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Modeling the role of public health education in Ebola virus disease outbreaks in Sudan

Infectious Disease Modelling 2017年第3期2卷 323-340页

作者： benjamin levy Christina Edholm Orou Gaoue Roselyn Kaondera-Shava Moatlhodi Kgosimore Suzanne Lenhart benjamin Lephodisa Edward Lungu Theresia Marijani Farai Nyabadza Department of Mathematics Fitchburg State UniversityUSA Department of Mathematics University of TennesseeUSA Department of Botany University of HawaiiUSA Department of Mathematics University of BotswanaBotswana Department of Mathematics Botswana International University of Science and TechnologyBotswana Department of Mathematics University of Dar es SalaamTanzania Department of Basic Sciences Botswana University of Agriculture and Natural ResourcesBotswana Department of Mathematics University of StellenboschSouth Africa

Public involvement in Ebola Virus Disease(EVD)prevention efforts is key to reducing disease *** education through practical health information to particular groups and sub-populations is crucial to controlling the *** this paper,we study the dynamics of Ebola virus disease in the presence of public health education with the aim of assessing the role of behavior change induced by health education to the dynamics of an *** power of behavior change is evident in two outbreaks of EVD that took place in Sudan only 3 years *** first occurrence was the first documented outbreak of EVD and produced a significant number of *** second outbreak produced far fewer cases,presumably because the population in the region learned from the first *** derive a system of ordinary differential equations to model these two contrasting *** the population in Sudan learned from the first outbreak of EVD and changed their behavior prior to the second outbreak,we use data from these two instances of EVD to estimate parameters relevant to two contrasting *** then simulate a future outbreak of EVD in Sudan using our model that contains two susceptible populations,one being more informed about *** finding show how a more educated population results in fewer cases of EVD and highlights the importance of ongoing public health education.

关键词： Ebola virus disease Public health education Outbreaks Mathematical model Simulations Infectious disease model

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A vaccination model for COVID-19 in Gauteng,South Africa

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Infectious Disease Modelling 2022年第3期7卷 333-345页

作者： Christina J.Edholm benjamin levy Lee Spence Folashade B.Agusto Faraimunashe Chirove C.Williams Chukwu David Goldsman Moatlhodi Kgosimore Innocent Maposa K.A.Jane White Suzanne Lenhart Department of Mathematics Scripps CollegeClaremontCAUSA Mathematics Department Fitchburg State UniversityFitchburgMAUSA Department of Mathematics University of TennesseeKnoxvilleTNUSA Department of Ecology and Evolutionary Biology University of KansasLawrenceKSUSA Department of Mathematics and Applied Mathematics University of JohannesburgSouth Africa H.Milton Stewart School of Industrial and Systems Engineering Georgia Institute of TechnologyAtlantaGAUSA Biometry and Mathematics Department Botswana University of Agriculture and Natural ResourcesGaboroneBotswana Division of Epidemiology and Biostatistics School of Public HealthFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Department of Mathematical Sciences University of BathBathUK

The COVID-19 pandemic provides an opportunity to explore the impact of government mandates on movement restrictions and non-pharmaceutical interventions on a novel infection,and we investigate these strategies in early-stage outbreak *** rate of disease spread in South Africa varied over time as individuals changed behavior in response to the ongoing pandemic and to changing government *** a system of ordinary differential equations,we model the outbreak in the province of Gauteng,assuming that several parameters vary over *** data from the time period before vaccination gives the approximate dates of parameter changes,and those dates are linked to government *** parameters are then estimated from available case data and used to assess the impact of each *** forward in time,possible scenarios give projections involving the implementation of two different vaccines at varying *** results quantify the impact of different government policies and demonstrate how vaccinations can alter infection spread.

关键词： COVID-19 Gauteng South Africa ODE epidemiology Model Vaccination Parameter estimation

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固定剂量合并利尿剂用于充血性心力衰竭的评价

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昆明医科大学学报 1982年第2期 102-103页

作者： benjamin levy 邓士贤

关于固定剂量合并药物治疗的问题已有多年。多数反对者认为:它並不具有较佳之药理反应,反之,应用各种单一药物分别治疗,却更灵活,且其剂量更具有个体化之特点。作者对螺旋内脂(Spironolactone)或氨苯喋啶(triamterene) (一种钾保留剂)... 详细信息

关于固定剂量合并药物治疗的问题已有多年。多数反对者认为:它並不具有较佳之药理反应,反之,应用各种单一药物分别治疗,却更灵活,且其剂量更具有个体化之特点。作者对螺旋内脂(Spironolactone)或氨苯喋啶(triamterene) (一种钾保留剂)与氢氯噻嗪(bydrochlorothiazide)固定剂量合并应用于32例慢性充血性心力衰竭的病人,并同时单独使用呋喃苯胺酸(速尿furosemido)共16周,并采用双盲法评价,虽然两种合并药物组

关键词：利尿剂心力病人充血性心力衰竭固定剂量

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Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas

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Asian Journal of Andrology 2020年第6期22卷 569-577页

作者： Margarita Vigodner benjamin Lucas Stav Kemeny Tamar Schwartz Rebecca levy Department of Biology Stern CollegeYeshiva UniversityNew YorkNY 10016USA Department of Developmental and Molecular Biology Albert Einstein College of MedicineBronxNY 10461USA

Spermatogenesis is regulated by a complex network of posttranslation ***(a modification by small ubiquiti like modifiers,or SUMO proteins)was identified as an importa nt cellular event in d iff ere nt cell *** proteins are highly expressed in the testis,and their role during spermatogenesis has begun to be *** the important role of sumoylation in the regulation of mitosis and cancer progress!on in other tissues,the aim of the current study was to identify the targets of SUMO in proliferating mouse spermatog onia and huma n semi noma tissues and to in itially exami ne the level of sumoylation in relation to the proliferative activity of the *** freshly purified spermatogonia and Cl8-4 spermatogonia cell line,mass spectrometry analysis identified several SUMO targets implicated into the proliferation of spermatogonia(such as heat shock protein 60[HSP60]and prohibitin).Tissue array and western blot approaches showed that SUMO expression is a prominent feature of human seminomas and that the proliferative activity of the tumor tissues was positively correlated with the level of SUMO *** regulation of sumoylati on with si-RNA was not sufficie nt to sign ificantly affect the proliferation of C18-4 spermatogonia;however,SUMO overexpression in creased the proliferation rate of the *** data suggest that cells are more sensitive to an elevated level of SUMO,and that this situation may lead to an upregulated cellular proliferation and,possibly,*** spectrometry analysis identified around a hundred SUMO targets in seminoma ***,many of the identified proteins(such as proliferating cell nuclear antigen[PCNA],DNA topoisomerase 2-alpha[Top2A],prohibitin,14-3-3 protein,and others)were implicated in oncogenic transformation and cancer progression.

关键词： proliferation seminoma spermatog onia sumoylation

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The medical treatment of cardiogenic shock

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Journal of Intensive Medicine 2023年第2期3卷 114-123页

作者： Mickael Lescroart benjamin Pequignot Dany Janah Bruno levy Service de Médecine Intensive et Réanimation Brabois CHRU NancyPole Cardio-Médico-ChirurgicalVandoeuvre-les-Nancy 54511France INSERM U1116 Facultéde MédecineVandoeuvre-les-Nancy 54511France Universitéde Lorraine Vandoeuvre-les-Nancy 54000France

Cardiogenic shock (CS) is a leading cause of mortality worldwide. CS presentation and management in the current era have been widely depicted in epidemiological studies. Its treatment is codified and relies on medical care and extracorporeal life support (ECLS) in the bridge to recovery, chronic mechanical device therapy, or transplantation. Recent improvements have changed the landscape of CS. The present analysis aims to review current medical treatments of CS in light of recent literature, including addressing excitation–contraction coupling and specific physiology on applied hemodynamics. Inotropism, vasopressor use, and immunomodulation are discussed as pre-clinical and clinical studies have focused on new therapeutic options to improve patient outcomes. Certain underlying conditions of CS, such as hypertrophic or Takotsubo cardiomyopathy, warrant specifically tailored management that will be overviewed in this review.

