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world Journal of Engineering and Technology 2015年第4期3卷 7-23页

作者： warren Burggren benjamin Dubansky aaron Roberts Matthew Alloy Developmental Integrative Research Group Department of Biological Sciences University of North Texas Denton TX USA

The Deepwater Horizon Oil Spill in the USA’s Gulf of Mexico created a high degree of exposure of marine organisms to toxic polyaromatic hydrocarbons (PAHs) present in crude oil. To determine the ecological and physiological effects of crude oil on the Gulf of Mexico ecosystem, the Gulf of Mexico Research Initiative created several research consortia to address overreaching questions concerning the biological impacts of the ecology of the Gulf of Mexico that would otherwise be beyond the capabilities of an individual investigator or a small group. One of these consortia, highlighted in this article, is the RECOVER Consortium, which brings together physiologists, developmental biologists, toxicologists and other life scientists to focus on the multifaceted physiological effects of PAHs, especially as they pertain to cardiovascular and metabolic physiology of economically important fish species. Using the Recover Consortium’s interdisciplinary approach to revealing the biological impacts of the Deepwater Horizon Oil Spill as a case study, we make the argument for interdisciplinary teams that bring together scientists with different specialties as an efficient way—and perhaps the only way—to unravel highly complex biological effects of marine oil spills.

关键词： Deepwater Horizon Oil Spill Gulf of Mexico Interdisciplinarity Research Consortium

Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu william J.Melvin Amrita D.Joshi Sonya J.wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer james Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel benjamin levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes JMJD3 STING

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可用于临床的脂肪组织基础知识概述

中国美容整形外科杂志 2011年第7期22卷 I0004-I0012页

作者： Spencer A. Brown benjamin levi Charlotte Lequex Victor w. wong All Mojallal Michael T. Longaker 魏峰(译) 高景恒(译) 张晨(译) 美国德克萨斯州达拉斯市德克萨斯大学西南医学中心整形外科斯坦福大学医学院整形外科中心整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

脂肪组织中含有干细胞，这一认识促使我们进一步探索在更广泛的临床状况下利用脂肪和脂肪来源干细胞的可能性。关于脂肪来源干细胞的获取、分离以及分离的脂肪来源干细胞的分化特性的新知识已带来新的研究，这些新研究的研究方向是新的... 详细信息

脂肪组织中含有干细胞，这一认识促使我们进一步探索在更广泛的临床状况下利用脂肪和脂肪来源干细胞的可能性。关于脂肪来源干细胞的获取、分离以及分离的脂肪来源干细胞的分化特性的新知识已带来新的研究，这些新研究的研究方向是新的组织工程构建，以及脂肪来源干细胞转化为诱发的多能干细胞。临床上，脂肪移植物和脂肪来源干细胞在美国及全世界范围内的使用急剧增加，同时，以脂肪来源干细胞为基础的治疗方法的安全性和有效性带来的问题也随之增多。当前，FDA还未批准分离的脂肪来源干细胞用于任何临床领域。

关键词：脂肪组织临床脂肪来源干细胞基础知识多能干细胞组织工程细胞转化世界范围

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22nm技术节点的成品率目标

集成电路应用 2008年第8期25卷 26-31页

作者： Dilip Patel Kye weon Kim Doron Arazi John Allgair benjamin Bunday Milton Godwin Victor Vartanian Pete Lipscomb aaron Cordes International Sematech Manufacturing Initiative(ISMI) AustinTexas

半导体行业正在开发必要的缺陷量测和薄膜量测解决方案,但22nm技术节点的监测还需开发新的成像套刻目标结构。

关键词：技术节点成品率半导体行业量测开发套刻

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胰岛素样生长因子-1和血小板源性生长因子-α对人类脂肪源性基质细胞成骨分化的调节作用

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中国美容整形外科杂志 2011年第7期22卷 I0003-I0003页

作者： benjamin levi.aaron w. james Derrick C. wan Jason P. Glotzbach George w. Commons Michael T. Longaker 魏峰(译) 高景恒(译) 张晨(译) 美国加利福尼亚州斯坦福斯坦福大学医学院整形再造外科中心外科部Hagey儿科再生研究室《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景人类脂肪源性基质细胞有巨大的用于组织工程的潜能。作者的实验室致力于研究人类脂肪源性基质细胞对骨骼组织的再生作用，并识别那些可增强人类脂肪源性基质细胞成骨性分化的因子。作者假设胰岛素样生长因子（insulin-like growth f... 详细信息

