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Chinese Journal of Integrative Medicine 2012年第10期18卷 723-729页

作者： Claudia M.Witt 黄文静 Lixing Lao berman bm Charit University Medical Center Institute for Social MedicineEpidemiology and Health Economics University of Maryland School of Medicine Center for Integrative Medicine Chengdu University of Traditional Chinese Medicine The Institute for Integrative Health

In clinical research on complementary and integrative medicine, experts and scientists have often pursued a research agenda in spite of an incomplete understanding of the needs of end users. Consequently, the majority of previous clinical trials have mainly assessed the efficacy of interventions. Scant data is available on their effectiveness. Comparative effectiveness research （CER） promises to support decision makers by generating evidence that compares the benefits and harms of the best care options. This evidence, more generalizable than the evidence generated by traditional randomized controlled trials （RCTs）, is better suited to inform real-world care decisions. An emphasis on CER supports the development of the evidence base for clinical and policy decision-making. Whereas in most areas of complementary and integrative medicine data on comparative effectiveness is scarce, available acupuncture research already contributes to CER evidence. This paper wil introduce CER and make suggestions for future research.

关键词： comparative effectiveness research decision making integrative medicine Chinese medicine acupuncture

农田土壤重金属污染修复研究进展-基于CiteSpace知识图谱分析

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土壤通报 2024年第2期55卷 573-583页

作者：管秀静苏燕阿娜尔田楚琪欧成浩姜绍元 bm.Soran Dinki 王坚党秀丽沈阳农业大学土地与环境学院/土肥高效利用国家工程研究中心/农业农村部东北耕地保育重点实验室辽宁沈阳110866 沈阳环境科学研究院辽宁沈阳110167

以中国知网及Web of Science数据库的文献资料为数据源,利用CiteSpace文献计量工具,对2000~2021年农田土壤重金属污染修复研究领域的相关中外文文献从发文量、发文国家及作者、关键词等进行分析,以此探讨国内外该领域研究现状及未来发... 详细信息

以中国知网及Web of Science数据库的文献资料为数据源,利用CiteSpace文献计量工具,对2000~2021年农田土壤重金属污染修复研究领域的相关中外文文献从发文量、发文国家及作者、关键词等进行分析,以此探讨国内外该领域研究现状及未来发展驱势。结果表明,农田土壤重金属污染修复研究文献数量呈快速增长态势,中国、美国、韩国等是外文文献发文量较多的国家;中国科研机构在外文文献发文数量上所占比重最大,表明我国在该领域对国际学术的影响力较大;从关键词出现频次分析可知,当前该领域主要研究内容是土壤镉、铅等多种金属的复合污染的累积特征及重金属复合污染的修复,而植物修复技术在农田土壤重金属污染修复研究中的应用是当前该领域研究热点;未来土壤重金属污染修复领域的主要研究方向为物理、化学联合生物等多种修复技术组成的综合修复体系。

关键词：重金属修复文献计量分析 CiteSpace 农田土壤

A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity

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World Journal of Gastroenterology 2007年第39期13卷 5196-5207页

作者： bm Srikanta MN Siddaraju Shylaja M Dharmesh Department of Biochemistry and Nutrition Central Food Technological Research InstituteMysore -570020KarnatakaIndia

AIM: To investigate H+, K+-ATPase inhibition, anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H+, K+-ATPase and gastric mucin levels were determined to assess the anti- ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H+, K+-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H+, K+-ATPase in vitro, at an IC50 of 77 μg/mL as opposed to that of 19.3 μg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 μg/mL. In addition, free radical scavenging (IC50-40 μg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H+, K+-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management.

关键词： Swallow root pectic polysaccharide Gastriculcer H^+, K^+-ATPase Histopathology Antioxidant activity H pylori

Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

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World Journal of Gastroenterology 2000年第4期6卷 526-531页

作者： Yang, CQ Wang, JY He, bm Liu, JJ Guo, JS Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat *** After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by *** different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and *** The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three *** liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the *** G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver.

关键词： liposomes glyco-poly-L-lysine targeted liver uptake exogenous gene

Stark characteristics of cesium atom studied in a thermionic bulb

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Chinese Science Bulletin 1997年第22期42卷 1877-1880页

作者： Gu, SH Liu, bm Wang, JM Dai, ZY Gong, SS Chinese Acad Sci Wuhan Inst Phys & Math Lab Magnet Resonance & Atom & Mol Phys Wuhan 430071 Peoples R China

MOST of the spectral studies of atomic strong electric effect are carried out by means of atomicbeam and pulse laser. The spectral linewidth is ranged from the order of one to ten GHz. Inrecent years, with the applica... 详细信息

关键词： cesium atom electric fleld Rydberg state spectrum.

