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Association between AcTN3 R577X genotype and risk of non-contact injury in trained athletes:A systematic review

Journal of Sport and Health Science 2023年第3期12卷 359-368页

作者： Hassane Zouhal Juan Del coso Ayyappan Jayavel claire Toumy Guillaume Ravé Nidhal Jebabli cain c.T.clark benjamin Barthélémy Anthony c.Hackney Abderraouf Ben Abderrahman M2S(Laboratoire Mouvement SportSanté)-EA 1274Department of Sport SciencesUniversity of RennesRennes F-35000France Rey Juan carlos University Centre for Sport StudiesMadrid 28032Spain SRM college of Physiotherapy SRM Institute of Science and TechnologySRM NagarKattankulathur 603203India Department of Sport Sciences University of RouenMont Saint AignanCETAPS EA 3832F-76821France Toulouse Football club Toulouse 31000France Higher Institute of Sport and Physical Education Ksar-SaidUniversity of ManoubaTunis 2010Tunisia centre for Intelligent Healthcare Coventry UniversityCoventry CV15FBUK Department of Exercise&Sport Science Department of NutritionUniversity of North CarolinaChapel HillNC 27514USA

Purpose:The aim of this study was to review,systematically,evidence concerning the link between the AcTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training ***:A computerized literature search was performed in the electronic databases PubMed,Web of Science,and SPORTDiscus,from inception until November *** included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the AcTN3 R577X ***:Our search identified 492 *** the screening of titles,abstracts,and full texts,13 studies examining the association between the AcTN3 genotypes and the rate and severity of non-contact injury were included in the *** studies were performed in 6 different countries(Spain,Japan,Brazil,china,the Republic of Korea,and Italy)and involved a total participant pool of 1093 *** the studies,2 studies involved only women,5 studies involved only men,and 6 studies involved both men and *** the studies included were classified as highquality studies(≥6 points in the Physiotherapy Evidence Database(PEDro)scale score).Overall,evidence suggests there is an association between the AcTN3 R577X genotype and non-contact injury in 12 *** studies observed a significant association between A cTN3 R577X polymorphism and exercise induced muscle damage:2 with non-contact ankle injury,3 with non-contact muscle injury,and 1 with overall non-contact ***:The present findings support the premise that possessing the AcTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.

关键词： α-actinin-3 deficiency Athletic performance Exercise-related injury Muscle injury Single nucleotide polymorphism

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chain length-dependent cooperativity in fatty acid binding and oxidation by cytochrome P450_(BM3)(cYP102A1)

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Protein & cell 2011年第8期2卷 656-671页

作者： benjamin Rowlatt Jake A.Yorke Anthony J.Strong christopher J.c.Whitehouse Stephen G.Bell Luet-Lok Wong Department of chemistry University of OxfordInorganic Chemistry LaboratorySouth Parks RoadOxford OX13QRUK

Fatty acid binding and oxidation kinetics for wild type P450_(BM3)(cYP102A1)from Bacillus megaterium have been found to display chain length-dependent homotropic *** and 13-methyl-myristate display Michaelis-Menten behavior while there are slight deviations with myristate at low ionic *** shows Michaelis-Menten kinetics and hyperbolic binding behavior in 100 mmol/L phosphate,pH 7.4,but sigmoidal kinetics(with an apparent intercept)in low ionic strength buffers and at physiological phosphate *** low ionic strength buffers both the heme domain and the full-length enzyme show complex palmitate binding behavior that indicates a minimum of four fatty acid binding sites,with high cooperativity for the binding of the fourth palmitate molecule,and the full-length enzyme showing tighter palmitate binding than the heme *** first flavin-to-heme electron transfer is faster for laurate,myristate and palmitate in 100 mmol/L phosphate than in 50mmol/L Tris(pH 7.4),yet each substrate induces similar high-spin heme *** palmitate in low phosphate buffer concentrations,the rate constant of the first electron transfer is much larger than *** results suggest that phosphate has a specific effect in promoting the first electron transfer step,and that P450_(BM3) could modulate Bacillus membrane morphology and fluidity via palmitate oxidation in response to the external phosphate concentration.

