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世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染

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胃肠病学 2011年第7期16卷 423-428页

作者： Hunt RH Xiao SD Megraud f Leon-Barua R bazzoli f van der Merwe S Vaz Coelho LG fock M fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖戴宁 WGO评审组浙江大学医学院附属邵逸夫医院消化科

世界上有一半人口感染幽门螺杆菌（***），其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异．在发展中国家较高．发达国家较低。但总体而言，近年世界许多地区的***感染率均呈下降趋势。

关键词：幽门螺杆菌感染发展中国家胃肠病学世界 H.pylori 指南组织社会经济状况

世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染

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胃肠病学 2007年第1期12卷 40-52页

作者： Hunt RH Xiao SD Megraud f Leon-Barua R bazzoli f Van der Merwe S vaz Coelho LG fock KM fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖丛衍群戴宁

我非常高兴向大家推荐这份发展中国家幽门螺杆菌（***）临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。

关键词：幽门螺杆菌感染发展中国家临床指南胃肠病学世界组织临床经验

Spawning induction and fecundity of commercial native fish species from the São francisco River basin,Brazil,under hatchery conditions

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Agricultural Sciences 2013年第8期4卷 382-388页

作者： fábio Pereira Arantes Yoshimi Sato Edson Vieira Sampaio Elizete Rizzo Nilo bazzoli Laboratório de Ictiohistologia Departamento de MorfologiaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteBrasil Estacao de Hidrobiologia e Piscicultura de Três Marias Companhia de Desenvolvimento dos Vales do Sao Francisco e Parnaíba(CODEVASF)Três MariasBrasil Programa de Pós-Graduacao em Zoologia de Vertebrados Pontifícia Universidade Católicade Minas GeraisPUC MinasBelo HorizonteBrasil

In order to exploit native fish species for aquaculture, basic parameters of artificial reproducetion and estimates of reproductive potential for this fish must be determined to improve hatchery success. We analyze seven Brazilian commercial fish. Spawning was induced using the hypophysation method, with injection of crude carp pituitary extract (CCPE). Characiformes species signaled the spawning time with behavioral alterations (usually circular movements). The time of oocyte extrusion varied from 5.3 ± 0.3 h in Salminus franciscanus to 8.6 ± 0.1 h in Prochilodus argenteus after the second CCPE injection. The greatest diameter of a vitellogenic oocyte was registered for P. argenteus (873.9 ± 122.2 μm) and the smallest was for Pimelodus maculates (465.4 ± 36.3 μm). The diameter of vitellogenic oocytes was very similar among species belonging to the same family. The highest ROI values were registered for Prochilodus costatus(27.0 ± 3.5 μm) and P. argenteus (23.4 ± 3.7 μm), while the lowest values were found in Pseudoplatystoma corruscans (4.6 ± 0.9 μm) and P. maculatus (6.0 ± 1.3 μm). Absolute fecundity (number of oocytes released at spawning) was lowest in P. maculatus and highest in P. corruscans. Relative fecundity (Rf) presented a high correlation (r = 0.98 to 0.99) with gonad weight, indicating high efficiency of spawning. The Rf also presented a high correlation with body weight (r = 0.88 to 0.97) and total length (r = 0.86 to 0.92). The highest Rf was registered for Leporinus obtusidens, and the lowest was for P. corruscans. Released fecundity had a negative correlation with the diameter of vitellogenic oocytes and with the height of the follicular cells, and a positive correlation with the thickness of the zona pelucida. These results indicate that the species studied herein are suitable candidates for aquaculture due to their reproductive and zootechnical characteristics.

关键词： Spawning Induction fecundity Oocyte Neotropical fish Sao francisco River

Gastric cancer, Helicobacter pylori infection and other risk factors

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 342-347页

作者： Lorenzo fuccio Leonardo Henry Eusebi franco bazzoli Department of Internal Medicine and Gastroenterology University of Bologna

Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identif ied for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The def inition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients.

关键词： Helicobacter pylori Eradication treatment Diet Gastric cancer

Diagnosis and management of gastric antral vascular ectasia

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World Journal of Gastrointestinal Endoscopy 2013年第1期5卷 6-13页

作者： Lorenzo fuccio Alessandro Mussetto Liboria Laterza Leonardo Henry Eusebi franco bazzoli Department of Clinical Medicine S.Orsola-Malpighi University Hospital40138 BolognaItaly Department of Gastroenterology S.Maria delle Croci Hospital48121 RavennaItaly

Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endoscopic pattern and, for uncertain cases, on histology. GAVE is characterized by a pathognomonic endoscopic pattern, mainly represented by red spots either organized in stripes radially departing from pylorus, defined as watermelon stomach, or arranged in a diffused-way, the so called honeycomb stomach. The histological pattern, although not pathognomonic, is characterized by four alterations:vascular ectasia of mucosal capillaries, focal thrombosis, spindle cell proliferation and fibrohyalinosis, which consist of homogeneous substance around the ectatic capillaries of the lamina propria. The main differential diagnosis is with Portal Hypertensive Gastropathy, that can frequently co-exists, since about 30% of patients with GAVE co-present a liver cirrhosis. Autoimmune disorders, mainly represented by Reynaud's phenomenon and sclerodactyly, are co-present in about 60% of patients with GAVE; other autoimmune and connective tissue disorders are occasionally reported such as Sjogren's syndrome, systemic lupus erythematosus, primary biliary cirrhosis and systemic sclerosis. In the remaining cases, GAVE syndrome has been described in patients with chronic renal failure, bone marrow transplantation and cardiac diseases. The pathogenesis of GAVE is still obscure and many hypotheses have been proposed such as mechanical stress, humoural and autoimmune factors and hemodynamic alterations. In the last two decades, many therapeutic options have been proposed including surgical, endoscopic and medical choices. Medical therapy has not clearly shown satisfactory results and surgery should only be considered for refractory severe cases, since this approach has significant mortality and morbidity risks, especially in the setting of portal hypertension and liver cirrhosis

关键词： Gastric antral vascular ectasia Bleeding Watermelon stomach Argon plasma coagulation

Pelvic radiation disease:Updates on treatment options

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World Journal of Clinical Oncology 2015年第6期6卷 272-280页

作者： Leonardo frazzoni Marina La Marca Alessandra Guido Alessio Giuseppe Morganti franco bazzoli Lorenzo fuccio Department of Medical and Surgical Sciences S.Orsola-Malpighi HospitalUniversity of Bologna Division of Radiation Oncologym S.Orsola-Malpighi Hospital University of Bologna

Pelvic cancers are among the most frequently diagnosed neoplasms and radiotherapy represents one of the main treatment options. The irradiation field usually encompasses healthy intestinal tissue,especially of distal large bowel,thus inducing gastrointestinal(GI) radiation-induced toxicity. Indeed,up to half of radiationtreated patients say that their quality of life is affected by GI symptoms(e.g.,rectal bleeding,diarrhoea). The constellation of GI symptoms- from transient to longterm,from mild to very severe- experienced by patients who underwent radiation treatment for a pelvic tumor have been comprised in the definition of pelvic radiation disease(PRD). A correct and evidence-based therapeutic approach of patients experiencing GI radiation-induced toxicity is mandatory. Therapeutic non-surgical strategies for PRD can be summarized in two broad categories,i.e.,medical and endoscopic. Of note,most of the studies have investigated the management of radiation-induced rectal bleeding. Patients with clinically significant bleeding(i.e.,causing chronic anemia) should firstly be considered for medical management(i.e.,sucralfate enemas,metronidazole and hyperbaric oxygen); in case of failure,endoscopic treatment should be implemented. This latter should be considered the first choice in case of acute,transfusion requiring,bleeding. More well-performed,high quality studies should be performed,especially the role of medical treatments should be better investigated as well as the comparative studies between endoscopic and hyperbaric oxygen treatments.

关键词： Pelvic radiation disease Radiation-induced proctopathy Radiotherapy Gastrointestinal toxicity Sucralfate Metronidazole Probiotics Argon plasma coagulation Hyperbaric oxygen formalin

对“相约上海——马赛高等美术学院作品展”部分参展艺术家的访谈

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上海艺术家 2010年第6期 22-26页

作者：傅军 PIOTR KIEMENSIEWICZ ANNE MARIE PECHEUR fRANCOIS bazzoli fRANCOIS MEZZAPELLE 葛峰马赛艺术学院

傅：我想问的第一个问题是，在这个展览上您扮演了一个组织者或者策展人的角色，我知道你其实是一个艺术家。那么您个人更认同自己是哪种身份？

关键词：参展艺术家高等美术学院作品展上海策展人组织者

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美国卫生组织体系20年的变革和经验

中国循证医学杂志 2010年第5期10卷 545-546页

作者：高军杨洪伟胡善联世界卫生组织西太平洋地区办公室卫生部卫生经济研究所北京100044 上海市卫生发展研究中心上海200032

1背景与资料上世纪80和90年代，美国的医院和医生组织投入大量时间和资源进行机构重组，以实现提高组织效率、改善财务绩效水平、机构长期生存、承担社区责任和救治病人的目的。而机构重组的主要趋势是建立“有组织的服务提供体系”，... 详细信息

1背景与资料上世纪80和90年代，美国的医院和医生组织投入大量时间和资源进行机构重组，以实现提高组织效率、改善财务绩效水平、机构长期生存、承担社区责任和救治病人的目的。而机构重组的主要趋势是建立“有组织的服务提供体系”，包括建立横向的医院联合体，横向的医生联合体，以及纵向的医院与医生联合体等。到目前为止，在美国开展的大量研究对上述机构重组效果的认识莫衷一是。

关键词：卫生组织美国医院联合体机构重组长期生存医生

MEf promotes stemness in the pathogenesis of gliomas

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中国神经肿瘤杂志 2013年第1期11卷 57-57页

作者： bazzoli E Pulvirenti T Oberstadt MC Perna f Wee B Schultz N Huse JT fomchenko EI Voza f Tabar V Brennan CW DeAngelis LM Nimer SD Holland EC Squatrito M Cancer Biology and Genetics Program Azienda Ospedaliera Universitaria Integrata

High-grade gliomas are aggressive and uniformly fatal tumors,composed of a heterogeneous population of cells that include many with stem-cell-like *** acquisition of stem-like traits might contribute to glioma initiation,growth,and *** we investigated the role of the transcription factor myeloid Elf-1 like factor(MEf,also known as ELf4) in *** found that MEf is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGf-driven glioma mouse *** show that modulation of MEf levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere ***,we identify Sox2 as a direct downstream target of *** together,our studies implicate MEf as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

关键词：脑胶质瘤 MEf 发病机制干性转录因子小鼠模型细胞水平干细胞