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Isotretinoin was not associated with depression or anxiety:A twelve-week study

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World Journal of Psychiatry 2016年第1期6卷 136-142页

作者： bella suarez Ana Serrano Yves Cova Trino Baptista Department of Psychiatry Los Andes University Medical School Department of Dermatology Los Andes University Medical School Department of Physiology Los Andes University Medical School

AIM: To investigate the frequency and severity of depression and/or anxiety in isotretinoin(ITT)-treated subjects and in a non-ITT control group. METHODS: Sixty consecutively-admitted non-psychiatric outpatients with acne were assigned to either ITT at a fixed dose of 30 mg/d(n = 36) or "other treatment" group(OT; n = 24). The Zung depression or anxiety scales(with cut-off points), two locally developed scales for depression(Ge Depr) and anxiety(Ansilet)(without cut-off points) and clinical global impression scales of acne severity were administered at baseline and at weeks 6 and 12 of treatment. Data was analyzed with the chi-squared test and covariance analysis. RESULTS: Gender distribution, age, marital status and education level did not differ between both treatment groups. The frequency of depression, as defined by the Zung scale cut-off points was similar in the ITT and in the non-ITT groups: Weeks 6 and 12: 8.3% in both groups, P = 0.9. The frequency of anxiety was similar in the groups as well: Week 6: ITT = 8.3%; OT = 0.0%, P > 0.05; week 12: ITT = 11.1%, OT = 4.2%, P > 0.05. The scores in both scales' sets did not differ between the treatment groups at any evaluation time point(P> 0.05). Five ITT-treated subjects(13.8%) and two from the OT-treated group(8.3%) developed clinically significant anxiety and/or depression during treatment(P > 0.05). CONCLUSION: Our study confirms the safety of ITT regarding psychological side effects in regular dermatological patients. Susceptible subjects may exist but their identification requires additional strategies.

关键词： Isotretinoin Short-term Psychopathology Depression Anxiety Other treatments

Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum:A Literature Review

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Maternal-Fetal Medicine 2024年第2期6卷 97-101页

作者： Putri Mirani Peby Maulina Lestari Krisna Murti Iche Andriyani Liberty Hana Andrina Cindy Kesty bella Stevanny Division of Maternal-Fetal Medicine Department of Obstetrics and GynecologyDr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangSouth SumateraIndonesia Division of Hematolymphoid and Endocrinology Department of Pathological AnatomyDr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangIndonesia Department of Public Health and Community Medicine Faculty of MedicineSriwijaya UniversityPalembangIndonesia Department of Obstetrics and Gynecology Dr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya UniversityPalembangSouth SumateraIndonesia.

The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections.A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of *** metalloproteinase(MMP)is crucial in every step of wound healing as it alters the wound matrix,facilitating cell migration,as well as tissue ***-9 expression is higher in placental and decidual tissue in cases of placenta *** on these findings,assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker.

关键词： Biomarker Etiopathogenesis Matrix metalloproteinase MMP-9 Placenta accreta spectrum disorder

Beyond total mesorectal excision: The emerging role of minimally invasive surgery for locally advanced rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2382-2385页

作者： Davina Perini Francesca Cammelli Maximilian Scheiterle Jacopo Martellucci Annamaria Di bella Carlo Bergamini Paolo Prosperi Alessio Giordano Department of Emergency and Acceptance Emergency Surgery UnitCareggi University HospitalFirenze 50137Italy

Multivisceral resection and/or pelvic exenteration represents the only potential curative treatment for locally advanced rectal cancer(LARC);however,it poses significant technical challenges,which account for the high risk of morbidity and mortality associated with the *** complete histopathologic resection is the most important determinant of patient outcomes,LARC often requires an extended resection beyond the total mesorectal excision plane to obtain clear re-section *** an era when laparoscopic surgery and robot-assisted surgery are becoming commonplace,the optimal approach to extensive pelvic inter-ventions remains ***,acceptance of the suitability of mini-mally invasive surgery is slowly gaining ***,there is still a lack of evidence in the literature about minimally invasive approaches in multiple and extensive surgical resections,highlighting the need for research studies to explore,validate,and develop this *** editorial aims to provide a critical overview of the currently available applications and challenges of minimally invasive abdo-minopelvic surgery for ***,we discuss recent developments in the field of robotic surgery for LARC,with a specific focus on new innovations and emerging frontiers.

关键词： Robotic surgery Pelvic exenteration Multivisceral resection Rectal cancer Total mesorectal excision

Endoscopic pancreatogastric anastomosis in the treatment of symptoms associated with inflammatory diseases of the pancreas

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 406-412页

作者： Mateusz Jagielski Eryk bella Marek Jackowski Department of General Gastroenterological and Oncological SurgeryNicolaus Copernicus UniversityToruń87-100Poland

BACKGROUND The outflow of pancreatic juice into the duodenum is often impaired in pancreatic inflammatory *** basis of interventional treatment in these cases is anatomical transpapillary access of the main pancreatic duct during endoscopic retrograde cholangiopancreatography(ERCP),which ensures the physiological outflow of pancreatic juice into the lumen of the digestive ***,in some patients,anatomical changes prevent transpapillary drainage of the main pancreatic *** is the treatment of choice in such *** To evaluate the effectiveness and safety of endoscopic pancreaticogastrostomy under endoscopic ultrasound(EUS)*** Retrospective analysis of treatment outcomes of all patients with acute or chronic pancreatitis who underwent endoscopic pancreatogastric anastomosis under EUS guidance in 2018-2023 at the Department of General,Gastroenterological and Oncological Surgery,Ludwik Rydygier Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Toruń,*** In 9 patients[7 men,2 women;mean age 53.45(36-66)years],endoscopic pancreatogastric anastomosis under EUS guidance was performed because of the lack of transpapillary access during *** of the main pancreatic duct at the head of the pancreas was observed in 4/9 patients(44.44%).Pancreatic fragmentation(disconnected pancreatic duct syndrome)was diagnosed in 3/9 patients(33.33%).In 2/9 patients(22.22%),narrowing of the pancreatoenteric anastomosis was observed after *** success of endoscopic pancreaticogastrostomy was observed in 8/9 patients(88.89%).Endotherapeutic complications were observed in 2/9 patients(22.22%).Clinical success was achieved in 8/9 patients(88.89%).The mean follow-up period was 451(42-988)***-term success of endoscopic pancreatogastric anastomosis was achieved in 7/9 patients(77.78%).CONCLUSION Endoscopic pancreaticogastrostomy under EUS guidance is an effective and safe treatment method,espec

关键词： Pancreaticogastrostomy Chronic pancreatitis Acute pancreatitis Disconnected pancreatic duct syndrome Endotherapy

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑Garcia Laura Morales‑Fernandez Javier Garcia‑bella Jose Manuel Benitez‑del‑Castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Exploring the Factors Associated with 12-Month Non-Return to Work among Motorcyclists Involved in Road Accidents

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Open Journal of Preventive Medicine 2024年第1期14卷 1-16页

作者： Yolaine Glèlè-Ahanhanzo Donatien Daddah Alphonse Kpozehouen bella Hounkpè Dos Santos Moussiliou N. Paraiso Multidisciplinary Research Unity for Road Crashes Prevention (ReMPARt) Department of Epidemiology and Bio-Statistics Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Regional Direction of Health Lokossa Benin Regional Direction of Health Abomey-Calavi Benin Health Promotion Department Regional Institute of Public Health Ouidah Benin

Introduction: Motorcyclists bear a disproportionate burden of morbidity and mortality from road accidents. In addition, the consequences of these accidents affect the ability of victims to return to work. This study aimed to determine the prevalence and factors associated with non-return to work among surviving motorcyclists involved in road accidents 12 months after the event. Materials and Methods: It was a cross-sectional study conducted using data from a cohort of motorcyclists involved in accidents and recruited in five hospitals in Benin from July 2019 to January 2020. The dependent variable was non-return to work 12 months after the accident (yes vs no). The independent variables were categorized into two groups: baseline and 12-month follow-up variables. Logistic regression was used to determine the factors associated with non-return to work at 12 months among the participants. Results: Among the 362 participants, 55 (15.19%, 95% CI = 11.84 - 19.29) had not returned to work 12 months after the accident. Risk factors for non-return to work identified were: smoking (aOR = 4.41, 95% CI = 1.44 - 13.56, p = 0.010), hospitalization (aOR = 2.87, 95% CI = 1.14 - 7.24, p Conclusion: The prevalence of non-return to work at 12 months was high among surviving motorcyclists involved in road accidents in Benin. Integrated support for patients based on identified risk factors should effectively improve their return to work.

关键词： Road Accident Return to Work Motorcyclists Hospital Mental Health Cohort Benin

Thoracoscopy in Cameroon: Indications, Technics and Short Term Results

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Surgical Science 2024年第4期15卷 278-288页

作者： Guy Aristide Bang Richard II Mbele Fabrice Stephane Arroye Betou Arlette Joelle Moukitek Banaken Amos bella Ela Charles Mve Mvondo Arthur Essomba Department of Surgery and Specialities Faculty of Medicine and Biomedical Sciences Yaound&#233 I University Yaound&#233 Cameroon Department of Surgery and Specialities Yaound&#233 Teaching Hospital Yaound&#233 Cameroon General Surgery Service Mvog-Ada District Hospital Yaound&#233 Cameroon Department of Cardiothoracic and Vascular Surgery Laquintinie Hospital Douala Cameroon Department of Cardiothoracic and Vascular Surgery Yaound&#233 General Hospital Yaound&#233 Cameroon Cardiac Center Shisong St. Elizabeth Catholic General Hospital Shisong Kumbo Cameroon

