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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de graaf Stef A.H.jansen Sandra M.C.Schoenmakers bas van genabeek Marle E.j.Vleugels Bart W.L.van den Bersselaar E.W.Meijer ghislaine Vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： j.A.Carter M.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.g.Sibeck M.Connors T.Yeoman X.Tan M.g.g.T.Taylor K.McWilliams j.gjerloev R.Barnes D.D.Billet g.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-j.Hu M.K.james L.juusola K.Kauristie E.A.Kronberg M.Lester j.Manuel j.Matzka I.McCrea Y.Miyoshi j.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang j.Weygand j.Wild j.Yan j.Zhang Q.-H.Zhang Planetary Sciences group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada gFZ german Research Centre for geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the ground-based and Additional Science Working group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease

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World journal of gastroenterology 2005年第38期11卷 6003-6008页

作者： David g Cox j Bart A Crusius Petra HM Peeters H bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian International Agency for Research on Cancer Laboratory of Immunogenetics julius Center for Health Sciences and Primary Care Department of Epidemiology Laboratory of Immunogenetics and Department of gastroenterology

AIM： Prostaglandin g/H synthase 2 （PTgS2 or COX2） is one of the key factors in the cellular response to inflammation. PTgS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases （IBD）. In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTgS2, may activate IBD and aggravate the symptoms. We aimed at examining genetic variants of PTgS2 that may be risk factors for IBD. METHODS： We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTg52 gene. Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5＇ exonuclease assay （TaqMan）. New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography, followed by fluorescent sequencing. RESULTS： Allele 5209g was weakly associated with Crohn＇s disease （odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57）, and allele 8473T with ulcerativecolitis （OR 1.50, 95%CI 1.00-2.27）. The haplotype including both alleles showed a strong association with IBD （OR 13.15, 95%CI 3.17-116.15）. This haplotype, while rare （-0.3%） in the general population, is found more frequently in patients （3.5%）. CONCLUSION： Our data suggest that this haplotype of PTgS2 contributes to the susceptibility of IBD.

关键词： Inflammatory bowel disease Prostaglandin g/H synthase Cyclooxygenase SNP Haplotype

Triassic (Anisian and Rhaetian) palaeomagnetic poles from the germanic basin (Winterswijk, the Netherlands)

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journal of Palaeogeography 2019年第4期8卷 393-407页

作者： Lars P.P.van Hinsbergen Douwe j.j.van Hinsbergen Cor g.Langereis Mark j.Dekkers bas Zanderink Martijn H.L.Deenen Fioretti College Sportlaan 32161 VA Lissethe Netherlands Department of Earth Sciences Utrecht UniversityPrincetonlaan 8A3584 CB Utrechtthe Netherlands Twents Carmel College De Thij Thijlaan 307576 ZB Oldenzaalthe Netherlands.

In this paper,we provide two new Triassic palaeomagnetic poles from Winterswijk,the Netherlands,in the stable interior of the Eurasian *** were respectively collected from the Anisian(~247–242 Ma)red marly limestones of the sedimentary transition of the Buntsandstein Formation to the dark grey limestones of the basal Muschelkalk Formation,and from the Rhaetian(~208–201 Ma)shallow marine claystones that unconformably overlie the Muschelkalk *** magnetization is carried by hematite or magnetite in the Anisian limestones,and iron sulfides and magnetite in the Rhaetian sedimentary rocks,revealing for both a large normal polarity overprint with a recent(geocentric axial dipole field)direction at the present latitude of the *** field and thermal demagnetization occasionally reveal a stable magnetization decaying towards the origin,interpreted as the Characteristic Remanent *** we find a pervasive(normal polarity)overprint,we can often still determine well-defined great-circle *** interpreted palaeomagnetic poles include the great-circle *** Anisian magnetic pole has declination D±ΔDx=210.8±3.0°,inclination I±ΔIx=-26.7±4.9°,with a latitude,longitude of 45.0°,142.0°respectively,K=43.9,A95=2.9°,N=*** Rhaetian magnetic pole has declination D±ΔDx=32.0±8.7°,inclination I±ΔIx=50.9±8.1°,with a latitude,longitude of 60.6°,123.9°respectively,K=19.3,A95=7.4°,N=*** poles plot close to the predicted location of global apparent polar wander paths(gAPWa Ps)in Eurasian coordinates and are feasible for future apparent polar wander path *** confirm that the intracontinental,shallow-marine germanic basin,in which the Muschelkalk Formation was deposited,existed at a palaeolatitude of 14.1°[11.3,17.1]N,in a palaeo-environment reminding of the Persian gulf *** Rhaetian times,palaeolatitudes of 31.6°[24.8,39.8]N were reached,on its way to the modern latitude of 52°N.

