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Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke:a systematic review and network meta-analysis

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Neural Regeneration Research 2021年第6期16卷 1168-1176页

作者： Yun-Juan Xie Yi Chen Hui-Xin Tan Qi-Fan Guo benson wui-man lau Qiang Gao Department of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Rehabilitation Medicine in Sichuan Province West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

Transcranial magnetic stimulation,a type of noninvasive brain stimulation,has become an ancillary therapy for motor function *** previous studies have focused on the effects of repetitive transcranial magnetic stimulation(rTMS)on motor function in stroke *** have been relatively few studies on the effects of different modalities of rTMS on lower extremity motor function and corticospinal excitability in patients with *** MEDLINE,Embase,Cochrane Library,ISI Science Citation Index,Physiotherapy Evidence Database,China National Knowledge Infrastructure Library,and *** databases were *** or crossover randomized controlled trials that addressed the effectiveness of rTMS in patients with stroke,published from inception to November 28,2019,were *** pairwise meta-analysis was conducted using R version 3.6.1 with the“meta”*** network analysis using the Markov chain Monte Carlo algorithm was conducted to investigate the effectiveness of different rTMS protocol *** meta-analysis results of 18 randomized controlled trials regarding lower extremity motor function recovery revealed that low-frequency rTMS had better efficacy in promoting lower extremity motor function recovery than sham *** meta-analysis results of five randomized controlled trials demonstrated that highfrequency rTMS led to higher amplitudes of motor evoked potentials than low-frequency rTMS or sham *** findings suggest that rTMS can improve motor function in patients with stroke,and that low-frequency rTMS mainly affects motor function,whereas high-frequency rTMS increases the amplitudes of motor evoked *** highquality randomized controlled trials are needed to validate this *** work was registered in PROSPERO(registration ***42020147055)on April 28,2020.

关键词： cortical excitability lower extremity motor function network meta-analysis noninvasive brain stimulation stroke systematic review transcranial magnetic stimulation

Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia

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Neural Regeneration Research 2021年第7期16卷 1252-1257页

作者： Qiang Gao Aaron Leung Yong-Hong Yang benson wui-man lau Qian Wang Ling-Yi Liao Yun-Juan Xie Cheng-Qi He Department of Rehabilitation Medicine West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina Institute of Disaster management and Reconstruction Sichuan University–The Hong Kong Polytechnic UniversityChengduSichuan ProvinceChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly *** this study, we established rat models of middle cerebral artery occlusion/*** day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive *** results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated *** number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated *** number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated ***-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated *** findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling *** study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019.

关键词： cerebral ischemia cognitive function electromagnetic fields hippocampus neurogenesis plasticity repair signaling pathway stroke rat

Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

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Neural Regeneration Research 2015年第12期10卷 1976-1981页

作者： Hua Wang benson wui-man lau Ning-li Wang Si-ying Wang Qing-jun Lu Raymond Chuen-Chung Chang Kwok-fai So Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Department of Rehabilitation Science The Hong Kong Polytechnic University Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam The State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgingFaculty of MedicineThe University of Hong Kong Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam GMH Institute of Central Nervous System Regeneration Jinan University

Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic ***,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body *** this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides（1 and 10 mg/kg）for 35 days and those intragastrically administered phosphate buffered saline served as *** number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline ***-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic *** findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.

关键词： nerve regeneration traditional Chinese medicine Lycium barbarum polysaccharides Lycium barbarum (wolJberry) retinal disease neurogenesis adult neural regeneration

Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition

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Neural Regeneration Research 2011年第34期6卷 2645-2655页

作者： Suk-Yu Yau Jada Chia-Di Lee benson wui-man lau Tatia M.C. Lee Yick-Pang Ching Siu-Wa Tang Kwok-Fai So Department of Anatomy LKS Faculty of Medicine the University of Hong Kong State Key Laboratory of Brain and Cognitive Science LKS Faculty of Medicine the University of Hong Kong Research Centre of Heart Brain Hormone and Health Aging LKS Faculty of Medicine the University of Hong Kong Laboratory of Neuropsychology the University of Hong Kong Laboratory of Cognitive Affective Neuroscience the University of Hong Kong Joint Laboratory for Brain Function and Health (BFAH) Jinan University and the University of Hong Kong

Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone （CORT） suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2＇-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.

关键词： hippocampal cell proliferation physical exercise spatial learning stress structural plasticity neural plasticity

帕罗西汀对皮质酮抑制成年大鼠海马细胞增殖的调制作用(英文)

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Neuroscience Bulletin 2007年第3期23卷 131-136页

作者：邱光 Daiga M.HELMESTE Asanka N.SAMARANAYAKE 刘汇文李湄珍邓兆华苏国辉香港大学医学院解剖学系加州大学尔湾分校精神医学系香港大学医学院精神医学系香港大学社会科学院心理学系脑神经心理实验室

目的慢性糖皮质激素治疗可能导致认知和情感变化,这或许是由于糖皮质激素对海马神经发生及细胞增殖的抑制作用造成。帕罗西汀是一种选择性血清素重摄取抑制剂,临床常用作减轻抑郁症状,近几年来发现它能促进海马神经发生。本研究探讨帕... 详细信息

目的慢性糖皮质激素治疗可能导致认知和情感变化,这或许是由于糖皮质激素对海马神经发生及细胞增殖的抑制作用造成。帕罗西汀是一种选择性血清素重摄取抑制剂,临床常用作减轻抑郁症状,近几年来发现它能促进海马神经发生。本研究探讨帕罗西汀与慢性糖皮质激素的相互作用。方法成年大鼠被分成四组,分别给予芝麻油、皮质酮、帕罗西汀或皮质酮和帕罗西汀十四天。溴脱氧尿嘧啶核苷(5-bromo-2-deoxyuridine,BrdU)免疫组化法被用于定量齿状回的细胞增殖。结果皮质酮抑制了海马的细胞增殖,帕罗西汀增加了海马的细胞增殖。同时给药组还显示帕罗西汀能逆转皮质酮的抑制作用。结论本研究结果对防止海马在类固醇治疗以后的损害或许有临床意义。

关键词：帕罗西汀溴脱氧尿嘧啶核苷皮质酮海马神经发生细胞增殖