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A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly Manon Vogrig bertrand boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

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迪拜阿玛哈沙漠度假酒店住进沙漠里，冲沙、射箭、看驯鹰！

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环球人文地理 2023年第11期 68-73页

作者：唐楠 boson 马桶 Ulia Koltyrina flickr

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Towards the Unification, Part 2: Simplified Equations, Covariant Derivative, Photons

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Journal of Modern Physics 2016年第16期7卷 2398-2417页

作者： Claude Daviau Jacques bertrand Dominique Girardot Le Moulin de la Lande 44522 Pouillé-les-Coteaux France 15 Avenue Danielle Casanova 95210 Saint-Gratien France 95 Rue Marceau 91120 Palaiseau France

We continue the study of the Standard Model of Quantum Physics in the Clifford algebra of space. We get simplified mass terms for the fermion part of the wave. We insert the simplified equations in the frame of General Relativity. We construct the electromagnetic field of the photon, alone boson without proper mass. We explain how the Pauli principle comes from the equivalence principle of General Relativity. We transpose in the frame of the algebra of space the second quantification of the electromagnetic field. We discuss the changes introduced here.

关键词： boson Clifford Algebra Dirac Equation Electromagnetism Electron Gravitation Magnetic Monopole Neutrino Photon Quark Relativistic Invariance Strong Interactions Weak Interactions

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Towards the Unification of All Interactions (The First Part: The Spinor Wave)

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Journal of Modern Physics 2016年第12期7卷 1568-1590页

作者： Claude Daviau Jacques bertrand Dominique Girardot Le Moulin de la Lande Pouillé-les-Coteaux France 15 Avenue Danielle Casanova Saint-Gratien France 95 Rue Marceau Palaiseau France

For the unification of gravitation with electromagnetism, weak and strong interactions, we use a unique and very simple framework, the Clifford algebra of space . We enlarge our previous wave equation to the general case, including all leptons, quarks and antiparticles of the first generation. The wave equation is a generalization of the Dirac equation with a compulsory non-linear mass term. This equation is form invariant under the group of the invertible elements in the space algebra. The form invariance is fully compatible with the gauge invariance of the standard model. The wave equations of the different particles come by Lagrange equations from a Lagrangian density and this Lagrangian density is the sum of the real parts of the wave equations. Both form invariance and gauge invariance are exact symmetries, not only partial or broken symmetries. Inertia is already present in the part of the gauge group and the inertial chiral potential vector simplifies weak interactions. Relativistic quantum physics is then a naturally yet unified theory, including all interactions.

关键词： Electromagnetism Weak Interactions Strong Interactions Gravitation Clifford Algebra Dirac Equation Lagrangian Formalism Gauge Groups Relativistic Invariance Electron Magnetic Monopole Quark Photon Gauge boson Unification

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