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Cardiac monitoring for patients with palpitations

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World Journal of Cardiology 2021年第11期13卷 608-627页

作者： Jaume Francisco-Pascual Javier Cantalapiedra-Romero Jordi Pérez-Rodon begoña Benito Alba Santos-Ortega Jenson Maldonado Ignacio Ferreira-gonzalez Nuria Rivas-Gándara Unitat d'Arritmies Servei de CardiologiaHospital Universitari Vall d'HebronVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Facultat de Medicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Enfermedades Cardiovasculares(CIBERCV) Instituto de Salud Carlos IIIMadrid 28029Spain

Palpitations are one of the most common reasons for medical consultation. Theytend to worry patients and can affect their quality of life. They are often asymptom associated with cardiac rhythm disorders, although there are otheretiologies. For diagnosis, it is essential to be able to reliably correlate the symptomswith an electrocardiographic record allowing the identification or rulingout of a possible rhythm disorder. However, reaching a diagnosis is not alwayssimple, given that they tend to be transitory symptoms and the patient isfrequently asymptomatic at the time of assessment. In recent years, electrocardiographicmonitoring systems have incorporated many technical improvements thatsolve several of the 24-h Holter monitor limitations. The objective of this review isto provide an update on the different monitoring methods currently available,remarking their indications and limitations, to help healthcare professionals toappropriately select and use them in the work-up of patients with palpitations.

关键词： Palpitation Cardiac monitoring Electrocardiogram Loop recorder

Energy Signaling in the Regulation of Gene Expression during Stress

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Molecular Plant 2010年第2期3卷 300-313页

作者： Elena Baena-gonzalez Instituto Gulbenkian de Ciencia Rua da Quinta Grande 6 2780-156 Oeiras Portugal

Maintenance of homeostasis is pivotal to all forms of life. In the case of plants, homeostasis is constantly threatened by the inability to escape environmental fluctuations, and therefore sensitive mechanisms must have evolved to allow rapid perception of environmental cues and concomitant modification of growth and developmental patterns for adaptation and survival. Re-establishment of homeostasis in response to environmental perturbations requires reprog- ramming of metabolism and gene expression to shunt energy sources from growth-related biosynthetic processes to defense, acclimation, and, ultimately, adaptation. Failure to mount an initial ＇emergency＇ response may result in nutrient deprivation and irreversible senescence and cell death. Early signaling events largely determine the capacity of plants to orchestrate a successful adaptive response. Early events, on the other hand, are likely to be shared by different conditions through the generation of similar signals and before more specific responses are elaborated. Recent studies lend credence to this hypothesis, underpinning the importance of a shared energy signal in the transcriptional response to various types of stress. Energy deficiency is associated with most environmental perturbations due to their direct or indirect deleterious impact on photosynthesis and/or respiration. Several systems are known to have evolved for monitoring the available resources and triggering metabolic, growth, and developmental decisions accordingly. In doing so, energy-sensing systems regulate gene expression at multiple levels to allow flexibility in the diversity and the kinetics of the stress response.

关键词： Abiotic/environmental stress metabolic regulation cell signaling gene expression post-transcriptionalcontrol transcriptional control and transcription factors.

Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： Jorge CARAVANTES Laureano gonzalez-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词： Topology computation Real plane curves Sweeping method

＂Takeaway＂ drug delivery： A new nanomedical paradigm

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Nano Research 2017年第7期10卷 2234-2243页

作者： Elena gonzalez-Domfnguez Benito Rodriguez-gonzalez Moises Perez-Lorenzo Miguel A. Correa-Duarte Department of Physical Chemistry Biomedical Research Center (CINBIO) and Southern Galicia Institute of Health Research (IISGS)Universidade de Vigo 36310 Vigo Spain

An alternative model to the well-established paradigm of the externally switchable drug delivery systems is herein proposed. In contrast to the on--off archetype, here the amount of released drug is pre-set by the application of an external stimulus, and is gradually released after the withdrawal of the exogenous signal. These attributes are achieved through an innovative approach featuring the integration of plasmonic nanovehicles in a polymer-based film. Such a platform is provided with optically responsive capabilities together with multiple diffusional barriers, allowing for an ＂on-demand＂ time-limited release where light acts as a therapeutic ＂starting shot＂. These nanoarchitectured depots have great potential as implantable drug delivery systems in clinical scenarios where a recurrent, sustained, and yet, on--off administration of medication is required. The application of these hybrid materials may extend the implementation of nanomedicine strategies beyond the point-of-care setting.

