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Strongyloides stercoralis prevalence and diagnostics in Vientiane, Lao People’s Democratic Republic

Infectious Diseases of Poverty 2020年第5期9卷 118-119页

作者： Somaphone Chankongsin Rahel Wampfler Marie-Therese Ruf Peter Odermatt Hanspeter Marti beatrice nickel Valy Keoluangkhot Andreas Neumayr 不详 University of Basel BaselSwitzerland Department of Medicine Swiss Tropical and Public Health InstituteBaselSwitzerland

Background:Despite the high prevalence of strongyloidiasis in the Laotian population,Laotian hospitals still lack diagnostic capacity to appropriately diagnose Strongyloides stercoralis *** cross-sectional hospital-based study was conducted to assess the prevalence of Strongyloides stercoralis infection among hospitalized patients treated at Mahosot Hospital,the primary reference hospital of Lao People’s Democratic Republic(Lao PDR),and to validate feasible methods for diagnosing *** infection at hospital’s ***:Between September and December 2018,stool samples of 104 inpatients were investigated for *** infection by wet smear,Baermann technique,Koga Agar plate culture(KAPC),and real-time detection polymerase chain reaction(RTD-PCR)at the Infectious Diseases Ward of the Mahosot Hospital in *** sensitivity,the specificity,the negative predictive value(NPV)of each diagnostic test,as well as their combination(s)was calculated using a composite reference standard(CRS).The correlation of the different test methods was assessed by chi-square or Fisher’s exact ***’s kappa coefficient was used to assess the diagnostic agreement of the different test ***:The overall prevalence of *** infections among the study population was 33.4%.The cumulative infection prevalence statistically significantly increased from the lowest age group of 40 years and below(22.4%),to the medium(40.0%)and to the oldest age group of 61 year and above(72.7%)(P=0.003).The cumulative infection prevalence of CRS was considerably higher in male(40.4%)compared to female patients(28.1%),but not statistically different(P=0.184).The diagnostic sensitivity of Baermann technique,KAPC,RTD-PCR,and the combination of Baermann technique and KAPC were 60.0,60.0,74.3,and 77.1%,*** 13 patients(37.1%)of the total 35 *** patients diagnosed with any technique had a simultaneously positive diagnostic test with Baer

关键词： Strongyloides stercoralis Strongyloidiasis Wet smear Baermann method Koga agar plate culture Real time detection PCR

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Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia

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Infectious Diseases of Poverty 2017年第1期6卷 1123-1135页

作者： Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens beatrice nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt Faculty of Basic Sciences University of Health SciencesMinistry of HealthVientianeLao People’s Democratic Republic Swiss Tropical and Public Health Institute P.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland National Institute of Public Health Ministry of HealthVientianeLao People’s Democratic Republic National Centre for Parasitology Entomology and Malaria ControlMinistry of HealthPhnom PenhCambodia Ingerod BrastadSweden Department of Parasitology Leiden University Medical CenterLeidenThe Netherlands Department of Molecular Cell Biology Leiden University Medical CenterLeidenThe Netherlands

Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems ***,sensitive diagnostic tools will be required to determine whether elimination has been *** compared several standard and novel diagnostic tools in ***-endemic ***:The prevalence and infection intensity of *** were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow *** highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were ***:Stool microscopy revealed an overall prevalence of *** of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia *** 50.4%,28.1%,3.5%,0.3%and 1.9%,*** the urine samples,the tests for CCA and CAA detected *** infections in 21.0%and 38.7%of the study participants,*** the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao ***:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for *** compared to Kato-Katz thick *** schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated ***,sustained control efforts are still needed to break transmission of ***

关键词： Cambodia Food-borne trematodes Kato-Katz Lao People’s Democratic Republic Point-of-care circulating cathodic antigen Schistosoma mekongi Serology Soil-transmitted helminths Up-converting phosphorlateral-flow circulating anodic antigen

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