检索结果-南通市图书馆

Thirty-day Outcomes of First-in-man Implantation of a Novel Transcatheter Edge-to-edge Mitral Repair System in Patients With Severe Mitral Regurgitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardiology Discovery 2024年第2期4卷 142-147页

作者： Kai Xu Yan Wang Shaoliang Chen Xiangbin Pan ben he Ruiyan Zhang Bin Wang Junjie Zhang Zhengbin Zhu Bin Wang Da Zhu Yaling Han Department of Cardiology General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamenFujan 361102China Department of Cardiology Nanjing First HospitalNanjingJiangsu 210006China Department of Structure heart Disease Fuwai Yunnan Cardiovascular HospitalKunmingYunnan 650102China Department of Cardiology Shanghai Chest HospitalShanghai 200030China Department of Cardiology Rujin Hospital Shanghai Jiaotong University School of MedicineShanghai 200025China

Objectives:The aim of this multicenter,prospective,single-arm pilot study(*** number:NCT05040074)was to observe the procedural and 30-day results of the novel transcatheter mitral valve repair system,SQ-Kyrin-M Clip(Shenqi Medical,Shanghai,China),in patients with severe mitral regurgitation(MR).Methods:The heart team considered patients from 5 centers in China with clinically significant functional mitral regurgitation≥3+despite optimal medical therapy or degenerative mitral regurgitation≥3+with high surgical risk as candidates for transcatheter *** patients received transcatheter edge-to-edge mitral valve repair under general *** primary outcome was technical success,which included all of the following measured at the exit from the catheterization laboratory:(1)absence of procedural mortality;(2)successful access,delivery,and retrieval of the device delivery system;(3)successful deployment and correct positioning of the frst intended device;and(4)no emergency surgery or reintervention related to the device or access *** secondary outcomes included all-cause mortality,serious adverse events,device success,and procedural success 30 d after the ***:From June 2021 to December 2021,18 patients were enrolled in this study with age(75.7±7.4)*** patients had MR 4+,while 3 had MR 3+.Technical success was achieved in all patients,including 6 degenerative mitral regurgitation and 12 functional mitral regurgitation *** was no all-cause mortality at 30 *** patient had single leaflet device attachment within 30 d,which was regarded as a serious adverse event,and the patient was successfully treated with reintervention by implanting another *** patient's transmitral gradient was 6 mmHg(>5 mmHg),with an effective orifice area of 2.57 cm?after the *** patients had device success and procedural success at 30 d *** patients had MR 1+,3 had MR 2+,and only 1 pati

关键词： heart failure Mitral regurgitation Transcatheter mitral valve repair Transcatheter edge-to-edge repair

STEMI患者的再灌注策略:药物介入策略与直接PCI对比研究的进展

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华心血管病杂志 2024年第3期52卷 295-299页

作者：张紫薇王晨宇何奔上海交通大学医学院附属胸科医院心血管内科上海200030

虽然直接经皮冠状动脉介入治疗(PCI)仍是急性ST段抬高型心肌梗死(STEMI)的首选再灌注策略,然而,每年仍有大量的新发STEMI患者无法于最佳时间窗内接受直接PCI治疗。近年来,学界开始越来越重视先溶栓再进行PCI治疗的“药物介入”策略,以... 详细信息

虽然直接经皮冠状动脉介入治疗(PCI)仍是急性ST段抬高型心肌梗死(STEMI)的首选再灌注策略,然而,每年仍有大量的新发STEMI患者无法于最佳时间窗内接受直接PCI治疗。近年来,学界开始越来越重视先溶栓再进行PCI治疗的“药物介入”策略,以及该策略与直接PCI在疗效和安全性方面的比较。近来的一些临床研究证据逐渐表明,药物介入策略对STEMI患者安全有效,特别是当确诊后无法于120 min内进行直接PCI治疗时,选择药物介入策略不亚于直接PCI。该文复习了近来这两大策略的对比研究,对STEMI患者的再灌注策略选择提出了新的建议。

关键词： ST段抬高型心肌梗死经皮冠状动脉介入治疗药物介入策略

在线全文

学校读者我要写书评

暂无评论

贵州关岭地区法郎组瓦窑段菊石类新材料

地质论评 2024年第2期70卷 769-776页

作者：马知恒李世鑫陈镜文何犇张廷山西南石油大学地球科学与技术学院成都610500 福州大学紫金地质与矿业学院福州350108 贵州省地质调查院贵阳550005

本文对采自于贵州关岭地区上三叠统卡尼阶法郎组瓦窑段上部的齿菊石目化石进行了研究,共识别出3属3种,其中包含一新种Arctosirenites ***.。Arctosirenites mingqingensis ***.以具有细密横肋及粗壮腹缘瘤为特征,属Klipsteinia在华南为... 详细信息

本文对采自于贵州关岭地区上三叠统卡尼阶法郎组瓦窑段上部的齿菊石目化石进行了研究,共识别出3属3种,其中包含一新种Arctosirenites ***.。Arctosirenites mingqingensis ***.以具有细密横肋及粗壮腹缘瘤为特征,属Klipsteinia在华南为首次发现。根据Klipsteinia和Arctosirenites组合特征判断贵州关岭地区上三叠统法郎组瓦窑段底部时代为晚三叠世早卡尼期早期(Julian 1),上部时代归属于晚卡尼期早期(Tuvalian 1),并且认为造成法郎组瓦窑段底部的岩性变化是由于构造因素导致,而并非受到卡尼期湿润幕事件(CPE,Carnian Pluvial Episode)的影响。

关键词： Arctosirenites mingqingensis sp.nov. 菊石类卡尼期湿润幕事件晚三叠世贵州关岭

在线全文

学校读者我要写书评

暂无评论

海上风机桩-筒复合基础基频特性分析

浙江工业大学学报 2024年第2期52卷 142-148页

作者：袁宗浩姚云龙何奔李娜许丹婷潘晓东浙江工业大学土木工程学院浙江杭州310023 中国电建集团华东勘测设计研究院有限公司浙江杭州311122

桩-筒复合基础作为海上风机的一种新型基础型式,在提高单桩承载力方面相较于单桩基础具有一定优势,然而筒体对风机结构基频特性的影响规律尚不明确。为研究该问题,对风机塔筒进行解析建模,结合有限元,建立了不同几何尺寸的单桩基础和桩... 详细信息

桩-筒复合基础作为海上风机的一种新型基础型式,在提高单桩承载力方面相较于单桩基础具有一定优势,然而筒体对风机结构基频特性的影响规律尚不明确。为研究该问题,对风机塔筒进行解析建模,结合有限元,建立了不同几何尺寸的单桩基础和桩-筒复合基础,将数值模型获得的基础刚度与上部塔筒解析模型进行耦合,提出了分析风机整机结构基频特性的有限元-解析耦合法。研究结果表明有限元-解析耦合法能够快速地实现风机整机结构基频预测。对比桩-筒复合基础与单桩基础基频特性发现:筒体的加入能有效提升单桩基础刚度,可以在不改变单桩基础桩径的前提下,有效提升结构第一阶固有频率,筒外径对基础基频的影响比筒壁高的影响更大。

关键词：第一阶固有频率有限元-解析耦合法桩-筒复合基础基础刚度动力特性

Novel protection systems for the improvement in soil and water stability of expansive soil slopes

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2023年第10期20卷 3066-3083页

作者： MA Shao-kun he ben-fu MA Min HUANG Zhen CheN Sheng-jia YUE Huan School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