Habitat suitability of Scapharca subcrenata (Lischke) inthe shallow water of the Xiaoheishan Island

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Acta Oceanologica Sinica 2016年第12期35卷 51-57页

作者： ZHOU Jian SONG Jingjing bm Qianling LIU Chengyue ZHANG Zhipeng TANG Haitian Shandong Marine Forecast and Hazard Mitigation Service Qingdao 266104 China Marine Biology Institute of Shandong Province Qingdao 266104 China Tianjin University of Science and Technology Tianjin 300457 China College of Marine Life Ocean University of China Qingdao 266100 China Yantai Marine Environment Monitoring Central Station of State Oceanic Administration Yantai 264006 China

The habitat suitability index(HSI) model was used to identify potential sites for sustainable restoration of ark shell, Scapharca subcrenata(Lischke), in the shallow water of Xiaoheishan Island, using a geographic information system framework. The seven input variables of the HSI model were sediment composition, water temperature, salinity, dissolved oxygen, water depth, p H, and ammonia. A non-linear suitability function for each variable factor was used to transform the value into a normalized quality index ranging from 0(nonsuitability) to 1(best suitability). In present study, the analysis of habitat suitability was conducted for four seasons respectively. The majority of the study area has a high HSI value(>0.6) year round, which implies a strong suitability for restoration, with the optimal habitat located on the eastern side of the *** analysis indicated that water temperature was the main factor causing seasonal variation,while sediment composition and water depth were the two major reasons for the differences in sites. The results of this work could provide support for restoration decision making through identification of potential sites for sustainable establishment of S. subcrenata.

关键词： Scapharca subcrenata(Lischke) habitat suitability index restoration shallow water

Effects of combined pre- and post-natal protein deprivation on the myenteric plexus of the esophagus of weanling rats:A histochemical,quantitative and ultrastructural study

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World Journal of Gastroenterology 2007年第26期13卷 3598-3604页

作者： Edson A Liberti Ricardo BV Fontes Verginia M Fuggi Laura bm Maifrino Romeu R Souza Autonomic Nervous System Laboratory (VQM) Department of AnatomyInstitute of Biomedical SciencesUniversity of So Paulo So PauloBrazil

AIM: To evaluate the effects of protein deprivation on the myenteric plexus of the esophagus of weanling rats. METHODS: Pregnant female Wistar rats were divided into 2 groups: nourished (N),receiving normal diet,and undernourished (D),receiving a protein-deprived diet,which continued after birth. At twenty-one days of age,13 esophagi from each group were submitted to light microscopy and morphometrical analysis employing the NADH diaphorase,NADPH diaphorase and acetylcholinesterase techniques. Three other esophagi from each group were evaluated with transmission electron microscopy (TEM). RESULTS: In both the NADH- and the NADPH-reactive mounts,the neurons of the N mounts were more intensely stained,while in the D esophagi only the larger neurons were reactive. Many myenteric neurons of N were intensely reactive for AChE activity but only a few neurons of D exhibited these aspects. Ultrastructural analysis revealed that the granular reticulum of N showed large numbers of ribosomes aligned on the outer surface of its regularly arranged membrane while the ribosomes of D were disposed in clusters. The chromatin was more homogeneously scattered inside the neuron nucleus of N as well as the granular component of the nucleolus was evidently more developed in this group. Statistically significant differences between N and D groups were detected in the total estimated number of neurons stained by the NADPH technique. CONCLUSION: The morphological and quantitative data shows that feeding with protein-deprived diet in 21-d old rats induces a delay in the development of the myenteric neurons of the esophagus.

