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Novel color center platforms enabling fundamental scientific discovery

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InfoMat 2021年第8期3卷 869-890页

作者： Victoria A.Norman Sridhar Majety Zhipan Wang William h.casey Nicholas Curro Marina Radulaski Department of Electrical and Computer Engineering University of California at DavisDavisCalifornia Department of Physics University of California at DavisDavisCalifornia Department of Chemistry Department of Earth and Planetary SciencesUniversity of California at DavisDavisCalifornia

Color centers are versatile systems that generate quantum light,sense magnetic fields and produce spin-photon *** review how these properties have pushed the limits of fundamental knowledge in a variety of scientific disciplines,from rejecting local-realistic theories to sensing superconducting phase *** the light of recent progress in material processing and device fabrication,we identify new opportunities for interdisciplinary fundamental discoveries in physics and geochemistry.

关键词： color centers magnetometry nano-sensing photonics quantum information

Development of donor specific antibodies after SARS-CoV-2 vaccination:What do we know so far?

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World Journal of Meta-Analysis 2024年第2期12卷 1-4页

作者： Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Sakshi Vaishnav Genta Uehara AhmedAbdelkader Tibor Fulop Michael J casey Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States Department of Medicine Cairo University Medical SchoolCairo 11211Egypt Department of Medicine Medical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States Department of Medicine Division of NephrologyMedical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States

Vaccination against Coronavirus disease-19(COVID-19)was pivotal to limit spread,morbidity and *** aim is to find out whether vaccines against COVID-19 lead to an immunological response stimulating the production of de novo donor specific antibodies(DSAs)or increase in mean fluorescence intensity(MFI)of pre-existing DSAs in kidney transplant recipients(KTRs).This study involved a detailed literature search through December 2nd,2023 using PubMed as the primary *** search strategy incorporated a combination of relevant Medical Subject headings terms and keywords:"COVID-19","SARS-CoV-2 Vaccination","Kidney,Renal Transplant",and"Donor specific antibodies".The results from related studies were collated and analyzed.A total of 6 studies were identified,encompassing 460 KTRs vaccinated against *** responses were detected in 8 KTRs of which 5 had increased MFIs,1 had de novo DSA,and 2 were categorized as either having de novo DSA or increased *** were 48 KTRs with pre-existing DSAs prior to vaccination,but one study(Massa et al)did not report whether pre-existing DSAs were associated with post vaccination *** the remaining 5 studies,35 KTRs with pre-existing DSAs were identified of which 7 KTRs(20%)developed de novo DSAs or increased ***,no immunological response was detected in 452(98.3%)*** study affirms prior reports that COVID-19 vaccination is safe for KTRs,especially if there are no pre-existing ***,if KTRs have pre-existing DSAs,then an increased immunological risk may be *** findings need to be taken cautiously as they are based on a limited number of patients so further studies are still needed for confirmation.

关键词： COVID-19 SARS-CoV-2 vaccination Kidney Renal transplant Donor specific antibodies

Kinematic analysis of penile reflexes in a rat model of spinal cord injury

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Asian Journal of Andrology 2021年第1期23卷 30-35页

作者： casey J Steadman Sai S Vangoor Charles h hubscher Department of Anatomical Sciences and Neurobiology University of LouisvilleLouisvilleKY 40202USA Kentucky Spinal Cord Injury Research Center LouisvilleKY 40202USA.

The ex-copula penile dorsiflexion reflex(PDFR)is an established measure of sexual dysfunction in male rat models of spinal cord *** the PDFR after complete spinal transection is well described,information regarding the more clinically relevant incomplete spinal contusion injury model is *** study examined,using two-dimensional(2D)kinematic analysis,the relationship between the PDFR and degree of white matter sparing(WMS).Male Wistar rats received a T9 contusion with varying degrees of impactor *** kinematic recordings of the PDFR were made 3-8 weeks *** reflex components examined included maximum angle of penile dorsiflexion,total penile event duration,and penile ascent *** hoc comparison between animals grouped based upon injury severity(moderate-severe:13.33%-17.15%WMS vs moderate:20.85%-33.50%WMS)ndicated PDFR ***,the numbers of animals with more moderate contusions having data points above the median n both maximum angle of penile dorsiflexion and penile ascent speed were significantly lower than animals with more severe *** penile event duration was also affected but only at more chronic time points(6-8 weeks).Thus,2D kinematic analysis of the PDFR allows for more consistent and quantifiable analysis of the subtle differences that can occur between injury severity groups in the rat contusion model.

关键词： erection penile sexual dysfunction spinal cord injury

Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage

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National Science Review 2020年第4期7卷 815-822页

作者： Alida M.Bailleul Wenxia Zheng John R.horner Brian K.hall casey M.holliday Mary h.Schweitzer Key Laboratory of Vertebrate Evolution and human Origins Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment Department of Biological Sciences North Carolina State University Department of Geology University of Lund honors Program Chapman University Department of Pathology and Anatomical Sciences University of Missouri North Carolina Museum of Natural Sciences Department of Biology Dalhousie University

A histological ground-section from a duck-billed dinosaur nestling(hypacrosaurus stebingeri) revealed microstructures morphologically consistent with nuclei and chromosomes in cells within calcified *** hypothesized that this exceptional cellular preservation extended to the molecular level and had molecular features in common with extant avian cartilage. histochemical and immunological evidence supports in situ preservation of extracellular matrix components found in extant cartilage, including glycosaminoglycans and collagen type II. Furthermore, isolated hypacrosaurus chondrocytes react positively with two DNA intercalating stains. Specific DNA staining is only observed inside the isolated cells, suggesting endogenous nuclear material survived fossilization. Our data support the hypothesis that calcified cartilage is preserved at the molecular level in this Mesozoic material, and suggest that remnants of once-living chondrocytes, including their DNA, may preserve for millions of years.

关键词： cartilage dinosaur nuclei chromosomes collagen Ⅱ DNA markers

Methods for latent image simulations in photolithography with a polychromatic light attenuation equation for fabricating VIAs in 2.5D and 3D advaneed packaging architectures

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Microsystems & Nanoengineering 2021年第3期7卷 85-96页

作者： Daniel C.Smallwood Paul McCloskey Cian OzMathuna Declan P.casey James F.Rohan MicroNano Systems Centre Tyndall National InstituteUniversity College CorkLee MaltingsCork T12 R5CPIreland School of Engineering University College CorkCollege RoadCorkIreland

As demand accelerates for multifunctional devices with a small footprint and minimal power consumption,2.5D and 3D advanced packaging architectures have emerged as an essential solution that use through-substrate vias(TSVs)as vertical in *** stacking en ables chip packages with increased functi on ality,enhanced desig n versatility,minimal power loss,reduced footprint and high *** the potential of photolithography for vertical interconnect access(VIA)fabrication requires fast and accurate predictive modeling of diffraction effects and resist film *** procedure is especially challenging for broad-spectrum exposure systems that use,for example,hg bulbs with g-,h-,and i-line UV *** this paper,we present new methods and equations for VIA latent image determination in photolithography that are suitable for broad-spectrum exposure and negate the need for complex and time-consuming in situ *** technique is accurate,converges quickly on the average modern PC and could be readily integrated into photolithography simulation *** derive a polychromatic light attenuation equation from the Beer-Lambert law,which can be used in a critical exposure dose model to determine the photochemical reaction *** in teg rate this equation with an exact scalar diffraction formula to produce a succinct equation comprising a complete coupling between light propagation phenomena and photochemical *** then perform a comparative study between 2D/3D photoresist latent image simulation geometries and directly corresponding experimental data,which demonstrates a highly positive *** anticipate that this technique will be a valuable asset to photolithography,micro-and nano-optical systems and advaneed packaging/system integration with applications in technology domains ranging from space to automotive to the Internet of Things(loT).

关键词： latent image equation

Modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.hamilton David A.Katz Laura T.haderxhanaj casey E.Copen Ian h.Spicknall Matthew hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

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论矿物溶解速率与温度的关系

地质地球化学 1994年第2期22卷 24-28页

作者： W.h.casey G.Sposito 杨秋剑

硅酸盐和氧化物矿物的溶解速率，在远未达到平衡的条件下，其实验活化能（Eexp）随Ph值的变化达几十个KJ/mol。在远比零净质子电荷点（PZNPC）更酸性或更碱性的Ph条件下，实测的Eexp。值从大于50／mol变化到在pznpc附近但未必在PZNPC点... 详细信息

硅酸盐和氧化物矿物的溶解速率，在远未达到平衡的条件下，其实验活化能（Eexp）随Ph值的变化达几十个KJ/mol。在远比零净质子电荷点（PZNPC）更酸性或更碱性的Ph条件下，实测的Eexp。值从大于50／mol变化到在pznpc附近但未必在PZNPC点的很小的值。我们通过经验的溶解速率定律与产生正表面电荷的质子吸附的条件平衡常数相结合的方法，解释了这种矿物溶解速率随ph值发生的变化。利用条件平衡常数中的静电势项，对矿物表面各带电位置之间的相互作用加以处理。产生正（或负）表面电行的质子吸附（或解吸）是放热（或吸热）反应。对Eexp贡献15～50KJ／mol；这种贡献取决于带电表面位置的摩尔分数，因而会随Ph值发生微弱的变化。随着矿物表面获得明显的正电荷或负电荷，静电势的贡献就会变得越来越重要；因此，它会随Ph值发生明显的变化。这种模型法不但解释了Eexp与Ph值的关系，而且还得出了下面几条重要的一般性预测成果：1）对于同价阳离子置换有差别的矿物，其从Eexp值也会随ph值的变化而发生类似的变化，2）由于Eexp是大小类似但符号相反的焓的总和，所以可想象到会出现负的Eexp值；3）就带电位置的浓度而言，Eexp与部分反应速率阶（Order）呈线性相关；4）在高温下，溶解速率会对Ph值越来越敏感；

关键词：矿物溶解速率温度硅酸盐

Cellular fi bronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury

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World Journal of hepatology 2011年第2期3卷 45-55页

作者： Razia S Aziz-Seible Benita L McVicker Kusum K Kharbanda Carol A casey Department of Biochemistry and Molecular Biology University of Nebraska Medical Center985870Nebraska Medical CenterOmahaNE68198-5870United States Liver Study Unit Omaha Veterans Affairs Medical Center4101 Woolworth AvenueOmahaNE68105United States

AIM:To examine the consequences of cellular f ibronectin(cFn)accumulation during alcohol-induced injury,and inv estigate whether increased cFn could have an effect on hepatocytes(hCs)by producing factors that could cont ribute to alcohol-induced liver ***:hCs were isolated from rats fed a control or ethanol liquid diet for four to six *** c Fn(up to 7.5 μg/mL)was added to cells cultured for 20 h,and viability(lactate dehydrogenase),apoptosis(caspase activity)and se cretion of proinflammat-ory cytokines(tumor ne c rosis fac tor alpha,TNF-α and interleukin 6,IL-6),mat rix metalloproteinases(MMPs)and their inhibitors(tissue inhibitors of metall-oproteinases,TIMPs)was det *** ation of iodinated cFn was det ermined over a 3 h time period in the ***:cFn degradation is impaired in hCs isolated from ethanol-fed animals,leading to its accumulation in the *** of exogenous cFn did not affect viability of hCs from control or ethanolfed animals,and apoptosis was affected only at the higher *** retion of MMPs,TIMPs,TNF-α and IL-6,however,was increased by exogenously added cFn,with hCs from ethanolfed animals showing increased susceptibility compared to the ***:These results suggest that the elevated amounts of cFn observed in alcoholic liver injury can stimulate hepatocytes to produce factors which promote further tissue damage.

关键词： Alcoholic liver diseases hepatocytes Fibronectin Asialoglycoprotein receptor Inflammation Fibrosis

Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from <i>Lagenaria siceraria</i>

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Advances in Biological Chemistry 2012年第4期2卷 403-410页

作者： Abul h. J. Ullah Kandan Sethumadhavan casey Grimm Jay Shockey Southern Regional Research Center ARS USDA New Orleans USA

Phosphatidic acid phosphohydrolase (PAP), EC 3.***.3.4, is the penultimate step in the Kennedy pathway of triacyl glycerol (TAG) synthesis leading to the formation of diacylglycerol (DAG), which is a key intermediate in TAG synthesis. We partially purified a soluble PAP from mid maturing seeds of bottle gourd, Lagenaria siceraria. The steps include both anionic and cationic ion exchanger columns. Catalytic characterization of the partially purified PAP revealed that the optimum ph and temperature for activity were at 5.5?C and 45?C. Under optimum assay condition using dioleoyl phosphatidic acid (DPA) as the substrate, the Vmax and Km were 0.36 ηkat/mg of protein and 200 μM, respectively. For the synthetic substrate, ρ-nitrophenylphosphate, ρ-NPP, the Vmax and Km were 33.0 nkat/mg of protein and 140 μM, respectively. The activity was neither inhibited nor enhanced by the presence of Mg2+ at a concentration range of 0 to 10 mM. Two major protein bands at 42-kDa and 27-kDa were visible in SDS-PAGE after partial purification. Bioinformatics analysis of tryp-sinized protein fractions containing PAP activity showed peptide sequences with sequence homology to various phosphate metabolizing enzymes including cucumber and castor bean purple acid phosphatase, polyphosphate kinase, fructose biphosphate aldolase, and enolase from various dicotyledonous plants including rice, corn, grape, and Arabidopsis lyrata.

关键词： Phosphatidic Acid Phosphohydrolase Lagenaria siceraria Bioinformatics TAG Biosynthesis