背景人类脂肪源性基质细胞有巨大的用于组织工程的潜能。作者的实验室致力于研究人类脂肪源性基质细胞对骨骼组织的再生作用，并识别那些可增强人类脂肪源性基质细胞成骨性分化的因子。作者假设胰岛素样生长因子（insulin-like growth factor，IGF）和血小板源性生长因子（platelet-derived growth factor，PDGF）可以刺激人类脂肪源性基质细胞骨生成，且IGF可刺激脂肪形成。方法从人脂肪抽吸组织中获取脂肪源性基质细胞，首先，采用微阵列分析法检测成骨性分化过程中的基因表达。获取标本中添加重组体IGF-1和PDGF-α的方式是：分别单独添加，二者联合添加。利用碱性磷酸酶、茜素红、油红O进行染色，并利用定量实时多聚酶链式反应（RUNX2，ALP，OCN，IGFl，PPARG，LPL，AP2，and GCP1）评估骨生成和脂肪形成。最后，评估IGF和PDGF信号途径的交叉点。结果所有标记物均可观察到IGF-1可增加成骨性分化作用（P〈0．01）。然而，初始时单独加入PDGF-α并不能影响骨生成标记物。PDG-α可上调IGF-1的转录活性。PDGF-α与IGF-1联合添加或在添加IGF-1前添加PDGF-α对骨生成的增加作用均大于单独加入任一种因子。IGF-1可增加人类脂肪源性基质细胞的脂肪生成，而PDGF-α的作用相反。结论IGF信号可显著增强人类脂肪源性基质细胞的骨生成，可以在组织工程中使用。PDGF和IGF联合使用对脂肪源性基质细胞骨生成的促进作用强于单独使用任一种。未来的体内应用将关注脂肪源性基质细胞，仿生支架和重组体IGF的结合。

关键词：血小板源性生长因子胰岛素样生长因子-1 脂肪形成基质细胞人类成骨分化 PDGF-α IGF-1

中国大陆肺炎发病率与死亡率:1985-2008年中英文文献的系统分析

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公共卫生与预防医学 2011年第1期22卷 14-19页

作者：官旭华 benjamin J Silk wenkai Li aaron T. Fleishchauer 邢学森蒋晓清余宏杰 Sonja J. Olsen Adam L. Cohen 湖北省疾病预防控制中心武汉430079 美国疾病预防控制中心呼吸道疾病部和细菌性疾病部美国疾病预防控制中心新发传染病和监测服务部中国疾病预防控制中心

目的肺炎是全球传染性疾病最主要的死因之一,但中国的肺炎疾病负担还知之甚少,因为很多数据资料都是以非英文文献的形式发表的。方法系统回顾了中国大陆关于肺炎发病率与死亡率的中文和英文文献,这些研究都是具有第一手数据的研究,1985-... 详细信息

目的肺炎是全球传染性疾病最主要的死因之一,但中国的肺炎疾病负担还知之甚少,因为很多数据资料都是以非英文文献的形式发表的。方法系统回顾了中国大陆关于肺炎发病率与死亡率的中文和英文文献,这些研究都是具有第一手数据的研究,1985-2008年有37篇论文符合纳入标准。结果各项研究的质量差异较大。5岁以下儿童肺炎发病率为(0.06～0.27)次/人年,肺炎死亡率为184/10万～1 223/10万人口。肺炎的发病率与死亡率随着时间稳定不变或者呈下降趋势,且农村高于城市。结论肺炎仍然是中国儿童的主要公共卫生问题之一。肺炎发病率与死亡率估计的变化差异大。继续降低发病率与死亡率需要可靠的监测数据和新的预防措施的实施,特别是在农村等高发地区。

关键词：肺炎发病率死亡率中国大陆

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未来显示屏候选

科技创业 2012年第7期 119-119页

作者： aaron Rathmell benjamin wiley

铜－镍钠米线不仅价格相对低谦，而且导电性更好，有可能成为未来显示屏材料的候选之一。概述：氧化铟锡（ITO）因为其导电和透明的特性，成为了手机显示屏的常用材料。不过铟是一种稀土元素，价格高昂，可达每千克600美元至800美元。... 详细信息

