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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response

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Bioactive Materials 2024年第2期32卷 415-426页

作者： Elizabeth E.Marr Brett C.Isenberg Joyce y.wong Boston University Division of Materials Science and EngineeringUnited States Charles Stark Draper Laboratory Bioengineering DivisionUnited States Boston University Department of Biomedical EngineeringUnited States

In the United States,1 in 10 infants are born *** majority of neonatal deaths and nearly a third of infant deaths are linked to preterm *** birth is initiated when the quiescent state of the uterus ends prematurely,leading to contractions and parturition beginning as early as 32 weeks,though the origins are not well *** enable research and discovery of therapeutics with potential to better address preterm birth,the capability to study isolated cell processes of pregnant uterine tissue in vitro is *** development of an in vitro model of the myometrium utilizing human uterine smooth muscle cells(uSMCs)responsible for contractions provides a methodology to examine cellular mechanisms of late-stage pregnancy potentially involved in preterm *** discuss culture of uSMCs on a flexible polydimethylsiloxane(PDMS)substrate functionalized with cationic poly-L-lysine(PLL),followed by extracellular matrix(ECM)protein *** work exploring uSMC behavior on PDMS substrates have utilized collagen-I coatings,however,we demonstrated the first exploration of human uSMC response to strain on fibronectin-coated flexible membranes,importantly reflecting the significant increase of fibronectin content found in the myometrial ECM during late-stage *** the model we developed,we conducted proof-of-concept studies to investigate the impact of substrate strain on uSMC cell morphology and gene *** was found that PLL and varied ECM protein coatings(collagen I,collagen III,and fibronectin)altered cell nuclei morphology and density on PDMS ***,varied strain rates applied to uSMC substrates significantly impacted uSMC gene expression of IL-6,a cytokine associated with instances of preterm *** results suggest that both surface and mechanical properties of in vitro systems impact primary human uSMC phenotype and offer uSMC culture methodologies that can be utilized to further the understanding of cellu

关键词： Uterine Myometrium Bioengineered in vitro models Strain Pregnancy Nuclei Interleukin 6 Preterm labor

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie yuanhui Guo yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Doxorubicin: The dogma and the bone

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 22-23页

作者： Jia y.wong Pornsak Sriamornsak Crispin R.Dass School of Pharmacy Curtin UniversityBentley 6102Australia Department of Pharmaceutical Technology and Pharmaceutical Biopolymer Group(PBiG)Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand

Doxorubicin is an anthracycline drug used as frontline chemotherapy of osteosarcoma among other types of *** quite effective in providing a good control over the tumours in some patients,it can cause significant toxicity to organs such as the heart[1].Attempts to ameliorate this toxicity with agents such as dexrazoxane have been successful,but not without complications[2]as will be discussed in this *** epithelium-derived factor(PEDF),a potent antiangiogenic and osteogenetic protein[3],was used to reduce this side-effect,together with an analysis of levels of adenosine triphosphate(ATP)and reactive oxygen species(ROS).The effects of low dose doxorubicin in a clinically relevant dosing model will be discussed.

关键词： Doxorubicin Cancer Tumour Apoptosis Cardiotoxicity

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： Jie Zhang yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

QUASI-INTERPOLATING OPERATORS AND THEIR APPLICATIONS IN HyPERSINGULAR INTEGRALS

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Journal of Computational Mathematics 1998年第4期16卷 337-344页

作者： wong, RH Lu, y Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

The purpose of this paper is to propose and study a class of quasi-interpolating operators in multivariate spline space S-1/2(Delta(mn)(2*)) on non-uniform type-2 triangulation. Based on the operators, we construct cubature formula for two-dimensional hypersingular integrals. Some computing work have been done and the results are quite satisfactory.

关键词： hypersingular integral finite-part integral quasi-interpolating operator non-uniform type-2 triangulation

Charge balance materials for homojunction and heterojunction OLED applications

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Frontiers of Optoelectronics 2009年第4期2卷 435-441页

作者： Louis M.LEUNG yik-Chung LAW Michael y.wong Tik-Ho LEE Kin Ming LAI Lok-yee TANG Department of Chemistry and Centre for Advanced Luminescence Materials Hong Kong Baptist University

In a homojunction device, a single organic layer assumes the multiple roles of hole, electron transportation, and emitter. Its ease in processing is highly desirable from the manufacturing point of view. In this paper, we shall describe the synthesis of a range of bipolar small molecules and conductive vinyl polymers for application in homojunction and heterojunction organic light emitting diodes（OLEDs）. The bipolar materials, in general, consist of three basic building blocks: an arylamine, a 1,3,4-oxadiazole, and a polycyclic aromatic moiety. The achievement of charge balance can be validated either by direct measurement of electron/hole mobility or indirectly via optimization of device properties.A series of conductive vinyl copolymers containing hole transporting N-（4-methoxyphenyl）-N-（4-vinylphenyl）naphthalen-1-amine（4MeONPA） and electron transporting 2-phenyl-5-（4-vinylphenyl）-1,3,4-oxadiazole（OXA）at different compositions was applied for heterojunction and homojunction OLEDs. For heterojunction devices employed the copolymers as the hole transporting layer and Alq3as the electron transporting and emitting layer,a maximum luminance and current efficiency of over 23000 cd/m2and 4.2 cd/A（PL of Alq3）, respectively, were achieved at the charge balance composition. Homojunction devices for the copolymers were demonstrated by the addition of rubrene as a dopant. The single layer devices at the optimal copolymer composition has ca 1500 cd/m2and 0.74 cd/A.

关键词： homojunction devices charge balance bipolar small molecules conductive vinyl copolymers

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工业以太网物理层设计应用

电子技术应用 2007年第6期33卷 108-111页

作者： Jim y.wong Tung Ngo 美国国家半导体

以美国国家半导体的单板解决方案,搭载了DP83848 PHy、LM5072 PoE PD接口和PWM控制器,探讨工业以太网物理层的应用设计。

关键词： Fieldbus 可编程逻辑控制器(PLC) CAN 工业以太网 Interbus

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise