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Intrapartum application of the continuous glucose monitoring system in pregnancies complicated with diabetes: A review and feasibility study

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World Journal of Obstetrics and Gynecology 2013年第3期2卷 42-46页

作者： Vicentia C Harizopoulou Panagiotis Tsiartas Dimitrios G Goulis Dimitrios Vavilis Grigorios Grimbizis Theodoros D Theodoridis basil C Tarlatzis Unit for Human Reproduction First Department of Obstetrics and Gynaecology Papageorgiou General HospitalRing Road Nea Efkarpia 54603 Thessaloniki Greece Department of Obstetrics and Gynecology Sahlgrenska University Hospital 41685 G?teborg Sweden

Intrapartum maternal normoglycemia seems to play an important role in the prevention of adverse perinatal, maternal and neonatal outcomes. Several glucose monitoring protocols have been developed, aiming to achieve a tight glucose monitoring and control. Depending on the type of diabetes and the optimal or suboptimal glycemic control, the treatment options include fasting status of the parturient, frequent monitoring of capillary blood glucose, intravenous dextrose infusion and subcutaneous or intravenous use of insulin. Continuous glucose monitoring system(CGMS) is a relatively new technology that measures interstitial glucose at very short time intervals over a specifi c period of time. The resulting profi le provides a more comprehensive measure of glycemic excursions than intermittent home blood glucose monitoring. Results of studies applying the CGMS technology in patients with or without diabetes mellitus(DM) have revealed new insights in glucose metabolism. Moreover, CGMS have a potential role in the improvement of glycemic control during pregnancy and labor, which may lead to a decrease in perinatal morbidity and mortality. In conclusion, the use of CGMS, with its important technical advantages compared to the conventional way of monitoring, may lead into a more etiological intrapartum management of both the mother and her fetus/infant in pregnancies complicated with DM.

关键词： Diabetes mellitus Pregnancy Intrapartum management Glucose monitoring protocols Continu-ous glucose monitoring system

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Diagnostic Performance of Serial bedside Capillary Lactate, Hemoglobin, and Shock Index for Severe Postpartum

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Advances in Reproductive Sciences 2021年第4期9卷 189-198页

作者： Roberto Arturo Castillo-Reyther Idelia Natalie Plata-Alcocer Salvador De la Maza-Labastida Venance basil Kway Ma. del Pilar Fonseca-Leal Department of Obstetrics and Gynecology Hospital Central Dr. Ignacio Morones Prieto San Luis Potosi Mexico Research and Clinical Postgraduate Department of the Faculty of Medicine Universidad Autonoma de San Luis Potosi Mexico

Objective: To assess the diagnostic capacity of bedside capillary lactate (CLact), capillary Haemoglobin (CHb), and shock index (SI) for severe postpartum haemorrhage (SPPH > 2000 ml) at diagnosis, 15 minutes and 30 minutes later. Method: A cohort study was carried out in a reference hospital in San Luis Potosi, Mexico from February 2020 to March 2021, and included sixty women in vaginal labor or c-section who presented PPH (≥500 ml in labor or ≥1000 ml in c-section) measured by the gravimetric method. CLact, SI, and CHb concentrations were analyzed at diagnosis of PPH, 15 minutes, and 30 minutes. Patients who presented total blood loss of >2000 ml were considered SPPH. A T-test or Wilcox test was performed to compare the groups of non-severe and severe. Sensitivity, specificity, and performance were calculated by A Receiver Operating Curve. Results: A CLact measurement at 30 minutes was significantly different between the non-severe and severe groups (4.0 + 1.9 vs 4.8 + 1.15 P-value 0.001, with an optimal cut point of 4.3 mmol/dl at AUC 0.75, sensitivity 0.85, and specificity of 0.62. With a cut-point of 1.17, an AUC of 0.76, sensitivity of 0.43, and specificity of 0.98, SI at diagnosis was significantly different between the non-severe and severe groups (0.70 + 0.20 vs. 0.90 + 0.38 P-value 0.0228). Conclusion: SI is an early sign of SPPH;CLact can significantly identify SPPH after 30 minutes.

关键词： Capillary Haemoglobin Lactate Obstetric Haemorrhage Shock Index

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因绝育或堕胎失败导致的意外怀孕判例

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私法研究 2012年第1期12卷 375-387页

作者：蒋言 basil S.Markesinis Hannes Unberath 中南财经政法大学法学院

目次一、案件事实二、判决理由三、本案注解四、附件判例10联邦最高法院（第六审判庭）1995年3月28日BGHZ 129,178=NJW 1995,1609[1]一、案件事实原告于1979年9月进行堕胎手术失败,导致其在1980年4月5日生下孩子E,因而向被告提出赔偿请... 详细信息

目次一、案件事实二、判决理由三、本案注解四、附件判例10联邦最高法院（第六审判庭）1995年3月28日BGHZ 129,178=NJW 1995,1609[1]一、案件事实原告于1979年9月进行堕胎手术失败,导致其在1980年4月5日生下孩子E,因而向被告提出赔偿请求。该堕胎手术是由被告医生依法定紧急事由所做[1976年5月18日颁布的《刑法典修正案（十五）》修订后的《刑法典》第218条a第2款第3项（以下称旧《刑法》第218条a）]。原告认为被告在治疗过程中存在过失。

关键词：绝育堕胎怀孕被告刑法典联邦最高法院治疗过程原告诉讼请求手术失败赔偿请求修正案医生修订审判判例过失抚养费用颁布

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Nutritional and Anti-Nutritional Quantification Assessment of <i>Cymbopopgon citratus</i>Leaf

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Pharmacology & Pharmacy 2015年第8期6卷 401-410页

作者： Anayo Joseph Uraku Stanley Chukwudozie Onuoha Nzube Edwin Nkiru Ezeani Moses Eji Ogbanshi Chukwu Ezeali basil Uchechukwu Nwali Mathias Chukwuemeka Ominyi Department of Biochemistry Ebonyi State University Abakaliki Nigeria Department of Biotechnology Ebonyi State University Abakaliki Nigeria

The leaf-extract of Cymbopogon citratus was evaluated for nutritional and anti-nutritional compositions. The results revealed that the plant leaves contained appreciable amounts of phyto-chemicals (alkaloids, glucosides, phenols, saponins, flavonoids and tannins), proximate compositions (proteins, carbohydrates, fats, crude fibre, ash and moisture), vitamins (A, C, E, B1, B2 and B9) and trace elements (Fe, Zn, Mn, Cu, Na, K, Ca and Co) in varying degrees. These chemical compositions obtained may be responsible for the nutritional and therapeutic uses. The proximate, vitamin and mineral compositions obtained suggested that the leaves may serve as cheap sources of vitamin A, C, E, B1, B2 and B9 as well as other macro- and micro-nutrients, and could be incorporated into human diets to meet-up with their recommended daily dietary allowances. The content of flavonoids, vitamin A, C and E in the leaf extract also suggests possible anti-oxidant effects of the plant leaves.

关键词： Cymbopogon citratus Phytochemicals Proximate and Chemical Compositions

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Evaluation of Peripheral Neuropathy in Diabetic Adults with and without Foot Ulcers in an African Population

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Journal of Biosciences and Medicines 2018年第12期6卷 71-78页

作者： Osita Ede Gabriel O. Eyichukwu Kenechi A. Madu Iheuko S. Ogbonnaya Kelechukwu A. Okoro Chinonso basil-Nwachuku Kelechi A. Nwokocha Department of Orthopaedics Plastic and Reconstructive Surgery National Orthopaedic Hospital Enugu Nigeria

Background: Foot ulcers frequently precede lower extremity amputations (LEA) in diabetic subjects. Peripheral neuropathy (PN) is a strong risk factor for diabetic foot ulceration. Majority of diabetic patients with PN are asymptomatic;hence foot ulceration may be the first clinical presentation. Early detection of PN can forestall the development of foot ulcers through active preventive strategies. Few studies have been done to assess PN in diabetic individuals in Africa. The study aims to evaluate the incidence and risk factors for PN in diabetic adults with and without foot ulcers in an indigenous African population. Method: This cross-sectional study involved 90 diabetic adults, 45 with foot ulcers and 45 without foot ulcers. Assessment of PN was done with the Michigan Neuropathy Screening Instrument (MNSI), the 10 g Semmes-Weinstein monofilament (SWM) and the 128-Hz vibrating tuning fork (VTF). Demographic data were collected by questionnaire. Associations between PN and risk factors such as age, alcohol consumption, duration of diabetes, cigarette smoking, BMI, height and sex were also investigated. Results: There were 59 males (65.6%) and 31 females (34.4%) in the study. The mean age of the subjects with foot ulcers was 59.62 years (SD = 6.47), while those without ulcers was 57.47 years (SD = 6.94). Forty-two subjects (93.33%) with foot ulcers have PN using the MNSI, while 33 subjects without foot ulcers (73.33%) have PN. Both the SWM and the VTF showed a high positive correlation with themselves and with the MNSI. Advancing age, duration of diabetes, alcohol intake, hyperglycaemia and cigarette smoking showed a significant association with peripheral neuropathy, while BMI, height and sex did not. Conclusion: The incidence of PN is quite high in diabetic adults in Africa. This calls for early screening and aggressive control of risk factors to prevent the development of diabetic foot ulceration.

关键词： Peripheral Neuropathy African Diabetic Adults Foot Ulcers

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Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

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Journal of Coastal Life Medicine 2015年第9期 728-732页

作者： Akuodor Godwin Christian Udia Pius Monday Akpan Joseph Linus Ezeokpo basil Chukwuma Okezie Ogwuegbu Alozie Ghasi Samuel Ikenna Nwadike Kenneth Ikechukwu Department of Pharmacology and Therapeutics Faculty of Clinical MedicineEbonyi State UniversityAbakalikiNigeria Department of Pharmacology College of Medical SciencesUniversity of CalabarCross River StateNigeria Department of Chemical Pathology Federal Teaching HospitalAbakalikiNigeria Department of Pharmacology and Therapeutics College of MedicineUniversity of NigeriaEnugu CampusNigeria

Objective:To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in ***:Ethanol-,acetylsalicylic acid-,histamine-and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf *** toxicity studies were also carried ***:The ethanolic leaf extract significantly(P<0.05)reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/*** LD_(50)values obtained were greater than 5000 mg/kg in ***:The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.

关键词： Byrsocarpus coccineus Leaves Ethanol extract Antiulcer Rats

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中国棉铃虫核型多角体病毒几丁质酶基因的定位与克隆

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中国病毒学 1998年第2期13卷 139-143页

作者：彭辉银李星张双民 basil M.Arif 陈新文胡志红中国科学院武汉病毒研究所

以α３２ＰｄＡＴＰ标记含ＣｆＭＮＰＶ几丁质酶基因的重组质粒为探针，在６８℃条件下对棉铃虫单粒包埋核型多角体病毒（ＨａＳＮＰＶ）进行Ｓｏｕｔｈｅｒｎ杂交，将ＨａＳＮＰＶ的几丁质酶基因分别定位在ＢａｍＨＩＥ、ＢｇｌⅡ... 详细信息

以α３２ＰｄＡＴＰ标记含ＣｆＭＮＰＶ几丁质酶基因的重组质粒为探针，在６８℃条件下对棉铃虫单粒包埋核型多角体病毒（ＨａＳＮＰＶ）进行Ｓｏｕｔｈｅｒｎ杂交，将ＨａＳＮＰＶ的几丁质酶基因分别定位在ＢａｍＨＩＥ、ＢｇｌⅡＥ、ＥｃｏＲＩＧ、ＨｉｎｄⅢＦ、ＸｂａＩＨ、ＢａｍＨＩ＋ＨｉｎｄＩＩＭ和ＢａｍＨＩ＋ＸｂａＩＨ，并以ｐＴＺ１９Ｒ为载体获得了ＸｂａＩＨ片段克隆。

关键词：棉铃虫核型多角体病毒几丁质酶基因定位

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Science:研究首次从结构上揭示细菌细胞器的结构和组装过程

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现代生物医学进展 2017年第27期17卷 I0001-I0001页

作者： Markus Sutter basil Greber Clement Aussignargues Cheryl A. Kerfeld,* Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA.

在一项新的研究中，来自美国能源部劳伦斯伯克利国家实验室和密歇根州立大学等研究机构的研究人员提供有史以来一种完整的被称作细菌微区室（bacterialmicrocompartments，BMC）的细胞器的最为清晰的图片，从而揭示出这种细胞器的蛋白... 详细信息

在一项新的研究中，来自美国能源部劳伦斯伯克利国家实验室和密歇根州立大学等研究机构的研究人员提供有史以来一种完整的被称作细菌微区室（bacterialmicrocompartments，BMC）的细胞器的最为清晰的图片，从而揭示出这种细胞器的蛋白外壳（proteinshell）在原子水平分辨率下的结构和组装过程。他们研究的这种细胞器的蛋白外壳来自一种生活在海洋中的粘细菌，

关键词：组装过程细胞器粘细菌结构国家实验室美国能源部水平分辨率研究人员

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Early on Set Presbyacusis in Gwagwalada Area Council of Federal Capital Territory, Abuja

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第3期10卷 238-249页

作者： David Femi Folorunso Enoch Auta Dahilo Ibeneche Onyemuchechi Gbujie Fredrick M. Damtong Oladeji Raheem Quadri basil E. Nwankwo Titus Sunday Ibekwe Onyekwere George Nwaorgu Department of ENT/Head & Neck Surgery University of Abuja Teaching Hospital Gwagwalada-Abuja Nigeria Department of ENT Federal Teaching Hospital Gombe Gombe State Nigeria Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Awka Anambra State Nigeria Department of Otorhinolaryngology University College Hospital Ibadan & College of Medicine University of Ibadan Oyo State Nigeria

Background: Presbyacusis is a major cause of hearing loss among seniors. The condition attracts attention following the prediction of World Health Organization that elderly population is expected to hit 1.2 billion by 2025 out of which more than 500 million of them will suffer from sensorineural hearing loss(SHL) worldwide. The studies have shown that this begins to reflect on audiograms as from the third decade, mainly in the high frequencies. Aim/objective: This study evaluated the early on-set presbyacusis at Gwagwalada Area Council of the Federal capital territory-Abuja. Method: It was a multi-stage sampling, prospective, cross-sectional study done in FCT, Abuja. Participants from age 20 years and above were recruited into the study after signing informed consent. The presumed risk factors as highlighted in the questionnaire were screened out. Results: Two hundred and two participants were recruited into the study, out of which twelve were excluded from the analysis on account of various exclusion criteria. The age range of the participants was 20 to 79 years, with an average age of 54.8 ± 5.6 years. One hundred and fourteen (60.0%) males and seventy-six (40.0%) females participated in the study. The commonly reported associated symptom was tinnitus. About 32.0% of the participants had moderate sensorineural hearing loss. However, the prevalence of presbyacusis was 28.2% for age below 65 years and 78.8% for 65 years and above. The cumulative prevalence was 54.2%. Conclusion: The study has shown that presbyacusis occur as early as the third decade of life, possibly subclinical before age 65 years. The prevalence was 28.2% before age 65 years and 78.8% from age 65 years, there was a steady increase in percentage of participants with SNHL from age 20 years, and a significant sudden increase from 65 years was observed with a sloping tracing at high frequency.

关键词： Presbyacusis Age-Related Hearing Loss Young Adults Sensorineural Hearing Loss and Pure Tone Audiometry

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Analgesic,anti-inflammatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia

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Journal of Coastal Life Medicine 2016年第3期4卷 225-230页

作者： Godwin Christian Akuodor Augustine Dick Essien Joseph Linus Akpan Kingsley Chimsorom Chilaka Nkemjika Jane Ikodiya Uwaezuoke Kenneth Ikechukwu Nwadike Ndubuisi Nwobodo Nwobodo basil Chukwuma Ezeokpo Department of Pharmacology and Therapeutics Faculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of Pharmacology College of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and Therapeutics College of Health SciencesNnamdi Azikiwe UniversityAwkaNigeria Department of Pharmacology and Therapeutics College of MedicineUniversity of NigeriaEnugu CampusNigeria Department of Internal Medicine Faculty of MedicineEbonyi State UniversityAbakalikiNigeria

Objective:To investigate the the analgesic,anti-inflammatory and antipyretic activities of the methanolic leaf extract of Maerua crassifolia in mice and ***:Acetic acid-induced writhing and tail immersion methods were used to assess analgesic activity,while xylene and carrageenan-induced paw oedema methods were used to evaluate the anti-inflammatory effect of the leaf *** and amphetamine-induced pyrexia were used to investigate the antipyretic *** phytochemical analysis and oral acute toxicity of the methanolic leaf extract of Maerua crassifolia were also ***:The leaf extract(100,200,and 400 mg/kg)showed a dose dependent and significant(P<0.05)inhibition of pain in acetic acid-induced writhing and tail immersion *** extract also produced significant(P<0.05)anti-inflammatory activity in both paradigms.A significant(P<0.05)reduction in hyperpyrexia was also observed with the leaf *** phytochemical screening revealed the presence of alkaloids,flavonoids,terpenoids,tannins,steroids,resins,saponins and cardiac *** oral median lethal dose of the leaf extract was estimated to be greater than 5000 mg/kg in ***:The findings confirmed its ethnomedical use in the treatment of pains and feverish conditions.

关键词： Maerua crassifolia Leaf Analgesia Inflammation Pyrexia Rodents

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