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A useful guide of effective mesh-size decision in predicting the ultimate strength of flat-and curved plates in compression

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Journal of Ocean Engineering and Science 2023年第4期8卷 401-417页

作者： Do Kyun Kim Imjun Ban bee Yee Poh sung-Chul Shin Department of Naval Architecture and Ocean Engineering College of EngineeringSeoul National UniversitySeoulSouth Korea Research Institute of Marine Systems Engineering Seoul National UniversitySeoulKorea Group of Marine Offshore and Subsea Technology(MOST)School of EngineeringNewcastle UniversityNewcastle upon TyneUK Department of Naval Architecture and Ocean Engineering Pusan National UniversityBusanSouth Korea Ocean and Ship Technology Research Group Department of Civil and Environmental EngineeringPETRONAS University of TechnologySeri IskandarPerakMalaysia

The present study aims to determine the appropriate size of mesh or the number of the element(NoE)for flat-and curved plates,which is suggested to assess its safety subjected to axial compression based on the ultimate limit state(ULS)design and analysis *** unstiffened panel(=plate)and stiff-ened panel,considered primary members of ships and ship-shaped offshore structures,are subjected to repeated axial compression and tension caused by continued vertical bending moments applied to the hull *** are attached with stiffeners by welding,and 6,8 or 10 elements are generally rec-ommended to allocate in flat-plate’s breadth direction in between stiffeners for finite-element(FE)mod-elling,which enables the presentation of the shape of initial deflection applied to the *** the case of the load-shorting curve for curved plate,it is reported that the nonlinear behaviour characteristics,i.e.,snap-through,snap-back,secondary buckling and others,appear in typical flank *** take this into account,we investigated the preferred number of elements(6,8 or 10)generally applied to the flat plate whether it is an appropriate or more fine-sized element(or mesh)that should be considered.A useful guide is documented based on obtained outcomes which may help structural engineers select optimised mesh-size to predict ultimate strength and understand its characteristic of the flat and curved plates.

关键词： Ultimate strength Unstiffened panel Longitudinal compression Mesh convergence Finite-element method

Effects of ethanol on the tonicity of corporal tissue and the intracellular Ca^2＋ concentration of human corporal smooth muscle cells

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Asian Journal of Andrology 2010年第6期12卷 890-898页

作者： sung Chul kam Mee Ree Chae Ji Young Kim Seol Ho Choo Deok Hyun Han sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea

Heavy alcohol consumption is associated with an increased risk of erectile dysfunction （ED）; however, the acute effects of ethanol （EtOH） on penile tissue are not fully understood. We sought to investigate the effects of EtOH on corporal tissue tonicity, as well as the intracellular Ca^2＋ concentration （[Ca^2＋]i） and potassium channel activity of corporal smooth muscle. Strips of corpus cavernosum （CC） from rabbits were mounted in organ baths for isometric tension studies. Electrical field stimulation （EFS） was applied to strips precontracted with 10 μmol L^-1 phenylephrine as a control. EtOH was then added to the organ bath and incubated before EFS. The [Ca^2＋]i levels were monitored by the ratio of fura-2 fluorescence intensities using the fura-2 loading method. Single-channel and whole-cell currents were recorded by the conventional patch-clamp technique in short-term cultured smooth muscle cells from human CC tissue. The corpus cavernosal relaxant response of EFS was decreased in proportion to the concentration of EtOH. EtOH induced a sustained increase in [Ca^2＋]i in a dose-dependent manner, Extracellular application of EtOH significantly increased whole-cell K^＋ currents in a concentration-dependent manner （P 〈 0.05）. EtOH also increased the open probability in cell-attached patches; however, in inside-out patches, the application of EtOH to the intracellular aspect of the patches induced slight inhibition of Ca^2＋-activated potassium channel （KCa） activity. EtOH caused a dose-dependent increase in cavemosal tension by alterations to [Ca^2＋]i. Although EtOH did not affect KCa channels directly, it increased the channel activity by increasing [Ca^2＋]i. The increased corpus cavemosal tone caused by EtOH might be one of the mechanisms of ED after heavy drinking.

关键词： alcohol Ca^2+-activated potassium channel corporal smooth muscle penile erection

Dendritic cell-mimicking scaffolds for ex vivo T cell expansion

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Bioactive Materials 2023年第3期21卷 241-252页

作者： Hye sung Kim Tzu-Chieh Ho Moshe J.Willner Michael W.Becker Hae-Won Kim kam W.Leong Department of Biomedical Engineering Columbia UniversityNew YorkNYUSA Institute of Tissue Regeneration Engineering Dankook UniversityCheonanRepublic of Korea Wilmot Cancer Institute University of Rochester Medical CenterRochesterNYUSA Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonanRepublic of Korea Department of Systems Biology Columbia University Irving Medical CenterNew YorkNY10032USA

We propose an ex vivo T cell expansion system that mimics natural antigen-presenting cells(APCs)for adoptive cell therapy(ACT).Microfiber scaffolds coated with dendritic cell(DC)membrane replicate physicochemical properties of dendritic cells specific for T cell activation such as rapid recognition by T cells,long duration of T cell tethering,and DC-specific co-stimulatory *** DC membrane-coated scaffold is first surface-immobilized with T cell stimulatory ligands,anti-CD3(αCD3)and anti-CD28(αCD28)antibodies,followed by adsorption of releasable interleukin-2(IL-2).The scaffolds present both surface and soluble cues to T cells ex vivo in the same way that these cues are presented by natural APCs in *** demonstrate that the DC-mimicking scaffold promotes greater polyclonal expansion of primary human T cells as compared toαCD3/αCD28-func-tionalized *** importantly,major histocompatibility complex molecules derived from the DC membrane of the scaffold allow antigen-specific T cell expansion with target cell-specific killing *** addition,most of the expanded T cells(~97%)can be harvested from the scaffold by density gradient ***,the DC-mimicking scaffold offers a scalable,modular,and customizable platform for rapid expansion of highly functional T cells for ACT.

关键词： Adoptive cell therapy Ex vivo T cell expansion Cytotoxic T cell Dendritic cell membrane Cell membrane coating Scaffold

Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

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Asian Journal of Andrology 2011年第5期13卷 742-746页

作者： Jung Jun Kim Deok Hyun Han Soo Hyun Lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung sung Chul kam Ju-Hong Jeon Jong Kwan Parks sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seou1135-710 Korea Department of Urology Gachon University Gil Hospital Incheon 405-760 Korea Department of Urology Gyeengsang National University College of Medicine Gyeongsangnam-do 660-702 Korea Department of Physiology and Biophysics Seeul National University College of Medicine Seeul 110-799 Korea Department of Urology Medical School Chonbuk National University and Institute for Medical Sciences Chonbuk National University and Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju-si 561-712 Korea

In this study, we investigated the effects of a combination of Ginkgo biloba extracts （GBE） and phosphodiesterase type 5 （PDE-5） inhibitors on the muscular tone of the corpus cavernosum and potassium channel activity of corporal smooth muscle cells. Strips of corpus cavernosum from male New Zealand white rabbits were mounted in organ baths for isometric tension studies. After contraction with 1 × 10^-5 mol I^-1 norepinephrine, GBE （0.01-1 mg ml^-1） and mirodenafil （0.01-100 nmol I^-1） were added together into the organ bath. In electrophysiological studies, whole-cell currents were recorded by the conventional patch-clamp technique in cultured smooth muscle cells of the human corpus cavernosum. The corpus cavemosum was relaxed in response to GBE in a dose-dependent manner （from 0.64%±8.35% at 0.01 mg ml^-1 to 52.28%±11.42% at 1 mg ml^-1）. After pre-treatment with 0.03 mg ml^-1 of GBE, the relaxant effects of mirodenafil were increased at all concentrations, After tetraethylammonium （TEA）（1 mmol I^-1） administration, the increased effects were inhibited （P〈0.01）. Extracellular administration of GBE increased the whole-cell K^＋ outward currents in a dose-dependent fashion. The increase of the outward current was inhibited by I mmol 1-1 TEA. These results suggest that GBE could increase the relaxant potency of mirodenafil even at a minimally effective dose. The K＋ flow through potassium channels might be one of the mechanisms involved in this synergistic relaxation.

关键词： calcium-activated potassium channels erectile dysfunction Ginkgo biloba phosphodiesterase inhibitors smooth muscles

Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis

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Journal of Integrative Medicine 2015年第4期13卷 241-247页

作者： sung Min Lim Sook-Hyun Lee Department of Clinical Research on Rehabilitation Korea National Rehabilitation Research Institute

BACKGROUND：Shoulder pain is a common complication of *** venom acupuncture（BVA）is increasingly used in the treatment of post-stroke shoulder ***：To summarize and evaluate evidence on the effectiveness of BVA in relieving shoulder pain after *** STRATEGY：Nine databases,namely MEDLINE,EMBASE,the Cochrane Library,the China National Knowledge Infrastructure（CNKI）,the Japan Science and Technology Information Aggregator,Electronic（J-STAGE）,and four Korean medical databases,namely,the National Assembly Library,the Research Information Service System,the National Discovery for Science Leaders,and OASIS,were searched from their inception through August 2014 without language *** CRITERIA：Randomized controlled trials（RCTs）were included if BVA was used at acupoints as the sole treatment,or as an adjunct to other treatments,for shoulder pain after *** EXTRACTION AND ANALYSIS：Two review authors independently selected trials for inclusion,assessed methodological quality and extracted ***：A total of 138 potentially relevant articles were identifi ed,4 of which were RCTs that met our inclusion *** quality of studies included was generally low,and a preponderance of positive results was *** four trials reported favorable effects of BVA on shoulder pain after *** RCTs assessing the effects of BVA on post-stroke shoulder pain,as opposed to saline injections,were included in the *** was signifi cantly lower for BVA than for saline injections（standardized mean difference on 10-cm visual analog scale：1.46 cm,95%CI=0.30–2.62,P=0.02,n=86）CONCLUSION：This review provided evidence suggesting that BVA is effective in relieving shoulder pain after ***,further studies are needed to confi rm the role of BVA in alleviating post-stroke shoulder *** studies should be conducted with large samples and rigorous study designs.

