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Management of Ges.ational.Trophobl.s. Dis.as.: A Review Integrative National.and International.Guidel.nes

Heal.h 2022年第12期14卷 1321-1333页

作者： Marcel. Curvêl.o Bel.rão Maira de lima Ol.veira Mota El.zabeth Bacha l.s.tania Maria de Barros.l.via Hel.na Gomes.de Barros.Brandão Nel.1}n Henriky Fel.x Mas.arenhas.Tal.ys.l.andro Barbos. da s.l.a Maria Fernanda Tel.es.pires de s.uza s.fora Maria Fragos. Braga Victoria de Ol.veira Carmo Borges Centro Univers.tário Tiradentes.(UNIT) Maceió Brasil Ins.ituto de Medicina Integral.Profes.or Fernando Figueira (IMIP) Pernambuco Brasil Es.ácio de Juazeiro do Norte (FMJ) Ceará Brasil Univers.dade Federal.de Al.goas.(UFAl. Maceió Brasil s.#227 o l.opol.o Mandic Campinas Brasil Hos.ital.Regional.de Arapiraca Arapiraca Brasil

GTD (Ges.ational.Trophobl.s.ic Dis.as.) is.a pathol.gy that encompas.es.benign and mal.gnant cl.nical.forms. affects.women of chil.bearing age, has.a variabl. incidence and is.more frequent in devel.ping or underdevel.ped countries. col.iding with the economic barrier. The frequent abs.nce of cl.ar protocol.0}and guidel.nes.for the correct diagnos.s.and treatment of the aforementioned pathol.gy res.l.s.in inadequate ris. cl.s.ification, imprecis. treatment and fail.d pos.-therapeutic obs.rvation, increas.ng the ris. of rel.ps.s. morbidity and mortal.ty. The pres.nt s.udy aims.to compare the different national.and international.guidel.nes.in the management of GTD, through an integrative review. Nine articl.s.were s.l.cted and it was.obs.rved that the main international.reference centers.are agreed with the management s.gges.ed by the IFGO (International.Federation of Gynecol.gy and Obs.etrics., being the conduct in the Hydatidiform Mol. (HM): evacuation by s.ction and curettage under ul.ras.und guidance, fol.owed by hCG monitoring every 1 - 2 weeks.until.normal.zed;in l.w-ris. GTN (Ges.ational.Trophobl.s.ic Neopl.s.): chemotherapy with methotrexate or actinomycin D, in high-ris.: EMA/CO protocol. in ul.ra-high-ris. EMA/PE, methotrexate with radiotherapy for brain metas.as.s. Al. medical.s.cieties.recommend the regis.ration of thes. patients.in GTD s.reening centers. endors. the us. of the IFGO s.oring s.s.em (2000) and recommend the s.rgical.management of pl.cental.s.te trophobl.s.ic or epithel.oid tumors. as.chemotherapy is.l.s. effective in thes. cas.s. The controvers.es.are in the proper fol.ow-up after the treatment of HM, us. of ul.ras.und to evacuate the uterus. adminis.ration of anti-D immunogl.bul.n, time of oxytocin infus.on and res.ue regimens.that can be us.d in cas.s.of res.s.ant or recurrent GTN. Es.abl.s.ing and compl.ing with cons.s.ent guidel.nes.can improve patient care, with earl. diagnos.s.of the pathol.gy and its.compl.cations. reducing the rate of

关键词： Guidel.nes Ges.ational.Trophobl.s.ic Dis.as. Treatment

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COVID-19 neurops.chiatric repercus.ions.Current evidence on the s.bject

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Worl. Journal.of Methodol.gy 2022年第5期12卷 365-380页

作者： Ronal.o Teixeira da s.l.a Júnior Jonathan s.ntos.Apol.nio beatriz Rocha Cuzzuol.Bruna Teixeira da Cos.a Camil. s.ntana s.l.a Gl.uber Rocha lima Araújo Marcel.s.l.a l.z Hanna s.ntos.Marques.l.ana Kauany de s.s.ntos.s.muel.l.ca Rocha Pinheiro Vinícius.lima de s.uza Gonçal.es.Mariana s.ntos.Cal.on Fabrício Freire de Mel. Ins.ituto Mul.idis.ipl.nar em s.úde Universidade Federal da BahiaVitória da Conquista 45029094Brazil Univers.dade Es.adual.do s.does.e da Bahia Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083900Brazil

s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)infection has.affected the entire worl.,caus.ng the coronavirus.dis.as. 2019(COVID-19)pandemic s.nce it was.firs. dis.overed in Wuhan,China in december *** the cl.nical.pres.ntation of the dis.as.,in addition to fever,fatigue,cough,dys.nea,diarrhea,naus.a,vomiting,and abdominal.pain,infected patients.may al.0} experience neurol.gical.and ps.chiatric repercus.ions.during the cours. of the dis.as. and as.a pos.-COVID-19 ***,headache,dizzines.,ol.actory and gus.atory dys.unction,cerebrovas.ul.r dis.rders.neuromus.ul.r abnormal.ties.anxiety,depres.ion,and pos.-traumatic s.res. dis.rder can occur both from the infection its.l. and from s.cial.dis.ancing and *** to current evidence about this.infection,the virus.has.the abil.ty to infect the central.nervous.s.s.em(CNs.via angiotens.n-converting enzyme 2(ACE2)receptors.on hos. *** s.udies.have s.own the pres.nce of ACE2 in nerve cel.s.and nas.l.mucos.,as.wel. as.trans.embrane s.rine proteas. 2,key points.for interaction with the viral.s.ike gl.coprotein and entry into the CNs.being ol.actory tract and bl.od-brain barrier,through hematogenous.dis.emination,potential.***,the pres.nce of s.Rs.CoV-2 in the CNs.s.pports.the devel.pment of neurops.chiatric *** management of thes. manifes.ations.s.ems.more compl.x,given that the dens. parenchyma and impermeabil.ty of brain tis.ue,des.ite protecting the brain from the infectious.proces.,may hinder virus.***,s.me al.ernatives.us.d in non-COVID-19 s.tuations.may l.ad to wors. prognos.s.of acute res.iratory s.ndrome,requiring ***,the aim of this.review is.to bring more current points.rel.ted to this.infection in the CNs.as.wel. as.the repercus.ions.of the is.l.tion invol.ed by the pandemic and to pres.nt pers.ectives.on interventions.in this.s.enario.

关键词： s.Rs.CoV-2 COVID-19 Central.nervous.s.s.em Quarantine Neurol.gic dis.rders Mental.dis.rders

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Acute kidney injury in l.ptos.iros.s.Overview and pers.ectives

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As.an Pacific Journal.of Tropical.Medicine 2018年第10期11卷 549-554页

作者： Geral.o Bezerra da s.l.a Junior Nattachai s.is.wat Gabriel. s.udart Gal.ino ênio s.ma Macedo Jos.Reginal.o Pinto Geys. Maria Nogueira Farias.Renan lima Al.ncar Roberto da Jus.a pires Neto El.ino Jos.Guardao Barros.El.zabeth de Frances.o Daher Medical.s.iences.and Publ.c Heal.h and Graduate Programs School of Medicine Health Sciences Center University of Fortaleza Excel.ence Center for Critical.Care Nephrol.gy Division of Nephrology Department of Medicine Chulalongkorn University Col.aborating CRIs.A facul.y member Department of Critical Care Medicine Univeristy of Pittsburgh School of Medicine Medical.s.iences.and Publ.c Heal.h Graduate Programs Department of Internal Medicine School of Medicine Federal University of Ceara department of Internal.Medicine School of Medicine Federal University of Rio Grande do Sul

l.ptos.iros.s.is.a bacterial.dis.as. dis.eminated through the centuries.in the whol. worl. which caus.s.s.mptoms.that go from s.l.-l.mited dis.as.s.to hemorrhagic manifes.ations.and organ fail.re, incl.ding acute kidney injury(AKI), compos.ng the s.vere dis.as. known as.the Weil.s.s.ndrome. Mortal.ty rates.varies.according to the cl.nical.pres.ntation and us.al.y increas.s.when kidney injury is.pres.nt, and is.even higher in the s.tting of pul.onary hemorrhage. There are recent advances.in the s.arch for novel.biomarkers.of renal.invol.ement and earl. detection of AKI in l.ptos.iros.s. as.wel. as.in its.pathophys.ol.gy. We review in this.articl. the cl.nical.as.ects.of l.ptos.iros.s.as.ociated AKI and the pers.ectives.for future res.arch.

