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Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste bettina couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

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Three thousand years in Tibet

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National Science Review 2020年第1期7卷 129-130页

作者： bettina Harr Trevor Price Max-Planck-Institut für Evolutionsbiologie Department of Ecology and Evolution University of Chicago

Humans have come to inhabit nearly every terrestrial environment. Their commensals have followed them and have consequently become some of the most abundant and widespread species on Earth, in the process becoming exposed to a variety of abiotic and biotic stressors. For example, the house sparrow was introduced from the UK to North America in the

关键词： Three thousand years in Tibet

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3nce upon a Time- Chloroplast Protein Imporl Research from Infancy to Future Challenges

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Molecular Plant 2016年第6期9卷 798-812页

作者： bettina Bolter Jurgen Soill Department Biotogie I-Botanik Ludwig-Maximilians-Universitat GroBhaderner Stral3e 2-4 82152 Planegg-Martinsried Germany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Feodor-Lynen-Strasse 25 81377 Munich Germany

Protein import into chloroplasts has been a focus of research for several decades. The first publications dealing with this fascinating topic appeared in the 1970s. From the initial realization that many plastid proteins are being encoded for in the nucleus and require transport into their target organelle to the identification of import components in the cytosol, chloroplast envelopes, and stroma, as well as elucidation of some mechanistic details, more fascinating aspects are still being unraveled. With this overview, we present a survey of the beginnings of chloroplast protein import research, the first steps on this winding road, and end with a glimpse into the future.

关键词： chloroplast protein import historical perspective Toc Tic evolution envelope membranes

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Can mouse models mimic sporadic Alzheimer’s disease?

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Neural Regeneration Research 2020年第3期15卷 401-406页

作者： bettina M.Foidl Christian Humpel Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of Innsbruck

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia *** age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age>60 ***<3%of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an age<30 *** order to study progression of AD,as well as therapeutic strategies,mouse models are *** far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms *** risk genes,such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a *** this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD.

关键词： Alzheimer’s disease beta-amyloid cerebral amyloid angiopathy cognitive impairment sporadic and genetic mouse models tau vascular risk factors

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BFP1:One of 700 Arabidopsis F-box proteins mediates degradation of JA oxidases to promote plant immunity

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Molecular Plant 2024年第3期17卷 375-376页

作者： Claus Wasternack bettina Hause Department of Molecular Signal Processing Leibniz Institute of Plant Biochemistry7 Weinberg 306120 Halle(Saale)Germany Department of Cell and Metabolic Biology Leibniz Institute of Plant Biochemistry06120 Halle(Saale)Germany

A switch off in jasmonate(JA)signaling by hydroxylation upon wounding was described in 2008(Miersch et al.,2008).This initiated the cloning of CYP450 enzymes involved in hydroxylation and carboxylation of JA and its amino acid conjugate JA-le,the most active form of JA compounds(reviewed by Wasternack and Feussner[2018]and Heitz et al.[2019]).Due to the central role of JA and JA-lle in plant stress responses and development(Wasternack and Hause,2013),catabolism of JA and its derivatives is an essential component in the sustainment of homeostasis of active JA compounds(Howe et al.,2018;Heitz et al.,2019).Catabolism of JA and JAIle takes place by JA-induced oxygenases(JOXs),also named JA-oxidases(JAOs),and by hydroxylation(CYP94B3/B1)followed by carboxylation(CYP94C1),respectively(Heitz et al.,2019).Another reaction performed by IAR3/ILL6 results in the deconjugation of JA-lle and 12-OH-JA-le to JA and 12-OH-JA,respectively(Heitz et al.,2019;Wasternack and Feussner,2018).

关键词： conjugate initiated media

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Biological soil crusts as an integral component of desert environments

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Ecological Processes 2013年第1期2卷 116-129页

作者： Jayne Belnap bettina Weber Department of Archaeology Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Biology Plant Ecology and SystematicsUniversity of KaiserslauternP.O.Box 3049Kaiserslautern 67653Germany Multiphase Chemistry Department Max Planck Institute for ChemistryHahn-Meitner-Weg 1Mainz 55128Germany

The biology and ecology of biological soil crusts,a soil surface community of mosses,lichens,cyanobacteria,green algae,fungi,and bacteria,have only recently been a topic of *** efforts began in the western U.S.(Cameron,Harper,Rushforth,and ***),Australia(Rogers),and Israel(Friedmann,Evenari,and Lange)in the late 1960s and 1970s(e.g.,Friedmann et al.1967;Evenari 1985,reviewed in Harper and Marble 1988).However,these groups worked independently of each other and,in fact,were often not aware of each other’s *** addition,biological soil crust communities were seen as more a novelty than a critical component of dryland eco*** then,researchers have investigated many different aspects of these communities and have shown that although small to microscopic,biological soil crusts are critical in many ecological processes of *** often cover most of desert soil surfaces and substantially mediate inputs and outputs from desert soils(Belnap et al.2003).They can be a large source of biodiversity for deserts,as they can contain more species than the surrounding vascular plant community(Rosentreter 1986).These communities are important in reducing soil erosion and increasing soil fertility through the capture of dust and the fixation of atmospheric nitrogen and carbon into forms available to other life forms(Elbert et al.2012).

关键词： soil fertility component

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Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids

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Science China Chemistry 2019年第11期62卷 1504-1506页

作者： Sankar Rao Suravarapu bettina Peter Philippe Renaud Department of Chemistry and Biochemistry University of Bern

A concise route for the preparation of two simple optically pure indolizidin-5-ones has been *** key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected *** using complementary strategies,these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5)and their conversion to a variety of indolizidine alkaloids such as coniceine,indolizidine 209D and 167B,5-epi-indolizidine 249A and monomorine has been reported in the literature.

关键词： alkenes carbohydrogenation radical reaction catechol triethylborane α-iodoesters allylamine

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Severe acute pancreatitis: Clinical course and management

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World Journal of Gastroenterology 2007年第38期13卷 5043-5051页

作者： Hans G Beger bettina M Rau Department of General Surgery Department of Viszeralsurgery University of Ulm (1982-2001) Donau-Klinikum Neu-Ulm Germany Department of General Viszeral Vascular and Pediatric Surgery Universit?tsklinikum des Saarlandes Homburg/ Saar Germany

Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%.

关键词： Severe acute pancreatitis Multiorgan failure syndrome Infected necrosis Fluid replacement Enteral feeding Surgical and interventional debridement

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On-going nitrification in chloraminated drinking water distribution system(DWDS) is conditioned by hydraulics and disinfection strategies

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Journal of Environmental Sciences 2020年第10期32卷 151-162页

作者： Yi Shi Akintunde Babatunde bettina Bockelmann-Evans Qijie Li Liang Zhang National Engineering Laboratory for Cereal Fermentation Technology Jiangnan UniversityWuxi 214122China Discipline of Ciuil Engineering Cardiff University School of EngineeringThe ParadeCardiffCF243AAUK School of Civil Engineering University of LeedsLeedsLS29JTUK

Within the drinking water distribution system(DWDS)using chloramine as disinfectant,nitrification caused by nitrifying bacteria is increasingly becoming a concern as it poses a great challenge for maintaining water *** investigate efficient control strategies,operational conditions including hydraulic regimes and disinfectant scenarios were controlled within a flow cell experimental *** test phases were conducted to investigate the effects on the extent of nitrification of three flow rates(Q=2,6,and 10 L/min)and four disinfection scenarios(total Cl2=1 mg/L,Cl2/NH3-N=3:1;total Cl2=1 mg/L,Cl2/NH3-N=5:1;total Cl2=5 mg/L,Cl2/NH3-N=3:1;and total Cl2=5 mg/L,Cl2/NH3-N=5:1).Physico-chemical parameters and nitrification indicators were monitored during the *** characteristics of biofilm extracellular polymetric substance(EPS)were evaluated after the *** main results from the study indicate that nitrification is affected by hydraulic conditions and the process tends to be severe when the fluid flow transforms from laminar to turbulent(2300

关键词： Nitrification Drinking water distribution system(DWDS) Biofilm Hydraulics Disinfection

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Ycf1/Tic214 Is Not Essential for the Accumulation of Plastid Proteins

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Molecular Plant 2017年第1期10卷 219-221页

作者： bettina Bölter Jürgen Soll Department Biologie I-Botanik Ludwig-Maximilians-Universität Großhadernerstraße 2-4 82152 Planegg-Martinsried Germany

Dear Editor,Protein import into chloroplasts is an essential process for plant survival. Numerous studies in recent years have revealed many facts about the components involved and mechanistic features, but have also turned up some controversies. Especially the composition and function of the Tic （translocon at the inner enve- lope of chloroplasts） complex（es） are vividly debated. Whereas the importance of one central Tic component,

关键词： Essential Accumulation Proteins

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