关键词： bee venoms acupuncture therapy stroke shoulder pain meta-analysis systematic review

A Simple Approach to Achieve Organic Radicals with Unusual Solid-State Emission and Persistent Stability

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CCS Chemistry 2022年第6期4卷 1912-1920页

作者： Xueqian Zhao Junyi Gong Parvej Alam Chao Ma Yanpei Wang Jing Guo Zebin Zeng Zikai He Herman H.Y.sung Ian D.Williams kam Sing Wong Sijie Chen Jacky W.Y.Lam Zheng Zhao Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced Study and Guangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsHong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan Province 410082 School of Science Harbin Institute of TechnologyShenzhenHIT Campus of University TownShenzhenGuangdong Province 518055 Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 School of Science and Engineering Chinese University of Hong KongShenzhenGuangdong Province 518172 HKUST-Shenzhen Research Institute South Area Hi-Tech ParkNanshanShenzhenGuangdong Province 518057 Center for Aggregation-Induced Emission SCUTHKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouGuangdong Province 510640 AIE Institute Guangzhou Development DistrictHuangpuGuangzhouGuangdong Province 510530

Sable organic radicals are promising materials for information storage,molecular magnetism,electronic devices,and biological *** organic radicals have been prepared,but most are non-or weakly emissive and degrade easily upon *** remains challenging to produce stable and efficient luminescent radicals because of the absence of general guidelines for their ***,we present a photoactivation approach to generate a stable luminescent radical from tris(4-chlorophenyl)phosph ine(TCPP)with red emission in the crystal *** mechanistic study suggests that the molecular symmetry breaking in the crystal causes changes of molecular conformation,redox properties,andmolecular packing that facilitates radical generation and *** design strategy demonstrates a straightforward approach to develop stable organic luminescent radicals that will open new doors to photoinduced luminescent radical materials.

关键词： luminescent radicals symmetry breaking tris(4-chlorophenyl)phosphine anticounterfeiting photoinduced electron transfer

Effects of resistance training on cardiovascular health in non-obese active adolescents

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World Journal of Clinical Pediatrics 2016年第3期5卷 293-300页

作者： Clare Chung-Wah Yu Alison Mary McManus Hung-Kwan So Ping Chook Chun-Ting Au Albert Martin Li Jack Tat-Chi kam Raymond Chi-Hung So Christopher Wai-Kei Lam Iris Hiu-Shuen Chan Rita Yn-Tz sung Department of Health and Physical Education the Education University of Hong Kong Institute of Human Performance the University of Hong Kong Centre for Heart Lung and Vascular HealthSchool of Health and Exercise SciencesUniversity of British Columbia Department of Paediatrics the Chinese University of Hong Kong Hong Kong Sports Institute Faculty of Health Sciences and University Hospital Macao University of Science and Technology Department of Chemical Pathology Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active ***:This is a pragmatic randomised controlled *** study was carried out in a Hong Kong Government secondary ***-eight lean and active boys and girls were randomised to either the resistance training group or the control *** in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 *** outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic ***:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(P<0.005) indicated that this improvement was a result of the 10-wk resistance *** effects for time(P<0.05) in a number of anthropometric,metabolic and vascular variables were noted;however,there were no significant interactions indicating the change was more likely an outcome of normal growth and development as opposed to a training ***:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.

关键词： Strength training Children Cardiometabolic risk factors Endothelial function School-based training program High sensitive C-reactive protein 24-h ambulatory blood pressure Aerobic fitness

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

Deadly Envenomation by Massive bee Stings in a 7-Year Old Child in Ouagadougou

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Open Journal of Pediatrics 2017年第4期7卷 289-293页

作者： F. Ouédraogo C. Yonaba A. Kalmogho C. Zoungrana C. Bouda O. Sawadogo M. Delma F. Koueta L. kam Department of Pediatrics Unit for Training and Research in Health Sciences (UFR/SDS) University Ouagadougou Ouagadougou Burkina Faso Department of Pediatrics University Hospital Center Yalgado Ouédraogo (CHUYO) in Ouagadougou Ouagadougou Burkina Faso

Introduction: We are reporting a deadly case of massive bee stings observed in a 7-year-old child in Ouagadougou. Observation: The first symptoms, which appeared two hours after the stings of about 200 bees, motivated a consultation in a nearby dispensary in which the child received intravenous betamethasone before being referred to the University Hospital Center Yalgado Ouédraogo (CHUYO). Seven hours after the accident, a rapid deterioration in the general condition was noted with hemorrhage, respiratory distress, coma, and shock. A grade 3 anaphylaxis was diagnosed. The patient didn’t survive despite of the cardiopulmonary resuscitation using adrenaline in intensive care. Conclusion: The massive bee stings have caused a severe biphasic anaphylactic reaction which could not be reversed by the adrenaline administered in the second phase. The development of a protocol would contribute to a better management of the cases.

关键词： Envenomation Massive Stings bees Ouagadougou