铜－镍钠米线不仅价格相对低谦，而且导电性更好，有可能成为未来显示屏材料的候选之一。概述：氧化铟锡（ITO）因为其导电和透明的特性，成为了手机显示屏的常用材料。不过铟是一种稀土元素，价格高昂，可达每千克600美元至800美元。此外，铟在地球上的分布并不广泛，世界上60％的铟产量来自中国。因此，寻找氧化铟锡的替代材料是材料学界一直在进行的工作。

关键词：手机显示屏氧化铟锡常用材料稀土元素替代材料导电性铜-镍材料学

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The SUPER reporting guideline suggested for reporting of surgical technique

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 534-544,I0024-I0026页

作者： Kaiping Zhang Yanfang Ma Jinlin wu Qianling Shi Leandro Cardoso Barchi Marco Scarci Rene Horsleben Petersen Calvin S.H.Ng Steven Hochwald Ryuichi waseda Fabio Davoli Robert Fruscio Giovanni Battista levi Sandri Michel Gonzalez benjamin wei Guillaume Piessen Jianfei Shen Xianzhuo Zhang Panpan Jiao Yulong He Nuria M.Novoa Benedetta Bedetti Sebastien Gilbert Alan D.L.Sihoe Alper Toker Alfonso Fiorelli Marcelo F.Jimenez Toni Lerut Aung Y.Oo Grace S.Li Xueqin Tang Yawen Lu Hussein Elkhayat Tomaz Stupnik Tanel Laisaar Firas Abu Akar Diego Gonzalez-Rivas Zhanhao Su Bin Qiu Stephen D.wang Yaolong Chen Shugeng Gao Editorial Office AME Publishing CompanyHong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Department of Cardiovascular Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Evidence-based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina Lanzhou University Institute of Health Data Science LanzhouChina Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineSão PauloBrazil Department of Cardiothoracic Surgery Imperial College Healthcare NHS TrustLondonUK Department of Cardiothoracic Surgery University Hospital of CopenhagenRigshospitaletCopenhagenDenmark The Chinese University of Hong Kong Prince of Wales HospitalShatinNew TerritoriesHong KongChina Department of Surgical Oncology Roswell Park Cancer InstituteBuffaloNYUSA Department of General Thoracic Breast and Pediatric SurgeryFukuoka UniversityFukuokaJapan Department of Thoracic Surgery AUSL RomagnaS.Maria delle Croci Teaching HospitalRavennaItaly Clinic of Obstetrics and Gynecology University of Milan-BicoccaSan Gerardo HospitalMonzaItaly Division of General Surgery and Liver Transplantation S.Camillo HospitalRomeItaly Service of Thoracic Surgery Lausanne University Hospital(CHUV)LausanneSwitzerland Division of Cardiothoracic Surgery Department of SurgeryUniversity of Alabama BirminghamBirminghamALUSA University of Lille CNRSInsermCHU LilleUMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to TherapiesLilleFrance Department of Cardiothoracic Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhaiChina The First School of Clinical Medicine Lanzhou UniversityLanzhouChina Thoracic Surgery Service University Hospital of SalamancaBiomedical Institute of SalamancaSalamancaSpain Department of Thoracic Surgery Helios Clinic Bonn/Rhein SiegBonnGermany Division of Thoracic Surgery Department of SurgeryThe Ottawa

Background:Existing reporting guidelines pay insufficient attention to the detail and comprehensiveness reporting of surgical *** Surgical techniqUe rePorting chEcklist and standaRds(SUPER)aims to address this gap by defining reporting standards for surgical *** SUPER guideline intends to apply to articles that encompass surgical technique in any study design,surgical discipline,and stage of surgical ***:Following the EQUATOR(Enhancing the QUAlity and Transparency Of health Research)Network approach,16 surgeons,journal editors,and methodologists reviewed existing reporting guidelines relating to surgical technique,reviewed papers from 15 top journals,and brainstormed to draft initial items for the *** initial items were revised through a three-round Delphi survey from 21 multidisciplinary Delphi panel experts from 13 countries and *** final SUPER items were formed after an online consensus meeting to resolve disagreements and a three-round wording refinement by all 16 SUPER working group members and five SUPER ***:The SUPER reporting guideline includes 22 items that are considered essential for good and informative surgical technique *** items are divided into six sections:background,rationale,and objectives(items 1 to 5);preoperative preparations and requirements(items 6 to 9);surgical technique details(items 10 to 15);postoperative considerations and tasks(items 16 to 19);summary and prospect(items 20 and 21);and other information(item 22).Conclusions:The SUPER reporting guideline has the potential to guide detailed,comprehensive,and transparent surgical technique reporting for *** may also assist journal editors,peer reviewers,systematic reviewers,and guideline developers in the evaluation of surgical technique papers and help practitioners to better understand and reproduce surgical technique.

