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Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor

World Journal of Gastroenterology 2016年第16期22卷 4201-4210页

作者： Mireen Friedrich-Rust beate wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga Department of Internal Medicine I (Gastroenterology Pulmonology Endocrinology) J.W. Goethe-University Hospital Institute of Biostatistics and Mathematical Modeling Faculty of Medicine J.W. Goethe-University Department of Internal Medicine II (Infectious Disease Oncology Hematology) J.W. Goethe-University Hospital Institute of Medical Microbiology and Infection Control J.W. Goethe-University Hospital

AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver ***: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on ***: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial ***: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-b

关键词： Intensive care unit Sepsis-bundle Early goal-directed therapy Liver cirrhosis Mortality

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Chinese lockdown as aerosol reduction experiment

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Advances in Climate Change Research 2021年第5期12卷 677-685页

作者： Hans VON STORCH beate GEYER LI Yan Volker MATTHIAS Burkhardt ROCKEL Institute of Coastal Systems Helmholtz-Zentrum GeesthachtGeesthacht21502Germany Ocean University of China Qingdao266100China College of Life Sciences and Oceanography Shenzhen UniversityShenzhen518061China Institute of Biogeochemistry in Coastal Seas Helmholtz-Zentrum GeesthachtGeesthacht21502Germany

The lockdown of large parts of Chinese economy beginning in late January 2020 lead to significant regional changes of aerosol loads, which suggests a reduction of backscatter and consequently a regional warming in the following months. Using local data and a numerical experiment with a limited area model, we have examined how strong this response may have been. The observed (local and reanalysis) observations point to a warming of less than 1.0 K, the simulations to a warming of the order of 0.5 K. These numbers are uncertain, because of large-scale natural variability and an ad-hoc choice of aerosol optical depth anomaly in the simulation. Thus, the result was, in short, that there was actually a weak warming of a few tenth of degrees, while noteworthy changes in circulation or in precipitation were not detected. More specifically, we found that at selected central China stations temperatures were found to be higher than in previous two years. This warming goes with a marked diurnal signal, with a maximum warming in the early afternoon (06 UTC), weakest at night (18 UTC). This may be related to a general warming of large swaths of Asia (including Siberia, which is not related to local aerosol forcing). Indeed, also the stations outside the immediate strong lockdown region are showing warming, albeit a weaker one. Thus, the difference 2020 minus 2019/2018 may overestimate the effect. The ad-hoc series of numerical experiments indicates that the simulated changes are robust and suffer little from internal dynamical variability. In particular, the overall reduction of the aerosol optical depth does not lead to phases of larger intermittent divergence among the model simulations, irrespective of the aerosol load. Instead, the simulations with reduced anthropogenic aerosol load show more a mere locally increased temperature. This may indicate that the aerosol effect is mostly thermodynamic in all local air columns in the region.

关键词： Lockdown China Aerosol Climate

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Short-Term Effect of Nitrogen Intensification on Aggregate Size Distribution, Microbial Biomass and Enzyme Activities in a Semi-Arid Soil Under Different Crop Types

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Pedosphere 2019年第4期29卷 483-491页

作者： Rajasekaran MURUGAN V. R. Ramakrishna PARAMA beate MADAN R. MUTHURAJU Bernard LUDWIG Department of Environmental Chemistry University of Kassel Nordbahnhof str. la Witzenhausen 37213 (Germany) Department of Soil Science and Agricultural Chemistry University of Agricultural Sciences (GKVK) Bangalore 560065 (India) Organic Plant Production and Agroecosystems Research in the Tropics and Subtropics University of Kassel Stein str. 19 Witzenhausen 37213 (Germany) Department of Agricultural Microbiology University of Agricultural Sciences (GKVK) Bangalore 560065 (India)

There is a lack of quantitative assessments available on the effect of agricultural intensification on soil aggregate distribution and microbial properties. Here, we investigated how short-term nitrogen(N) intensification induced changes in aggregate size distribution and microbial properties in a soil of a hot moist semi-arid region(Bangalore, India). We hypothesised that N intensification would increase the accumulation of macroaggregates > 2 mm and soil microbial biomass and activity, and that the specific crop plant sowed would influence the level of this increase. In November 2016, surface(0–10 cm) and subsurface(10–20 cm) soil samples were taken from three N fertilisation treatments, low N(50 kg N ha-1), medium N(75 and 100 kg N ha-1 for finger millet and maize, respectively),and high N(100 and 150 kg N ha-1 for finger millet and maize, respectively). Distribution of water-stable aggregate concentrations,carbon(C) and N dynamics within aggregate size class, and soil microbial biomass and activity were evaluated. The high-N treatment significantly increased the concentration of large macroaggregates in the subsurface soil of the maize crop treatment, presumably due to an increased C input from root growth. Different N fertilisation levels did not significantly affect C and N concentrations in different aggregate size classes or the bulk soil. High-N applications significantly increased dehydrogenase activity in both the surface soil and the subsurface soil and urease activity in the surface soil, likely because of increased accumulation of enzymes stabilised by soil colloids in dry soils. Dehydrogenase activity was significantly affected by the type of crop, but urease activity not. Overall, our results showed that high N application rates alter large macroaggregates and enzyme activities in surface and subsurface soils through an increased aboveground and corresponding belowground biomass input in the maize crop.