关键词： release plasmonic nanocapsule hydrogel near infrared (NIR)

Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors

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Bioactive Materials 2022年第9期7卷 1-14页

作者： Kihak Gwon Hye Jin Hong Alan M.gonzalez-suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.Peterson Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMN55902USA Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Chemical and Biomolecular Engineering Case Western Reserve UniversityClevelandOH44106USA

Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver *** of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation *** this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel ***,the shell contained heparin moieties for growth factor(GF)binding and *** aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal ***,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble ***,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard ***,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs.

关键词： Droplet microfluidics Bioactive core-shell microcapsule Growth factor release 3D stem cell culture Stem cell differentiation

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz gonzalez Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Impact of emulated inertia from wind power on under-frequency protection schemes of future power systems

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Journal of Modern Power Systems and Clean Energy 2016年第2期4卷 211-218页

作者： Francisco Manuel gonzalez-LONGATT Loughborough University Loughborough LE652JGUK

Future power systems face several *** of them is the use of high power converters that decouple new energy sources from the AC power *** situation decreases the total system inertia affecting its ability to overcome system frequency *** wind power industry has created several controllers to enable inertial response on wind turbines generators:artificial,emulated,simulated,or synthetic *** paper deals with the issues related to the emulated inertia of wind turbines based on full-converters and their effect on the under-frequency protection schemes during the recovery period after system frequency disturbances *** main contribution of this paper is to demonstrate the recovery period of under-frequency transients in future power systems which integrate wind turbines with emulated inertia capability does not completely avoid the worse scenarios in terms of under-frequency load *** extra power delivered from a wind turbine during frequency disturbances can substantially reduce the rate of frequency *** it provides time for the active governors to respond.

关键词： Frequency controller Frequency stability Power system Protection scheme Wind turbine generator

Comparison between metabolic-associated fatty liver disease and nonalcoholic fatty liver disease:From nomenclature to clinical outcomes

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World Journal of Hepatology 2023年第4期15卷 477-496页

作者： Mohammad Alomari Mamoon Ur Rashid Pravallika Chadalavada Jonathan Ragheb Hammad Zafar Zoilo Karim suarez Shrouq Khazaaleh Adalberto Jose gonzalez Fernando J Castro Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFL 33331United States Department of Internal Medicine Florida Atlantic University Charles E Schmidt College of MedicineBoca RatonFL 33431United States Department of Internal Medicine Cleveland Clinic Fairview HospitalClevelandOH 44126United States

As a result of the obesity epidemic,Nonalcoholic fatty liver disease(NAFLD)and its complications have increased among millions of ***,a group of experts recommended changing the term NAFLD to an inclusive terminology more reflective of the underlying pathogenesis;metabolic-associated fatty liver disease(MAFLD).This new term of MAFLD has its own disease epidemiology and clinical outcomes prompting efforts in studying its differences from *** article discusses the rationale behind the nomenclature change,the main differences,and its clinical implications.

关键词： Metabolic associated fatty liver disease Non alcoholic fatty liver disease Fatty liver disease Obesity Diabetes mellitus

Modeling gut neuro-epithelial connections in a novel microfluidic device

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Microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose M.de Hoyos-Vega Xi Yu Alan M.gonzalez-suarez Sisi Chen Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez Yaroslav Fedyshyn Brooke R.Druliner David R.Linden Arthur Beyder Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs