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Empowerment in chronic wound care——exploring the scope for patient contribution

Frontiers of Nursing 2024年第1期11卷 1-16页

作者： benedikt Hackert Ewa Klara Stürmer Ulrich Weger Department of Psychology and Psychotherapy University of Witten/HerdeckeAlfred-Herrhausen-Straße 5058448 WittenGermany Department for Vascular medicine University Heart and Vascular Center HamburgUniversity Medical Center Hamburg-EppendorfMartinistreet 5220246 HamburgGermany

Objective:In this study,we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom(DOF):that is,shaping of everyday wound care tasks initiated by patients and based on their wishes,mostly in terms of patients executing treatment steps,requesting or directing health care professionals to under take changes,or modifications of internal ***:As a first step,we conducted a systematic literature search,followed by an inductive form of qualitative content analysis,which resulted in the identification of 5 dimensions as main elements of empowerment:education and shared decision making,adherence to self-care behaviors,responsibility and control,general call for empowerment,and ***,the latter are noticeably absent in the *** investigate patients'freedom in shaping the wound care process,we conducted a second literature ***:A number of possibilities for patients to influence the wound care process could be identified,but experimental or clinical evidence about their effects is missing,their variety is limited,and they are only inadequately ***:However,DOF should be an indispensable aspect of genuine empowerment,since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling ***,in the third part,we develop a research proposal on how to investigate and include DOF in the clinical practice of wound ***,limitations about implementations are discussed(e.g.,patients being reluctant to overcome their passive role,resulting in frustration for health care professionals).

关键词： adherence chronic wounds control degrees of freedom empowerment shared decision making

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Themechanism of resistance to CDK4/6 inhibition and novel combination therapy with RNR inhibition for chemo-resistant bladder cancer

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Cancer Communications 2024年第6期44卷 700-704页

作者： Zhichao Tong Yubo Zhao Shiyu Bai benedikt Ebner Lou Lienhard Yuling Zhao Ziqi Wang Qi Pan Pengyu Guo Thilo Bracht Barbara Sitek Jürgen E.Gschwend Wanhai Xu Roman Nawroth Department of Urology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China NHC and CAmS Key Laboratory of molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Klinikum rechts der IsarTechnical university of MunichMunichGermany Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Ludwig-Maximilians-University of MunichMunichGermany Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiP.R.China medizinisches Proteom-Center Ruhr-Universität BochumBochumGermany Clinic for Anesthesiology Intensive Care and Pain TherapyUniversity Medical Center Knappschaftskrankenhaus BochumBochumGermany

Bladder cancer(BCa)is the most prevalent urological cancer worldwide[1].A significant proportion of BCa(89%)exhibits molecular alterations in the cell cycle pathway,and targeting cyclin-dependent kinases 4 and 6(CDK4/6)is deemed as a promising therapeutic strategy[2].Selective inhibitors of CDK4/6(CDK4/6is)have been approved by the US Food and Drug Administration(FDA)[3].

关键词： bladder CDK4 alterations

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氢能技术的成功无需怀疑

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现代制造 2024年第7期 32-34页

作者： benedikt Hofmann 不详

Lauda ***有限两合公司是一家专注于温度精确控制技术的专业厂。十多年时间里,Lauda公司一直致力于氢能技术的研究开发。在接受本刊记者的采访时,Lauda两合公司的业务发展经理Jasper Laug先生介绍了氢能技术的最大机遇在哪里,介绍了工... 详细信息

Lauda ***有限两合公司是一家专注于温度精确控制技术的专业厂。十多年时间里,Lauda公司一直致力于氢能技术的研究开发。在接受本刊记者的采访时,Lauda两合公司的业务发展经理Jasper Laug先生介绍了氢能技术的最大机遇在哪里,介绍了工业企业为什么要开发氢能技术。

关键词：两合公司专业厂控制技术氢能技术

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我国优秀越野滑雪运动员有氧和无氧能力与短距离比赛竞技表现的相关性探究

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首都体育学院学报 2024年第3期36卷 303-312,345页

