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World Journal of Experimental medicine 2015年第2期5卷 50-63页

作者： Dubravka Kojic benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth markus A Weigand Stefan Hofer Thorsten Brenner Department of Anesthesiology Heidelberg University Hospital Department of Internal medicine I and Clinical Chemistry Heidelberg University Hospital

Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach.

关键词： Clinical decision-making Biomarkers Early prediction Sepsis and mortality

Interband cascade technology for energy-efficient mid-infrared free-space communication

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Photonics Research 2023年第4期11卷 582-590页

作者： PIERRE DIDIER HEDWIG KNÖTIG OLIVIER SPITZ LAURENT CERUTTI ANNA LARDSCHNEIDER ELIE AWWAD DANIEL DIAZ-THOmAS ANBARANOV ROBERT WEIH JOHANNES KOETH benedikt SCHWARZ FRÉDÉRIC GRILLOT LTCI Télécom Paris Institut Polytechnique de ParisPalaiseau 91120France mirSense Centre d’intégration NanoInnovPalaiseau 91120France Institute for Solid State Electronics TU Wien1040 ViennaAustria Currently with CREOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFlorida 32816USA Institut d’Electronique et des Systèmes Universitéde MontpellierCNRS UMR 5214Montpellier 34000France Nanoplus Nanosystems and Technologies GmbH 97218 GerbrunnGermany Center for High Technology materials University of New MexicoAlbuquerqueNew Mexico 87106USA

Space-to-ground high-speed transmission is of utmost importance for the development of a worldwide broadband ***-infrared wavelengths offer numerous advantages for building such a system,spanning from low atmospheric attenuation to eye-safe operation and resistance to inclement weather *** demonstrate a full interband cascade system for high-speed transmission around a wavelength of 4.18μ*** low-power consumption of both the laser and the detector in combination with a large modulation bandwidth and sufficient output power makes this technology ideal for a free-space optical communication *** proof-of-concept experiment employs a radio-frequency optimized Fabry–Perot interband cascade laser and an interband cascade infrared photodetector based on a type-II InAs/GaSb *** bandwidth of the system is evaluated to be around 1.5 *** allows us to achieve data rates of 12 Gbit/s with an on–off keying scheme and 14 Gbit/s with a 4-level pulse amplitude modulation *** quality of the transmission is enhanced by conventional pre-and post-processing in order to be compatible with standard error-code correction.

关键词： communication system free

Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients:Experiences of a tertiary care single center

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Current Urology 2023年第4期17卷 292-298页

作者： benedikt Hoeh marina Kosiba mike Wenzel Nicola meister Felix Preisser Shahrokh F.Shariat Jan Lukas Hohenhorst Andreas Becker Philipp mandel Severine Banek Frederik Roos Pierre I.Karakiewicz Felix K.H.Chun Luis A.Kluth Department of Urology University Hospital FrankfurtGoethe University Frankfurt am MainFrankfurt am Main60590Germany Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity of Montreal Health CenterMontrealQuebecCanada Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany

Objectives:To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy(RNU)for upper tract urothelial carcinoma(UTUC).materials and methods:We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional *** undergoing laparoscopic or open RNU with no suspicion of metastasis(cm0)were for the current study *** with suspected metastases at diagnosis(cm1)or those undergoing other surgical treatments were *** was performed according to the laparoscopic versus open surgical ***-meier plots were used to test for differences in overall and recurrence-free survival with regard to the surgical ***,separate Kaplan-meier plots were used to test the effect of preoperative ureterorenoscopy on overall and recurrence-free survival within the overall study ***:Of the 59 patients who underwent nephroureterectomy,29%(n=17)underwent laparoscopic nephroureterectomy,whereas 71%(n=42)underwent open *** and tumor characteristics were comparable between groups(p≥0.2).The median overall survival was 93 and 73 months in the laparoscopic nephroureterectomy group compared to the open nephroureterectomy group(p=0.5),*** median recurrence-free survival did not differ between open and laparoscopic nephroureterectomies(73 months for both groups;p=0.9).Furthermore,the median overall and recurrence-free survival rates did not differ between patients treated with and without preoperative ***:The results of this retrospective,single-center institution showed that overall and recurrence-free survival rates did not differ between patients with UTUC treated with laparoscopic and open ***,preoperative ureterorenoscopy before RNU was not associated with higher overall or recurrence-free survival rates.

