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Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review

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World Journal of Gastroenterology 2008年第9期14卷 1459-1462页

作者： beom gyu kim In Taik Chang Jun Seok Park Yoo Shin Choi Gi Hyeon kim Eon Sub Park Chang Hwan Choi Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Radiology College of MedicineChung-Ang University Seoul 156-755Korea Department of Pathology College of MedicineChung-Ang University Seoul 156-755 Korea Department of Internal Medicine College of Medicine Chung-Ang UniversitySeoul 156-755Korea

Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transana local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

关键词： Malignant fibrous histiocytoma Anorectal junction Transanal local excision

Intrauterine midgut volvulus without malrotation:Diagnosis from the 'coffee bean sign'

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World Journal of Gastroenterology 2008年第9期14卷 1456-1458页

作者： Jun Seok Park Seong Jae Cha beom gyu kim Yong Seok kim Yoo Shin Choi In Taik Chang Gwang Jun kim Woo Seok Lee Gi Hyeon kim Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Obstetrics and Gynecology College of Medicine Chung-Ang UniversityKorea Department of Radiology College of Medicine Chung-Ang University Seoul 156-755Korea

Fetal midgut volvulus is quite rare, and most cases are associated with abnormalities of intestinal rotation or fixation. We report a case of midgut volvulus without malrotation, associated with a meconium pellet, during the gestation period. This 2.79 kg, 33-wk infant was born via a spontaneous vaginal delivery caused by preterm labor. Prenatal ultrasound showed dilated bowel loops with the appearance of a 'coffee bean sign'. This patient had an unusual presentation with a distended abdomen showing skin discoloration. An emergency laparotomy revealed a midgut volvulus and a twisted small bowel, caused by complicated meconium ileus. Such nonspecific prenatal radiological signs and a low index of suspicion of a volvulus during gestation might delay appropriate surgical management and result in ischemic necrosis of the bowel. Preterm labor, specific prenatal sonographic findings (for example, the coffee bean sign) and bluish discoloration of the abdominal wall could suggest intrauterine midgut volvulus requiring prompt surgical intervention.

关键词： Midgut volvulus Coffee bean sign Meconium ileus

Effectiveness of gastric cancer screening programs in South Korea:Organized vs opportunistic models

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World Journal of Gastroenterology 2013年第5期19卷 736-741页

作者： beom Jin kim Chae Heo Byoung Kwon kim Jae Yeol kim Jae gyu kim Department of Internal Medicine Chung-Ang University College of MedicineHeukseok-dongDongjak-guSeoul 156-755South Korea Department of Pathology Green Cross Reference Laboratory314 Pojung-dongGiheung-guYongin-siKyunggi-do 446-913South Korea

AIM:To investigate the outcome and effectiveness of two screening programs,National Cancer Screening Program(NCSP)and opportunistic screening(OS),for the detection of gastric cancer. METHODS:A total of 45 654 subjects underwent upper endoscopy as part of the NCSP or OS at the Chung-Ang University Healthcare System in Korea between January 2007 and December *** study population was comprised of subjects over the age of 40 *** specifically,subjects who took part in the NCSP were Medicaid recipients and beneficiaries of the National Health Insurance *** photo-graphs from the endoscopies diagnosed as gastric cancer were reviewed by two experienced endoscopists. RESULTS:The mean age of the screened subjects was 55 years for men and 54 years for women.A total of 126 cases(0.28%)of gastric cancer were detected from both screening programs;100 cases(0.3%)from NCSP and in 26 cases(0.2%)from *** proportion of early gastric cancer(EGC)detected in NCSP was higher than that in OS(74.0%vs 53.8%,P=0.046). Among the 34 416 screenees in NCSP,6585(19.1%) underwent upper endoscopy every other year as *** the 11 238 screenees in OS,3050(27.1%) underwent upper endoscopy at least once every two years during the study *** detection rate of gastric cancer was found to be significantly higher during irregular follow-up than during regular follow-up in both screening programs(0.3%vs 0.2%,P=0.036).A higher incidence of EGC than advanced gastric cancer was observed during regular follow-up compared with irregular follow-up. CONCLUSION:Compliance to the screening program is more important than the type of screening system used.

