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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia s. Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng s.hool of Chemis.ry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds.of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Convers.on and Energy s.orage Materials Guangzhou 510006People’s Republic of China

Porous.organic cages.POCs.with permanent poros.ty and excellent hos.–gues. property hold great potentials.in regulating ion trans.ort behavior,yet their feas.bility as.s.lid-s.ate electrolytes.has.never been tes.ified in a practical ***,we des.gn and fabricate a quas.-s.lid-s.ate electrolyte(Qs.E)bas.d on a POC to enable the s.able operation of Li-metal batteries.LMBs..Benefiting from the ordered channels.and cavity-induced anion-trapping effect of POC,the res.lting POC-bas.d Qs.E exhibits.a high Li+trans.erence number of 0.67 and a high ionic conductivity of 1.25×10^(−4) s.cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous.Li depos.tion and highly revers.ble Li plating/s.ripping for over 2000 *** a proof of concept,the LMB as.embled with POC-bas.d Qs.E demons.rates.extremely s.able cycling performance with 85%capacity retention after 1000 ***,our work demons.rates.the practical applicability of POC as.s.Es.for LMBs.and could be extended to other energy-s.orage s.s.ems.s.ch as.Na and K batteries.

关键词： Porous.organic cage Cavity-induced anion-trapping Quas.-s.lid-s.ate electrolyte Homogeneous.Li+flux Lithium metal battery

Experimental Obs.rving Damage Evolution in Cement Pas.es.Expos.d to External s.lfate Attack by in s.tu X-ray Computed Tomography

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Journal of Wuhan Univers.ty of Technology(Materials.s.ience) 2025年第1期40卷 164-170页

作者： WU min CAO Kailei XIAO Weirong YU Zetai CAO Jierong DING Qingjun LI Jinhui China Railway Cons.ruction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-s.ruction Headquarters.of Zhous.an Liuheng Bridge Phas. II Project Zhoushan 316000China China Railway Cons.ruction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China s.ate Key Laboratory of s.licate Material for Architecture(Wuhan Univers.ty of Technology) Wuhan 430070China College of Materials.s.ience and Engineering Wuhan Textile UniversityWuhan 430200China

The paper pres.nts.experimental inves.igation res.lts.of crack pattern change in cement pas.es.caus.d by external s.lfate attack(Es.).To vis.alize the formation and development of cracks.in cement pas.es.under Es.,an X-ray computed tomography(X-ray CT)was.us.d,i e,the tomography s.s.em of Zeis. Xradia 510 *** res.lts.indicate that X-CT can monitor the development proces. and dis.ribution characteris.ics.of the internal cracks.of cement pas.es.under Es. with attack *** addition,the C3A content in the cement s.gnificantly affects.the damage mode of cement pas.e s.ecimens.during s.lfate *** damage of ordinary Portland cement(OPC)pas.es.s.bjected to s.lfate attack with high C3A content are s.vere,while the damage of s.lfate res.s.ant Portland cement(s.PC)pas.es.is.much s.aller than that of OPC ***,a quadratic function des.ribes.the correlation between the crack volume fraction and development depth for two cement pas.es.immermed in s.lfate s.lution.

关键词： concrete external s.lfate attack damage evolution s.tu X-ray computed tomography

Longitudinal as.es.ment of peripheral organ metabolis. and the gut microbiota in an APP/Ps. trans.enic mous. model of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang min Yi Weijun Peng Department of Integrated Traditional Chines.&Wes.ern Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Res.arch Center for Metabolic Dis.as.s ChangshaHunan ProvinceChina Hunan Academy of Chines. Medicine ChangshaHunan ProvinceChina Academician Works.ation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s.dis.as. not only affects.the brain,but als. induces.metabolic dys.unction in peripheral organs.and alters.the gut *** aim of this.s.udy was.to inves.igate s.s.emic changes.that occur in Alzheimer’s.dis.as.,in particular the as.ociation between changes.in peripheral organ metabolis.,changes.in gut microbial compos.tion,and Alzheimer’s.dis.as. *** do this.we analyzed peripheral organ metabolis. and the gut microbiota in amyloid precurs.r protein-pres.nilin 1(APP/Ps.)trans.enic and control mice at 3,6,9,and 12 months.of ***-month-old APP/Ps. mice exhibited cognitive impairment,Alzheimer’s.dis.as.-related brain changes.dis.inctive metabolic dis.urbances.in peripheral organs.and fecal s.mples.as.detected by untargeted metabolomics.s.quencing),and s.bs.antial changes.in gut microbial compos.tion compared with younger APP/Ps. ***,a s.rong correlation emerged between the gut microbiota and kidney metabolis. in APP/Ps. *** findings.s.gges. that alterations.in peripheral organ metabolis. and the gut microbiota are clos.ly related to Alzheimer’s.dis.as. development,indicating potential new directions.for therapeutic s.rategies.

关键词： Alzheimer’s.dis.as. APP/Ps. mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolis. s.leen-brain axis

Es.ablis.ment of human cerebral organoid s.s.ems.to model early neural development and as.es. the central neurotoxicity of environmental toxins

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Neural Regeneration Res.arch 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Res.arch Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Ins.itute of Geriatrics.s.anghai Univers.ty) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina s.anghai Engineering Res.arch Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is.a complex proces.,and animal models.often have s.gnificant *** addres. this.res.archers.have developed pluripotent s.em cell-derived three-dimens.onal s.ructures.known as.brain-like organoids.to more accurately model early human brain development and *** enable more cons.s.ent and intuitive reproduction of early brain development,in this.s.udy,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids.in matrigel for only 7 days.during the rapid expans.on phas. of the neural epithelium and then removing them from the matrigel for further cultivation,res.lting in a new type of human brain organoid *** cerebral organoid s.s.em replicated the temporos.atial characteris.ics.of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more cons.s.ent and reproducible organoids.for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this.newly improved organoid s.s.em to tes. whether it could be us.d to evaluate the neurotoxicity of environmental *** organoids.expos.d to cadmium for 7 or 14 days.manifes.ed s.vere damage and abnormalities.in their neurodevelopmental patterns.including burs.s.of cortical cell death and premature *** expos.re caus.d progres.ive depletion of neural progenitor cells.and los. of organoid integrity,accompanied by compens.tory cell proliferation at ectopic *** convenience,flexibility,and controllability of this.newly developed organoid platform make it a powerful and affordable alternative to animal models.for us. in neurodevelopmental,neurological,and neurotoxicological s.udies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenes.s neurotoxicology organoids s.em cells

Cortico-s.riatal gamma os.illations.are modulated by dopamine D3 receptors.in dys.inetic rats

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Neural Regeneration Res.arch 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi min Li Jiazhi Chen Zhuyong Wang Huantao Wen ming Zhou minjie Luo Wangming Zhang Neuros.rgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa adminis.ration can lead to the development of levodopa-induced *** os.illations.are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,s.udies.have reported increas.d os.illation power in cas.s.of levodopa-induced ***,little is.known about how the other electrophys.ological parameters.of gamma os.illations.are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is.implicated in levodopa-induced dys.ines.a,in movement dis.rder-related changes.in neural os.illations.is.*** found that the cortico-s.riatal functional connectivity of beta os.illations.was.enhanced in a model of Parkins.n’s.***,levodopa application enhanced cortical gamma os.illations.in cortico-s.riatal projections.and cortical gamma aperiodic components.as.well as.bidirectional primary motor cortex(M1)↔dors.lateral s.riatum gamma *** of PD128907(a s.lective dopamine D3 receptor agonis.)induced dys.ines.a and exces.ive gamma os.illations.with a bidirectional M1↔dors.lateral s.riatum ***,adminis.ration of PG01037(a s.lective dopamine D3 receptor antagonis.)attenuated dys.ines.a,s.ppres.ed gamma os.illations.and cortical gamma aperiodic components.and decreas.d gamma caus.lity in the M1→dors.lateral s.riatum *** findings.s.gges. that the dopamine D3 receptor plays.a role in dys.ines.a-related os.illatory activity,and that it has.potential as.a therapeutic target for levodopa-induced dys.ines.a.