关键词： Upper tract urothelial carcinoma Laparoscopic radical nephroureterectomy Open radical nephroureterectomy Overall survival

在立式的工艺干燥器中干燥具有膏状相或含膏状物组分的产品

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在立式的工艺干燥器中干燥具有膏状相或含膏状物组分的产品

第六届化学工程与生物技术展览暨会议

作者： benedikt Simons 林仙钦 EKATO SOLIDmIX GmbH

＜正＞对于在干燥期间需要强烈而完全混合的产品干燥,市场上有许多不同的干燥设备。所有这些设备有一个共同点,那就是产品在干燥器中的循环均借助与转动轴安装在一起的混合工具。干燥过程需用的热量通常是依靠器壁、转轴和搅拌器与物...

＜正＞对于在干燥期间需要强烈而完全混合的产品干燥,市场上有许多不同的干燥设备。所有这些设备有一个共同点,那就是产品在干燥器中的循环均借助与转动轴安装在一起的混合工具。干燥过程需用的热量通常是依靠器壁、转轴和搅拌器与物料接触的表面来传递的。干燥设备可以在负压条件下操作,这样可以加速干燥过程或者可以借助气提法

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布拉格CAmP建筑与城市规划中心

现代装饰 2020年第4期 142-149页

作者： benedikt markel Dominik Saitl martina Pozárová Vilém Kocáb BoysPlayNice(摄影) 刘印梅(编译) 方钰丹不详

CAmP位于布拉格市中心,是当地的建筑与城市规划中心,旨在增进公众对捷克首都发展的讨论。CAmP希望为布拉格的现在和未来发展提供清晰、可访问的信息,它是一个开放的平台,是对布拉格的城市总体规划和发展感兴趣的人的"大本营"。

关键词：布拉格建筑与城市

A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases

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Science China(Life Sciences) 2023年第10期66卷 2380-2398页

作者： Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo benedikt mKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang State Key Laboratory of Common mechanism Research for major Diseases Department of BiochemistryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of Chinese medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaEngineering Research Center of Chinese Medicine Resource of Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Department of Traditional Chinese medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China Hefei National Laboratory for Physical Sciences at the microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China mRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxford OX37FZUK Chinese Academy of medical Sciences(CAmS) CAMS Oxford Institute(COI)Nuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Shanghai Research Center for modernization of Traditional Chinese medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Target Discovery Institute Centre for Medicines DiscoveryNuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Department of Electrical Engineering and Computer Science and Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbia MO 65211USA

Cross-kingdom herbal mi RNA was first reported in *** a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese medicine(TCm),of which 20,758,257 were unique *** constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://***),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s *** profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi *** software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal *** established roadmaps for oligonucleotide drugs development and optimization of TCm ***,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical *** propose a Bencao(herbal)Index,including small-molecule compounds(Sm),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(Lm)and elements from mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic *** Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine.

关键词： small RNA herbal decoction cross-kingdom regulation traditional Chinese medicine RNA oligonucleotide drug RNA therapeutics Bencao small RNA Atlas

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变幻的动感美国耐克体验店

室内设计与装修 2011年第5期 34-37页

作者： Rafael de Cárdenas Allen benedikt 和维

越来越多品牌开始选择设立体验店,通过更为直观的方式将品牌理念、未来发展、最新产品等展现给客户,以强化其品牌形象。尤其是一些不以盈利为主要目的的体验店,更像一个展示空间,

关键词：动感耐克美国品牌理念品牌形象展示空间客户

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百年灵改变需要时间

商业周刊（中文版） 2019年第1期 14-15页

作者： Corinne Gretler benedikt Kammel Jan Dahinten 竹西(译) 不详

这家飞行员手表制造商及其私人股本拥有者正进行品牌现代化改造乔治斯·克恩(Georges Kem)一度貌似将登顶奢侈品集团历峰集团(*** Rlchemont SA)。他在那里工作经营了17年,从历峰集团旗下一个重要品牌的最年轻的首席执行官做到了所有制... 详细信息

这家飞行员手表制造商及其私人股本拥有者正进行品牌现代化改造乔治斯·克恩(Georges Kem)一度貌似将登顶奢侈品集团历峰集团(*** Rlchemont SA)。他在那里工作经营了17年,从历峰集团旗下一个重要品牌的最年轻的首席执行官做到了所有制表业务的领导者,这些业务中包括了卡地亚(Cartier)、伯爵(Piaget)和江诗丹顿等传奇品牌。

关键词：时间现代化改造首席执行官私人股本品牌制造商飞行员奢侈品

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Egyptian art

Egyptian art