关键词： Gastric cancer National Cancer Screening Program Opportunistic screening Early gastric cancer

Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway

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Neural Regeneration Research 2013年第35期8卷 3269-3274页

作者： Ji-Young kim beom Seok Jeon Han-Joon kim Tae-beom Ahn Department of Neurology Inje University Seoul Paik Hospital Department of Neurology College of Medicine Seoul National University Hospital Department of Neurology Kyung Hee University Medical Center

Although alpha-synuclein is generally thought to have a pathological role in Parkinson＇s disease, accumulative evidence exists that alpha-synuclein has a neuroprotective effect. The aim of this study was to evaluate the effect of extracellular alpha-synuclein on dopaminergic cell survival. We assessed cell viability using the 3-（4,5-dimethyt-thiazol-2-yt）-2,5-diphenyltertazolium bromide （MTT） assay both in undifferentiated SH-SY5Y （SHSY） cells and neuronally-differentiated SH-SY5Y （ndSHSY） cells after 24 hour treatment with monomeric alpha-synuclein at various concentrations （0 [control], 50, 100 nmol/L, 1 IJmol/L）. To determine whether cell viability assessed by MTT assay was affected by cell proliferation, 5-bromo-2＇-deoxyuridine （BrdU） incorporation assay was per- formed. Level of both Akt and phosphorylated Akt was measured using western blot method in ndSHSY cells with or without 24 hour alpha-synuclein treatment. Cell viability was increased in ndSHSY cells at the nanomolar concentration of alpha-synuclein, but not in SHSY cells. Proportion of BrdU-positive ndSHSY cells was decreased in alpha-synuclein-treated group compared with control group. Level of phosphorylated Akt in alpha-synuclein-treated group was higher compared with the control group. Our study shows that extracellular alpha-synuclein at nanomolar concentra- tion benefits dopaminergic cell survival via Akt pathway.

关键词： neural regeneration alpha-synuclein neuronal survival nanomolar extracellular phosphorylatedAkt SH-SY5Y cell neuronal differentiation proliferation dopaminergic 5-bromo-2'-deoxyuridine grants-supported paper neuroregeneration

Role of milk carbohydrates in intestinal health of nursery pigs: a review

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Journal of Animal Science and Biotechnology 2022年第3期13卷 628-641页

作者： Ki beom Jang Sung Woo kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

Intestinal health is essential for the resistance to enteric diseases and for nutrient digestion and absorption to support *** intestine of nursery pigs are immature and vulnerable to external challenges,which cause negative impacts on the structure and function of the *** nutritional interventions,the benefits of milk are significant for the intestinal health of *** coproducts have traditionally been used in starter feeds to improve the growth of nursery pigs,but their use is somewhat limited due to the high costs and potential risks of excessive lactose on the ***,understanding a proper feeding level of milk carbohydrates is an important start of the feeding *** nursery pigs,lactose is considered a highly digestible energy source compared with plant-based starch,whereas milk oligosaccharides are considered bioactive compounds modulating intestinal immunity and ***,milk carbohydrates,mainly composed of lactose and oligosaccharides,have essential roles in the intestinal development and functions of nursery *** proper feeding levels of lactose in starter feeds could be variable by weaning age,body weight,or genetic *** of lactose and milk oligosaccharides have been broadly studied in human health and animal ***,this review focuses on the mechanisms of lactose and milk oligosaccharides affecting intestinal maturation and functions through modulation of enterocyte proliferation,intestinal immunity,and intestinal microbiota of nursery pigs.

关键词： Intestinal health Lactose Milk carbohydrates Milk oligosaccharides Nursery pig

Numerical Study on Air Turbines with Enhanced Techniques for OWC Wave Energy Conversion

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China Ocean Engineering 2017年第5期31卷 517-527页

作者： CUI Ying HYUN beom-Soo kim Kilwon Department of Ocean Engineering College of EngineeringOcean University of China Division of Naval Architecture and Ocean Engineering Korea Maritime and Ocean University

In recent years,the oscillating water column(OWC) wave energy converter,which can capture wave energy from the ocean,has been widely applied all over the *** the essential part of the OWC system,the impulse and Wells turbines are capable of converting the low pressure pneumatic energy into the mechanical shaft *** an enhanced technique,the design of endplate or ring attached to the blade tip is investigated numerically in this paper.3 D numerical models based on a CFD-software FLUENT 12.0 are established and validated by the corresponding experimental results from the reports of Setoguchi et al.(2004) and Takao et al.(2001).Then the flow fields and non-dimensional evaluating coefficients are calculated and analyzed under steady *** show that the efficiency of impulse turbine with ring can reach up to 0.49 when Ф=1,which is 4% higher than that in the cases for the endplate-type and the original *** the ring-type Wells turbine with fixed guide vanes shows the best performance with the maximal efficiency of 0.55,which is 22% higher than that of the original *** addition,the quasi-steady analysis is used to calculate the mean efficiency and output-work of a wave cycle under sinusoidal flow *** all together,this study provides support for structural optimization of impulse turbine and Wells turbine in the future.

