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molecular Cloning and Functional Characterization of the Tomato E3 Ubiquitin Ligase SlBAH1 Gene

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Molecular Cloning and Functional Characterization of the Tom...

中国植物病理学会2016年学术年会

作者： zHOU S m WANG S m LIN C SONG Y z zHENG X X SONG F m zHU C X State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop BiologyShandong Agricultural University

Emerging evidence suggests that E3 ligases play critical roles in diverse biological processes,including pathogen resistance in *** this study,an ubiquitin ligase gene（SlBAH1）was cloned from a tomato plant,and the functions of the gene were *** SlBAH1 gene contained1002 nucleotides and encoded a protein with 333 amino *** SlBAH1 protein contained a SPX domain and a RING ***1 displayed E3 ubiquitin ligase activity in ***1 was demonstrated to localize in the nucleus,cytoplasm and plasma membrane by a subcellular localization *** expression of SlBAH1 was induced by various hormones and Botrytis cinerea ***1-silencing in plants obtained by Virus-induced gene silencing（VIGS） technology enhanced resistance to Botrytis cinerea,and the expression of pathogenesis-related（pr） genes,including pr1,pr2,pr4,pr5,and pr7,was significantly *** results indicated that the SlBAH1-dependent activation of defense-related genes played a key role in the enhanced fungal resistance observed in the SlBAH1-silenced plants and may be related to the SA-dependent and JA-dependent signaling pathways.

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和田河气田凝析油油源及油气成因关系判识

中国科学：地球科学 2015年第9期45卷 941-952页

作者：宋到福王铁冠李美俊倪智勇中国石油大学油气资源与探测国家重点实验室北京102249

运用有机地球化学方法,对和田河凝析油进行了油源对比,并对相伴生的凝析油与天然气的成因关系进行了判识.研究结果表明,和田河凝析油具有高的姥鲛烷/植烷比(pr/Ph),高的C28规则甾烷相对含量(>25%),丰富的C26-C27三芳甾烷和三芳甲藻甾烷... 详细信息

运用有机地球化学方法,对和田河凝析油进行了油源对比,并对相伴生的凝析油与天然气的成因关系进行了判识.研究结果表明,和田河凝析油具有高的姥鲛烷/植烷比(pr/Ph),高的C28规则甾烷相对含量(>25%),丰富的C26-C27三芳甾烷和三芳甲藻甾烷以及较重的碳同位素组成等地球化学特征,与寒武系烃源岩具有良好的可比性,应源自寒武系烃源岩.多项分子化合物成熟度参数表明,和田河凝析油成熟度并不高,为成熟-高成熟原油范畴.和田河凝析油与天然气虽均源自寒武系烃源岩,天然气亦为原油裂解气,但一系列证据表明,和田河气田的天然气并不是由伴生的凝析油裂解而成,原油裂解生成天然气的过程也不是在现今储层内发生的(非原位裂解气).井口条件下产出的液态凝析油应该是呈分散状溶解在天然气中,是由天然气携带注入气藏的.

关键词：和田河气田凝析油成熟度油源对比成因关系

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Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study

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Stroke & Vascular Neurology 2021年第1期6卷 48-56页

作者： Dearbhla m.Kelly Linxin Li Annette I Burgess Deborah L Poole Julia m Duerden Peter m.Rothwell Wolfson Centre for the prevention of Stroke and Dementia Nuffield Department of Clinical NeurosciencesOxford UniversityOxfordUK

Background and purpose Non-traditional risk factors such as chronic inflammation,oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease(CKD)by triggering vascular injury and endothelial *** aimed to determine how well a panel of biomarkers representative of these factors would correlate with estimated glomerular filtration rate(eGFR)in patients with recent transient ischaemic attack(TIA)or *** also investigated whether eGFR would confound previously reported associations between biomarkers and *** We studied a panel of 16 blood biomarkers related to inflammation,thrombosis,atherogenesis and cardiac or neuronal cell damage in TIA or ischaemic stroke in a population-based study(Oxford Vascular Study).Biomarker levels were log-transformed and correlated with eGFR,adjusted for *** proportional hazard models were used for survival *** Among 1297 patients with TIA or stroke,52.7%(n=684)of patients had CKD(eGFRmL/min/1.73 m^(2)).There was a moderate correlation between log-eGFR and the log-transformed soluble tumour necrosis factor receptor-1(R^(2)=0.21),attenuating with adjustment for age(R^(2)=0.12).There were moderate-to strong correlations with markers of cardiac injury,N-terminal pro-brain natriuretic peptide and heart-type fatty acid binding protein(hFABP,R2=0.14 and 0.34,respectively).The strongest correlation after adjustment for age was between hFABP and eGFR(R^(2)=0.20).Adjusting for eGFR did not impact any biomarker associations with *** Correlations between biomarkers related to inflammation and thrombosis with renal dysfunction in the setting of cerebrovascular events were generally modest after adjustment for age,suggesting that putative risk factors such as chronic inflammation or coagulopathy are unlikely to be important stroke mechanisms in patients with CKD.

关键词： inflammation patients mortality

The complete sequence of the mitochondrial genome for three Taenia tapeworm species and sequence analysis

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The complete sequence of the mitochondrial genome for three ...

prognostic and Clinicopathological Value of the Expression of FOXC2 &YKL-40 in Carcinoma of the Breast, an Immunohistochemical Study

中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十次学术研讨会

作者： G.H.Liu~(1,2),R.Q.Lin~1,z.G.Yuan~1,m.W.Li~3,H.Q.Song~1,W.Liu~2,Y.Liu~(2*),X.Q.zhu~(1**) (1.College of Veterinary medicine,South China Agricultural University,Guangzhou,Guangdong province 510642, pr China 2.College of Veterinary medicine,Hunan Agricultural University,Changsha 410128,Hunan province,pr China 3.Department of Veterinary medicine,Agricultural College,Guangdong Ocean University,Guangdong province,The People’s Republic of China)

The complete mitochondrial gonome of three Taenia species was amplified in two overlapping fragments and then *** sizes of the entire nat genome are 13700 bp for ***,13489 bp for *** and 13647 bp for ***,*** contains 36 genes(consisting of 12 genes for encoding proteins,2 genes for rRNA and 22 genes for tRNA),but a gene for ATP synthetase subunit 8 is missing,which is consistent with all other species of cestode studied to *** genes are transcribed in the same direction and have a nucleotide composition high in A and T,but low in G and *** contents of A+T of the complete genomes are 71.3%for T. multiceps,70.8%for *** and 73.0%for *** AT bias had a significant effect on both the codon usage pattern and amino acid composition of *** the noncoding region,*** and *** have two noncoding regions,but *** only one the location of the noncoding *** include: a short non-coding region(SNR,73nucleotides) and a long non-coding region(LNR,176nucleotides),*** include:a short non-coding region(SNR,64nucleotides) and a long non-coding region(LNR,124nucleotides),T. taeniaeformis include:non-coding region 414 *** are substantial differences when compared with T. saginata,***,*** and Echinococcus multilocularis and other of non-coding *** analyses based on concatenated amino acid sequences of 3 protein-coding genes(cox1,cox2,nad6),revealed that the newly described species *** was more closely related to the others of Taenia genus, consistent with results of a previous classification based upon their morphology.

关键词： complete sequence Taenia tapeworm sequence analysis

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Advances in Breast Cancer Research 2018年第3期7卷 211-230页

作者： Enas m. Fouad Abla S. mahmoud Rham z. Ahmed Basant Sh El Shafaay Ramadan mahmoud Gamal Osman mohamed Farouk Amin Loay m. Gertallah manar A. Bessar Lecturer of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Lecturer of Pathology Faculty of Medicine Beni-Suef University Cairo Egypt Lecturer of medical Oncology Faculty of Medicine Zagazig University Zagazig Egypt Lecturer of Clinical Oncology & Nuclear medicine Faculty of Medicine Zagazig Egypt Lecturer of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt Lecturer of Radiology Faculty of Medicine Zagazig University Zagazig Egypt

Background: Breast cancer is considered the commonest and the most fatal female cancer worldwide. There is to an urgent need for discovering recent therapies to identify patient prognosis and improve treatment strategies. Fork-head Box C2 (FOXC2) is a transcription factor which is a key regulator of cancer stem cells (CSC) properties and epithelial mesenchymal transition (EmT) e.g. cancer initiation, metastatic capacity, and resistance to chemotherapy. FOXC2 roles in CSCs properties and EmT regulation in breast cancer needs detailed studies. YKL-40 is known as chitinase-3-like-1 belongs to a family of mammalian proteins that have an amino acid sequence which is similar to the 18-glycosyl hydrolase bacterial chitinases group. Recent studies have found aberrant YKL-40 elevated expression in cancer of various organs, so it may be used as a recent prognostic biomarker for patients with breast cancer. Former researchers have assessed the expression of FOXC2 & YKL-40 separately in cancer patients and relations to prognosis of patients;however, no studies assessed them together in breast cancer patients and the previous results were inconclusive. Accordingly, our study aimed at evaluation of immunohistochemical expressions of FOXC2 & YKL-40 in carcinoma of the breast in a trial to clarify the relation among their expressions, clinicopathological parameters and recurrence of the disease after successive therapy and patients’ prognosis. methods: we have evaluated expressions of FOXC2 & YKL-40 in sections from 50 paraffin blocks of carcinoma of the breast using immunohistochemistry. We followed up our patients for 3 years for assessment of recurrence of the disease after successive therapy and survival rates. We analyzed the relationship between their combined expression clinicopathological and prognostic parameters. Results: high FOXC2 expression was associated with older age of the patient (p = 0.002), negative ER (p = 0.009), & pr (p = 0.008), positive HER2neu (p = 0.02),

