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鸡小脑生长过程中生长激素的表达、细胞的分布和异质性的研究

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饲料博览 2012年第1期22卷 24-24页

作者： Alba-Betancourt C Arámburo C vila-mendoza J Ahumada-Solórzano S M Carranza M Rodríguez-Méndez A J Harvey S L 不详

虽然生长激素(GH)主要有脑垂体合成和分泌,但已有研究表明,GH基因可以在垂体以外的组织中表达,包括中枢神经系统(CNS)。试验研究了生长激素在鸡小脑的表达,采用原位杂交和cDNA测序以及免疫组化和共聚焦显微镜分析小脑GH表达。此外,GH异... 详细信息

虽然生长激素(GH)主要有脑垂体合成和分泌,但已有研究表明,GH基因可以在垂体以外的组织中表达,包括中枢神经系统(CNS)。试验研究了生长激素在鸡小脑的表达,采用原位杂交和cDNA测序以及免疫组化和共聚焦显微镜分析小脑GH表达。此外,GH异质性研究采用Westernblotting方法进行。结果表明,鸡小脑的GH基因及其核苷酸序列与垂体GHcDNA具有同源性。GH基因在鸡小脑中主要在浦肯野细胞和颗粒层细胞中表达。通过神经元标记和组织化学技术鉴定GH-免疫反应(IR)在小脑的浦肯野细胞和颗粒层细胞中丰富表达。此外,小脑的GH浓度与年龄有关,成年鸡小脑中GH含量高于胚胎期和青年鸡。采用Westernblot检测小脑GH-IR,异构体主要有15、23、26、29、35、45、50、55、80kDa,其中15kDa的异构体为主(>30%)。GH受体(GHR)mRNA和蛋白质在小脑中也同样主要集中在浦肯野和颗粒细胞。研究结果表明,GH和GHR是可在鸡小脑局部中表达,说明GH可作为组织自分泌或旁分泌因子。

关键词：生长激素生长激素受体小脑浦肯野细胞颗粒细胞 GH的异质性鸡发展

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

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索他西普治疗肺动脉高压的3期试验

中华高血压杂志 2023年第7期31卷 687-687页

作者：刘青(译) 练桂丽(审) 不详

肺动脉高压是一种进行性疾病,涉及肺血管的增殖性重塑。尽管治疗取得了进展,但与疾病相关的发病率和死亡率仍然很高。索他西普是一种融合蛋白,可捕获与肺动脉高压有关的激活素和生长分化因子。方法:研究者进行了一项多中心、双盲、临床... 详细信息

肺动脉高压是一种进行性疾病,涉及肺血管的增殖性重塑。尽管治疗取得了进展,但与疾病相关的发病率和死亡率仍然很高。索他西普是一种融合蛋白,可捕获与肺动脉高压有关的激活素和生长分化因子。方法:研究者进行了一项多中心、双盲、临床3期试验,接受稳定背景治疗的肺动脉高压成人(世界卫生组织功能分级为Ⅱ或Ⅲ级)以1:1的比例随机分配至每3周接受皮下注射索他西普(起始剂量为0.3mg/kg,目标剂量为0.7mg/kg)或安慰剂。

关键词：进行性疾病肺动脉高压安慰剂肺血管随机分配目标剂量激活素生长分化因子

良性的术后胆道狭窄球囊扩张术的30年经验:长期结果

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国际医学放射学杂志 2009年第1期32卷 81-81页

作者： C. P. Cantwell C. S. pena D. A. Gervais P. F. Hahn S. L. Dawson P. R. Mueller 余华君 Division of Abdominal and Interventional Radiology Massachusetts General Hospital and Harvard Medical School Boston Mass USA

目的确定经皮球囊扩张术对良性术后胆道狭窄的有效性。材料和方法这项遵从HIPAA的回顾性研究经机构委员会批准，免除知情同意书。从1977年4月1日—2007年4月1日．85例良性胆道狭窄病人行经皮胆道球囊扩张术（PBBD）。在随访的75例... 详细信息

目的确定经皮球囊扩张术对良性术后胆道狭窄的有效性。材料和方法这项遵从HIPAA的回顾性研究经机构委员会批准，免除知情同意书。从1977年4月1日—2007年4月1日．85例良性胆道狭窄病人行经皮胆道球囊扩张术（PBBD）。在随访的75例病人中（男31例，女44例；平均年龄56岁：平均随访时间为8a），84处胆道狭窄的112次治疗中总共行205次PBBD操作。

关键词：经皮球囊扩张术良性胆道狭窄长期结果随访时间 HIPAA 知情同意书平均年龄有效性

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改善低收入少数族裔残障青年的过渡成效

国际社会科学杂志（中文版） 2024年第1期41卷 142-155,10,16页

作者：法布里奇奥·巴尔卡扎尔蒂娜·泰勒-里兹勒肖恩·蒂姆弗纳尔逊·波蒂罗-佩尼亚阿尔贝托·古兹曼雷切尔·希福米歇尔·默维张大川(译) 伊利诺伊大学芝加哥分校多米尼加大学萨尔瓦多的唐博斯科大学亚利桑那大学克莱蒙特研究生大学马里奥基金会不详