关键词： Surgical technique surgical innovation reporting guideline reporting checklist Surgical techniqUe rePorting chEcklist and standaRds(SUPER)

Malignant melanoma in the pediatric population

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world Journal of Surgical Procedures 2015年第3期5卷 229-234页

作者： John Psaltis Eric Reintgen Ali Antar Mark Giori Leah Alvin Alyssa benjamin Bridget Budny Taylor Gianangelo aaron Gruman Anna Stamas Michael Reintgen Rosemary Giuliano Jeff Smith Douglas Reintgen Department of Surgery Morsani School of Medicine University of South Florida Department of Pathology Florida Hospital-N Pinellas

Controversial pigmented lesions in children are a problem for pathologist, clinicians and families that are confronted with this dilemma. Some skin lesions in this population defy diagnosis with pathologists split between a benign diagnosis and a cancer diagnosis. Three cases of controversial pigmented lesions in the pediatric population are presented. Three patients underwent radical resection of the controversial pigmented lesion, intra-operative lymphatic mapping and sentinel lymph node(SLN) biopsy. Due to the low morbidity of the SLN procedure a case is made to perform lymphatic mapping in this clinical scenario. If the SLNs are negative, not much is lost except for the scar and this becomes another line of evidence that perhaps the original lesion was benign. If the SLN shows metastatic cells, then the original skin lesion must be malignant and the patient is offered stage Ⅲ recommendations that would include complete node dissections and adjuvant Interferon therapy. This strategy provides for adequate treatment of the worse-case scenario, that the skin lesion is malignant. The cost to the patient is a low morbidity procedure, the SLN biopsy.

关键词： Pediatric pigmented skin lesions Sentinel lymph node biopsy Melanoma

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史密森南广场园区规划

城市环境设计 2019年第2期118卷 160-169页

作者： aaron Hales Alana Goldweit Alexandre Hamlyn Andriani Atmadja Annette Miller benjamin DiNapoli benjamin Novacinski Cadence Bayley Choonghyo Lee Chris Falla Daisy Zhong Daniele Pronesti Doug Stechschulte Emily Chen Gabriel Hernandez Solano Janice Rim Jennifer Shen Jeremy Alain Siegel Jihoon Hyun Julian Andres Ocampo Salazar Kalina Pilat Katarzyna Starczewska Lina Bondarenko Mahsa Malek Manon Otto Martin Voelkle Ola Hariri Otilia Pupezeanu Saecheol Oh Sara Ibrahim Stephen Kwok Stephen Steckel Suemin Jeon Tammy Teng Taylor Fulton Tianqi Zhang Vincent Fulia wells Barber wesley Chiang Zhifei Xu 陈子钰

通过与史密森学会、当地居民以及决策者的密切合作,我们为南广场园区制定了总体规划,作为对旧与新的重新诠释——方案利用园区内的现有元素,在严格监管与历史保护的限制中寻求自由。该提案旨在提升并扩大游客服务和教育空间,在博物馆与... 详细信息

通过与史密森学会、当地居民以及决策者的密切合作,我们为南广场园区制定了总体规划,作为对旧与新的重新诠释——方案利用园区内的现有元素,在严格监管与历史保护的限制中寻求自由。该提案旨在提升并扩大游客服务和教育空间,在博物馆与花园之间建立清晰的入口和联系,并取代已达到使用寿命的老化建筑机械系统。与此同时,团队致力于保留豪普

关键词：园区规划总体规划 Avenue 史密森史密森学会基础隔震弗里尔交通流线