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Chirality enables thermal magnon transistors

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 161-166页

作者： Tao Yu Chengyuan Cai Gerrit E.W.bauer School of Physics Huazhong University of Science and TechnologyWuhan 430074China .WPI-AIMR and Institute for Materials Research and SCIS Tohoku UniversitySendai 980-8577Japan kavli Institute for Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China

We report a theory of thermal spin pumping into proximity magnets under a transverse-bias-driven heat flow of magnons in magnetic films when the dipolar coupling to the magnetic gate is tuned to be “chiral”. While there is no rectification of the magnon current in the film, we predict that chirality diverts a large percentage(50% for perfect chirality) of it into the gate. This transverse thermal spin pumping effect can be controlled by rotating the film magnetization and may help manage the heat flow in future magnonic circuits.

关键词： magnon chirality quantum transport transistor

Experienced Involvement (ExIn) in Social-Psychiatric Care of Germany-Challenges and Chances

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Journal of Sociology Study 2024年第3期14卷 129-142页

作者： Susanne Iris bauer Fulda University of Applied Sciences FuldaGermany

This study explores the integration of Experienced Involvement(ExIn)in social-psychiatric care in Germany,emphasizing both the challenges and opportunities it presents.The European Leonardo da Vinci Project(2005-2007)established a curriculum for ExIn,promoting participatory structures in psychiatric services.While peer support is well-established in other European countries,Germany’s experience is still developing.This research uses a mixed methods design,combining quantitative surveys and qualitative interviews,to investigate the professional experiences of ExIn recovery companions and team colleagues in German clinics and support services.The findings reveal numerous benefits:for social-psychiatric services,ExIn enhances service quality,inclusivity,and accessibility;for team colleagues,it fosters reflexivity,hope,and trust,and improves self-care;for service users,it provides empowerment,easy access to support,trust,and hope,and offers credible role models.Despite these benefits,challenges such as stigmatization,lack of recognition,and financial constraints remain and require to be addressed.The study highlights the need and provides implications for a dedicated and inclusive approach to effectively implementing ExIn,ultimately enriching psychiatric care through experiential knowledge and reducing prejudice within mental health services.

关键词： peer involvement professionalized peer support social psychiatry inclusion education of social works

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis klaus Eder karsten krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular disease.Since pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early interventions.There is evidence that regulatory T cells(Tregs)are involved in the development of atherosclerosis.Therefore,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated signatures.Methods:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking medication.Ultrasound of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were performed.Additionally,tests were conducted to assess blood lipids and determine glucose levels.Immunophenotyping of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow cytometry.Participants were categorized according to atherosclerotic plaque status.Linear and logistic regression models were used to analyze associations between parameters.Results:SAP was detected in a total of 29 participants.The participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and mTregs(OR=1.05(95%CI:1.021.10))as independent

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten komila Rasuleva Md Saimon Mia Aaron bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease stages.Innovative and selective treatments are urgently needed,since current therapies have limited efficacy and significant side effects.Through proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor cells.Our findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular vesicles.These amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor cells.Both in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC cells.Mechanistically,we also identified XRN1 as a potential target for these amino acids.The high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal tissues.Furthermore,we found this treatment approach is easy-to-administer and with sustained tumor-killing effects.Together,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra C.Mota J.bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IkERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering applications.However,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell fate.Grafting of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface density.Here,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different ratios.Stable porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL 5k.As a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was assessed.After two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated peptide.In addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface density.Taken together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material interface.Moreover,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(modified)polymers.Furthermore,the use of alkyne-a

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

传统与现代的一场偶遇加拿大Muskoka别墅

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室内设计与装修 2024年第5期 136-141页

作者： Reigo & bauer Reigo&bauer 加拿大

Muskoka别墅坐落在安大略省风景秀丽的湖区,距离加拿大最大城市多伦多北部仅2小时车程,是一座拥有近200年历史的典型当地风格住宅。这座湖边别墅曾是一个庞大度假村的一部分,后来逐渐被拆除,如今被现任屋主作为夏季度假屋使用,并在过去... 详细信息

Muskoka别墅坐落在安大略省风景秀丽的湖区,距离加拿大最大城市多伦多北部仅2小时车程,是一座拥有近200年历史的典型当地风格住宅。这座湖边别墅曾是一个庞大度假村的一部分,后来逐渐被拆除,如今被现任屋主作为夏季度假屋使用,并在过去几十年里进行了不断的增建和更新。此次的设计工作,屋主邀请了Reigo&bauer设计工作室,这已经是他们第3次合作。屋主的诉求是尽可能保留和恢复别墅的原始魅力和历史底蕴,同时赋予空间当代的审美取向。

关键词：设计工作室安大略省历史底蕴别墅传统与现代加拿大度假村多伦多

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以较低成本改善纱线质量的变形加工系统

合成纤维工业 1992年第2期15卷 18-23页

作者： k.bauer G.W.klawonn 赵庆章

研究了包括原料运送在内的变形纱生产工艺,讨论了变形纱加工过程中连续质量校制的几种构想,着重介绍了巴马格公司新近开发成功的UNITENS纱线张力检测系统、CD83型自动落筒机及AGV运输系统。利用UNITENS质量控制系统,人们不仅可以对每一... 详细信息

研究了包括原料运送在内的变形纱生产工艺,讨论了变形纱加工过程中连续质量校制的几种构想,着重介绍了巴马格公司新近开发成功的UNITENS纱线张力检测系统、CD83型自动落筒机及AGV运输系统。利用UNITENS质量控制系统,人们不仅可以对每一个卷装实现真正的100%的检测,而且可以借助计算机系统了解到变形纱降等的各种原因。从而实现以较低的成本改善变形纱质量的目的。

关键词：合成纤维质量拉伸变形机变形纱

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制备洋茉莉醛的新方法

香料与香精 1982年第4期 49-55页

作者： R.G.Mlleken k.A.bauer 陈丽华

工业合成洋茉莉醛的起始原料一般是天然的黄樟素。因为黄樟素仍然价格合理,所以不需要全合成的洋茉莉醛。但由于最近出现了大规模生产邻苯二酚的工艺,邻苯二酚易转为1,2-甲叉二氧苯（1）,因而大大改变了目前这种情况,全合成洋茉莉醛（4... 详细信息

工业合成洋茉莉醛的起始原料一般是天然的黄樟素。因为黄樟素仍然价格合理,所以不需要全合成的洋茉莉醛。但由于最近出现了大规模生产邻苯二酚的工艺,邻苯二酚易转为1,2-甲叉二氧苯（1）,因而大大改变了目前这种情况,全合成洋茉莉醛（4）现在在经济上是可行的。

关键词：洋茉莉醛全合成邻苯二酚甲叉苯酚甲撑异黄樟素苯乙酸苯乙醇酸扁桃酸

Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade Pereira Lucas Moraes Berneira Claudio Martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares kütter Janice Luehring Giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage