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Rhabdomyosarcoma in Children: About 10 Cases

Open Journal of Pediatrics 2024年第3期14卷 522-530页

作者： Ayad Ghanam Manal Azizi Hind Zahiri Houssain Benhaddou Imane Kamaoui amal bennani Aziza El Ouali Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Pediatric Surgery Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Radiology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Anatomopathology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Introduction: Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumor arising from striated muscle cells. It accounts for 60% - 70% of malignant mesenchymal tumors and 5% of pediatric cancers. Two-thirds of these cancers are diagnosed in children under 6 years of age, with a slight male predominance. Materials and Methods: This is a retrospective descriptive study of 10 cases of RMS collected in the pediatric hematology and oncology department of the Oujda university hospital, over a 5-year period, running from January 2018 to December 2022. Results: The median age at diagnosis was 3 years, with a sex ratio of 1. The mean time to diagnosis was 2 months. The most common site was the head and neck (50%), followed by the genitourinary tract (20%), the extremities (20%) and finally the abdomen (10%). The most frequent mode of discovery was a mass or swelling found in 90% of patients (all sites included), followed by exophthalmos in 30% of cases. At the diagnostic stage, CT scans were performed in 70% of cases and MRI in 5 patients (50%). Histological diagnosis was determined by immunohistochemical pathology in all our patients, with a predominance of embryonal (70%) versus alveolar (20%) and spindle cell types (10%). All patients underwent an extension workup, and a cervico-thoraco-abdominopelvic CT was performed in all patients (100%);MRI was performed in 2 patients (20%);lymph node involvement was present in 5 patients (50%). Metastases at the time of diagnosis were noted in only 1 patient (10%), who simultaneously presented with two metastatic sites;testicular and abdominal wall. Sixty percent of patients presented with advanced disease (high risk) and 40% with standard risk. Chemotherapy was used in all patients (100%), with upfront tumor resection performed in 40%. Fifty percent of patients received radiotherapy at a mean dose of 43 Gy, with the orbit the most frequently irradiated area (30%). All patients underwent CTscan and/or MRI and/or ultrasound surveillance.

关键词： Rhabdomyosarcoma Child Chemotherapy Surgery Radiotherapy

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Cutaneous Symptoms Revealing M5 Acute Myeloid Leukemia: A Case Report

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Journal of Cancer Therapy 2022年第11期13卷 640-647页

作者： Sara Anane Ayad Ghanam amal bennani Manal Azizi Noufissa Benajiba Pediatric Department Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed 1st University Oujda Morocco Anatomo Pathological Department Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed 1st University Oujda Morocco

Cutaneous presentation revealing acute myeloid leukemia (AML) is rare, and the prognosis is poor. We report a case of an 11-month-old male who presented with cutaneous lesions present as diffuse purplish papulo-nodular lesions, revealing M5 acute myeloid leukemia. Skin biopsy and immunohistochemical examination, combined with routine blood analysis and bone marrow examination, contributed to early diagnosis. However, despite intensive chemotherapy treatment, the prognosis was poor and death occurred during the first months of treatment.

关键词： Acute Myeloid Leukemia AML-M5 Skin Nodules Case Report Child

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Pleural Effusion Revealing Bone Ewing Sarcoma: About Three Cases

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Journal of Cancer Therapy 2022年第5期13卷 284-290页

作者： Sara Anane Ayad Ghanam Manal Azizi amal bennani Houssain Benhaddou Imane Kamaoui Noufissa Benajiba Pediatric Department Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed 1st University Oujda Morocco Anatomical Pathology Department Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed 1st University Oujda Morocco Pediatric Surgery Department Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed 1st University Oujda Morocco Radiology Department Mohammed VI University Hospital Faculty of medicine and pharmacy Mohammed 1st University Oujda Morocco

Costal Ewing sarcoma is a rare primary malignant bone tumor with delayed diagnosis and complex treatment. The diagnosis, evoked in front of swelling, a parietal pain, supported on the tomodensitometry, rests on the anatomopathological examination. The treatment is based on the combination of chemotherapy surrounding complete surgical removal of the tumor. Radiotherapy should remain reserved for a few specific indications because of its complications. We report the case of three children who presented with a pleural effusion revealing Ewing’s sarcoma affecting the ribs.

关键词： Ewing Sarcoma Rib Treatment

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Hematochezia Revealing an Adenocacinoma

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Open Journal of Pediatrics 2023年第3期13卷 428-431页

作者： amal Hamami Madiha Benhachem Ayad Ghannam Aziza El Ouali Abdeladim Babakhouya Noura Seghrouchni Nassira Karich amal bennani Maria Rkain Department of Pediatrics Faculty of Medicine and Pharmacy of Oujda Mohammed First University Oujda Morocco Laboratory of Pathological Anatomy Faculty of Medicine and Pharmacy of Oujda Mohammed First University Oujda Morocco

Colorectal carcinoma (CRC) is a common pathology in the adult population but remains a very rare neoplasia in childhood with delayed diagnosis and advanced stage with grim prognosis that can be fatal, research regarding pediatric adenocarcinoma remain very rare. IT represents approximately 1% of pediatric neoplasms. It is usually associated with predisposing genetic factors;this pathology is closely linked with the inheritance of familial syndromes. The pediatric clinical presentations are nonspecific, with a grim prognosis. This review aimed to report a case of a 10-year-old girl who presented with constipation and hematochezia evolving since three months’ diagnosis with rectal adenocarcinoma.

关键词： Adenocarcinoma Colorectal Cancer Rare Child Grim Prognosis

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Tumor Misdiagnosed As Cancer of the Sphenoid Sinus: Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第2期1卷 48-50页

作者： El Fatemi Hinde bennani amal Souaf Ihsane Zaki Zouhir Alami Noureddine Amarti Afaf Department of Oto-Rhino-Laryngology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract first described by Wenig and Heffner in 1995 as prominent glandular proliferations lined by ciliated respiratory epithelium originating from the surface epithelium. Case Report: We report a case of 48-year-old women with nasal polyposis history, which consults for nasal obstruction, with suspicion of malignancy on CT. Surgical resection showed a respiratory epithelial adenomatoid hamartoma (REAH) of the nasal cavity. Conclusion: REAH is a recently described pathologic entity that can present rhinorrhea, epistaxis, hyposmia, and headaches. It is a rare lesion of nasal and paranasal sinuses, but should be considered in the differential diagnosis because it is a benign lesion and complete surgical resection is curative.

关键词： Nasal Cavity REAH Nasal Polyposis Hamartoma Nasal Obstruction

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Papillary Carcinoma Derived from Ovarian Mature Cystic Teratoma: A New Case Report and Literature Review

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Case Reports in Clinical Medicine 2014年第4期3卷 197-202页

作者： Ihsane Souaf Hinde El Fatemi amal bennani Chbani Leila Hammas Nawale Harmouch Tawfik Afaf Amarti Department of Pathology Hassan II Teaching Hospital Fez Morocco

Introduction: Papillary carcinoma arising from thyroid tissue in mature cysticteratoma (MCT) of the ovary is extremely rare, and it is not easy to diagnose preoperatively. No clinical, no radiological, no biological signs are specific to malignant transformation. Case presentation: A 51-year-old woman had a left ovarian tumor measuring approximately 18 cm diameter with malignant transformation of a mature cysticteratoma, who was diagnosed postoperatively with follicular variant of papillary thyroid carcinoma. A laparoscopic hysterectomy and left salpingo-oophorectomy were performed. During surgery, there were no signs of invasion or metastasis. Conclusion: Consideration should be given to thyroidectomy followed by total-body scanning and serum studies for foci of thyroid carcinoma and adjuvant therapy with thyroidectomy and radio ablation if residual disease is identified.

关键词： Ovarian Teratoma Papillary Carcinoma Malignant Transformation Thyroid Ovarian Neoplasm

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Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 279-282页

作者： El Fatemi Hinde bennani amal Saadi Hannane Bouchikhi Cherhazade Bannani Abdelaziz Mellas Nawfel Mesbahi Omar Department of Gynecology Hassan II Teaching Hospital Fez Morocco Department of Oncology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Introduction: Malignant melanoma (MM) represents 1% of all cancers and has an incidence of 3% - 7% in the female genital tract, the majority of cases being reported in the vulva. The cervico-vaginal region is an unsual primary location of the malignant mela-noma. Case report: The clinical and morphologic findings of 3 MM patients with cervico-vaginal tumours mimicking cervical polyp in third case. Histologically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with pleomorphic nuclei with prominent nucleolae. Tumor cells were positive for S-100 protein, Melan A, HMB 45 and CD117. The authors discuss three cases of cervico-vaginal melanoma and analyze clinical and prognostic aspects of this disease. Conclusion: Primary MM of the cervix should be considered in the differential diagnosis of cervical malignancies. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

关键词： Genital Tract Malignant Melanoma Cervix Vagina Chemotherapy CD117

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Congenital Cystic Adenomatoid Malformation: A Case Report with Clinical, Radiological, Histological, and Surgical Features

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Open Journal of Pediatrics 2023年第4期13卷 465-472页