一般认为,给残障者提供有效的过渡规划和服务,其主要的长期成效是使其就业更具竞争力,以及(或者)能在中学后继续接受教育(Wagneretal.2005)。为了实现这种效果,《残障人教育法》(DisabilitiesEducation Act[IDEA]2004)规定:过渡规划和... 详细信息

一般认为,给残障者提供有效的过渡规划和服务,其主要的长期成效是使其就业更具竞争力,以及(或者)能在中学后继续接受教育(Wagneretal.2005)。为了实现这种效果,《残障人教育法》(DisabilitiesEducation Act[IDEA]2004)规定:过渡规划和过渡支持须做到个性化,以职业发展为目标,能够把残障青年和其他参与过渡的服务系统联系在一起(Sabbatino and Macrine 2007)。尽管明确了过渡的最佳方法(Kohler1996),法律也规定了要改善面向残障青年的、与过渡相关的服务和辅助支援(IDEA 2004),但是,过渡的成效一直乏善可陈(Wagneret al.2005)。

关键词：少数族裔残障人教育法乏善可陈残障者 IDEA

The Genomic Variation of 3,000 diverse Rice (Oryza sativa L.)Accessions:Discoveries And Applications In Rice Improvement

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The Genomic Variation of 3,000 diverse Rice (Oryza sativa L....

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

2018中国作物学会学术年会

作者：黎志康 Fan Zhang Whensheng Wang Ramil Mauleon Zhiqiang Hu Dmytro Chebotarov Shuaishuai Tai Zhichao Min Li Tianqing Zheng Roven Rommel Fuentes Locedie Mansueto Dario Copetti Millicent Sanciangco Kevin Christian Palis Jianlong Xu Chen Sun Hongliang Zhang Binying Fu Yongming Gao Xiuqin Zhao Fei Shen Xiao Cui Hong Yu Zichao Li Miaolin Chen Jeffery Detras Yongli Zhou Xinyuan Zhang Yue Zhao Dave Kudrna Chunchao Wang Rui Li Ben Jia Jinyuan Lu Xianchang He Zhaotong Dong Jiabao Xu Yanhong Li Miao Wang Jianxin Shi Jing Li Dabing Zhang Seunhee Lee Wushu Hu Alexander Poliakov Inna Dubchak Victor Jun Ulat Frances Nikki Borja John Robert mendoza Jauhar Ali Ming Yang Yongchao Niu Zhen Yue Ma.Elizabeth B.Naredo Jayson Talag Xueqiang Wang Jinjie Li Xiaodong Fang Ye Yin Jean-Christophe Glaszmann Jianwei Zhang Jiayang Li Ruaraidh Sackville Hamilton Rod A.Wing Chaochun Wei Jue Ruan Gengyun Zhang Kenneth L.Mcnally Nickolai Alexandrov Hei Leung Hei Institute of Crop Sciences Chinese Academy of Agricultural Sciences Shenzhen Institute for Innovative Breeding Chinese Academy of Agricultural Sciences International Rice Research Institute School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai Center for Bioinformation Technology BGI Genomics BGI-Shenzhen Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Anhui Agricultural University Arizona Genomics Institute School of Plant SciencesUniversity of Arizona China Agricultural University Institute of Genetics and Developmental Biology Chinese Academy of Sciences Lawrence Berkeley National Laboratory

Asian cultivated rice(Oryza sativa L.) is the staple food for the half world population with rich within species *** analyses of the genome resequencing data of a core collection of 3,010 rice accessions revealed four important aspects of the genomic diversity within ***,over 42 million SNPs and >3 million small InDels were discovered against five reference ***,we discovered more than 90,000 structural(>100 bps) variations(SVs) when compared with the Geng reference genome,consisting primarily of small-sized deletions and translocations,plus many duplications and *** SVs accounted for significant portion of the rice genome and involved most(～80%) rice ***,we discovered >12,000 full-length novel protein-coding genes plus 9000+ novel genes of partial sequences that are absent in the Nipponbare reference *** rice pan genome consists of ～62%core genes/gene families that are present in all rice lines,and ～38%distributed genes that are present only some of rice ***,using large-effect SNPs and InDels of all loci in the PG,a rice functional haplotype database was *** SNP,PG and SV variation clearly resolve the 3,010 rice accessions into two major subspecies,Xian(indica) and Geng(japonica),plus Aus and Aro groups and multiple subpopulations within Xian and *** reduced diversity was found in genomic regions where over 1,000 agronomically important and domestication-related genes *** efforts have been taken to identify and mine genes/QTLs/alleles associated with a wide range of important traits in rice using the 3 k materials and SNP *** demonstrate how the results of the 3 k RGP could be used in rice improvement,genomic constitutions of 476 BC F introgression lines(ILs) from our breeding program were constructed using high-quality reference genomes of their 9 parents and the 3 k RGP *** compared with their recurrent parent,Huang-hua-

关键词： Rice genome diversity population structure pan genomes genomics-based breeding by design

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING