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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial

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Stroke & Vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai my Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance Victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute

The Grammars of mystical Experience in Christian Theological Dialogue

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Journal of Philosophy Study 2018年第4期8卷 151-168页

作者： Marc Jean-bernard University of Puerto Rico

The philosophical horizon of this essay is theoretically comparative and hermeneutically dialogic. Its main philosophical and theological tonality expresses, in first person and through three discursive moments, the differentiated fusion of horizons between phenomenological and grammatical description and understanding of experience. After a philosophical overture-outlining the ethos of the dialogic problematic and situating it within the contemporary diverse and dialogic dynamic of phenomenology-I will expose the consistent, possible modalities of convergence between Husserlian phenomenology and Wittgensteinian grammar of the mystical shapes of experience. The tense, responsorial dialogue among Husserl, Heidegger, Levinas, and Wittgenstein＇s styles of thinking, far from being anymore limited to the debates between the analytical and phenomenological, will be considered from the crossed categorial spaces of Austrian philosophy and German culture in general. In a second section, I will show how the styles of phenomenology today are advancing into a cautious micro-logical grammar of comparative inquiry. This thematization will first consider some precise semantic clarifications： Experience, the mystical, extasis, evidence, and truth; in a second section, the theoretical levels of grammar and phenomenology of mystical experience are heralded in the context of the Christian theological dialogue, where I emphasize the rebirth of French theological thinking and dialogic transcendence, beginning with Maritain and de Chardin to Marcel, de Lubac, Levinas, and Marion. Finally, I consider the aesthetic expressions of mystical experience, both from the visual and musical dimensions. I will conclude this talk by highlighting theological perspectives drawn from my research in musico-philosophical problematics, through an awakening to the resonance of Being and the Divine in sonic and musical life. Through a theology of the musical λογοζ, the grammar of mystical experience reveals

关键词： phenomenology grammar mysticism theology ontology dialogue music silence

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As I See It

中国翻译 1985年第8期 46-48页

作者： bernard Shaw 吴燕泉

What about this danger of war, which is making us all shake in our shoes at present? I am like yourself: I have an intense objection to having my house demolished by a bomb from an aeroplane and myself killed in a horribly painful wayby mustard gas. I have visions of streets heaped with mangled corpses in which children wander crying for their parents, and babies gasp and strangle in the clutches of dead mothers. That is what war means nowadays. This is what is happening in Spain and in China whilst I speak to you; and it may happen to us tomorrow. And the worst of

关键词：翻译定语从句萧伯纳标题主句分句

Evidence of SARS-CoV-2 infection in pets,captive non-human primates and farm animals in Central Africa

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 232-235页

作者： Gael D.Maganga Barthelemy Ngoubangoye Jumafra P.Koumba Sonia Lekana-Douki Ivan C.Moussadji Kinga Thierry A.Tsoumbou Antoine M.Mbeang Beyeme Telstar G.Ndong Mebaley Jean-bernard Lekana-Douki Centre Interdisciplinaire de Recherches Medicales de Franceville(CIRMF) Unite Emergence des Maladies ViralesBP 769FrancevilleGabon Institut National Superieur d’Agronomie et de Biotechnologies(INSAB) Universite des Sciences et Techniques de Masuku(USTM)BP 941FrancevilleGabon Universite de Lyon Universite Lyon 1CNRSLaboratoire de Biometrie et Biologie evolutive UMR 555869622 VilleurbanneFrance LabEx ECOFECT Eco-evolutionary Dynamics of Infectious DiseasesUniversity of LyonLyonFrance

It has been reported that the host of SARS-CoV-2 can be extremely wide due to the conservation of angiotensin converting enzyme 2 in mammals[1].Several studies have reported natural or experimental infection with SARS-CoV-2 in pets,farm and captive wild animals[2-4].However,to the best of our knowledge,there was no published study assessing virus circulation among domestic or captive animals in Central,West and East *** this study,we assessed the presence and circulation of SARS-CoV-2 or other betacoronaviruses in pets,livestock and animals kept in captivity in conservation centers in Haut-Ogoouéprovince,southeastern Gabon.

关键词： Central southeastern Africa

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阿莱西亚战役博物馆

城市环境设计 2016年第1期 212-223页

作者： bernard Tschumi Joel Rutten Kim Starr Rémy Cointet Adam Dayem Jane Kim KJ Min Adrien Durrmeyer Matt Stofen Véronique Descharrèires Antoine Santiard Rémy Cointet Jean-Jacques Hubert

这个项目坐落于法国中部的一处考古遗址,博物馆纪念并展示了公元前52年尤利乌斯·恺撒与高卢人之间的一场历史性战役。项目要求设计两座分开而又相互关联的建筑——博物馆与体验中心,前者位于可以俯览城镇的山顶上,是围城时高卢军团曾... 详细信息

这个项目坐落于法国中部的一处考古遗址,博物馆纪念并展示了公元前52年尤利乌斯·恺撒与高卢人之间的一场历史性战役。项目要求设计两座分开而又相互关联的建筑——博物馆与体验中心,前者位于可以俯览城镇的山顶上,是围城时高卢军团曾经据守的地点,而后者则位于城镇下方罗马军团曾经驻扎过的田野之中。

关键词：博物馆博物院文化机构战役

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人行天桥

城市环境设计 2016年第1期 102-109页

作者： bernard Tschumi Hugh Dutton(HDA) Francoise Akinosho Ben Edelberg Kim Starr Véronique Descharrèires Vincent Prunier Rémy Cointet

该项目是和休·达顿共同设计的一条城市连桥,是联结建于拿破仑时期的旧城区和铁道另一侧的西城新兴社区这一长期城市规划与愿景的一部分。设计并未采用随意而缺乏根据的造型,而是将重点放在了解决超长平行跨距的力学结构上。虚实之间,...

该项目是和休·达顿共同设计的一条城市连桥,是联结建于拿破仑时期的旧城区和铁道另一侧的西城新兴社区这一长期城市规划与愿景的一部分。设计并未采用随意而缺乏根据的造型,而是将重点放在了解决超长平行跨距的力学结构上。虚实之间,部分紧密而不透明的结构感展现了最大化的压缩力,而其他轻盈且几近透明的构件则展现了最大程度的张力。

关键词：

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江诗丹顿总部大楼及制造中心扩建

城市环境设计 2016年第1期 142-148页

作者： bernard Tschumi Joel Rutten Paul Arthur Heller Clinton Peterson Nicolas Grillet Dustin Brugmann Véronique Descharrières Rémy Cointet Emmanuel Desmazières

离日内瓦不远的江诗丹顿总部大楼及制造中心扩建沿用了之前所采用的曲线表皮包裹制造设施的手法,使其成为园区内共同的建筑语言。基地附近即将展开有轨电车的建设,同时客户希望新建筑低于旧建筑,这些复杂的限制条件使最终设计呈现为一... 详细信息

离日内瓦不远的江诗丹顿总部大楼及制造中心扩建沿用了之前所采用的曲线表皮包裹制造设施的手法,使其成为园区内共同的建筑语言。基地附近即将展开有轨电车的建设,同时客户希望新建筑低于旧建筑,这些复杂的限制条件使最终设计呈现为一栋拥有独特几何造型的扩建大楼。大楼的屋面被太阳能板所覆盖。这次扩建是为原有的概念谱写的一个变奏。

关键词：总部大楼制造中心日内瓦瑞士

反思科学史:过去、现状以及可能的未来（英文）

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自然辩证法通讯 2019年第1期41卷 55-60页

作者：伯纳德.莱特曼约克大学人文学系

科学史的未来如何?这并非我们历史学者常问的一个问题,因为我们并非先知或预言家,且我们研究的是过去而非未来。不过,通过审视科学史的过去和现状,也许可以一窥科学史未来的走向。本文首先回顾了西方科学史学科自上世纪80年代开始的由"... 详细信息

科学史的未来如何?这并非我们历史学者常问的一个问题,因为我们并非先知或预言家,且我们研究的是过去而非未来。不过,通过审视科学史的过去和现状,也许可以一窥科学史未来的走向。本文首先回顾了西方科学史学科自上世纪80年代开始的由"内在主义"到"语境主义"的过渡,然后结合笔者自2004至2014主编《爱西斯》期刊以及编辑《科学史指南》的经历讨论了语境主义近15年来的发展。接着,笔者探讨了在语境主义继续发挥主导作用的条件下科学史的未来走向问题。在此,笔者强调了学者们对"全球科学史"的兴趣—-这种兴趣很有可能促生新的语境主义研究方向,从而促进中国科学史学者与其西方同行的合作。

关键词：未来科学史内在主义语境主义《爱西斯》

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十九世纪英国科学和历史大图景

自然辩证法通讯 2023年第7期45卷 65-78页

作者：伯纳德·莱特曼约克大学人文学系加拿大多伦多M3J1P3

本文运用《科学史指南》一书中的四个分析范畴来描绘19世纪英国科学的大图景。角色、地方、传播实践和物质材料是目前驱动科学史领域发展的最重要的分析范畴。本文首先回顾1973年新马克思主义科学史家罗伯特·杨提出的19世纪英国科学的... 详细信息

本文运用《科学史指南》一书中的四个分析范畴来描绘19世纪英国科学的大图景。角色、地方、传播实践和物质材料是目前驱动科学史领域发展的最重要的分析范畴。本文首先回顾1973年新马克思主义科学史家罗伯特·杨提出的19世纪英国科学的大图景,讨论四十多年来的科学史工作对该研究路径的挑战、突破和补充。随后,本文将围绕这四个分析范畴整合19世纪英国科学史研究的新进展。19世纪中叶自然哲学家和博物学家被科学人所替代,笔者将讨论科学角色发生变迁的原因及其影响和意义。接着,笔者考察了科学场所的演变,特别是实验室如何成为发现知识的特权空间。对科学传播中的转变,笔者将着重探讨传播革命带来的廉价科学图书的爆发式增长和新期刊的大量出版。最终,笔者提出一个新的综合的19世纪英国科学的历史大图景。

关键词：科学认同科学传播科学空间科学自然主义科学职业化和科学普及

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