Introduction: Thoracoscopy is a video-assisted surgical approach that mirrors the techniques used in thoracotomy. Our aim is to map the current state of thoracoscopy practice in Cameroon’s hospitals. Methods: This was a descriptive study that collected both retrospective and prospective data over 57 months across four hospitals in Cameroon. It included 13 patients and focused on variables such as socio-demographic factors, clinical profiles, surgical procedures, and postoperative follow-up. Results: Thirteen patients, predominantly male (84.6%, n = 11), with a mean age of 37.5 ± 16 years, were enrolled. Alcohol use (61.5%) and smoking (38.5%) were the most common past histories. The major complaints were dyspnea (84.6%) and chest pain (58.3%). The primary surgical procedure was clot-free thoracoscopy in 30.8% of cases, mainly for persistent hemothorax (41.8%). Most surgeries were elective (76.9%) and performed under general anesthesia with selective intubation (61.5%). The most common approach was single-port thoracoscopy (U-VATS) (76.9%), with no reported difficulties;however, one intraoperative incident occurred and was successfully treated. Drainage was performed systematically in all patients, and one case required conversion to open surgery. Postoperative complications were minor (Clavien-Dindo grade I) and mainly consisted of pain, with a mortality rate of 15.4%. No significant association was found between risk factors and the occurrence of complications or postoperative mortality. Conclusion: Thoracoscopy, a novel approach in our context, primarily focuses on minor thoracic surgeries.

关键词： Thoracoscopy Single-Port Hemothorax Cameroon

Substitution of Aggregates in Concrete and Mortar with Coltan Mining Waste: Mechanical, Environmental, and Economic Impact Case Study

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 139-163页

作者： Alinabiwe Nyamuhanga Ally Élodie Ruffine Zang Masika Muhiwa Grâce Manjia Marcelline Blanche Ursula Joyce Merveilles Pettang Nana Ngapgue François bella Nabil Chrispin Pettang Laboratory Engineering Civil and Mechanics Doctoral Research Unit for Engineering and Applications University of Yaound&#233 I Yaound&#233 Cameroon Department of Civil Engineering Faculty of Applied Sciences and Technologies Free University of Great Lakes Countries (ULPGL) Goma DRC Department of Civil Engineering National Advanced School of Engineering of Yaoundé University of Yaoundé I Yaoundé Cameroon Department of Civil Engineering Fotso Victor University Institute of Technology University of Dschang Bandjoun Cameroon FIMAS Laboratory Faculty of Technologies Tahri Mohamed University Bechar Algeria

The mining process involves drilling and excavation, resulting in the production of waste rock and tailings. The waste materials are then removed and stored in designated areas. This study aims to evaluate the mechanical strength and the environmental and economic impact of using Coltan Mining Waste (CMW) as a substitute for aggregates in concrete and mortar production. To achieve this, the CMW needs to be characterised. The Dreux Gorisse method was primarily used to produce concrete with a strength of 20 MPa at 28 days. The mortars, on the other hand, were formulated according to the NF P 18-452 standard. The environmental impact of using CMW as substitutes for natural aggregates in the production of concrete and mortar was analysed using SimaPro software. The results showed that mortars and concrete made with CMW have comparable compressive strengths to the reference mortar and concrete;reduce the negative impact on ecosystem quality, human health, resources, and climate change. It has also been shown that the substitution of aggregates by CMW reduces the cost of concrete and mortar as a function of the distance from the aggregate footprint.

关键词： Aggregate Coltan Mining Waste Concrete Mortar Mechanical Strength Life Cycle Analysis

Truth and consequences:the bioinvasion of the Mediterranean Sea

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Integrative Zoology 2012年第3期7卷 299-311页

作者： bella Sarah GALIL National Institute of Oceanography Israel Oceanographic and Limnological ResearchHaifaIsrael

Over 660 alien marine multicellular species have been recorded in the Mediterranean Sea,with many establishing viable populations and subsequently dispersing from their points of entry.A brief overview is presented of the current state of knowledge of bioinvasions in the Mediterranean Sea,with particular attention paid to gelatinous invasive species.A database of alien species records was used to characterize their identity,pattern of expansion and native region,and to discuss the relative importance of different taxa and vectors in the various regions of the *** temporal and spatial spread of 4 alien scyphozoans and 2 alien ctenophores is *** thermophilic species constitute the majority of Mediterranean aliens,Erythrean aliens are predominant in the east,with shipping and mariculture being mainly responsible for introductions in the *** propagule pressure driving the Erythrean invasion is powerful in the establishment and spread of alien species in the eastern *** implications of the enlargement of the Suez Canal,reflecting patterns in global trade and economy,are briefly ***,as alien species inventories play a pivotal role in informing regional policy and management decisions and identifying resource priorities,the scientific community is called upon to pay particular attention to their accuracy and veracity.

关键词： alien gelatinous inventories Mediterranean Sea trends vectors