关键词： agricultural intensification biomass input C and N dynamics large macroaggregate microaggregate N application small macroaggregate water-stable aggregates

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Vorbereitung auf den TestDaF-richtig und falsch

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德语学习 2010年第3期 61-67页

作者： beate Geist Reprsentantin des TestDaF-Instituts in China

Der TestDaF(Test Deutsch als Fremdsprache) ist die weltweit gr(o|¨)βte Sprachpr(u|¨)fung zum Nachweis deutscher Sprachkenntnisse f(u|¨)r den *** ist eine kompetenzorientierte Pr(u|¨)fung auf den Niveaustufen B2.1... 详细信息

关键词： der Pr Hg Vorbereitung auf den TestDaF-richtig und falsch

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A BETTER FUTURE FOR ALL

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Beijing Review 2020年第42期63卷 18-19页

作者： beate Trankmann the United Nations Development Programme(UNDP)in China

beate Trankmann, Resident Representative of the United Nations Development Programme (UNDP) in China, tells Beijing Review about the cooperation between the UNDP and China and what the results mean for the world. This is an edited excerpt of the interview:Beijing Review:What is going to be the focus of development in the post-novel coronavirus pandemic period?

关键词： interview UNDP cooperation

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Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options

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World Journal of Pediatrics 2018年第4期14卷 322-329页

作者： Irene Schmid Anne K.Klenk Monika Sparber-Sauer Ewa Koscielniak Rebecca Maxwell beate Haberle Division of Pediatric Hematology and Oncology Dr.von Hauner Children’s HospitalLudwig-Maximilians University of MunichLMULindwurmstr.480337 MunichGermany Klinikum Stuttgart-Olgahospital Stuttgart Cancer CenterZentrum fur Kinder-Jugend-und FrauenmedizinPediatrics 5(OncologyHematologyImmunology)StuttgartGermany Department of P ediatric Hematology and Oncology Children’s HospitalTubingenGermany Pediatric Surgery Dr.von Hauner Childen’s HospitalLudwig-Maximilians University of Munic hMunichGermany

Background Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor affecting infants and young children. Although benign, it can be associated with an aggressive locally growing tumor and/or a life-threatening Kasabach–Merritt phenomenon (KMP). To date, only reviews of limited cases have been performed. We, therefore, conducted a comprehensive literature search to collect relevant data and make recommendations for future treatment trials. Methods Review of the available literature between 1993 and 2017 revealed a total of 105 publications involving 215 patients of less than 21 years of age. To this, we added 12 from our department and 4 from the Cooperative Weichteilsarkomstudie database. Results We found that KMP was present in 79% of the infants, in 47% of the 1–5-year olds, in 43% of the 6–12-year olds, and in 10% of the 13–21-year-old patients. KMP was present in nearly all (94%) patients with retroperitoneal tumors and in all patients with extra-regional tumors. The median size of a KHE without KMP was 12 cm2 as compared to 49 cm2 when associated with a KMP. With complete (not further classifiable if R0 or R1) resection, all patients were cured. If inoperable, response regarding KMP/regression of tumor size was seen in 29/28% with steroid-, 47/39% with vincristine-, 44/43% with interferon alpha-, 65/61% with anti-platelet agents-, and in 97/100% with sirolimus-containing therapies. Conclusions Patients with progressive KHE should undergo resection whenever it is considered a safe option. If inoperable, sirolimus should be the first choice for treating KMP and reducing tumor size.

关键词： Kaposiform hemangioendothelioma Kasabach–Merritt phenomenon Pediatric

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TestDaF und TestAS-Zwei Prfungen zur Vorbereitung auf das Studium in Deutschland

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德语学习 2010年第1期 67-69页

作者： beate Geist Reprsentantin des TestDaF-Instituts in China

2009:失败者Nach nur zehn Monaten ist diera JrgenKlinsmann beim FC Bayern Mnchen *** Trost fr Klinsmann:Nachseinem Abgang* finden die Bayern auch nichtzurck in die Erfolgsspur.*离职。

关键词： der TestDaF und TestAS-Zwei Pr fungen zur Vorbereitung auf das Studium in Deutschland

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Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy:Contribution of neurochemical markers to early diagnosis

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Infectious Medicine 2022年第2期1卷 140-142页

作者： Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein beate Hagenkötter Infectious Diseases Department Nord Franche-ComtéHospitalFrance Diabetology Department Nord Franche-ComtéHospitalFrance Internal Medicine Department Groupe Hospitalier Sud Ile de FranceMelunFrance Neurology Department Nord Franche-ComtéHospitalFrance

Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late *** recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 *** report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological *** patient was successfully treated after high-dose intravenous thiamine,but areflexia *** COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid ***:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely *** mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.

关键词： COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain Protein

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fentliche Toiletten

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德语人文研究 2001年第4期 25-26页

作者：余华 beate Geist

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Organizational Culture Content of the Manufacturing Companies in Austria and the Czech Republic

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Journalism and Mass Communication 2014年第9期4卷 585-592页

作者： Zdenka Konecna beate Huber Bmo University of Technology Bmo Czech Republic FH Wien-Studiengange der WKW Wien Austria

The main focus of this scientific article is organizational culture that represents very complicated and complex social phenomenon. Organizational culture is understood as the set of basic assumptions, values, standards, and artifacts, shared in the company in long-term horizon. The main objective of empirical research was to map organizational culture content in manufacturing companies in the Czech Republic and Austria. The content of organizational culture in the selected level of analysis was identified by means of qualitative methods--individual interviews and focus group discussions. With respect to specified objective, research was implemented in the sample of 10 companies in the Czech Republic and Austria. Data acquired by qualitative method of focus group were processed by means of content analysis. The main result of this part of empirical research was to describe the organizational culture content in the manufacturing companies operating in Austrian and Czech environment.

关键词： organizational culture company performance manufacturing companies Austria Czech Republic

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