To improve the soil and water stability of expansive soil slopes and reduce the probability of slope failure,novel protection systems based on polymer waterproof coatings(PWC)were used in this ***,three groups of expansive soil slope model tests were designed to investigate the effects of polyester nonwovens and PWC(P-PWC)composite protection system,three-dimensional vegetation network and PWC(T-PWC)composite protection system,and nonprotection on the soil and water behavior in the slopes under precipitation–evaporation *** results showed that the moisture change of P-PWC and T-PWC composite protected slopes was significantly smaller than that of bare slope,which reduced the sensitivity of slope moisture to environmental changes and improved its *** soil temperature of the slope protected by the P-PWC and T-PWC systems at a depth of 70 cm increased by 5.6℃ and 2.7℃,*** PWC composite protection systems exhibited better thermal storage performance,which could increase the utilization of shallow geothermal ***,the maximum average crack widths of the bare slopes were 7.89 and 3.17 times those of the P-PWC and TPWC protected slopes,respectively,and the maximum average crack depths were 6.87 and 3 times those of the P-PWC and T-PWC protected slopes,*** PPWC protection system weakened the influence of hydro–thermal coupling on the slopes,inhibited the development of cracks on the slopes,and reduced the soil *** maximum soil erosion of slopes protected by P-PWC and T-PWC systems was 332 and 164 times lower than that of bare slope,*** P-PWC and T-PWC protection systems achieved excellent"anti-seepage and moisture retention"and anti-erosion effects,thus improving the soil and water stability of *** findings can provide important guiding reference for controlling rainwater infiltration and soil erosion in expansive soil slope projects.

关键词： Soil and water stability Expansive soil slope Polymer waterproof coating Model test Soil erosion

骨质疏松性椎体压缩骨折网袋成形是否手法复位比较

在线全文

学校读者我要写书评

暂无评论

中国矫形外科杂志 2024年第2期32卷 139-144页

作者：罗世科钟睿何本祥熊小明王传恩但晶李井泉成都体育学院附属体育医院四川成都610041

[目的]比较网袋成形术(vesselplasty,VP)治疗骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture,OVCF)是否手法复位的临床疗效。[方法]回顾性分析2020年7月—2022年4月本院采用VP治疗OVCF 65例患者的临床资料。根... 详细信息

[目的]比较网袋成形术(vesselplasty,VP)治疗骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture,OVCF)是否手法复位的临床疗效。[方法]回顾性分析2020年7月—2022年4月本院采用VP治疗OVCF 65例患者的临床资料。根据医患沟通结果,31例VP术前进行手法复位(复位组),34例术前未进行手法复位(未复位组)。比较两组围手术期、随访及影像结果。[结果]所有患者手术均顺利完成,无严重并发症发生。复位组手术时间[(31.4±6.7)min vs(38.9±13.0)min,P=0.006]、骨水泥渗漏率(22.6%vs 58.8%,P=0.003)显著优于未复位组,两组术中透视次数、骨水泥注入量、下地行走时间、住院时间、住院费用差异均无统计学意义(P>0.05)。所有患者均获得1年以上随访,两组完全负重活动时间的差异无统计学意义(P>0.05)。术后随时间推移,VAS和ODI评分均显著减少(P0.05)。影像方面,与术前相比,术后两组局部Cobb角、椎体前缘高度均显著改善(P0.05)。[结论]VP联合手法复位在骨质疏松性椎体压缩性骨折的治疗中能更好地降低骨水泥渗漏率,缩短手术时间。

关键词：骨质疏松椎体压缩性骨折手法复位网袋成形术骨水泥渗漏

嘉兴市≥60岁老年人流感疫苗和23价肺炎球菌多糖疫苗联合接种对呼吸系统感染疾病的保护效果和成本效益分析

在线全文

学校读者我要写书评

暂无评论

中国疫苗和免疫 2024年第1期30卷 6-11页

作者：向泽林胡洁何奔亓云鹏王远航周晚玲姚叶斌蔡莹富小飞嘉兴市疾病预防控制中心浙江嘉兴314050 嘉兴市第一医院浙江嘉兴314001

目的评价老年人联合接种流感疫苗(Influenza vaccine,InfV)和23价肺炎球菌多糖疫苗(23-valent pneumococcal polysaccharide vaccine,PPV23)对呼吸系统感染疾病的保护效果(Vaccine effectiveness,VE)和成本效益。方法在嘉兴市预防接种门诊选取联合接种InfV和PPV23(接种组)、未接种InfV和PPV23(对照组)的≥60岁老年人,观察两组受试者1年内呼吸系统感染疾病临床结局,收集疫苗接种成本和相关医疗费用,分析联合接种的VE、人均净效益和效益成本比(benefit-cost ratio,BCR)。结果接种组、对照组分别纳入受试者364名、360名,联合接种InfV和PPV23对呼吸系统感染疾病发病、就诊、住院、死亡的VE(95%CI)分别为38.30%(27.81%-47.26%)、47.56%(35.09%-57.65%)、31.04%(-3.21%-53.96%)、67.03%(-64.42%-93.39%);两组平均住院时间分别为6.75 d、11.53 d(t=15.74,P<0.001),平均住院次数分别为0.87次、1.85次(t=13.62,P<0.001)。联合接种的人均净效益为695元,BCR为2.61。结论老年人联合接种InfV和PPV23可显著减少呼吸系统感染疾病的发病、就诊和住院,且具有较好的成本效益。

关键词：流感疫苗 23价肺炎球菌多糖疫苗联合接种呼吸系统感染疾病保护效果成本效益分析

在线全文

学校读者我要写书评

暂无评论

细胞和基因治疗产品现状与我国监管政策研究

中国食品药品监管 2024年第6期 46-55页

作者：史海涛谢正福何本霞邹毅国家药品监督管理局药品审评检查大湾区分中心广东省药品监督管理局审评认证中心

细胞和基因治疗产品在许多无法治愈的疾病领域(例如恶性肿瘤、遗传病等)取得了重大进展。近年来,随着我国各项政策的审慎出台,细胞和基因治疗产品的监管框架逐步清晰,企业管理日趋严格,并走出了一条科学、规范、健康的发展之路。本文简... 详细信息

细胞和基因治疗产品在许多无法治愈的疾病领域(例如恶性肿瘤、遗传病等)取得了重大进展。近年来,随着我国各项政策的审慎出台,细胞和基因治疗产品的监管框架逐步清晰,企业管理日趋严格,并走出了一条科学、规范、健康的发展之路。本文简要介绍了细胞和基因治疗产品的国内外临床应用及产业现状、我国监管政策发展和技术评价研究成果,探讨了我国发展细胞和基因治疗产品面临的挑战,并提出针对性建议,以期为我国细胞和基因治疗产品发展提供参考。

关键词：细胞和基因治疗产品临床应用产业现状监管政策面临挑战

Nanoconfinement-induced water molecules and hydrogen molecules transport behaviors in ball-in-ball structure photocatalysts to improve hydrogen evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 3752-3760页

作者： ben Chong Baorong Xu he Li Honghui Ou Guidong Yang XJTU-Oxford Joint International Research Laboratory of Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

The diffusion,adsorption/desorption behaviors of water molecules and hydrogen molecules are of great importance in heterogeneous photocatalytic hydrogen *** the study of structure-property-performance relationships,nanoconfined space provides an ideal platform to promote mass diffusion and transfer due to their extraordinary properties that are different from the bulk ***,we designed and prepared a nanoconfined CdS@SiO_(2)-NH_(2) nanoreactor,whose shell is composed of amino-functionalized silica nanochannels,and encapsulates spherical CdS as a photocatalyst *** and simulated results reveal that the amino-functionalized nanochannels promote water molecules’and hydrogen molecules’directional diffusion and *** molecules are enriched in the nanocavity between the core and the shell,and promote the interfacial photocatalytic *** a result,the maximized water enrichment and minimized hydrogen-occupied active sites enable photocatalyst with optimized mass transfer kinetics and localization electron distribution on the CdS surface,leading to superior hydrogen production performance with activity as high as 37.1 mmol·g^(-1)·h^(-1).

关键词： nanochannels photocatalytic hydrogen evolution mass transfer amino-functionalized CdS