作者： Karim Lahrache Samia Malki Soulaimane M’harzi Anas Ayyad Sahar Messouadi Houssain Benhaddou amal bennani Rim Amrani Faculty of Medicine and Pharmacy of Oujda Mohammed I University of Oujda Oujda Morocco Department of Neonatology and Neonatal Reanimation Mohammed VI University Hospital of Oujda Oujda Morocco Anatomopathology Department Mohammed VI University Hospital of Oujda Oujda Morocco Paediatric Surgery Department Mohammed VI University Hospital of Oujda Oujda Morocco

Background: Congenital cystic adenomatoid malformation (CCAM) is a congenital anomaly of lung development, accounting for approximately 25% of congenital lung lesions. Respiratory distress often occurs during the neonatal period, and in 80% to 85% of cases, the diagnosis is made before the age of 2 years following respiratory infections. Case Report: We report a case of MAKC diagnosed in the neonatal period. The diagnosis was based on clinical, radiological and histological elements. Our patient underwent surgical resection. Histological examination confirmed the diagnosis of MAKC without any sign of malignancy. The postoperative evolution was good. Conclusion: Clinicians and pathologists should recognize the early discovery of MAKC in neonatal age. The clinical diagnosis strongly guided by the radiological approach is confirmed by the pathological anatomy insofar as the therapeutic sanction is surgical in the majority of the cases.

关键词： Congenital Cystic Adenomatoid Malformation Congenital Disorder Lung Respiratory Distress Newborn

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Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature

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World Journal of Gastrointestinal Endoscopy 2022年第7期14卷 455-466页

作者： Kaouthar Rais Oumayma El Eulj Najoua El Moutaoukil Imane Kamaoui amal bennani Ghizlane Kharrasse Abdelkrim Zazour Wafaa Khannoussi Zahi Ismaili Department of Hepatogastroenterology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Radiology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Anatomo-Pathology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco

BACKGROUND Pancreatic metastases from squamous cell lung carcinoma(SCLC)are *** lesions are often asymptomatic and detected incidentally or during followup investigations,occasionally several years after removal of the primary *** SUMMARY A 56-year-old male with SCLC developed jaundice 1 mo after the cancer *** abdominal computed tomography(CT)scan showed a mass in the pancreatic head with distention of both intra-and extrahepatic biliary *** retrograde cholangiopancreatography and sphincterotomy were performed first,culminating with plastic biliary stent *** examination of the pancreatic mass sample collected by fine-needle aspiration(FNA)under endoscopic ultrasound(EUS)guidance revealed the presence of malignant cells compatible with well-differentiated squamous cell *** liver function normalized,chemotherapy was initiated with carboplatin and paclitaxel;however,4 d later,the patient presented ***-thoracoabdominal CT showed tracheoesophageal fistula and stent *** replacement with a 10 cm/10 mm uncovered metallic biliary stent and treatment of the tracheoesophageal fistula with a fully covered esophageal stent,the patient was able to start oral feeding *** died 9 mo after the initial *** The diagnosis of pancreatic metastasis from SCLC is challenging for ***-FNA is the primary exam for confirmatory diagnosis.

关键词： Squamous cell lung carcinoma Pancreatic metastasis Jaundice Esotracheal fistula Ultrasound endoscopy Case report

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Neuroendocrine tumors of the ovary: What support?

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Open Journal of Obstetrics and Gynecology 2013年第10期3卷 739-742页

作者： H. Al Moubaker S. Errarhay S. Mahmoud amal bennani C. Bouchikhi Affaf Amarti A. Banani Service Gynecology Obstetricsi Chuhassan Iifes Fez Morocco Service Pathological Anatomy Chuhassan Iifes Fez Morocco

Neuroendocrine tumors of the ovary tumors are little known and infrequent. They are made up of cells appearing in the endocrine and nervous systems. These tumors are rare, but most of them are very aggressive, especially when they are diagnosed beyond FIGO Stage I. The distinction among the different subtypes is difficult and requires efficient techniques. Symptoms of neuroendocrine tumors are often nonspecific (redness in the face, diarrhea, asthma, abdominal pain and etc.,) and confused with more common diseases. Misdiagnosis is often asked: menopause or irritable bowel syndrome. Often the correct diagnosis is not made until years after the onset of symptoms. The relative rarity of these diseases and the lack of specificity of the symptoms make them often be diagnosed several years after onset. Fortunately, science has made significant advances in the diagnosis and treatment of neuroendocrine tumors. We report the case of a woman of 54 years, with abdominopelvic mass, in whom abdominal ultrasound revealed a mass avascular tissue Doppler taking the screen. The abdominopelvic CT showed a large cystic mass solido—abdominopelvic whose origin is difficult to determine. The patient underwent an exploratory laparotomy. Anapath the results of the right ovary were in favor of a well-differentiated neuroendocrine lesion.

关键词： Tumor Neuroendocrine-Diagnosis-Treatment

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