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Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases

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Neural Regeneration Research 2018年第11期13卷 1887-1889页

作者： basant k.puri Gerwyn Morris Department of Medicine Imperial College LondonHammersmith Hospital IMPACT Strategic Research Centre School of MedicineDeakin University

In 1945,Porter et *** an electon microscopy study of cultured chick fibroblasts in which they observed：＇a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of＂vesicles＂＇（Porter et al.,1945）.This constituted the first published observation of the endoplasmic reticulum（ER）and,while it was not evident at that time,this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.

关键词： Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases UPR NAC

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Estimates for Lyme borreliosis infections based on models using sentinel canine and human seroprevalence data

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Infectious Disease Modelling 2020年第1期5卷 871-888页

作者： Michael J.Cook basant k.puri Vis a Vis Symposiums Bury St EdmundsUK CAR CambridgeUK

Two models were developed to estimate Lyme borreliosis(LB)*** was based on the seroprevalence of Borrelia infections in human *** model used corrections for false negative and false positive results from published test sensitivity and specificity measures.A second model based on Borrelia infections in sentinel dogs was used to quantify the prevalence of Lyme disease Borrelia infections in humans;the reference baseline for this model was human and canine infections in Germany.A comparison of the two models is shown and differences *** relationships between incidence,prevalence and total infection burden for LB were derived from published data and these were used in both models to calculate annual incidence,prevalence and total LB *** modelling was conservative and based on medical insurance records coded for erythema *** model growth rates were used in place of the commonly adopted exponential *** mean of the two models was used to create estimates for various countries and *** from the analyses for LB estimated for 2018 include:incidence e USA 473,000/year,Germany 471,000/year,France 434,000/year and Uk 132,000/year;prevalence e USA 2.4 million,Germany 2.4 million,France 2.2 million and Uk 667,000;total infections e USA 10.1 million,Germany 10.0 million,France 9.3 million and Uk 2.8 *** for the world for 2018 are:incidence 12.3 million/year;prevalence 62.1 million;and total infection burden 262.0 *** figures are far higher than officially published data and reflect not only the underestimation of diagnosed cases,which is acknowledged by health agencies,but also undiagnosed and misdiagnosed cases.

关键词： Lyme disease Borreliosis Linear regression models Seropositive Companion animals Sentinel animals

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Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds

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World Journal of Psychiatry 2018年第1期8卷 20-26页

作者： basant k.puri Mary Egan Fintan Wallis Philip Jakeman Department of Medicine Hammersmith HospitalImperial College London Department of Radiology University Hospital Limerick Centre for Interventions in Infection Inflammation and Immunity University of Limerick

AIM To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds(Cho).METHODS Two consecutive scans were carried out in six healthy resting subjects at a magnetic field strength of 1.5 T. On each occasion, neurospectroscopy data were collected from 64 voxels using the same 2 D chemical shift imaging(CSI) sequence. The data were analyzed in the same way, using the same software, to obtain the values for each voxel of the ratio of Cho to creatine. The Wilcoxon related-samples signed-rank test, coefficient of variation(CV), repeatability coefficient(RC), and intraclass correlation coefficient(ICC) were used to assess the repeatability. RESULTS The CV ranged from 2.75% to 33.99%, while the minimum RC was 5.68%. There was excellent reproducibility, as judged by significant ICC values, in 26 voxels. Just three voxels showed significant differences according to the Wilcoxon related-samples signed-rank test. CONCLUSION It is therefore concluded that when CSI multivoxel proton neurospectroscopy is used to measure cerebral choline-containing compounds at 1.5 T, the reproducibility is highly acceptable.

关键词： Cerebral metabolites Chemical shift imaging Choline Neurospectroscopy Neuropsychiatric disorders

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Respiratory modulation of cardiac vagal tone in Lyme disease

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World Journal of Cardiology 2014年第6期6卷 502-506页

作者： basant k.puri Mussadiq Shah Jean A Monro Michele C kingston Peter OO Julu Department of Medicine Imperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Imaging Directorate Imperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Department of Neuroscience Breakspear Medical GroupHertfordshire HouseHemel HempsteadHertfordshire HP2 4FDUnited Kingdom Department of Medicine Imperial College LondonLondon SW7 2AZUnited Kingdom National Rett Center SE-832 23 FrsnSweden

AIM: To conduct the first systematic test of the hypothesis that modulation of cardiac vagal tone is impaired in Lyme ***: The response of cardiac vagal tone to respiratory modulation was measured in 18 serologically positive Lyme disease patients and in 18 ***: The two groups were matched in respect of age,sex,body mass,mean arterial blood pressure,mean resting heart rate and mean resting cardiac vagal tone. The mean maximum cardiac vagal tone during deep breathing in the Lyme disease patients [11.2(standard error 1.3)] was lower than in the matched controls [16.5(standard error 1.7); P = 0.02].CONCLUSION: Respiratory modulation of cardiac vagal tone is impaired in Lyme disease,which suggests that Lyme disease may directly affect the vagus nerve or the brainstem.

关键词： Cardiac vagal tone Lyme disease

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