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Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds

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Bioactive Materials 2024年第2期32卷 1-11页

作者： Roman Menze bernhard hesse Maciej Kusmierczuk Duote Chen Timm Weitkamp Stephanie Bettink Bruno Scheller MeKo Manufacturing e.K. Im Kirchenfelde 12-1431157SarstedtGermany Xploraytion GmbH Bismarckstr.10-1210625BerlinGermany Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190Saint-AubinFrance InnoRa GmbH Robert-Koch-Platz 410115BerlinGermany Universität des Saarlandes Campus Homburg66421HomburgGermany

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(<1 year),long-term device-related clinical events could be reduced compared to treatments with conventional drug eluting *** clinical trials indicate a return of vasomotion after one year,which may be associated with improved long-term clinical ***,even after decades of development,the degradation process,ideal degradation time and biological response in vivo are still not fully *** present study investigates the in vivo degradation of magnesium scaffolds in the coronary arteries of pigs influenced by different strut thicknesses and the presence of antiproliferative *** to high 3D image contrast of synchrotron-based micro-CT with phase contrast(SR-μCT),a qualitative and quantitative evaluation of the degradation morphology of magnesium scaffolds was *** the segmentation of theμCT images a convolutional network architecture(U-net)was exploited,demonstrating the huge potential of merging high resolution SR-μCT with deep learning(DL)supported data *** total,30 scaffolds,made of the rare earth alloy Resoloy^(®),with different strut designs were implanted into the coronary arteries of 10 domestic pigs for 28 days using drug-coated or uncoated angioplasty balloons for *** degradation morphology was analyzed using scanning electron microscopy,energy dispersive x-ray spectroscopy and SR-μ*** data from these methods were then related to data from angiography,optical coherence tomography and histology.A thinner strut size(95 vs.130μm)and the presence of paclitaxel indicated a slower degradation rate at 28 d in vivo,which positively influences the late lumen loss(0.5 and 0.6 mm vs.1.0 and 1.1 mm)and recoil values(0 and 1.7%vs.6.1 and 22%).

关键词： Resoloy Magnesium scaffold DCB Paclitaxel Degradation Inflammation Artificial intelligence

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Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

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Bioactive Materials 2022年第8期7卷 152-168页

作者： Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel bernhard hesse Frank Witte Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as *** collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second ***,biodegradable GBR membranes made of pure magnesium might be an *** this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological *** implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft *** the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect *** the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier *** the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new *** the membrane had completely resorbed,only healthy tissue *** in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen ***,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

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Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

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Bioactive Materials 2022年第8期7卷 15-30页

作者： Zeljka Peric Kacarevic Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Till Kammerer bernhard hesse Emely Bortel Marco Bartosch Frank Witte Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4–614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany University Hospital Munich Department of Dermatology and AllergyFrauenlobstr.9-1180337MunichGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical *** the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these *** mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable *** demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of *** of the magnesium fixation screw was demonstrated in several in vitro and in vivo *** of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing ***,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

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