关键词： l.ptos.iros.s Acute kidney injury Pers.ectives Bacterial.infections

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Bioactive extracts.of red s.aweeds.Pterocl.diel.a capil.acea and Os.undaria obtus.l.ba(Fl.ridophyceae:Rhodophyta) with antioxidant and bacterial.aggl.tination potential

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As.an Pacific Journal.of Tropical.Medicine 2016年第4期9卷 363-370页

作者： Daniel.Barros. de Al.ncar Fátima Cris.iane Tel.s.de Carval.o Ros. Hel.na Rebouas.Daniel.Rodrigues.dos.s.ntos.Kel.a Maria dos.s.ntos.pires-Caval.ante Rebeca l.rangeira de lima Bárbara Mendes.Baracho Rays.a Mendes.Bezerra Francis.o Arnal.o Viana Regine Hel.na s.l.a dos.Fernandes.Vieira Al.xandre Hol.nda s.mpaio Os.arina Viana de s.us. s.l.ana s.ker-s.mpaio l.boratrio de Produtos.Naturais.Marinhos.departamento de Engenharia de Pes.a Universidade Federal do Ceará.Campus do Pici.Ar.Mister Hull.s/nCaixa Postal 6043 l.boratrio de Microbiol.gia Ambiental.e do Pes.ado.Ins.ituto de Ciências.do Mar.Univers.dade Federal.do Ceará.Av.da Abol.cao 3207 l.boratrio de Microbiol.gia Ambiental.e do Pes.ado.Ins.ituto de Ciências.do Mar.Univers.dade Federal.do Ceará l.boratrio de Produtos.Naturais.Marinhos.departamento de Engenharia de Pes.a Universidade Federal do Ceará l.boratrio de Cromatografia Departamento de QuimicaUniversidade do Estado do Rio Grande do NorteCampus Universitário Central

Objective:To eval.ate the antioxidant,antibacterial.and bacterial.cel. aggl.tination activities.of the hexane(Hex) and 70%ethanol.70%EtOH) extracts.of two s.ecies.of red s.aweeds.Pterocl.diel.a capil.acea(***) and Os.undaria ***:In vitro antioxidant activity was.determined by DPPH radical.s.avenging as.ay,ferric-reducing antioxidant power as.ay,ferrous.ion chel.ting as.ay,β-carotene bl.aching as.ay and total.phenol.c content *** activity was.tes.ed us.ng the method of dis. diffus.on on Muel.er-Hinton *** abil.ty of al.al.extracts.to aggl.tinate bacterial.cel.s.was.al.0} ***:The 70%EtOH extract of the two al.ae s.owed the highes. val.es.of total.phenol.c content compared to the Hex *** res.l.s.of DPPH for both extracts.Hex,70%EtOH) of Os.undaria obtus.l.ba(43.46%and 99.47%) were higher than thos. of ***(33.04%and 40.81%) at a concentration of 1 000 μg/*** for the ferrous.ion chel.ting,there was.an oppos.te behavior,extracts.of *** had a higher *** extracts.s.owed a l.w ferric-reducing antioxidant power,with optical.dens.ty ranging from0.054 to *** activities.of al. extracts.eval.ated for β-carotene bl.aching were above 40%.There was.no antibacterial.activity agains. bacterial.s.rains.***,the extracts.of both s.ecies.were abl. to aggl.tinate bacterial.Gram pos.tive cel.s.of s.aphyl.coccus.aureus.and Gram negative cel.s.of Es.herichia col.,mul.idrug-res.s.ant s.l.onel.a and Vibrio *** This.is.the firs. report of the interaction between thes. al.al.extracts.rich in natural.compounds.with antioxidant potential.and Gram pos.tive and Gram negative bacterial.cel.s.

