuk Training and Research Hospital Istanbu134147 Turkey Department of Pathology Kanuni Sultan Suleyman Training and Research Hospital Istanbu134303 Turkey Department of Ophthalmology Acibadem University School of Medicine Istanbu134457 Turkey

AIM： To investigate the effect of pomegranate juice（PJ） intake on overall oxidation status in retinas of diabetic ***： Twenty-seven rats were divided into four groups as control（CO）, diabetic（DM）, control treated with PJ（CO-PJ）, and diabetic treated with PJ（DM-PJ）.The retina tissues were used to determine 8-hydroxy-2＇-deoxyguanosine（8 OHd G）, malondialdehyde（MDA）, reduced glutathione（GSH） levels, and the enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）. RESULTS： The levels of 8 OHdG and MDA were significantly increased in the retina of DM group compared to CO group（P=0.001, P〈0.001 respectively）. Both 8 OHd G and MDA levels were decreased in PJ-DM group compared to DM group（P=0.004, P〈0.001 respectively）. The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group（P≤0.01）. GSH and GSH-Px activities were higher in PJ-DM group compared with DM group（P=0.010, P=0.042, respectively） but SOD activity was not statistically different（P=0.938）. CONCLUSION： PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.

关键词： antioxidant enzymes diabetic retinopathy immunohistochemical staining oxidative stress pomegranate juice

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A novel mutation of SGK-1 gene in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 23-28页

作者： Mahmut Akyol Muhammet Kazιm Erol ozdemir ozdemir Deniz Turgut Coban Ahmet Burak Bilgin Esin Sogutlu Sari Elif betul Turkoglu Department of Medical Biology and Genetics Akdeniz University Faculty of Medicine Department of Ophthalmology Antalya Education and Research Hospital Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Akdeniz University Faculty of Medicine Department of Ophthalmology Balιkesir University Faculty of Medicine

AIM: To investigate the association of serum glucocorticoid kinase gene-1(SGK-1) DNA variants with chronic central serous chorioretinopathy(CSC).METHODS: We enrolled 32 eyes of 32 patients who were diagnosed with chronic CSC and composed 32 normal eyes as a control group. Peripheral blood was used for DNA extraction and polymerase chain reaction amplification. SGK1 gene was sequenced by using Big Dye Terminator v3.1 cycle sequencing Kit(Applied Biosystems, Foster City, CA, USA). The SGK-1 gene and its variants were investigated in CSC patient group and control ***: We identified a new polymorphism M32 V in two person in the patient group [Minor allele frequency(MAF) =0.009] on the region of 1-60 amino acids. The rs1057293 was located in the encoder region of the SGK- 1 gene but not associated with CSC(P =0.68). An intrinsic rs1743966 is also not associated(P =0.28).CONCLUSION: The new polymorphism M32 V is located on the region of 1-60 amino acids which is necessary for localization to the mitochondria in CSC patient. This mutation is probably important for the energy metabolism and plays an important role in the cellular response to hyperosmotic stress and other stress stimuli. Both rs1057293 and rs1743966 are not associated with CSC.

关键词： central serous chorioretinopathy mutation polymerase chain reaction serum glucocorticoid kinase gene-1

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