关键词： Cardiogenic shock Etiology Epidemiology Medical treatment Monitoring

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Beta-blockers in septic shock: What is new?

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Journal of Intensive Medicine 2022年第3期2卷 150-155页

作者： Mickael Lescroart benjamin Pequignot Antoine Kimmoun Thomas Klein Bruno levy Service de Médecine Intensive et Réanimation Brabois CHRU NancyPôle Cardio-Médico-ChirurgicalUniversity Hospital of Nancy-BraboisRue du MorvanVandoeuvre-les-Nancy 54511France INSERM U1116 Facultéde MédecineVandoeuvre-les-Nancy 54511France Universitéde Lorraine Nancy 54000France

The use of beta(β)-blockers during septic shock aimed at countering peripheral adrenergic stress may be justified by the early reduction in deleterious effects resulting from sympathetic overactivation,and could improve the prognosis of patients in septic *** studies have demonstrated either a maintenance or increase in cardiac output(CO)despite the decrease in heart rate(HR)associated with improved myocardial *** mechanism by which𝛽-blockers alter hemodynamics in septic shock is debated;however,preclinical and clinical data show that𝛽-blockers are safe when started at a low *** publications(2019-2021)on adrenergic𝛽1 receptor antagonists used in septic shock indicate that esmolol and landiolol should not be used in the early *** there is no optimal timing for their administration,a minimum of 12 h after the initiation of vasopressor therapy in stabilized euvolemic patients is a reasonable *** should have a normal cardiac function,although a slight depression is compatible with landiolol use under hemodynamic *** titration in patients who remain tachycardic is preferable to rapid *** used to decrease HR,landiolol is also effective in reducing the incidence of new *** of a well-performed and well-powered randomized controlled trial(RCT)demonstrating a positive effect on survival-or at least on hard surrogates such as the incidence/duration of organ failure-are pending.

关键词： Septic shock Adrenergic𝛽β_(1)receptor antagonists Norepinephrine

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Dilemmas in end-stage heart failure

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Journal of Geriatric Cardiology 2015年第1期12卷 57-65页

作者： Carol Chen-Scarabelli Louis Saravolatz benjamin Hirsh Pratik Agrawal Tiziano M. Scarabelli Veterans Affairs Healthcare System Ann Arbor 2215 Fuller Rd. Ann Arbor M148105 USA St. John Hospital and Medical Center~Wayne State University 22101 Moross Rd. Detroit M148236 USA Zena and Michael A. Wiener Cardiovascular Institute Mount Sinai Medical Center One Gustave L. Levy Place Box 1030 New York NY 10029-6574 USA

Heart failure （HF）, a complex clinical syndrome due to structural or functional disorder of the heart, is a major global health issue, with a prevalence of over 5.8 million in the USA alone, and over 23 million worldwide. As a leading cause of hospitalizations among patients aged 65 years or older, HF is a major consumer of healthcare resources, creating a substantial strain on the healthcare system. This paper discusses the epidemiology of HF, financial impact, and multifaceted predicaments in end-stage HF care. A search was conducted on the U.S National Library of Medicine website （***） using keywords such as end-stage heart failure, palliative care, ethical dilemmas. Despite the poor prognosis of HF （worse than that for many cancers）, many HF patients, caregivers, and clinicians are unaware of the poor prognosis. In addition, the unpredictable clinical trajectory of HF complicates the planning of end-of-life care, such as palliative care and hospice, leading to underutilization of such resources. In conclusion, ethical dilemmas in end-stage HF are numerous, embroiling not only the patient, but also the caregiver, healthcare team, and society.

关键词： Ethical dilemmas Heart failure Palliative care

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肥胖与新发房颤危险之间的关系

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 20-21页

作者： Parise H. levy D. E. J. benjamin 王亭忠 Framingham Heart Study 73 Mount Wayte Ave Framingham MA 01702-5827 United States Dr.

Context: Obesity is associated with atrial enlargement and ventricular diastol ic dysfunction, both known predictors of atrial fibrillation(AF). However, it is unclear whether obesity is a risk factor for AF. Objective: To examine the asso ciation between body mass index(BMI) and the risk of developing AF. Design, Sett ing, and Participants: Prospective, communitybased observational cohort in Fra mingham, Mass. We studied 5282 participants(mean age, 57[SD, 13] years; 2898 wom en[55%]) without baseline AF(electrocardiographic AF or arterial flutter). Body mass index(calculated as weight in kilograms divided by square of height in met ers) was evaluated as both a continuous and a categorical variable(normal define d as < 25.0; overweight, 25.0 to < 30.0; and obese, ≥30.0). In addition to adju sting for clinical confounders by multivariable techniques, we also examined mod els including echocardiographic left atrial diameter to examine whether the infl uence of obesity was mediated by changes in left atrial dimensions. Main Outcome Measure: Association between BMI or BMI category and risk of developing newon set AF. Results: During a mean followup of 13.7 years, 526 participants(234 wo men) developed AF. Age adjusted incidence rates for AF increased across the 3 BM I categories in men(9.7, 10.7, and 14.3 per 1000 personyears) and women(5.1, 8 .6, and 9.9 per 1000 personyears). In multivariable models adjusted for cardio vascular risk factors and interim myocardial infarction or heart failure, a 4%i ncrease in AF risk per 1-unit increase in BMI was observed in men(95%confidenc e interval[CI], 1%-7%; P=.02) and in women(95%CI, 1%-7%; P=.009). Adjuste d hazard ratios for AF associated with obesity were 1.52(95%CI, 1.09-2.13; P=. 02) and 1.46(95%CI, 1.03-2.07; P=.03) for men and women, respectively, compare d with individuals with normal BMI. After adjustment for echocardiographic left atrial diameter in addition to clinical risk factors, BMI was no longer associat ed

关键词：舒张功能不全房扑左房扩大临床危险因素连续变量队列研究马萨诸塞州血管危险因素多变量模型混杂因素

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中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究

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中华高血压杂志 2017年第3期25卷 299-299页

作者： Torjesen A Cooper LL Rong J Larson MG Hamburg NM levy D benjamin EJ Vasan RS Mitchell GF 刘莉叶鹏

Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, levy D, benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults：the Framingham heart study. Hyperten- sion,2017,69（4）：685-690.站立位血压稳定调节受损可导致不良结果，包括跌倒、晕厥和定向障碍。平均动脉压（meanarterialpressure，MAP）通常在站立位时增加，然而，站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道，在动脉硬度增加的老年人中存在体位性低血压，年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人（女性1693人，占53％）的直立性血压反应和全面血液动力学数据。

关键词： Framingham心脏研究平均动脉压动脉硬度中年人体位改变 arterial 体位性低血压成人

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循环脂肪因子和血管功能:以社区为基础的横断面研究

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中华高血压杂志 2015年第11期23卷 1086-1086页

作者：刘莉叶鹏 Zachariah JP Hwang S Hamburg NM benjamin EJ Larson MG levy D Vita JA Sullivan LM Mitchell GF Vasan RS

脂肪细胞因子可能是过度肥胖和血管功能障碍之间关系的潜在调节因子。该研究在一以社区为基础的较年轻人群中对循环脂肪因子和血管弹性的横断面关系进行评估。方法：研究人员在Framingham第3代队列研究无心血管病的3505例受试者中（平... 详细信息

脂肪细胞因子可能是过度肥胖和血管功能障碍之间关系的潜在调节因子。该研究在一以社区为基础的较年轻人群中对循环脂肪因子和血管弹性的横断面关系进行评估。方法：研究人员在Framingham第3代队列研究无心血管病的3505例受试者中（平均40岁,53%为女性）,研究循环瘦素和瘦素受体浓度、脂联素、视黄醇结合蛋白4、

关键词：脂肪因子脂肪酸结合蛋白脂肪细胞因子血管功能血管弹性视黄醇结合蛋白过度肥胖队列研究瘦素受体动脉僵硬度

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