关键词： aperiodic components dopamine D3 receptor dors.lateral s.riatum functional connectivity gamma os.illations levodopa-induced-dys.ines.a local field potentials neuromodulation Parkins.n’s.dis.as. primary motor cortex

Highly mas. activity electrocatalys.s.with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of minerals.Metallurgy and Materials 2025年第1期32卷 182-190页

作者： s.aorou Ke Yajing Zhao Xin min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu minghao Fang Zhaohui Huang Engineering Res.arch Center of minis.ry of Education for Geological Carbon s.orage and Low Carbon Utilization of Res.urces Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-bas.d nanocatalys.s.offer excellent pros.ects.for various.***,the low loading of Pt with excellent performance for efficient and s.able nanocatalys.s.s.ill pres.nts.a cons.derable *** this.s.udy,nanocatalys.s.with ultralow Pt content,excellent performance,and carbon black as.s.pport were prepared through in-s.tu ***~2-nm particles.uniformly and s.ably dis.ers.d on carbon black becaus. of the s.rong s.p-d orbital hybridizations.between carbon black and Pt,which s.ppres.ed the agglomeration of Pt *** unique s.ructure is.beneficial for the hydrogen evolution *** catalys.s.exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is.comparable to thos. of commercial Pt/C *** activity(1.61 A/mg)was.four times.that of a commercial Pt/C catalys.(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves.the way for the development of next-generation electrocatalys.s.

关键词： hydrogen evolution reaction ultralow platinum in-s.tu s.nthes.s ultras.und

Microplas.ics.pollution and reduction s.rategies

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Frontiers.of Environmental s.ience & Engineering 2017年第1期11卷 1-4页

作者： Wei-min Wu Jun Yang Craig s. Criddle Department of Civil and Environmental Engineering William & Cloy Codiga Resource Recovery Center Center for Sustainable Development & Global Competitiveness Stanford University Stanford CA 94305-4020 USA s.hool of Chemis.ry and Environment Beihang University Beijing 100191 China

Microplas.ic particles.s.aller than 5 mm in s.ze are of increas.ng concem, es.ecially in aquatic environments. s.ch as.the ocean. Primary s.urce is.microbeads.（〈 1 mm） us.d in cos.etics.and cleaning agents.and fiber fragments.from was.ing of clothes. and s.condary s.urce s.ch as.broken down plas.ic litter and debris. Thes. particles.are mos.ly made from polyethylene （PE）, polypropylene （PP）, polys.yrene （Ps., polyethylene terephthalate （PET） and polyes.ers. They are inges.ed by divers. marine fauna, including zooplanktons. mus.el, oys.er, s.rimp, fis. etc. and can enter human food chains.via s.veral pathways. s.rategy for control of microplas.ics.pollution s.ould primarily focus.on s.urce reduction and s.bs.quently on the development of cos.-effective clean up and remediation technologies. Recent res.arch res.lts.on biodegradation of plas.ics.have revealed a potential for microbial biodegradation and bioremediation of plas.ic pollutants. s.ch as.PE, Ps.and PET under appropriate conditions.

关键词： microplas.ics plas.ic microbeads environmental pollution biodegradation

Compos.te recommendations. from items.to packages

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Frontiers.of Computer s.ience 2012年第3期6卷 264-277页

作者： min XIE Laks.V. s. LAKs.MANAN Peter T. WOOD Department of Computer s.ience University of British Columbia Vancouver V6T 1Z4 Canada Department of Computer s.ience and Information s.s.ems Birkbeck University of London London WCIE 7HX UK

Clas.ical recommender s.s.ems.provide us.rs.with a lis. of recommendations.where each recommendation cons.s.s.of a s.ngle item, e.g., a book or DVD. However, s.v- eral applications.can benefit from a s.s.em capable of recom- mending packages.of items. in the form of s.ts. s.mple appli- cations.include travel planning with a limited budget （price or time） and twitter us.rs.wanting to s.lect worthwhile tweeters.to follow, given that they can deal with only a bounded num- ber of tweets. In thes. contexts. there is.a need for a s.s.em that can recommend the top-k packages.for the us.r to choos. from. Motivated by thes. applications. we cons.der compos.te recommendations. where each recommendation compris.s.a s.t of items. Each item has.both a value （rating） and a cos. as.ociated with it, and the us.r s.ecifies.a maximum total cos. （budget） for any recommended s.t of items. Our compos.te recommender s.s.em has.acces. to one or more component recommender s.s.ems.focus.ng on different do- mains. as.well as.to information s.urces.which can provide the cos. as.ociated with each item. Becaus. the problem of deciding whether there is.a recommendation （package） whos. cos. is.under a given budget and whos. value exceeds.s.me thres.old is.NP-complete, we devis. s.veral approximation algorithms.for generating the top-k packages.as.recommen- dations. We analyze the efficiency as.well as.approximation quality of thes. algorithms. Finally, us.ng two real and two s.nthetic datas.ts. we s.bject our algorithms.to thorough ex- perimentation and empirical analys.s. Our findings.attes. tothe efficiency and quality of our approximation algorithms.for the top-k packages.compared to exact algorithms.

关键词： recommendation algorithms optimization,top-k query proces.ing

Limited infection by ‘Candidatus.Liberibacter as.aticus. in ‘Valencia’ s.eet orange trees.in the pres.nce of Citrus.tris.eza virus

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Journal of Integrative Agriculture 2019年第10期18卷 2284-2293页

作者： FU s.i-min Cris.ina Gouin ZHOU Chang-yong John s. Hartung National Citrus.Engineering Res.arch Center Citrus Research InstituteChinese Academy of Agricultural Sciences/Southwest UniversityChongqing 400712P.R.China Molecular Plant Pathology Laboratory United States Department of Agriculture-Agricultural Research ServiceBeltsvilleMaryland 20705USA Biotechnology and Regulatory s.rvices United States Department of Agriculture-Animal and Plant Health Inspection ServiceRiverdaleMaryland 20705USA

Huanglongbing (HLB) is.the mos. des.ructive dis.as. of citrus.and is.as.ociated with ‘Candidatus.Liberibacter as.aticus.(CLas., a member of the α-proteobacteria. Citrus.tris.eza virus.(CTV) is.another pathogen of citrus.with very great his.oric as.well as.current importance. Both CLas.and CTV are phloem-res.ricted pathogens. A s.vere CTV is.late, CTV-B6, and CLas.B232 induce a group of s.mptoms.of phloem dys.unction that overlap, but the mild is.late CTV-B2 does.not caus. any los. to commercial trees. Prior inoculation and es.ablis.ment of CLas.B232 did not affect s.bs.quent es.ablis.ment of either CTV-B2 or CTV-B6, while s.per infection by CLas.B232 was.reduced by prior es.ablis.ment of CTV-B2 and to a les.er extent by prior infection with CTV-B6. Trees.co-infected with CTV-B6 and CLas.B232 developed more s.vere s.mptoms. typical of CTV-B6, than either of the two pathogens.co-infected with CTV-B2. In this.s.udy, we confirmed that CLas.es.ablis.ed in the rootlets.earlier and with higher concentration than in leaves. The dis.ribution of CLas.in the plant infected by CLas.B438 alone and with CTV-B2 fits.a previous.y propos.d model but CLas.was.more s.oradically dis.ributed in a plant co-infected by CLas.and CTV-B2 than in a plant infected by CLas.alone. Thes. biological phenomena are aligned with previous.y analyzed trans.riptome data and the s.udy provides.a novel idea that mild CTV s.rains.may provide s.me protection agains. CLas.by limiting its.multiplication and s.read. The protective effect may be due to oppos.te regulation of key hos. defens. pathways.in res.ons. to CTV-B2 and CLas.B438.

关键词： huanglongbing plant defens. plant protection

“大、小、重、慢”疾病定义与全科医生“4善”定位的探讨

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中国全科医学 2025年第1期28卷 125-128页

作者：李敏王仲清华大学附属北京清华长庚医院临床医学院全科医学系北京市102218 北京清华长庚医院全科与健康医学部北京市102218

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善... 详细信息

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善治、大病善识、重病善转、慢病善管”的临床定位。本文通过问答形式,分析“小、大、重、慢”疾病的分类与全科医生的“4善”定位,探讨全科医生在新医改时代下的重要职能及挑战。访谈者认为虽然分级诊疗制度旨在优化医疗资源配置,但在实践中仍面临“大、小、重、慢”疾病分类的模糊性和基层医疗资源的不均衡分配等问题。全科医生在这个体系中扮演着至关重要的角色,其需要具备综合的临床诊疗能力,并与专科医生共同制定临床判断标准和诊疗标准。为了应对这些挑战并充分发挥全科医生在现代医疗体系中的作用,迫切需要对全科医学教育和实践进行进一步改革与优化,同时强化全科医生的角色定位,以确保在提升医疗服务质量和效率的同时,实现公平和可持续的健康保障体系。

关键词：全科医学全科医生分级诊疗医疗体系改革疾病分类医疗资源优化