关键词： OWC impulse turbine Wells turbine CFD endplate ring quasi-steady analysis

How to deliver palliative care for patients with management in decompensated cirrhosis

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 576-579页

作者： beom Kyung kim Department of Internal medicine Yonsei University College of MedicineSeoulRepublic of Korea Institute of Gastroenterology Yonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea

Palliative care is defined as multidisciplinary,specialized medical care that meets the needs of patients with serious illnesses and their caregivers from the standpoints of the physical,spiritual,and emotional levels(1).Nowadays,it is also considered to be one of the fundamental care programs for patients with decompensated cirrhosis,as has also been demonstrated in the field of other cancers(2).Recently,the guidance regarding“palliative care and symptom-based management in decompensated cirrhosis”had been published in 2022 by the American Association for the Study of Liver Diseases(AASLD)(3).

关键词： Palliative care decompensation cirrhosis

Measurement of biological age may help to assess the risk of colorectal adenoma in screening colonoscopy

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World Journal of Gastroenterology 2017年第37期23卷 6877-6883页

作者： Sang-Jung kim beom Jin kim Hyun Kang Department of Internal Medicine Bundang Jesaeng Hospital Sungnam-si Department of Internal Medicine Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine.Chung-Ang University College of Medicine

AIM To investigate the clinical utility of biological age(BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk *** A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. Colorectal adenoma was classified according to size, number, and location. BAs were calculated using the MEDIAGETM Biological Age Measurement *** A total of 2696 subjects were investigated(1876 men and 820 women). The mean chronological age(CA) was 46.0 years and the mean BA was 44.7 years. Metabolic syndrome(MS) was diagnosed in 218 subjects(8.1%). The prevalence of overall colorectal adenoma was 23.1%(622/2,696). When the subjects were divided into four groups based on BA(≤ 39 years; 40-49 years; 50-59 years; ≥ 60 years), the prevalence of colorectal adenoma was increased as BA increased(P < 0.001). Colorectal adenoma located in the proximal colon was more prevalent in the BA-dominant group(BA-CA ≥ 5years) than the CA-dominant group(CA-BA ≥ 5 years)(P = 0.034). When the subjects were categorized into four groups according to MS and age gap between BA and CA, the incidence of colorectal adenoma increased with MS and BA-dominance(P < 0.05).CONCLUSION Measurement of BA may help to assess the risk of colorectal adenoma in screening colonoscopy.

关键词： Chronological age Biological age Colorectal adenoma Age gap

Submergence promotes auxin-induced callus formation through ethylene-mediated post-transcriptional control of auxin receptors

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Molecular Plant 2022年第12期15卷 1947-1961页

作者： Seung Yong Shin Yuri Choi Sang-gyu kim Su-Jin Park Ji-Sun Park Ki-beom Moon Hyun-Soon kim Jae Heung Jeon Hye Sun Cho Hyo-Jun Lee Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea Department of Functional Genomics KRIBB School of BioscienceUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Korea Department of Biosystems and Bioengineering KRIBB School of BiotechnologyUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Korea

Plant cells in damaged tissue can be reprogrammed to acquire pluripotency and induce callus ***,in the aboveground organs of many species,somatic cells that are distal to the wound site become less sensitive to auxin-induced callus formation,suggesting the existence of repressive regulatory mechanisms that are largely *** we reveal that submergence-induced ethylene signals promote callus formation by releasing post-transcriptional silencing of auxin receptor transcripts in non-wounded *** determined that short-term submergence of intact seedlings induces auxin-mediated cell dedifferentiation across the entirety of Arabidopsis thaliana *** constitutive triple response 1-1(ctr1-1)mutation induced callus formation in explants without submergence,suggesting that ethylene facilitates cell *** show that ETHYLENE-INSENSITIVE 2(EIN2)post-transcriptionally regulates the abundance of transcripts for auxin receptor genes by facilitating microRNA393 ***-induced calli in non-wounded regions were suitable for shoot regeneration,similar to those near the wound *** also observed submergence-promoted callus formation in Chinese cabbage(Brassica rapa),indicating that this may be a conserved mechanism in other *** study identifies previously unknown regulatory mechanisms by which ethylene promotes cell dedifferentiation and provides a new approach for boosting callus induction efficiency in shoot explants.

关键词： cell dedifferentiation auxin signaling ethylene callus formation EIN2