关键词： P450_(BM3) monooxygenase fatty acid cooperativity allosteric effect cYP102A1

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High-grade pancreatic intraepithelial lesions： prevalence and implications in pancreatic neoplasia

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 202-208页

作者： Jean R Park Feng Li Veeral M Oza Brett c Sklaw Kevin M cronley Michael Wellner benjamin Swanson Somashekar G Krishna Division of Hospital Medicine The Ohio State University Wexner Medical Center Columbus Ohio USA Division of Gastroenterology Hepatology and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio USA

BAcKGROUND： High-grade pancreatic intraepithelial neoplasia（Pan IN-3）, a precursor of pancreatic ductal adenocarcinoma（PDAc）, is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDAcs and intraductal papillary mucinous neoplasms（IPMNs）.METHODS： A retrospective review of a tertiary care center pathology database（1/2000-6/2014） was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were ***： A total of 458 patients who underwent primary pancreatic resection were included. “Pan IN-3” lesions were found in 74（16.2%） patients who either had PDAc（n=67） or main duct（MD）-IPMN（n=7）. Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDAcs, the median overall survival（OS） for pancreata with Pan IN-3 lesions was significantly better than those without（OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04）. Multivariate cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death（HR=0.43; 95% cI： 0.23-0.82; P=0.01）.cONcLUSIONS： Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management.

关键词： pancreatic intraepithelial neoplasia intraductal papillary mucinous neoplasms pancreatic neoplasia pancreatic ductal adenocarcinoma

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Positivity in electron-positron scattering:testing the axiomatic quantum field theory principles and probing the existence of UV states

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chinese Physics c 2021年第2期45卷 176-199页

作者： benjamin Fuks Yiming Liu cen Zhang Shuang-Yong Zhou Sorbonne Université CNRSLaboratoire de Physique Théorique et HautesÉnergiesLPTHEF-75005 ParisFrance Institut Universitaire de France 103 boulevard Saint-Michel75005 ParisFrance Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China center for High Energy Physics Peking UniversityBeijing 100871China Interdisciplinary center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu center for Fundamental Theory Hefei 230026China

We consider the positivity bounds on dimension-8 four-electron operators and study two related phenomenological aspects at future lepton ***,if positivity is violated,probing such violations will revolutionize our understanding of the fundamental pillars of quantum field theory and the S-matrix *** observe that positivity violation at scales of 1-10 TeV can potentially be probed at future lepton colliders even if one assumes that dimension-6 operators are also ***,the positive nature of the dimension-8 parameter space often allows us to either directly infer the existence of UV-scale particles together with their quantum numbers or exclude them up to certain scales in a model-independent *** particular,dimension-8 positivity plays an important role in the test of the Standard *** no deviations from the Standard Model are observed,it allows for simultaneous exclusion limits on all kinds of potential UV-complete *** the dimension-6 case,these limits apply regardless of the UV model setup and cannot be removed by possible cancellations among various UV *** thus consists of a novel and universal test to confirm the Standard *** demonstrate with realistic examples how all the previously mentioned possibilities,including the test of positivity violation,can be ***,we provide an important motivation for studying dimension-8 operators more comprehensively.

关键词： electron-positron collider positivity bound Standard Model Effective Field Theory

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The current Development of cubic Equations of State-Implications and Advantages

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南京工业大学学报(自然科学版) 1991年第3期 1-9页

作者： benjamin c.Y.Lu

INTRODUcTIONcubic equations of state(EOS)of the van der Waals(VDW)type are frequcntly used inrepresentation/prediction of vapor-liquid equilibrium and density values required in *** solution of equations for the calculation is frequently based on the familiaritywith a particular equation and the availability of the computer program for the ***,it is generally accepted that no single cubie equation can describe real fluidbehavior without limitations

关键词： The current Development of cubic Equations of State-Implications and Advantages EOS

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OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae

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Journal of Integrative Plant Biology 2014年第12期56卷 1179-1192页

作者： Shimin Zuo Xiaogang Zhou Mawsheng chen Shilu Zhang benjamin Schwessinger Deling Ruan can Yuan Jing Wang Xuewei chen Pamela c.Ronald Department of Plant Pathology and the Genome center University of California Joint Bioenergy Institute Emeryville California 94710 USA Key Laboratory of crop Genetics and Physiology of Jiangsu Province College of Agriculture Yangzhou University Key Laboratory of Plant Functional Genomics of the Ministry of Education College of Agriculture Yangzhou University Rice Research Institute Sichuan Agricultural University at Wenjiang

Somatic embryogenesis receptor kinase（SERK）proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae（Xoo） and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid（BR） signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, ***1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae.

关键词： Oryza sativa OsSERK1 somatic embryogenesis receptor kinase Xanthomonas oryzae pv.Oryzae Magnaporthe oryzae

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Incorporation of Biochar carbon into Stable Soil Aggregates:The Role of clay Mineralogy and Other Soil characteristics

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Pedosphere 2017年第4期27卷 694-704页

作者： charlene N. KELLY Joseph benjamin Francisco c. cALDERON Maysoon M. MIKHA David W. RUTHERFORD colleen E. ROSTAD West Virginia University Division of Forestry and Natural Resources337 Percival HallMorgantownWV 26506USA USDA-ARS Central Great Plains Research Station40335 County RoadGGAkronCO 80720USA U.S.Geological Survey MS 408PO Box 25046Building 95Denver Federal CenterDenverCO 80225USA

Aggregation and structure play key roles in water-holding capacity and stability of *** this study,the incorporation of carbon(c) from switchgrass biochar into stable aggregate size fractions was assessed in an Aridisol(from colorado,USA) dominated by 2:1 clays and an Alfisol(from Virginia,USA) containing weathered mixed 1:1 and 2:1 mineralogy,to evaluate the effect of biochar addition on soil *** biochar was applied at 4 levels,0,25,50,and 100 g kg^(-1),to the soils grown with wheat in a growth chamber *** changes in soil strength and water-holding capacity using water release curves were *** the colorado soil,the proportion of soil occurring in large aggregates decreased,with concomitant increases in small size *** changes in aggregate size fractions occurred in the Virginia *** the colorado soil,c content increased from 3.3 to 16.8 g kg^(-1),whereas in thection c content increased from 5.7 to 22.6 g kg^(-1) with 100 g kg^(-1)biochar *** the Virginia soil,c content within aggregate size fractions increased for each size fraction,except the>2 000 μm *** greatest increase(from 6.2 to 22.0 g kg^(-1)) occurred in the 53–250 μm *** results indicated that c was incorporated into larger aggregates in the Virginia soil,but remained largely unassociated to soil particles in the colorado *** addition had no significant effect on water-holding capacity or strength *** biochar to more weathered soils with high native soil organic content may result in greater stabilization of incorporated c and result in less loss because of erosion and transport,compared with the soils dominated by 2:1 clays and low native soil organic content.

关键词： aggregate size fractions, aggregate stability, mineralogy, soil strength, water-holding capacity, weathered soil

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Anticorrosion behavior of conversion coatings obtained from unbuffered cerium salts solutions on AA6061-T6

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Journal of Rare Earths 2011年第10期29卷 961-968页

作者： KIYOTA Sayuri VALDEZ benjamin STOYTcHEVA Margarita ZLATEV Roumen BASTIDAS Jose Maria Engineering Institute of UABc B.Juárez Blvd.and Normal St.21280 MexicaliB.C.Mexico cENIM-National centre for Metallurgical Research CSIC8Gregorio del Amo Ave.28040 MadridSpain

The anticorrosive properties of cerium based conversion coatings deposited on AA6061-T6 alloy by immersion in tmbuffercd cerium chloride and cerium nitrate solutions in the presence of hydrogen peroxide were investigated and characterized by potentiodynamic po- larization （PDP） and electrochemical impedance spectroscopy （EIS） in 0.5 mol/L Nacl aqueous solution. The microstructure and chemical composition of the protective films were examined by scanning electron microscopy （SEM） and energy dispersive X-ray spectroscopy （EDS）. It was found that the best corrosion protection was afforded by the samples treated during 600 s in cerium chloride solution at pH values ~5.5-4, showing higher amounts of cerium and polarization resistance values greater than 10 f~ m2. Moreover, an ennoblement of the corro- sion potential and decreasing of the cathodic and anodic currents were obtained compared with the cerium nitrate solutions application. This behavior was attributed to the influence of the deposition parameters such as type of the salt anion, i.e., chelating effect and chaotropic characteristics, pH fluctuations in the conversion solution and deposition time.

关键词： cerium based conversion coatings EIS PDP anticorrosion properties rare earths

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Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas

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Asian Journal of Andrology 2020年第6期22卷 569-577页

作者： Margarita Vigodner benjamin Lucas Stav Kemeny Tamar Schwartz Rebecca Levy Department of Biology Stern CollegeYeshiva UniversityNew YorkNY 10016USA Department of Developmental and Molecular Biology Albert Einstein College of MedicineBronxNY 10461USA

Spermatogenesis is regulated by a complex network of posttranslation ***(a modification by small ubiquiti like modifiers,or SUMO proteins)was identified as an importa nt cellular event in d iff ere nt cell *** proteins are highly expressed in the testis,and their role during spermatogenesis has begun to be *** the important role of sumoylation in the regulation of mitosis and cancer progress!on in other tissues,the aim of the current study was to identify the targets of SUMO in proliferating mouse spermatog onia and huma n semi noma tissues and to in itially exami ne the level of sumoylation in relation to the proliferative activity of the *** freshly purified spermatogonia and cl8-4 spermatogonia cell line,mass spectrometry analysis identified several SUMO targets implicated into the proliferation of spermatogonia(such as heat shock protein 60[HSP60]and prohibitin).Tissue array and western blot approaches showed that SUMO expression is a prominent feature of human seminomas and that the proliferative activity of the tumor tissues was positively correlated with the level of SUMO *** regulation of sumoylati on with si-RNA was not sufficie nt to sign ificantly affect the proliferation of c18-4 spermatogonia;however,SUMO overexpression in creased the proliferation rate of the *** data suggest that cells are more sensitive to an elevated level of SUMO,and that this situation may lead to an upregulated cellular proliferation and,possibly,*** spectrometry analysis identified around a hundred SUMO targets in seminoma ***,many of the identified proteins(such as proliferating cell nuclear antigen[PcNA],DNA topoisomerase 2-alpha[Top2A],prohibitin,14-3-3 protein,and others)were implicated in oncogenic transformation and cancer progression.

关键词： proliferation seminoma spermatog onia sumoylation

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PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA-PK complex

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Genes & Diseases 2024年第6期11卷 24-27页

作者： Yue Lang Dexuan Gao Lan Yu Xiang-Xiang Zhang Debabrata Saha benjamin P.c.chen Meng-Meng Gu Zeng-Fu Shang Department of Nuclear Medicine The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of Nuclear Medicine The Affliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu 215002China State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionMedical College of Soochow UniversityCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhouJiangsu 215123China Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China Department of Radiation Oncology University of Texas Southwestern Medical CenterDallasTX75390USA Department of Pathology University of Texas Southwestern Medical CenterDallasTX 75390USA

PDZ and LIM domain protein 1(PDLIM1)is a cytoplasmic LIM protein that regulates cytoskeleton organization and functions as a platform to coordinate various cellular processes.1 Accumulated evidence suggests that PDLIM1 plays important roles in tumorigenesis,tumor progression,and response to cancer ***,our results demonstrated that silencing PDLIM1 significantly inhibited the migration and the invasion of HeLa cells compared with control cells(Fig.S1).However,the feasibility of targeting PDLIM1 as an effective strategy for radiotherapy remains to be determined.

关键词： invasion inhibited damage

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