关键词： Enteric nervous system Myenteric plexus Nutrition Microscopy Electron Transmission Esopha-gus Rat Wistar

Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 718-722页

作者： Al-Bahry SN Al-Mashani bm Al-Ansari AS Elshafie AE Mahmoud IY Department of Biology College of ScienceSultan Qaboos University Department of Biological Sciences and Chemistry University of Nizwa

Objective:To screen for Escherichia coli(***)resistant to tetracycline,followed by identification of tet efflux genes by polymerase chain reaction(PCR).In addition,detection of tetracycline residues in chicken livers and kidneys were conducted using high performance liquid chromatography-tandem quadrupole mass spectrometry(HPLC-MS-MS).Methods:Strains of *** were isolated from samples of chicken colon and screened for tetracycline *** genes conferring resistance(Tc^r)were detected by polymerase chain reaction(PCR).Most of the isolates were resistant to tetracycline(97.9%).Results:PCR analysis indicated that Tc^r *** R-plasmids contained tet(A),tet(B)and a combination of both efflux *** of the isolates contained other efflux tet genes tet(C,D,E and Y).High performance liquid chromatography-tandem quadrupole mass spectrometry(HPLC-MS-MS),a sensitive technique,was used to detect residues of chlortetracycline(CTC),oxytetracyeline(OTC),doxveycline(DC)in chicken livers and *** samples containing tetracycline residues were at 0.13-0.65pg/μL ***:Tetracycline and other antibiotics are commonly used in the poultry and meat production industry for prevention of microbial *** antibiotic resistant bacteria in Oman have increased to alarming levels,threatening public health,domestic and may have adverse effect on environment.

关键词： Chicken Escherichia coli Antibiotic resistance genes Tetraeyeline

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

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Genes & Diseases 2023年第2期10卷 381-384页

作者： Jeroen Vierstraete Charlotte Fieuws David Creytens Jo Van Dorpe Andy Willaert Anne Vral Kathleen bm Claes Center for Medical Genetics Department of Biomolecular MedicineGhent University Hospital and Ghent University9000 GhentBelgium Department of Human Structure and Repair Ghent University9000 GhentBelgium Cancer Research Institute Ghent (CRIG) Ghent University and Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University and Ghent University Hospital9000 GhentBelgium

Biallelic loss-of-function variants in ATM (Ataxia Telangiectasia Mutated) cause Ataxia Telangiectasia (AT), a rare disorder associated with cerebellar degeneration and ataxia, cancer predisposition, infertility, growth retardation, etc. ATM is a phosphoinositide 3-kinase-related kinase (PIKK) with a role in DNA repair and maintenance of genome stability. Studying a multisystem genetic disease like AT requires animal models to ascertain its pathogenesis at the level of tissues, organs and the organism. Due to its small size, cheap maintenance, large progeny, rapid development and initial transparency, zebrafish (Danio rerio) is an increasingly popular vertebrate model organism, suitable for genetic modifications and large-scale in vivo therapeutic screens as embryos are chemically permeable to small compounds. Currently, no zebrafish model for AT exists.1 We generated atm knock-outs through CRIPSR-Cas9 mutagenesis. We show that atm conserved its function as a tumour suppressor gene and is involved in gametogenesis and fertility. Therefore, this mutant is of great value for further studies investigating the role of atm in reproduction and tumorigenesis.

关键词： ATM function transparency

Direct laser interference patterning of nonvolatile magnetic nanostructures in Fe60Al40 alloy via disorder‐induced ferromagnetism

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Opto-Electronic Advances 2020年第1期3卷 1-7页

作者： Philipp Graus Thomas bmöller Paul Leiderer Johannes Boneberg Nikolay I.Polushkin Department of Physics University of Konstanz78457 KonstanzGermany Institute for Physics of Microstructures of RAS 603950 GSP-105 Nizhny NovgorodRussian

Current magnetic memories are based on writing and reading out the domains with opposite orientation of the magnetization ***,information can be encoded in regions with a different value of the saturation *** latter approach can be realized in principle with chemical order-disorder transitions in intermetallic ***,we study such transformations in a thin-film(35 nm)Fe60Al40 alloy and demonstrate the formation of periodic magnetic nanostructures(PMNS)on its surface by direct laser interference patterning(DLIP).These PMNS are nonvolatile and detectable by magnetic force microscopy(MFM)at room temperature after DLIP with a single nanosecond *** provide different arguments that the PMNS we observe originate from increasing magnetization in maxima of the interference pattern because of chemical disordering in the atomic lattice of the alloy at temperatures T higher than the critical temperature Tc for the order(B2)-disorder(A2)***,our simulations of the temporal evolution of a partially ordered state at T>Tc reveal that the disordering rate is significant even below the melting ***,we find that the PMNS are erasable with standard thermal annealing at T

关键词： thin films laser patterning magnetic dots magnetic memory