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Regenerative Biomaterials 2023年第1期10卷 590-602页

作者： Nima Meyer Daniel V.bax Jochen Beck Ruth E.Cameron Serena M.Best Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Geistlich Pharma AG Product DevelopmentWolhusenSwitzerland

Collagen-based biomaterials are used widely as tissue engineering scaffolds because of their excellent bioactivity and their similarity to the natural *** regeneration of healthy bone tissue requires simultaneous support for both osteoblasts and,where angiogenesis is intended,endothelial *** it is important to tailor carefully the biochemical and structural characteristics of the scaffold to suit the needs of each cell *** work describes for the first time a systematic study to gain insight into the cell type-specific response of primary human osteoblast(hOBs)and human dermal microvascular endothelial cells(HDMECs)to insoluble collagen-based *** behaviour was evaluated on both 2D films and 3D scaffolds,produced using *** collagen was cross-linked at various EDC/NHS concentrations and mono-cultured with hOBs and HDMECs to assess the effect of architectural features and scaffold stabilization on cell *** was observed that 3D scaffolds cross-linked at 30%of the standard conditions in literature offered an optimal combination of mechanical stiffness and cellular response for both cell types,although endothelial cells were more sensitive to the degree of cross-linking than *** features have a time-dependent impact on the cell migration profile,with alignment being the most influential parameter overall.

关键词： angiogenesis collagen scaffolds cell migration EDC/NHS cross-linking

Avoiding artefacts in MicroCT imaging of collagen scaffolds:Effect of phosphotungstic acid(PTA)-staining and crosslink density

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Bioactive Materials 2022年第2期7卷 210-219页

作者： Kyung-Ah Kwon Daniel V.bax Jennifer H.Shepherd Ruth E.Cameron Serena M.Best Cambridge Centre for Medical Materials Department of Materials Science and MetallurgyUniversity of CambridgeCambridgeUnited Kingdom School of Engineering University of LeicesterLeicesterUnited Kingdom

X-ray micro-computed tomography(μ-CT)can be used to provide both qualitative and quantitative information on the structure of three-dimensional(3D)bioactive *** performed in a dry state,μ-CT accurately reflects the structure of collagen-based scaffolds,but imaging in a wet state offers challenges with *** we have used phosphotungstic acid(PTA)as a contrast agent to visualise fully hydrated collagen scaffolds in a physiologically relevant environment.A systematic investigation was performed to understand the effects of PTA on the results of μ-CT imaging by varying sample processing variables such as crosslinking density,hydration medium and staining *** samples in 0.3% PTA solution overnight completely stained the samples and the treatment provided a successful route forμ-CT analysis of crosslinked ***,significant structural artefacts were observed for samples which were either non-crosslinked or had low levels of crosslinking,which had a heterogeneous interior architecture with collapsed pores at the scaffold *** work highlights the importance of optimising the choice of processing and staining conditions to ensure accurate visualisation for hydrated 3D collagen scaffolds in an aqueous medium.

关键词： MicroCT crosslinking qualitative

Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-Daniel Malcor Emma J.Hunter Natalia Davidenko Daniel V.bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

Impact of age on transcatheter aortic valve implantation outcomes：a comparison of patients aged≤ 80 years versus patients ＆gt; 80 years

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Journal of Geriatric Cardiology 2016年第1期13卷 31-36页

作者： Frank van der Kley Philippe J van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen Jeroen J bax Martin J Schalij Victoria Delgado Heart Lung Center Leiden University Medical Center Leiden the Netherlands

ObjectiveTo investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation （TAVI） and compare study results of patients≤ 80 years and patients ＆gt; 80 years *** total of 240 patients treated with TAVI were divided into two groups according to age≤ 80 years （n = 105; 43.8%） and ＆gt; 80 years （n= 135; 56.2%）. The baseline characteristics and the pro-cedural outcomes were compared between these two groups of *** the exception of peripheral artery disease and hypercho-lesterolemia, which were more frequently observed in the older age group, baseline characteristics were comparable between groups. Complica-tion rates did not differ significantly between patients≤ 80 years and patients ＆gt; 80 years. There were no differences in 30-day mortality rates be-tween patients aged≤ 80 years and patients ＆gt; 80 years old （9.5%vs. 7.4%, respectively;P = 0.557）. After a median follow-up of 28 months （in-terquartile range： 16-42 months）, 50 （47.6%） patients aged≤ 80 years died compared to 57 （42%） deaths in the group of patients ＆gt; 80 years old （P= 0.404）.ConclusionThe results of the present single center study showed that age did not significantly impact the outcomes of TAVI.

关键词： Age Survival rate Transcatheter aortic valve implantation

The Semantic Data Dictionary-An Approach for Describing and Annotating Data

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Data Intelligence 2020年第4期2卷 443-486页

作者： Sabbir M.Rashid James P.McCusker Paulo Pinheiro Marcello P.bax Henrique O.Santos Jeanette A.Stingone Amar K.Das Deborah L.McGuinness Tetherless World Constellation Rensselaer Polytechnic InstituteTroy NY 12180USA School of Information Science Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil Mailman School of Public Health Columbia UniversityNew York NY 10032USA IBM Research Cambridge MA 02142USA

It is common practice for data providers to include text descriptions for each column when publishing data sets in the form of data *** these documents are useful in helping an end-user properly interpret the meaning of a column in a data set,existing data dictionaries typically are not machine-readable and do not follow a common specification *** introduce the Semantic Data Dictionary,a specification that formalizes the assignment of a semantic representation of data,enabling standardization and harmonization across diverse data *** this paper,we present our Semantic Data Dictionary work in the context of our work with biomedical data;however,the approach can and has been used in a wide range of *** rendition of data in this form helps promote improved discovery,interoperability,reuse,traceability,and *** present the associated research and describe how the Semantic Data Dictionary can help address existing limitations in the related *** discuss our approach,present an example by annotating portions of the publicly available National Health and Nutrition Examination Survey data set,present modeling challenges,and describe the use of this approach in sponsored research,including our work on a large National Institutes of Health(NIH)-funded exposure and health data portal and in the RPI-IBM collaborative Health Empowerment by Analytics,Learning,and Semantics project.

关键词： Semantic Data Dictionary Dictionary mapping Codebook Knowledge modeling Data integration Data dictionary Mapping language Metadata standard Semantic Web Semantic ETL FAIR Data

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登山客和下潜族武装起来

中国国家旅游 2012年第1期 176-177页

作者： bax

在这个数码泛滥的时代，“登山客”和“下潜族”这两大旅途派别，将如何选择既轻盈便捷，又适合自己行程的特色摄影装备？

关键词：数码相机单反相机镜头闪光灯

PEPE HEYKOOP:旧物翻新从零开始

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设计 2012年第11期25卷 118-123页

作者： Yxiang Annemarijne bax

荷兰埃园霍芬设计学院（DESIGN ACADEMY EINDHOVEN）出7很多人才，比如当年还没毕业就出名的VIAARTE NBAAS，那一系列烧的黑呼呼的家具，让人摸不清头脑j却也迅速让他成为画廊和拍卖行的明星。现在同门师弟PEPEHEYKOOP同样迅速崛起，但...

荷兰埃园霍芬设计学院（DESIGN ACADEMY EINDHOVEN）出7很多人才，比如当年还没毕业就出名的VIAARTE NBAAS，那一系列烧的黑呼呼的家具，让人摸不清头脑j却也迅速让他成为画廊和拍卖行的明星。现在同门师弟PEPEHEYKOOP同样迅速崛起，但他可不是“破坏者”，而是介“拯救家”。

关键词：翻新设计学院拍卖行

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萨尔瓦多阳光豪宅

设计 2014年第5期27卷 50-51页

作者： Jacob Jason bax

这座住宅位于圣萨尔瓦多的一座小山上，萨尔瓦多是中美洲面积最小的国家。业主注重环保，并期望这个建筑有“夏天的感觉”，同时设计兼具现代先进性。落成后的住宅顶部采用了多切面设计，充分吸收自然光源，从主卧室里向外望去风景一览...

这座住宅位于圣萨尔瓦多的一座小山上，萨尔瓦多是中美洲面积最小的国家。业主注重环保，并期望这个建筑有“夏天的感觉”，同时设计兼具现代先进性。落成后的住宅顶部采用了多切面设计，充分吸收自然光源，从主卧室里向外望去风景一览无余，是一栋兼具美感和环保价值的豪宅。该住宅以中央的娱乐区为中心布置了一系列的楼层。

关键词：萨尔瓦多豪宅 La 阳光环保价值自然光源住宅中美洲

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Characterization of a Liquid Crystal Stabilized Pharmaceutical Oil-in-Water Emulsion Optimized for Skin Delivery

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 207-217页

作者： Melinda J. Sutton David W. Osborne Kevin Dahl Victoria bax G. Alan Schick Department of Chemistry Missouri State University Springfield MO USA Dow Development Institute Petaluma CA USA KBI Biopharma Boulder CO USA

A moisturizing cream containing 25 wt% of an organic solvent, diethylene glycol monoethyl ether (DEGEE), is observed to be stabilized by an emulsifying wax blend of cetearyl alcohol, dicetyl phosphate, and ceteth-10 phosphate (tradename Crodafos CES). Polarized light microscopy indicates that the Crodafos CES helps to produce a liquid-crystal stabilized oil-in-water emulsion, which is physically stable for months under accelerated aging conditions and chemically stable over the full topical pH range of 3.5 to 9. Emulsion globule size in the cream is observed to be dependent on the degree of emulsifying wax neutralization, with the globule size decreasing with increasing cream pH. The superior solubilizing properties of DEGEE combined with the full pH range and liquid-crystal stabilizing properties of the Crodafos CES give this formulation the potential for a wide range of applications in the topical delivery of active pharmaceutical ingredients.

关键词： Pharmaceutical Emulsion Skin Delivery Liquid Crystal Stabilized Emulsion Polarized Light Microscopy Topical Formulation

THE PROMOTER ACTION OF LANTHANA ON METHANOL DECOMPOSITION ON Pd-La2O3/SiO2 CATALYSTS AND THE INTERACTION BETWEEN COADSORBED SPECIES STUDIED BY TPD

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Journal of Energy Chemistry 1992年第2期 93-105页

作者： Xu,Yi-De ZHU,Ke-Ming HUANG,Jia-Sheng LIN,Zhi-Ying GUO,Xie-Xian State key Ladoratory of Catalysis,Dalian Instate of Chemical Physics,Academia Sinica,P.O.bax 110,Dalian,Liaoning 116023

TPD of methanol was used to study the promoter effect of lanthana on Pd-La2O3/SiO2catalysts and the coadspecies *** lanthana additive resulted in an increase in adsorp-tion of methanol and mobility of the adsorbed methanol on the surface,and,in turn,facilitated thedesorption of the CO produced and inhibited CO disproportionation to *** TPD spectra followingadsorption of D2O and CH3OH,and/or CH3OH and13CH3OH in sequence on Pd-La2O3/SiO2catalystsdemonstrated the presence of three different adsorption states,i.e.,physical,dissociative,and strongdissociative adsorption states on the surface.A repulsive interaction of CO and13CH3OH coadspecies onthe catalysts was postulated to account for the facile CO desorption and inhibition of CO dispropor-tionation.

关键词： Pd CO TPD THE PROMOTER ACTION OF LANTHANA ON METHANOL DECOMPOSITION ON Pd-La2O3/SiO2 CATALYSTS AND THE INTERACTION BETWEEN COADSORBED SPECIES STUDIED BY TPD SiO La ACTION