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Estimating the frequency of traffic overloading on road bridges

Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 776-796页

作者： Roberto Ventura benedetto barabino Giulio Maternini Department of Civil EnvironmentalArchitectural Engineering and MathematicsUniversity of BresciaBrescia 25123Italy

Load limits,which appear to be routinely exceeded by trucks,occasionally result in road bridge ***,predicting failures is crucial for safeguarding road *** studies have largely focused on forecasting bridge failure event probability using the reliability analysis method,whilst occasionally accounting for vehicular overloading *** recently,a study has investigated design traffic overloading event frequency using generalised linear regression models(GLRMs),including a power component and negative binomial regressions(NBRs).However,as far as the authors know,artificial neural network models(ANNMs)have never been applied to this *** paper is an attempt to fill in these *** a frequencybased metric of traffic overloading was adopted as a driver of failure ***,two alternative‘frequency'models were specified,calibrated,and *** former was based on a GLRM,the latter on ***,these models were compared using regression plots(RPs),measures of errors(Mo Es)and the ratio between the number of observed vs predicted design load overcoming events to evaluate their *** models analysed more than 2 million weigh-in-motion(WIM)data records from a pilot station on a bridge on a heavily used ring road in Brescia(Italy).Results showed that ANNMs outperformed *** have a higher correlation coefficient(between predicted and target frequencies),lower Mo Es,and a closer-to-unity ratio(between predicted and target frequencies).These findings may increase prediction accuracy of design traffic overloading events and give road authorities more effective traffic management to protect bridges from load hazards.

关键词： Road bridges Traffic load hazard Econometry Machine learning Weigh-in-motion Big-data analysis

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BME2.1: The Need for a Systems Approach to Addressing Race-Based Disparities in Health and Health Care

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Biomedical Engineering Frontiers 2023年第1期4卷 100-102页

作者： Naomi C.Chesler Gilda A.barabino Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center and Department of Biomedical Engineering Samueli School of EngineeringUniversity of CaliforniaIrvineCAUSA Olin College of Engineering NeedhamMAUSA

The recent article by Miller et al.[1]in BMEF on reimagining the Biomedical Engineering(BME)curriculum of the future proposes several exciting and transformative core *** include(a)incorporating modern molecular biology and analytical/computational modeling,(b)providing instruction in data science fundamentals,(c)integrating clinical needs for innovation and translation,(d)fostering an educational culture of inclusive excellence,and(e)ensuring that new research discoveries inform the core curriculum.

关键词： integrating translation culture

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Radical cholecystectomy without liver resection for peritoneal side early incidental gallbladder cancer

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World Journal of Gastroenterology 2024年第32期30卷 3739-3742页

作者： Gaetano Piccolo Matteo barabino Guglielmo NiccolòPiozzi Paolo Pietro Bianchi Department of Health Sciences(DISS) University of MilanSan Paolo HospitalMilan 20142LombardyItaly Department of Colorectal Surgery Portsmouth Hospitals University NHS TrustPortsmouthUnited Kingdom

Gallbladder cancer(GBC)is a rare disease with a poor *** cholecystectomy may be an adequate treatment only for very early disease(Tis,T1a),whereas reoperation is recommended for more advanced disease(T1b and T2).Radical cholecystectomy should have two fundamental objectives:To radically resect the liver parenchyma and to achieve adequate clearance of the lymph ***,recent studies have shown that compared with lymph node dissection alone,liver resection does not improve survival *** oncological roles of lymphadenectomy and liver resection is ***,for patients with incidental GBC without liver invasion,hepatic resection is not always mandatory.

关键词： Incidental gallbladder cancer Reoperation Radical cholecystectomy Early stage Liver resection

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Minimally invasive surgery for paediatric inflammatory bowel disease: Personal experience and literature review

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World Journal of Gastroenterology 2015年第40期21卷 11312-11320页

作者： Alessio Pini-Prato Maria Grazia Faticato Arrigo barabino Serena Arrigo Paolo Gandullia Cinzia Mazzola Nicola Disma Giovanni Montobbio Girolamo Mattioli Istituto Giannina Gaslini DINOGMI University of Genoa

The incidence of paediatric inflammatory bowel disease(PIBD) has dramatically increased in the last 20 years. Although first reported in mid 1970s',diagnostic laparoscopy has started to be routinely adopted in paediatric surgical practice since late 1990s'. Minimally invasive surgery was first limited to diagnostic purposes. After 2002 it was also applied to the radical treatment of PIBD,either Crohn's disease(CD) or Ulcerative colitis. During the last decade minimally invasive approaches to PIBD have gained popularity and have recently became the "gold standard" for the treatment of such invalidating and troublesome chronic diseases. The authors describe and track the historical evolution of minimally invasive surgery for PIBD and address all available opportunities,including most recent advancements such as robotic surgery,single port approaches and minimally invasive treatment of perianal fistulising CD. A systematic review of all series of PIBD treated with minimally invasive approaches published so far is provided in order to determine the incidence and type of patients' complications reported up to present days. The authors also describe their experience with minimally invasive surgery for PIBD and will report the results of 104 laparoscopic procedures performed in a series of 61 patients between January 2006 and December 2014.

关键词： Paediatric inflammatory bowel disease Ulcerative c

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Sudden blindness in a child with Crohn's disease

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World Journal of Gastroenterology 2011年第38期17卷 4344-4346页

作者： Arrigo Vittorio barabino Paolo Gandullia Angela Calvi Silvia Vignola Serena Arrigo Riccardo De Marco Gastroenterology and Endoscopy Unit G.Gaslini Institute for Children Ophthalmology Department G.Gaslini Institute for Children

Inflammatory bowel disease(IBD) is often associated with extraintestinal manifestations(EIMs) such as optic neuritis(ON),although this has been described in only a few adult patients so far,all of whom were affected with Crohn's disease(CD).Furthermore,ON and demyelinating diseases have been demonstrated to be more frequent in IBD patients than in control *** our current case report,we describe a child with active CD who developed sudden blindness due to bilateral ON that was not related to any known cause,and that promptly responded to a high dose of *** and a clinical follow-up have so far ruled out the development of demyelinating diseases in this *** our knowledge,this is the first report of ON in a pediatric patient with *** explanations for this case include an episodic EIM of an active bowel disease,an associated autoimmune disorder such as a recurrent isolated ON,the first manifestation of multiple sclerosis,or another demyelinating disease that could appear in a later follow-up.

关键词： Crohn's disease Extraintestinal manifestations Optic neuritis Demyelinating disease

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Usefulness of ω-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: A double-blind, randomized, placebo-controlled study

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World Journal of Gastroenterology 2005年第45期11卷 7118-7121页

作者： C Romano S Cucchiara A barabino V Annese C Sferlazzas SIGENP Italian Study Group of Pediatric Inflammatory Bowel Diseases Pediatric Department University "La Sapienza" IRCCS G.Gaslini IRCCS University of Messina

AIM： To assess the value of long-chain w-3 fatty acids （FAs） supplementation in addition to amino-salicylic-acid （5-ASA） in pediatric patients with Crohn＇s disease （CD）. METHODS： Thirty-eight patients （20 males and 18 females, mean age 10.13 years, range 5-16 years） with CD in remission were randomized into two groups and treated for 12 too. Group Ⅰ （18 patients） received 5-ASA （50 mg/kg/d）＋w-3 FAs as triglycerides in gastroresistant capsules, 3 g/d （eicosapentanoic acid, EPA, 400 mg/g, docosahexaenoic acid, DHA, 200 mg/g）. Group Ⅱ （20 patients） received 5-ASA （50 mg/kg/d）＋olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment. RESULTS： The number of patients who relapsed at 1 year was significantly lower in group I than in group Ⅱ （P〈0.001）. Patients in group I had a significant increase in the incorporation of EPA and DHA （P〈0.001） and a decrease in the presence of arachidonic acids. CONCLUSION： Enteric-coated w-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD.

关键词： Crohn's disease ω-3 fatty acids Remission maintenance Treatment

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乳腺癌病人乳腺MRI中的肌肉质量评估:CT腰肌面积与MRI胸肌面积的比较

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国际医学放射学杂志 2019年第2期42卷 248-249页

作者： F.Rossi F.Valdora E.barabino M.Calabrese A.S.Tagliafico 李爽(译) 赵世华(校) Department of Health Sciences DISSAL-University of GenovaVia Pastore116138 GenoaItaly 不详

目的在乳腺癌病人中评价CT成像的腰肌面积(TPA)与MR成像的胸肌面积(PMA)的相关性。方法该回顾性研究经机构伦理委员会批准,参与研究的女性均签署了书面知情同意书。

关键词：乳腺癌肌肉质量 MRI CT

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Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children

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World Journal of Gastroenterology 2016年第5期22卷 1877-1883页

作者： Sabrina Cardile Massimo Martinelli Arrigo barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano Gastroenterology and Endoscopic Unit Department of PediatricsUniversity of Messina98100 MessinaItaly Department of Translational Medical Science Section of PediatricsUniversity of Naples“Federico II”80131 NaplesItaly Department of Pediatric Gastroenterology Gaslini Institute16148 GenoaItaly Department of Pediatrics and Infantile Neuropsychiatry Pediatric Gastroenterology and Liver UnitSapienza University of Rome00185 RomeItaly Digestive Surgery and Endoscopy Unit Bambino GesùChildren’s Hospital00165 RomeItaly Gastroenterology and Endoscopy Service University of Parma43126 ParmaItaly Unit of Paediatric Gastroenterology Digestive EndoscopyHepatologyand Care of Children with Liver TransplantationDepartment of Women’s and Children’s HealthUniversity Hospital of Padova35128 PadovaItaly Gastrointestinal Endoscopy Azienda Ospedaliera San Paolo University HospitalUniversity of Milan20142 MilanItaly

AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in ***: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was ***: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in

关键词： Hematemesis Gastrointestinal bleeding non-steroidal anti-inflammatory drug Melena Pediatrics

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*** of a novel anti-angiogenic protein for the treatment of exudative age-related macular degeneration

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Annals of Eye Science 2018年第1期 429-429页

作者： Erika Hooker Natalija Popovic Andrea barabino Anthony Flamier Gilbert Bernier Bruno Larrivée Department of Biochemistry Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada

Background:Age-related macular degeneration(AMD)is a leading cause of blindness in *** exudative(wet)form of AMD accounts for approximately 15%of AMD patients,but is responsible for the majority of severe vision loss associated with the *** AMD is characterized by choroidal neovascularization,the abnormal growth of blood vessels from the choroid into the sub-retinal *** therapies for exudative AMD directly target and inhibit the vascular endothelial growth factor(VEGF)signaling pathway,a signaling axis that promotes endothelial cell *** initially effective at restoring visual acuity,recent studies suggest that chronic use of anti-VEGF therapies can lead to further vision impairment through off-target effects on photoreceptors and other non-vascular *** off-target effects of anti-VEGF therapy highlights the need for alternative treatments for this increasingly common *** have recently identified a novel anti-angiogenic protein,AAP1 that inhibits retinal angiogenesis during *** a regulator of the vasculature,our current work aims to characterize the function of AAP1 in endothelial cells and determine the potential of AAP1 as a therapy for exudative ***:To address our aims,we used various in vivo and in vitro models of normal and pathological vascular *** were injected intravitreally with AAP1 to investigate its effects on developmental and pathological *** HUVECs,we employed immunofluorescent quantifications to determine the impact of AAP1 on sprouting angiogenesis by measuring cellular proliferation,apoptosis and *** investigate the signaling events that mediate the actions of AAP1,we examined key signaling pathways involved in angiogenesis by western blotting and ***:We evaluated the role of AAP1 as a regulator of angiogenesis during retinal development and mouse models of *** pilot data show that AAP1 prevents angiogenesis in vitro and in vivo,and th

关键词： Age-related macular degeneration(AMD) angiogenesis

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