关键词： Carcinoma of the Breast FOXC2 YKL-40 prognosis Immunohistochemistry

La1-xprxCrO3纳米晶的结构和磁性质

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低温物理学报 2007年第3期29卷 184-187页

作者：郑保忠张建武浦其荣张增明丁泽军中国科技大学物理系中国科技大学天文与应用物理系

我们用柠檬酸溶胶凝胶法成功制备了pr掺杂La1-xprxCrO3(x=0～0.6)纳米晶.在硝酸盐溶液中加入柠檬酸作为螯合剂,乙二醇为分散剂,得到干凝胶并在烧结温度为600℃时获得纯相钙钛矿结构纳米晶粉体,颗粒直径大约为40nm且大小分布均匀.La0.5pr... 详细信息

我们用柠檬酸溶胶凝胶法成功制备了pr掺杂La1-xprxCrO3(x=0～0.6)纳米晶.在硝酸盐溶液中加入柠檬酸作为螯合剂,乙二醇为分散剂,得到干凝胶并在烧结温度为600℃时获得纯相钙钛矿结构纳米晶粉体,颗粒直径大约为40nm且大小分布均匀.La0.5pr0.5CrO3在场冷条件下的磁化强度以及在7K时的磁滞回线的测量结果表明,在260K表现出顺磁到反铁磁转变,在200K时磁化率达到最大值,随后磁化率随着温度的降低而急剧减小,在大约94K的时候磁化率为0,随着温度的进一步降低,磁化率为负值.

关键词：溶胶凝胶法 La1-xprxCrO3 纳米晶类钙钛矿结构氧化物

食物中添加ι-卡尼汀对大鼠肝代谢ι-丙氨酸的作用(英文)

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Acta Pharmacologica Sinica 2002年第4期23卷 10-13页

作者： Vilma A F G GAzOLA, Gisele LOPES, Daniel m LImEIRA, Ricardo GALLETTO, Sebastiao GAzOLA, Rui CURI, Roberto B BAzOTTE (State University of maringa, SUm, Department of Pharmacy and Pharmacology, maringa, pr, 87020-900 University of Sao Paulo, Sao Paulo, SP, 05508-900, Brazil) State University of maringo SUM Department of Pharmacy and PharmacologyMaringo PR

AIm:To investigate the effects of chronic supplementation with l-carnitine (LCT) on hepatic catabolism of l-alanine. mETHODS: Two groups of male adult Wistar rats were used: 1) supplemented with LCT (1.2 mmol·kg-1·d-1) dissolved in the drinking water (LCT group) and 2) control group (COG) without LCT supplementation . After one week of LCT supplementation livers from 24 h-fasted rats were perfused in situ and the production of glucose, urea, pyruvate, and l-lactate from l-alanine (5 mmol/L) were measured. RESULTS: LCT decreased the production of glucose and urea from l-alanine. In agreement, pyruvate and l-lactate production from l-alanine were decreased. However, the supplementation with LCT did not show any significant effect on hepatic glucose production from pyruvate (5 mmol/L) and l-lactate (2 mmol/L). CONCLUSION: LCT supplementation decreased the conversion of l-alanine to pyruvate. However the ability of the liver to convert pyruvate to glucose was not affected by LCT treatment.

关键词：卡尼汀肝代谢糖原异生丙氨酸

measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev m.m.Aggarwal z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied m.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.z.Cai H.Caines m.Calderon de la Barca Sanchez D.Cebra R.Cendejas m.C.Cervantes z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng m.Cherney A.Chikanian K.E.Choi W.Christie P.Chung m.J.m.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.m.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov m.Elnim J.Engelage G Eppley m.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.m.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle m.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger m.Krus L.Kumar P.Kurnadi m.A.C.Lamont J.m.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight m.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li z.m.Li m.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.ma Y.G.mai D.P.mahapatra R.majka O.I.mall L.K.mangotra R.manweiler S.margetis C.markert H.masui H.S.matis Yu.A.matulenko D.meDonald T.S.mcShane A.meschanin R.milner N.G.minaev S.mioduszewski A.mischke m.K.mitrovski B.mohanty m.m.mondal B.morozov D.A.morozov m.G.munhoz m Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA massachusetts Institute of Technology CambridgeMA 02139-4307USA mx-Planck-Institut fir Physik MunichGermany michigan State University East LansingMichigan 48824USA moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming zero Yield At minimum(zYAm),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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Determination of thalidomide in human plasma by liquid chromatography-tandem mass spectrometry

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Determination of thalidomide in human plasma by liquid chrom...