检索结果-南通市图书馆

Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

molecular Plant 2024年第2期17卷 277-296页

作者： mengxiao Yan ming Li Yunze Wang Xinyi Wang m-Hossein moeinzadeh Dora G.Quispe-Huamanquispe Weijuan Fan Yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko Tanaka bettina Heider Jan F.Kreuze Godelieve Gheysen Hongxia Wang martin Vingron Ralph Bock Jun Yang Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Department of Computational molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAS Center for Excellence of molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China max-Planck-Institut fur molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops ***,its genetic origin remains controversial,and its domestication history remains *** this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of *** diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to *** tetraploid progenitor of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast *** most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome *** analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can mouse models mimic sporadic Alzheimer’s disease?

引用

Neural Regeneration Research 2020年第3期15卷 401-406页

作者： bettina m.Foidl Christian Humpel Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of Innsbruck

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia *** age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age>60 ***mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an agemouse models are *** far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms *** risk genes,such as Apolipoprotein E4 and TREm-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a *** this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD.

关键词： Alzheimer’s disease beta-amyloid cerebral amyloid angiopathy cognitive impairment sporadic and genetic mouse models tau vascular risk factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Severe acute pancreatitis: Clinical course and management

引用

World Journal of Gastroenterology 2007年第38期13卷 5043-5051页

作者： Hans G Beger bettina m Rau Department of General Surgery Department of Viszeralsurgery University of Ulm (1982-2001) Donau-Klinikum Neu-Ulm Germany Department of General Viszeral Vascular and Pediatric Surgery Universit?tsklinikum des Saarlandes Homburg/ Saar Germany

Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (mOFS) occurs in the later course after the first week. To predict sepsis, mOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%.

关键词： Severe acute pancreatitis multiorgan failure syndrome Infected necrosis Fluid replacement Enteral feeding Surgical and interventional debridement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients

引用

World Journal of Gastroenterology 2018年第28期24卷 3171-3180页

作者： bettina m Buchholz Panagis m Lykoudis Reena Ravikumar Joerg m Pollok Giuseppe K Fusai Department of HPB Surgery and Liver Transplantation Royal Free Hospital London

AIm To study the published evidence on the impact of colectomy in preventing recurrent primary sclerosing cholangitis(r PSC). mETHODS An unrestricted systematic literature search in Pub med, EmBASE, medline Ovid SP, ISI Web of Science, Lista(EBSCO) and the Cochrane library was performed on clinical studies investigating colectomy in liver transplantation(LT) recipients with and without r PSC in the liver allograft. Study quality was evaluated according to a modification of the methodological index for non-randomized studies(mINORS) criteria. Primary endpoints were the impact of presence, timing and type of colectomy on r PSC. Overall presence of inflammatory bowel disease(IBD), time of IBD diagnosis, posttransplant IBD and immunosuppressive regimen were investigated as secondary *** The literature search yielded a total of 180 publications. No randomized controlled trial was identified. Six retrospective studies met the inclusion criteria of which 5 studies were graded as high quality articles. Reporting of IBD was heterogenous but in four publications, either inflammatory bowel disease, ulcerative colitis or in particular active colitis post-LT significantly increased the risk of r PSC. The presence of an intact(i.e., retained) colon at LT was identified as risk factor for r PSC in two of the high quality studies while four studies found no effect. Type of colectomy was not associated with r PSC but this endpoint was underreported(only in 33% of included studies).Neither tacrolimus nor cyclosporine A yielded a significant benefit in disease recurrence of primary sclerosing cholangitis(PSC).CONCLUSION The data favours a protective role of pre-/peri-LT colectomy in r PSC but the current evidence is not strong enough to recommend routine colectomy for r PSC prevention.

关键词： Recurrent primary sclerosing cholangitis Risk factor Ulcerative colitis Colectomy Liver transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spontaneous elimination of hepatitis C virus infection: A retrospective study on demographic, clinical, and serological correlates

引用

World Journal of Gastroenterology 2007年第31期13卷 4224-4229页

作者： Perdita Wietzke-Braun Larissa bettina mnhardt Albert Rosenberger Angela Uy Giuliano Ramadori Sabine mihm Department of Gastroenterology and Endocrinology Robert-Koch-Str.40 37075 Gttingen Germany Department of Genetic Epidemiology Humboldtallee 32 Gttingen 37073 Germany Department of microbiology Kreuzbergring 57 Gttingen Georg-August-Universitt Gttingen 37075 Germany

To find correlates to spontaneous clearance of hepatitis C virus （HCV） infection, this study compared individuals with self-limited and chronic infection with regard to clinical, demographic, and serological pa- rameters. mETHODS： Sixty-seven anti-HCV positive and repeatedly HCV RNA negative individuals were considered to have resolved HCV infection spontaneously. To determine the viral genotype these patients had been infected with HCV serotyping was performed. For comparison reasons, 62 consecutive patients with chronic hepatitis C were enrolled. Cases and controls were compared stratified for age and sex. RESULTS： Retrospective analysis showed （1） a lower humoral reactivity to HCV in patients with self-limited compared to chronic HCV-infection and （2） that younger age, history of iv drug use, and acute/post-acute hepatitis A or B co-infections, but not viral genotypes, are independent correlates for spontaneous HCV clearance. CONCLUSION： The stronger humoral reactivity to HCV in patients with persistent infections and in those with a history of iv drug use is supposed to be due to continuous or repeated contact（s） to the antigen. metachronous hepatitis A or hepatitis B infections might favor HCV clearance.

关键词： Hepatitis C virus Hepatitis Self-limitedinfection Anti-HCV antibodies Co-infection HCVserotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ex vivo limb perfusion for traumatic amputation in military medicine

引用

military medical Research 2020年第4期7卷 489-496页

作者： Alexander Kaltenborn Nicco Krezdorn Sebastian Hoffmann AndréGutcke Kirsten Haastert-Talini Peter m.Vogt Axel Haverich bettina Wiegmann Department of Trauma and Orthopedic Surgery PlasticHand and Reconstructive SurgeryArmed Forces Hospital WesterstedeWesterstedeGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Institute of Neuroanatomy and Cell Biology Hannover Medical SchoolHannover and Center for Systems Neuroscience(ZSN)WesterstedeGermany Department of Cardiothoracic Transplantation and Vascular SurgeryHannover Medical SchoolHannoverGermany

Background:Limb loss has a drastic impact on a patient’s *** trauma to the extremities is common in current military *** other aspects,"life before limb"damage control surgery hinders immediate replantation within the short post-traumatic timeframe,which is limited in part by the ischemic time for successful *** vivo limb perfusion is currently being researched in animal models and shows promising results for its application in human limb replantation and *** of the hypothesis:The current lack of replantation possibilities in military operations with high rates of amputation can be addressed with the development of a portable ex vivo limb perfusion device,as there are several opportunities present with the introduction of this technique on the *** hypothesize that ex vivo limb perfusion will enable overcoming the critical ischemic time,provide surgical opportunities such as preparation of the stump and limb,allow for spare-part surgery,enable rigorous antibiotic treatment of the limb,reduce ischemiareperfusion injuries,enable a tissue function assessment before replantation,and enable the development of large limb transplant *** the hypothesis:Data from in vivo studies in porcine models are limited by the relatively short perfusion time of 24 *** the military setting,notably longer perfusion times need to be ***,future animal studies must focus especially on long-term perfusion,since this represents the military setting,considering the time for stabilization of the patient until evacuation to a tertiary treatment *** of the hypothesis:The development and clinical introduction of ex vivo limb perfusion in the military setting could lead to a drastic reduction in the number of limb amputations among service *** vivo limb perfusion enables replantation surgery in Role 4 facilities and changes the clinical setting from a highly urgent,lifethreatening s

关键词： Ex vivo limb perfusion traumatic amputation ischemia and reperfusion-related injuries hypothesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stability of Ni/SiO2-ZrO2 catalysts towards steaming and coking in the dry reforming of methane with carbon dioxide

