Effects of crude thymus gland extract on some physiological and biochemical parameters in local rabbits
作者机构：Collage of ScienceUniversity of DuhokDuhokIraq Department of Medical BiologyFaculty of MedicineNigdeomer Halisdemir UniversityNigdeTurkey Department of CardiologyFaculty of MedicineNigdeomer Halisdemir UniversityCampusNigdeTurkey
出 版 物：《Clinical Research Communications》 (临床研究通讯)
年 卷 期：2021年第4卷第3期
页 面：9-13页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Blood Rabbit Serum Thymus extract
摘 要：In the present study,36 local rabbits of different ages were divided into two groups:18 infants and 18 adult rabbits of both sexes were *** group of rabbits were subdivided randomly into two subgroups(control and treated).Treated groups,received intraperitoneally calf thymus extract obtained from abattoir and homogenized with 0.15M NaCl,centrifuged and the supernatant was Millipore filtrated and stored at-20ºC and used in a dose of 0.25 mL/kg body weight daily for two *** groups received similar doses of normal saline *** obtained from each treated group were compared to those of the control *** days after the last injection,animals were anesthetized and blood samples were collected for biochemical,hematological *** treated with crude thymus extract showed significant decreases in RBC,Hb and *** indices(MCV and MCHC)also showed significant decreases in treated *** count and the percentage of lymphocytes showed highly significant decrease in both treated groups,crude extract seems to induce immunosup-pressive action through anti proliferative *** parameters showed high significant decrease of serum albumin level in the treated adult group but no changes were observed in the infant group,while total protein markedly decreased only in treated adult,which could be explained on the base of decreased negative acute protein and increased catabolism of proteins in the *** in the lipid profile showed significant increase in triglyceride,VLDL,and LDL level,while HDL level was decreased in both treated *** in the HDL composition which is expected and decrease of antioxidant lead to increase in free radicals which induced LDL and VLDL oxidation and initiation of *** all treated groups highly significant increase of AST,ALT and ALP activation were obvious as a result of liver cell damages.
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