MEF promotes stemness in the pathogenesis of gliomas

作     者：Bazzoli E Pulvirenti T Oberstadt MC Perna F Wee B Schultz N Huse JT Fomchenko EI Voza F Tabar V Brennan CW DeAngelis LM Nimer SD Holland EC Squatrito M 

作者机构：Cancer Biology and Genetics ProgramAzienda Ospedaliera Universitaria Integrata 

出 版 物：《中国神经肿瘤杂志》 (Chinese Journal of Neuro-Oncology)

年 卷 期：2013年第11卷第1期

页      面：57-57页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 12[管理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 081201[工学-计算机系统结构] 10[医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：脑胶质瘤 MEF 发病机制 干性 转录因子 小鼠模型 细胞水平 干细胞 

摘      要：High-grade gliomas are aggressive and uniformly fatal tumors,composed of a heterogeneous population of cells that include many with stem-cell-like *** acquisition of stem-like traits might contribute to glioma initiation,growth,and *** we investigated the role of the transcription factor myeloid Elf-1 like factor(MEF,also known as ELF4) in *** found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse *** show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere ***,we identify Sox2 as a direct downstream target of *** together,our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.