引用

Frontiers of Chemical Science and Engineering 2016年第2期10卷 281-293页

作者： bettina Stolze Juliane Titus Stephan A. Schunk Andrian milano Ekkehard Schwab Roger Glaser Institute of Chemical Technology Universitat Leipzig Lirmestr. 3 04103 Leipzig Germany hte GmbH Kurpfalzring 104 69123 Heidelberg Germany BASF SE Carl-Bosch-Straβe 38 67056 Ludwigshafen Germany

Ni/SiO2-ZrO2 catalysts with Ni loadings of 1 to 13 wt-% were prepared, characterized by elemental analysis, X-ray diffraction, N2 sorption, temperature programmed oxidation, temperature programmed reduc- tion, and tested for their activity and stability in the dry reforming of methane with carbon dioxide at 850 ℃, gas hourly space velocity of 6000 and 1800 h^-1 and atmo- spheric pressure. The SiO2-ZrO2 support as obtained through a simple and efficient sol-gel synthesis is highly porous （ABET = 90 m^·g^-1, dp= 4.4 nm） with a homogeneously distributed Si-content of 3 wt-%. No loss of Si or formation ofmonoclinic ZrO2, even after steaming at 850 ℃ for 160 h, was detectable. The catalyst with 5 wt-% Ni loading in its fully reduced state is stable over 15 h on-stream in the dry reforming reaction. If the catalyst was not fully reduced, a reduction during the early stages of dry reforming is accompanied by the deposition of up to 44 mg· g^-1 carbon as shown by experiments in a magnetic suspension balance. Rapid coking occurs for increased residence times and times-on-stream starting at 50 h. The Ni loading of 5 wt-% on SiO2-ZrO2 was shown to provide an optimal balance between activity and coking tendency.

关键词： Ni/SiO2-ZrO2 synthesis gas dry reforming,coking steaming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The impact of salps(Salpa thompsoni)on the Antarctic krill population(Euphausia superba):an individual-based modelling study

引用

Ecological Processes 2023年第1期12卷 680-695页

作者： Bruno Walter Pietzsch Aaron Schmidt Jürgen Groeneveld Dominik Bahlburg bettina m.yer Uta Berger Faculty of Environmental Sciences Institute of Forest Growth and Forest Computer SciencesTechnische Universität Dresden01062 DresdenGermany Department of Ecological modelling Helmholtz Centre for Environmental Research-UFZLeipzigGermany Section Polar Biological Oceanography Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchBremerhavenGermany Institute for Chemistry and Biology of the marine Environment(ICBm) Carl-Von-Ossietzky UniversityOldenburgGermany Helmholtz Institute for marine Functional Biodiversity(HIFmB) OldenburgGermany

Background Krill(Euphausia superba)and salps(Salpa thompsoni)are key macrozooplankton grazers in the Southern Ocean ***,due to differing habitat requirements,both species previously exhibited little spatial *** ongoing climate change-induced seawater temperature increase and regional sea ice loss,salps can now extend their spatial distribution into historically krill-dominated areas and increase rapidly due to asexual reproduction when environmental conditions are *** the potential effects on krill is crucial,since krill is a species of exceptional trophic significance in the Southern Ocean food *** impacts on krill could trigger cascading effects on its predators and *** address this question,we combined two individual-based models on salps and krill,which describe the whole life cycle of salp individuals and the dynamic energy budget of individual *** resulting new model PEKRIS(PErformance of KRIll ***)simulates a krill population for 100 years under varying chlorophyll-a concentrations in the presence or absence of *** All of the investigated krill population properties(abundance,mean length,and yearly egg production)were significantly impacted by the presence of *** the other hand,salp density was not impacted if krill were *** medians of krill population properties deviated during variable maximum chlorophyll-a density per year when salps were introduced by−99.9%(−234 individuals per 1000 m3)for krill density,−100%(−22,062 eggs per 1000 m3)for krill eggs and−0.9%(−0.3 mm)for mean length of *** If both species compete for the same food resource in a closed space,salps seem to inhibit krill *** simulation studies should investigate whether this effect prevails if different phytoplankton sizes and consumption preferences of krill are ***,direct predation of the two species or consumption of krill fecal pellets by salps could c

关键词： Euphausia superba Salpa thompsoni Individual-based model Food competition Population dynamics DEB theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sperm banking before gonadotoxic treatment:is it worth the effort?

引用

Asian Journal of Andrology 2021年第5期23卷 490-494页

作者： Kilian Vomstein Elisabeth Reiser Germar m Pinggera Peter Toerzsoek Susanne Deininger Thomas Kriesche Wolfgang Biasio Lukas Lusuardi bettina Toth Department of Gynecological Endocrinology and Reproductive medicine Medical University InnsbruckInnsbruck 6020Austria Department of Urology Medical University InnsbruckInnsbruck 6020Austria Department of Urology and Andrology University Hospital of SalzburgSalzburg 5020Austria

We aimed to compare the sperm quality in different cancer types and benign diseases before gonadotoxic treatment,and assess the usage rate of cryopreserved sperm for assisted reproductive treatment(ART).This retrospective study was conducted at two university clinics between January 2008 and July 2018.A total of 545 patients suffering from cancer or benign diseases were included in the *** pretreatment sperm analyses were based on the World Health Organization(WHO)*** with testicular malignancy(Tm)showed a significantly lower sperm count(median[interquartile range]:18.7×10^(6)[5.3×10^(6)-43.0×10^(6)]ml^(-1);P=0.03)as well as total sperm count(42.4×10^(6)[13.3×10^(6)-108.5×10^(6)]per ejaculate;P=0.007)compared to other malignant and benign *** addition,patients with nonseminomatous Tm showed the lowest sperm count(14.3×10^(6)[6.0×10^(6)-29.9×10^(6)]ml^(-1),vs seminomas:16.5 x 106[4.6×10^(6)-20.3×10^(6)]ml^(-1);P=0.001).With reference to the WHO 2010 guidelines,approximately 48.0%of the patients with Tm and 23.0%with hematological malignancies(Hm)had *** the observation period,only 29 patients(5.3%)used their frozen sperms for 48 ART cycles,resulting in 15 clinical pregnancies and 10 live *** sperm quality varies with the type of underlying disease,with Tm and Hm patients showing the lowest sperm *** to the observed low usage rate of cryopreserved sperm,further patient interviews and sperm analyses should be included in the routine oncologic protocols to avoid unnecessary storage ***,sperm banking is worth the effort as it provides hope for men who cannot reproduce naturally after gonadotoxic treatment.

关键词： cryopreservation fertility gonadotoxic treatment sperm count testicular disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

引用

World Journal of Gastroenterology 2007年第37期13卷 4996-5002页

作者： Claudia Rubie Vilma Oliveira Frick Sandra Pfeil mathias Wagner Otto Kollmar Berit Kopp Stefan Grber bettina m Rau martin K Schilling Department of General Visceral Vascular and Paediatric Surgery University of the Saarland Homburg 66421 Germany Institute of Pathology University of the Saarland Homburg 66421 Germany Institute of medical Biometrics Epidemiology and Medical Informatics University of the Saarland Homburg 66421 Germany

AIm： To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer （CRC） and the development of colorectal liver metastases （CRLm）.mETHODS： IL-8 expression was assessed by quantitative real-time PCR （Q-RT-PCR） and the enzyme-linked immunosorbent assay （ELISA） in resected specimens from patients with ulcerative colitis （UC, n = 6） colorectal adenomas （CRA, n = 8）, different stages of colorectal cancer （n = 48） as well as synchronous and metachronous CRLm along with their corresponding primary colorectal tumors （n = 16）.RESULTS： IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. moreover, [L-8 expression revealed a close correlation with tumor grading. most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLm, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found.CONCLUSION： Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases.

关键词： Interleukin-8 Gene expression profiling RNA and protein expressioni Colorec cal cancer Colorectalliver metastases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：