Kinematic analysis of penile reflexes in a rat model of spinal cord injury
作者机构：Department of Anatomical Sciences and NeurobiologyUniversity of LouisvilleLouisvilleKY 40202USA Kentucky Spinal Cord Injury Research CenterLouisvilleKY 40202USA.
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2021年第23卷第1期
页 面：30-35页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Funding support for this work was provided through the Kentucky Spinal Cord and Head Injury Research Trust the Department of Defense
主 题：erection penile sexual dysfunction spinal cord injury
摘 要：The ex-copula penile dorsiflexion reflex(PDFR)is an established measure of sexual dysfunction in male rat models of spinal cord *** the PDFR after complete spinal transection is well described,information regarding the more clinically relevant incomplete spinal contusion injury model is *** study examined,using two-dimensional(2D)kinematic analysis,the relationship between the PDFR and degree of white matter sparing(WMS).Male Wistar rats received a T9 contusion with varying degrees of impactor *** kinematic recordings of the PDFR were made 3-8 weeks *** reflex components examined included maximum angle of penile dorsiflexion,total penile event duration,and penile ascent *** hoc comparison between animals grouped based upon injury severity(moderate-severe:13.33%-17.15%WMS vs moderate:20.85%-33.50%WMS)ndicated PDFR ***,the numbers of animals with more moderate contusions having data points above the median n both maximum angle of penile dorsiflexion and penile ascent speed were significantly lower than animals with more severe *** penile event duration was also affected but only at more chronic time points(6-8 weeks).Thus,2D kinematic analysis of the PDFR allows for more consistent and quantifiable analysis of the subtle differences that can occur between injury severity groups in the rat contusion model.
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