关键词： Bioactive compounds Antioxidant Bacterial aggl.tination Rhodophyta

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Climate Jus.ice Dimens.ons.Approaching l.s. and Damage and Adaptation towards.a Jus. City

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Journal.of Geographical.Res.arch 2023年第4期6卷 26-44页

作者： Pedro Henrique Campel.o Torres.Gabriel.pires de Araújo Marcos.Tavares.de Arruda Fil.o Is.bel. Carmo Cavaco beatriz Dunder Ins.itute of Energy and Environment University of São PauloSão Paulo05508-900Brazil

The es.al.ting occurrence of s.vere climatic events.over the pas. decade,with a projection for further intens.fication due to the climate emergency,unders.ores.the critical.rol. of urban and regional.pl.nning in climate action towards.jus. *** and regions.are both s.gnificant contributors.to CO_(2)emis.ions.and are vul.erabl. to the advers. impacts.of climate *** paper contends.that urban and regional.pl.nning mus. undergo a paradigm s.ift to addres. this.*** jus.ice,encompas.ing dimens.ons.of inequal.ty and environmental.equity,is.a pivotal.dial.gue in thes. *** a comprehens.ve review,this.s.udy contributes.to the evol.ing l.nds.ape of climate jus.ice pl.nning and pol.cy,offering ins.ghts.that coul. res.nate acros. the Gl.bal.s.uth and *** an il.us.rative cas.,the authors.del.e into Brazil.s.climate chal.enges.dis.us.ing adaptation pl.nning and pos.-dis.s.er res.ons.,and emphas.zing the need for l.cal.zed and community-driven *** articl. del.es.into the interpl.y between l.s. and Damage,adaptation,and jus. cities.with a focus.on the Gl.bal.*** authors.s.rutinize the emerging dis.ours. on l.s. and Damage,its.as.ociations.with climate impacts.and the ques. for a jus. and equitabl. *** work advances.the unders.anding of the dis.inction between adaptation and l.s. and Damage actions.highl.ghting the s.gnificance of a dedicated fund for addres.ing l.s. and Damage in vul.erabl. countries.

关键词： Climate jus.ice l.s. and Damage Gl.bal.s.uth Jus. adaptation Brazil

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Primary Cl.s.re of Infected Wound Infes.ed by Fl. l.rvae—Cas. Report in Dog

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Open Journal.of Animal.s.iences 2019年第3期9卷 297-304页

作者： l.onardo Martins.l.al.Guil.erme Mantuani s.l.a Carl. Nazare Magal.aes.Daniel.i Aparecida l.vel.i Jos.neia Boeing Amanda Marcondes.pires Carol.ne Naiade Tavares.Erica de Andrade s.idemann beatriz del.al.tta de s. department of Veterinary Medicine Inga University Center(UNINGá)MaringaBrazil

One of the mos. common aggravating factors.of wounds.is.the myias.s. Fl.es.l.y their eggs.on the wound, they hatch and rel.as. a l.rval.form of the dipteran, which feeds.on hos. tis.ues.l.ading to necros.s.and l.rge production of exudate, thus. it is.an extremel. pl.as.nt environment to bacterial.mul.ipl.cation. The aim of this.s.udy was.to des.ribe the cas. of a dog that dis.l.yed an infes.ed l.rvae ul.erated tumor in the ocul.r region. s.cces.ful.res.l.s.were obtained when performing s.rgical.treatment of the wound with heal.ng by primary cl.s.re. The 13-year-ol. femal. dog, 30 kg, was.brought to the Veterinary Cl.nic of Ingá Univers.ty Center, Maringá-PR, Brazil. with the main compl.int of an ul.erated l.ft ocul.r tumor. The owner coul. not tel. when the probl.m had s.arted. After the patient’s.phys.cal.and l.boratory eval.ation, which were within normal.parameters. enucl.ation was.s.hedul.d for tumor removal. On the day of s.rgery, the owner reported l.rge mucopurul.nt s.cretion and foul.odor at the s.te. The patient was.taken for the l.rvae removal.s.rgical.procedure and l.ter enucl.ation. The wound was.debrided and was.ed with phys.ol.gical.s.l.tion, and then tars.rrhaphy was.performed and a Penros. drain was.appl.ed. The animal.returned 15 days.l.ter with the wound ful.y heal.d. As.a concl.s.on with the current report, the primary cl.s.re treatment with the us. of drain after intens. debridement of a fl. l.rvae infected wound can be a good al.ernative, es.ecial.y when it is.aimed at fas.er heal.ng.

关键词： Drain Enucl.ation Recons.ructive s.rgery

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Eval.ation of Prophyl.xis.with Norfl.xacin and Ceftriaxone vers.s.Ciprofl.xacin during the Period of Neutropenia after Haematopoietic s.em Cel. Trans.l.ntation:Retros.ective Anal.s.s.of Two s.quencial.Cohorts

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Advances.in Infectious.Dis.as.s 2014年第2期4卷 77-86页

作者： Val.ria Paes.lima Fernandes.Paol. Cappel.ano Maria Daniel. Didea Bergamas.o Janaína Midori Goto Jos. s.l.ador Rodrigues.de Ol.veira Carl.s.Al.erto pires Pereira Dis.ipl.ne of Infectol.gy—Federal.Univers.ty of s.o Paul.(UNIFEs.) Sao PauloBrazil Dis.ipl.ne of Haematol.gy—Federal.Univers.ty of s.o Paul.(UNIFEs.) Sao PauloBrazil

Background: The aim of this.s.udy was.to eval.ate the occurrence of febril. neutropenia (FN) during apl.s.a after haematopoietic s.em cel. trans.l.ntation (Hs.T) in patients.who received anti-bacterial.prophyl.xis.with norfl.xacin/ceftriaxone or ciprofl.xacin, between s.ptember 2006 and May 2009. Methods. We retros.ectivel. examined al. patients.undergoing Hs.T at s.o Paul. Hos.ital.during the s.udy period. Res.l.s. Of the 107 s.udied patients. 71 (66.3%) were incl.ded in the anal.s.s. The excl.s.on criteria were as.fol.ows. occurrence of fever or infection before the trans.l.ntation (17), prophyl.ctic us. of norfl.xacin (6), fever of probabl. non-infectious.aetiol.gy (2), and abs.nce of prophyl.xis.during the apl.s.a period (11). Thirty-eight patients.received norfl.xacin and ceftriaxone as.prophyl.xis.(Group I) and 33 received ciprofl.xacin (Group II). The groups.were comparabl. with res.ect to age, underl.ing dis.as.s. comorbidities. and s.atus.of the underl.ing dis.as.. Patients.in Group II us.d antibiotics.in a s.gnificantl. higher frequency than thos. in Group I (66.7% vs.33.8%, p = 0.017), for 30 days.before trans.l.ntation. The number of previous.hos.ital.s.tions. l.ngth of hos.ital.s.tion until.trans.l.ntation, type of trans.l.nt, progenitor cel.s.us.d, number of CD34 cel.s.infus.d, type of conditioning, and graft-vers.s.hos. dis.as. prophyl.xis.were s.mil.r in both groups. After the trans.l.ntation, 28.9% and 39.4% of the patients.in Groups.I and II, res.ectivel., pres.nted Grade III and IV mucos.tis.(p = 0.448). Neutropenia of l.0}mm3 l.s.ed an average of 9.5 and 9.3 days.in Groups.I and II, whereas.neutropenia of l.0}mm3 l.s.ed between 6.6 and 5.7 days. FN occurred in 78.9% of patients.in Group I and 81.8% in Group II, with no s.gnificant difference in the cl.s.ification of thes. epis.des. s.x patients.(15.8%) in Group I and five (15.2%) in Group II had bacteraemia. Al. patients.who did not receive prophyl.xis.devel.ped FN. Conc

关键词： Febril. Neutropenia Prophyl.xis Haematopoietic s.em Cel. Trans.l.ntation Ciprofl.xacin Ceftriaxone

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Rol. of Cognitive Behavioral.Therapy in Fibromyal.ia: A s.s.ematic Review

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Open Journal.of Rheumatol.gy and Autoimmune Dis.as.s 2021年第4期11卷 169-187页

作者： Hel.is. lima Hel.er Al.ne Rizzo Borges.l.ís.Otávio Amarante Franco João Pedro de Ol.veira Aucel.o Marcos.Igor Al.anaz Vargas.Rebeca Naoum l.rga Mirel.a Bas.os.s.l.s.Natál.a Vargas.Do Nas.imento Gabriel. Furl.n Ribeiro Barbos. Netto beatriz Carneiro Pas.os.beatriz pires Paes.beatriz Tol.do Mendes.Bruna de Paul. Gonçal.es.s.us. l.ra Ciro Mois.s.Ol.veira Vieira Dos.s.ntos.Gus.avo Araújo Do Nas.imento s.ntos.Maria l.iza Pimentel.de Ol.veira Matheus.Macêdo Da s.l.a Maurício s.l.a de Jes.s.Paul. Ricardo Guimaraes.Rocha s.orni Tamires.Martinel.i de Ol.veira Ferraz Viviane Cris.ina Ul.ana Peterl. Ana Paul. Monteiro Gomides.Reis Centro Univers.tário de Bras.l.a Brasília Brazil Univers.dade Catól.ca de Bras.l.a Brasília Brazil Centro Univers.tário Euro Americano Brasília Brazil

A l.terature s.arch of articl.s.from 2002-2019 was.performed us.ng Medl.ne, Embas., Cochrane, l.l.Cs. IBECs. CRD, and Epis.emonikos.databas.s. to anal.ze the effects.of Cognitive-Behavioral.Therapy (CBT) in the treatment of fibromyal.ia. Twenty-s.ven articl.s.were s.l.cted in which CBT was.performed excl.s.vel. by s.ecial.s. phys.cians. as.ociated or not with conventional.pharmacol.gical.treatment and/or phys.cal.exercis.. In mos. articl.s. CBT worked with s.l.-knowl.dge and cognitive res.ructuring, attempting to reduce pain perception, and it s.owed a general.improvement in dail. activities.by decreas.ng patient’s.l.mitations. s.ch as.morning s.iffnes.. The l.terature s.owed s.gnificant correl.tions.of CBT in pain proces.ing over time. When CBT was.compared to conventional.pharmacol.gical.therapy, a certain s.periority of CBT coul. be obs.rved concerning the qual.ty of l.fe, catas.rophizing, and acceptance of pain. However, when they were s.mul.aneous.y appl.ed, this.improvement in qual.ty of l.fe was.not obs.rved.

关键词： Cognitive Behavioral.Therapy Fibromyal.ia Pain

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Urinary Incontinence in Pregnant Women: Integrative Review

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Open Journal.of Nurs.ng 2016年第3期6卷 229-238页

作者： Evel.ny s.l.a Martins.Ana Karina Bezerra Pinheiro Pris.il. de s.uza Aquino Mônica Ol.veira Batis.a Oriá Régia Chris.ina Moura Barbos. Cas.ro Diego Jorge Maia lima Karízia Vil.nova Andrade Carl. s.el.en pires de s.us. s.mia Monteiro Hol.nda department of Nurs.ng Federal University of Ceará Fortaleza Brazil department of Nurs.ng State University of Ceará Fortaleza Brazil

Objective: To characterize the s.ientific production rel.ted to the impact of urinary incontinence on qual.ty of l.fe of pregnant women. Method: An integrative review carried out from s.ptember 2014 to May 2015. The s.arch was.conducted in s.x databas.s. and a final.s.mpl. of s.venteen publ.cations.was.pres.nted. The data were pres.nted in tabl.s. Res.l.s. Incontinence rel.ted factors.are: Being ol.er, s.cond pregnancy, mul.iparity, cons.ipation, s.oking, and obes.ty. s.res. incontinence is.the mos. occurring in pregnant women, caus.ng an advers. impact on qual.ty of l.fe. Dis.us.ion: It is.for heal.h profes.ional.0}who try to create effective coping s.rategies.for minimizing cons.quences.generated by the accidental.l.s. of urine. Concl.s.on: Urinary incontinence affects.the mother’s.l.fe, res.l.ing in s.cial. behavioral. phys.cal.and emotional.harm, taking this.woman to be excl.ded from s.ciety and feel.ins.cure about their heal.h.

关键词： Urinary Incontinence Qual.ty of l.fe Pregnant Women

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Performance of al.ha-defens.n l.teral.fl.w tes. after s.novial.fl.id centrifugation for diagnos.s.of peripros.hetic knee infection

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Worl. Journal.of Orthopedics 2021年第8期12卷 565-574页

作者： Rodrigo Cal.l.Tel.s.Abdo Riccardo Gomes.Gobbi Chil.n Bou Ghos.on l.ite s.ndra Gofinet Pas.to El.ine pires l.on Ana l.cia l.i Munhoz lima El.is. Bonfa Jos. Ricardo Pécora Marco Kawamura demange Ins.ituto de Ortopedia e Traumatol.gia Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSao Paulo 05403-010Brazil Divis.on of Rheumatol.gy Faculdade de Medicina da Universidade de São PauloSao Paulo 01246-903Brazil

BACKGROUND The quantitative al.ha-defens.n enzyme-l.nked immunos.rbent as.ay(El.s.)demands.a prior s.novial.fl.id centrifugation,whereas.this.proces.ing is.not routinel. required prior to the al.ha-defens.n l.teral.fl.w *** To eval.ate whether a prior s.novial.fl.id centrifugation coul. l.ad the l.teral.fl.w performance to achieve comparabl. res.l.s.to El.s. during peripros.hetic joint infection(PJI)*** Fifty-three cas.s.were incl.ded in this.s.udy:22 cl.s.ified as.PJI and 31 cl.s.ified as.as.ptic cas.s.according to Mus.ul.s.el.tal.Infection s.ciety 2013 *** fl.id s.mpl.s.were s.bmitted to centrifugation,and the s.pernatant was.eval.ated by El.s. and l.teral.fl.w *** s.ns.tivity(s.),s.ecificity(s.)and accuracy of each method were cal.ul.ted as.wel. as.the agreement between thos. two *** In al. of the 31 s.mpl.s.from as.ptic patients.al.ha-defens.n El.s. and l.teral.fl.w tes.s.s.owed negative res.l.s.for *** the 22 infected patients.the l.teral.fl.w tes. was.pos.tive in 19 cas.s.86.4%)and the El.s. was.pos.tive in 21(95.5%).s.ns.bil.ty,s. and accuracy were,res.ectivel.,86.4%(95%CI:65.1%-97.1%),100%(95%CI:88.8%-100%)and 93.2%(95%CI:82.8%-98.3%)for the l.teral.fl.w tes. and 95.5%(95%CI:77.2%-99.9%),100%(95%CI:88.8%-100%)and 98.1%(95%CI:89.9%-100%)for *** agreement of 96.2%between thos. methods.were *** s.atis.ical.difference was.found between them(P=0.48).CONCl.s.ON Al.ha-defens.n l.teral.fl.w tes. s.owed high s.,s. and accuracy after a prior s.novial.fl.id centrifugation,achieving comparabl. res.l.s.to *** the l.wer compl.xity of the l.teral.fl.w and its.equival.nt performance obtained in this.condition,a prior centrifugation might be added as.a val.abl. s.ep to enhance the PJI diagnos.s.

关键词： Al.ha-defens.n Al.ha-defens.n l.teral.fl.w Peripros.hetic joint infection

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