作者：尚磊史瑞应蔡旭旦 benedikt Fasel 张蓓陈小平清华大学体育部北京100084 中国政法大学社会学院北京102269 南京师范大学体育科学学院江苏南京210023 洛桑联邦理工大学移动分析与测量实验室瑞士1015 国家体育总局冬季运动管理中心北京100044 国家体育总局体育科学研究所运动训练中心北京100061

目的:探究我国优秀越野滑雪运动员短距离比赛竞技表现以及与其有氧、无氧能力的相关关系,其数据和成果对训练和比赛具有重要指导作用。方法:对21名越野滑雪国家集训队男子运动员分别进行有氧、无氧能力和短距离比赛测试;使用GNSS定位系... 详细信息

目的:探究我国优秀越野滑雪运动员短距离比赛竞技表现以及与其有氧、无氧能力的相关关系,其数据和成果对训练和比赛具有重要指导作用。方法:对21名越野滑雪国家集训队男子运动员分别进行有氧、无氧能力和短距离比赛测试;使用GNSS定位系统和计时设备记录短距离比赛中运动员时间、速度和技术等数据;通过典型相关分析方法,评价有氧、无氧能力指标与短距离比赛竞技表现指标的相关关系。结果:1)有氧能力测试中乳酸阈摄氧量、最大摄氧量和总效率指标及无氧能力测试中上肢最大功率、平均功率指标分别与短距离比赛的竞技表现指标密切相关(p<0.05);2)短距离比赛的比赛时间、上坡段时间、平地段时间、G3使用比例、G3最大速度与有氧、无氧能力指标具有较高的相关性(p<0.05)。结论:以测试氧摄取指标为主的有氧能力和以测试上肢最大功率指标为主的无氧能力与越野滑雪短距离比赛竞技表现高度相关;乳酸阈摄氧量、最大摄氧量、总效率等有氧能力指标是影响比赛成绩的重要因素,更高的上肢爆发力水平与更好的短距离比赛竞技表现显著相关。建议:注重发展我国越野滑雪运动员专项技术的有氧能力和上肢峰值功率水平。未来的研究可以通过实验室和雪上环境下进行标准化实验设计,进一步探讨有氧和无氧能力的动态变化对短距离比赛全程和分段竞技表现的直接影响。

关键词：短距离项目有氧能力无氧能力竞技表现

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monitoring concept for structural integration of PZT-fiber arrays in metal sheets:a numerical and experimental study

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International Journal of Smart and Nano materials 2018年第1期9卷 56-67,I0003页

作者： Welf-Guntram Drossel Andreas Schubert matthias Putz Hans-Joachim Koriath Volker Wittstock Sebastian Hensel Alexander Pierer benedikt m.ller marek Schmidt Fraunhofer Institute for machine Tools and Forming Technology ChemnitzGermany Professorship for Adaptronics and Lightweight Design Chemnitz University of TechnologyChemnitzGermany Professorship micromanufacturing Technology Chemnitz University of TechnologyChemnitzGermany Professorship for machine Tools and Forming Technology Chemnitz University of TechnologyChemnitzGermany

The technique joining by forming allows the structural integration of piezoceramic fibers into locally microstructured metal sheets without any elastic interlayers.A high-volume production of the joining partners causes in statistical deviations from the nominal dimensions.A numerical simulation on geometric process sensitivity shows that the deviations have a high significant influence on the resulting fiber stresses after the joining by forming operation and demonstrate the necessity of a monitoring *** this basis,the electromechanical behavior of piezoceramic array transducers is investigated experimentally before,during and after the joining *** piezoceramic array transducer consists of an arrangement of five electrical interconnected piezoceramic *** findings show that the impedance spectrum depends on the fiber stresses and can be used for in-process monitoring during the joining *** on the impedance values the preload state of the interconnected piezoceramic fibers can be specifically controlled and a fiber overload.

关键词： Impedance spectroscopy joining by forming process monitoring function integration sensitivity

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Towards Realistic Vibration Testing of Large Floor Batteries for Battery Electric Vehicles (BEV)

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Sound & Vibration 2022年第1期56卷 1-19页

作者： benedikt Plaumann Faculty of Engineering and Computer Science Department Automotive and Aeronautical EngineeringHamburg University of Applied Sciences(HAW Hamburg)Hamburg20099Germany

This contribution shows an analysis of vibration measurement on large floor-mounted traction batteries of Battery Electric Vehicles(BEV).The focus lies on the requirements for a realistic replication of the mechanical environments in a testing *** the analysis on global bending transfer functions and local corner bending coherence indicate that neither a fully stiff fixation of the battery nor a completely independent movement on the four corners yields a realistic and conservative test *** contribution will further show what implication these findings have on future vibration&shock testing equipment for large traction ***,it will cover an outlook on how vibration behavior of highly integrated approaches(cell2car)changes the mechanical loads on the cells.

关键词： Battery electric vehicle BEV shock and vibration vehicle floor bending rechargeable energy storage system RESS

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The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad marcus Graefen michele Gallucci Alberto Briganti Francesco montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano Guglielmo mantica marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSm)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSmrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSm that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

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From herbal small RNAs to one medicine

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Science China(Life Sciences) 2019年第3期62卷 285-287页

作者： Chao Ji Skirmantas Kriaucionis benedikt m.Kessler Chengyu Jiang Institute of Basic medical Sciences Chinese Academy of Medical SciencesDepartment of PharmacologyPeking Union Medical College Ludwig Institute for Cancer Research University of Oxford Target Discovery Institute Nuffield Department of MedicineCAMS-Oxford InstituteUniversity of Oxford State Key Laboratory of medical molecular Biology Institute of Basic Medical SciencesCAMS-Oxford InstituteChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical College

In this special topic "Herbal small RNAs, novel precision medicine from mother Nature", we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al., 2017;Huang et al., 2018;Zhang et al., 2018;Li et al., 2019;Xin et al., 2018).

关键词： From herbal small RNAs one medicine

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Earthquake motion input and its dissemination via the Internet

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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 20-26页

作者： benedikt Halldorsson 董刚 Apostolos S.Papageorgiou Department of Civil Structural and Environmental EngineeringUniversity at BuffaloState University of New YorkBuffaloNew York14260USA Doctoral Candidate Department of Civil Structural and Environmental EngineeringUniversity at BuffaloState University of New YorkBuffaloNew York14260USA Post-doctoral Research Associate Department of Civil Structural and Environmental EngineeringUniversity at BuffaloState University of New YorkBuffaloNew York14260USA Professor

Objectives of this task are to conduct research on seismic hazards,and to provide relevant input on the expected levels of these hazards to other *** tasks requiring this input include those dealing with inventory,fragility curves, rehabilitation strategies and demonstration *** corresponding input is provided in various formats depending on the intended use:as peak ground motion parameters and/or response spectral values for a given magnitude,epicentral distance and site conditions;or as time histories for scenario earthquakes that are selected based on the disaggregated seismic hazard mapped by the *** Survey and are incorporated in building *** user community for this research is both academic researchers and practicing engineers who may use the seismic input generated by the synthesis techniques that are developed under this task for a variety of *** include ground motions for scenario earthquakes,for developing fragility curves and in specifying ground motion input for critical facilities (such as hospitals) located in the eastern U.S.

关键词： strong motion synthesis stochastic modeling approach specific barrier model

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Smooth free-cycle dynamic soaring in unspecified shear wind via quadratic programming

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Chinese Journal of Aeronautics 2022年第7期35卷 19-29页

作者： Haichao HONG benedikt GRüTER Patrick PIPREK Florian HOLZAPFEL Institute of Flight System Dynamics Technical University of MunichGarching D-85748Germany

Harvesting wind energy is promising for extending long-endurance flights,which can be greatly facilitated by a flight technique called dynamic *** presented study is concerned with generating model-based trajectories with smooth control histories for dynamic soaring maneuvers exploiting wind *** desired smoothness is achieved by introducing a trigonometric series parameterization for the controls,which are formulated with respect to the normalized ***,the periodicity of the trigonometric functions is leveraged to facilitate the connection of cycles and streamline the problem *** relying on a specified wind profile,a freefinal-time quadratic programming-based control strategy is developed for the online correction of the flight trajectory,which requires only the instant wind *** and online numerical studies show the trade-off to achieve the smoothness and demonstrate the effectiveness of the proposed method in a varying wind field.

关键词： Dynamic soaring Optimal control Quadratic programming Trajectory generation Trigonometric series

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