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Cecal duplication cyst in an infant presenting as shock:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6931-6937页

作者： Seung Mo Kim Sun Hyang Lee Ga Young Park Sung shin Kim Cheol Gu Lee soo Ji Jin Department of Pediatrics Soonchunhyang University Bucheon HospitalSoochunhyang University College of MedicineBucheon 14584Gyeonggi-doSouth Korea Department of General Surgery Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea

BACKGROUND Although intestinal obstruction is one of the most common surgical emergencies in an infant,it is difficult to diagnose neonatal enteric duplication cysts(EDC)preoperatively owing to their rarity as a cause of intestinal *** describe a case report of a neonatal EDC presenting intestinal obstruction and *** SUMMARY A 32-d-old male infant with a prenatal sonographic finding of bladder distension was admitted to our hospital for a severely distended abdomen,fever,and *** first diagnostic hypothesis was septic shock and intestinal *** patient’s symptoms worsened;following an emergency surgical exploratory laparotomy and histopathological findings,the final diagnosis of cecal duplication cyst was *** patient’s postoperative course was uneventful,and on the fifth postoperative day,oral feeding *** days later,the patient was discharged from the *** Although EDC located in the cecum is exceptional,it should be considered when evaluating suspected intestinal obstruction and shock.

关键词： Duplication cyst Cecum Intestinal obstruction Infant Shock Case report

Solitary acral persistent papular mucinosis nodule:A case report and summary of eight Korean cases

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World Journal of Clinical Cases 2023年第13期11卷 3086-3091页

作者： Yu Jeong Park Hui Young shin Woo Kyoung Choi Ai-Young Lee Seung Ho Lee Jong soo Hong Department of Dermatology Dongguk University Ilsan HospitalCollege of MedicineDongguk UniversityGoyang-siGyeonggi-doKorea 10326South Korea

BACKGROUND Acral persistent papular mucinosis(APPM)is a rare idiopathic subtype of localized lichen *** date,there have been 40 APPM cases reported worldwide;however,only 7 cases have been reported in the Korean *** SUMMARY A 70-year-old man was referred to our hospital with a solitary pinkish nodule on the dorsum of his right *** the absence of symptoms,the patient wanted to know the exact diagnosis;thus,a biopsy was *** examination of a biopsy specimen obtained from the nodule on the dorsum of his hand revealed orthokeratotic hyperkeratosis with patchy parakeratosis,prominent hypergranulosis,and diffuse dissecting mucinous deposition between collagen bundles,along with some bland-looking spindle cells throughout the *** nodule was histologically diagnosed as an APPM,and an intralesional triamcinolone injection(2.5 mg/mL)was started every 2 *** three sessions of treatment,the patient showed marked *** To the best of our knowledge,this is the first case of a Korean APPM presenting as a solitary nodule that showed a marked response to triamcinolone intralesional *** it is a rare disease,we report this case to contribute to future research on the pathogenesis and treatment of APPM.

关键词： Acral persistent papular mucinosis Localized lichen myxedematosus Cutaneous mucinosis Mucin Case report

Optimal laboratory testing protocol for patients with acne taking oral isotretinoin

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World Journal of Clinical Cases 2023年第11期11卷 2435-2442页

BACKGROUND Isotretinoin is a widely prescribed drug for various dermatological conditions,especially *** tests are routinely performed to monitor its side ***,the optimal testing schedule remains *** To evaluate the laboratory monitoring tests and schedules of patients with acne taking isotretinoin to determine the most efficient testing *** We retrospectively reviewed electronic medical records from the Dermatology Department of Dongguk University Ilsan Hospital from 2005 to 2020 for patients prescribed isotretinoin for acne who underwent monthly blood *** Aspartate aminotransferase(AST),alanine aminotransferase(ALT),and trigly-ceride(TG)levels significantly changed between 5 and 6 mo when the total prescription period and dose variables were considered *** high-density lipoprotein level also significantly changed between 5 and 6 ***,low-density lipoprotein(LDL)and total cholesterol levels significantly changed between 1 and 2 *** We recommend testing AST,ALT,and TG levels once every 5 to 6 *** also suggest testing LDL and total cholesterol levels during the first and second months.

关键词： Acne vulgaris Isotretinoin Clinical laboratory techniques Vitamin A Liver

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo Kim Sujin Kim soo Jung shin Yong Ho Park Yunkwon Nam Chae won Kim Kang won Lee Sung-Min Kim In Duk Jung Hyun Duk Yang Yeong-Min Park Minho Moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive *** in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic *** gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD ***,an altered distribution of gram-negative bacteria and their LPS has been reported in AD ***,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and ***,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive *** multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been ***,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in ***,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau

Mobile lens- induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1080-1082页

作者： Dong Hyun Lee Jonghoon shin Jae Hyun Seo Ik soo Byon Jae Ho Jung Ji Eun Lee Department of Ophthalmology Pusan National University Yangsan Hospital Department of Ophthalmology Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Yangsan Pusan National University Hospital Medical Institute School of MedicinePusan National University

Dear Sir,I am Dong Hyun Lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,***,I present the development of a lens-induced angle closed glaucoma and iris neovascularization in the patient with Sturge Weber syndrome(SWS)with open angle *** consent was obtained from a patient before each procedure The study was conducted in accordance with the tenets of the Declaration of Helsinki.

关键词： induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome SWS open IOP Mobile lens Figure

Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 662-664页

作者： Seok-Hwan Kim Gi-Won Song shin Hwang Chul-soo Ahn Deok-Bog Moon Tae-Yong Ha Sung-Gyu Lee Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul 05505 Korea

To the Editor:In Korea,the annual number of deceased donors for or gan transplantation per million people is still less ***,approximately 40%of patients with acute liver failure or acute-on-chronic liver failure undergo living donor liver transplantation（LDLT）.;Although the use of ABO-incompatible（ABOi）living donors is an attrac tive option,ABOi LDLT has very restricted applications

关键词： ABO Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure RIT

Prognostic value of decision criteria for emergency liver transplantation in patients with wild mushroom induced acute liver injury

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 210-213页

作者： Youn-Jung Kim Hyung Joo Lee Seung Mok Ryoo shin Ahn Chang Hwan Sohn Dong-Woo Seo Kyoung soo Lim Won Young Kim Department of Emergency Medicine University of Ulsan College of Medicine Asan Medical Center

Background： The reported mortality rate of mushroom-induced acute liver failure with conventionaltreatment is 1.4%–16.9%. Emergency liver transplantation may be indicated and can be the only curativetreatment option. This study aimed to assess the prognostic value of criteria for emergency livertransplantation in predicting 28-day mortality in patients with mushroom-induced acute liver ***： A retrospective cohort study was performed between January 2005 and December 2015. Alladult patients aged≥18 years admitted with mushroom intoxication at our emergency department wereevaluated. All patients with acute liver injury, defined as elevation of serum liver enzymes （〉5 timesthe upper limit of normal, ULN） or moderate coagulopathy （INR 〉 2.0） were included. The ability of the King’s College, Ganzert’s, and Escudié’s criteria to predict 28-day mortality was evaluated.

关键词： Liver failure Mushroom poisoning Liver transplantation Clinical decision making

Eradication rate and histological changes after Helicobacter pylori eradication treatment in gastric cancer patients following subtotal gastrectomy

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World Journal of Gastroenterology 2015年第13期21卷 3936-3943页

作者： Jae Jin Hwang Dong Ho Lee Kyu Keun Kang Ae-Ra Lee Hyuk Yoon Cheol Min shin Young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeonggi-do 463-707South Korea

AIM: To investigate the eradication rate and histological changes after Helicobacter pylori(H. pylori) eradication treatment following subtotal gastrectomy for gastric ***: A total of 610 patients with H. pylori infection who had undergone surgery for either early or advanced gastric adenocarcinoma between May 2004 and December 2010 were retrospectively studied. A total of 584 patients with proven H. pylori infection after surgery for gastric cancer were enrolled in this study. Patients received a seven day standard triple regimen as first-line therapy and a 10 d bismuthcontaining quadruple regimen as second-line therapy in cases of eradication failure. The patients underwent an esophagogastroduodenoscopy(EGD) between six and 12 mo after surgery, followed by annual EGDs. A further EGD was conducted 12 mo after confirming the result of the eradication and the histological changes. A gastric biopsy specimen for histological examination and Campylobacter-like organism testing was obtained from the lesser and greater curvature of the corpus of the remnant stomach. Histological changes in the gastric mucosa were assessed using the updated Sydney system before eradication therapy and at follow-up after 12 ***: Eradication rates with the first-line and second-line therapies were 78.4%(458/584) and 90%(36/40), respectively, by intention-to-treat analysis and 85.3%(458/530) and 92.3%(36/39), respectively, by per-protocol analysis. The univariate and multivariate analyses revealed that Billroth Ⅱ surgery was an independent factor predictive of eradication success in the eradication success group(OR = 1.53, 95%CI: 1.41-1.65, P = 0.021). The atrophy and intestinal metaplasia(IM) scores 12 mo after eradication were significantly lower in the eradication success group than in the eradication failure group(0.25 ± 0.04 vs 0.47 ± 0.12, P = 0.023; 0.27 ± 0.04 vs 0.51 ± 0.12, P = 0.015, respectively). The atrophy and IM scores 12 mo after successful eradication were

关键词： Helicobacter pylori Eradication Atrophy Intestinal

Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk Yoon Cheol Min shin Young soo Park Nayoung Kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line