关键词： Palaeomagnetic Palaeolatitude Anisian Rhaetian Muschelkalk Formation germanic basin

Chemical compositions of carbonate minerals from Bayan Obo, Inner Mongolia, North China, and their petrogenetic implications

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Chinese Science Bulletin 1999年第S2期44卷 7-8页

作者： M. j. Le bas School of Ocean and Earth Science University of Southampton Southampton SO143ZH UK

THE origin of the giant Bayan Obo REE-Nb-Fe ore deposit has been under much debate since its discoveryas an iron deposit by Prof. Ding Daoheng in 1927. The main dispute is concentrated on the genesis of theore-hosted dolomite marbles of the deposit, Some authors considered them to be sedimentary in origin,while others pointed out that they could be carbonatite. However, there are very few researches concerning the compositions of carbonate minerals which may provide a direct clue to their petrogenesis. Herewe show the variations of compositions in carbonate minerals from Bayan Obo. Carbonate rocks from Bayan Obo, Inner Mongolia, could be divided into sedimentary limestone anddolostone (H8_s), coarse-grained dolomite marble (H8_c), fine-grained dolomite marble (H8_f) and carbonatite dykes (D) based on their texture, structure, mineral progenesis and occurrences. H8_s thatshows weak metamorphism and deformation is distributed to the north of the Kuangou fault, occurring

关键词： carbonate minerals dolomite carbonatite Bayan Obo.

Simulation Architecture for Modelling Interaction Between User and Elbow-articulated Exoskeleton

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journal of Bionic Engineering 2017年第4期14卷 706-715页

作者： bas j. de Kruif Emilio Schmidhauser Konrad S. Stadler Leonard W. O'Sullivan School of Design & Health Research Institute University of Limerick Limerick Ireland Netherlands Organisation for Applied Scientific Research Equipment for Additive Manufacturing 5600 HE Eindhoven The Netherlands Zurich University of Applied Sciences School of Engineering 8401 CH Winterthur Switzerland

The aim of our work is to improve the existing user-exoskeleton models by introducing a simulation architecture that can simulate its dynamic interaction, thereby altering the initial motion of the user. A simulation architecture is developed that uses the musculoskeletal models from OpenSim, and that implements an exoskeleton control algorithm and human response model in Matlab. The musculoskeletal models need to be extended with the response of a user to external forces to simulate the dy- namic interaction. A set of experiments was performed to fit this response model. A validation test showed that more than 80% of the variance of the motion could be explained. With the human response model in the combined simulation architecture, a simulation in which an object connects with the exoskeleton or with the human is performed. The effect of the exoskeleton on, among others, muscle excitation and altered motion can be assessed with this architecture. Our work can be used to better predict the effect an exoskeleton has on the user.

关键词： human-exoskeleton modelling human response modelling exoskeleton musculoskeletal system exoskeletondesign

A geochemical Study of an REE-rich Carbonatite Dyke at Bayan Obo,Inner Mongolia,Northern China

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Acta geologica Sinica(English Edition) 2000年第3期74卷 605-612页

作者： YANg Xueming ZHENg Yongfei YANg Xiaoyong ZHANg Peishan M.j.LE bas Department of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of geology and geophysics Chinese Academy of SciencesBeijing 100029China School of Ocean and Earth Science University of SouthamptonSO14 3ZHU.K.

An REE-rich carbonatite dyke was found in Dulahala, close to the Bayan Obo superlarge REE-Nb-Fe mineral deposit in Inner Mongolia, northern China. The REE content in the dyke varies greatly, from 1% up to 20% (wt), which might constitute rich REE ores. Light REEs in the carbonatite are enriched and highly fractionated relative to heavy REEs and there is no Eu anomaly. The REE and trace element distribution patterns of the carbonatite are identical to those of fine-grained dolomite marble which is the host rock of the Bayan Obo REE-Nb-Fe superlarge mineral deposit. This indicates a petrogenetic linkage between the REE-rich carbonatite and the mineralizations in this region.

关键词： rare earth elements(REE) carbonatite Bayan Obo

LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2

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Molecular Plant 2018年第8期11卷 1038-1052页

作者： Haifeng Wang Danhua jiang Elin Axelsson Zdravko j. Lorkovic Sean Montgomery Sarah Holec bas j.g.E. Pieters Abbas H.K. AI Temimi jasmin Mecinovic Frederic Berger gregor Mendel Institute (gMI) Austrian Academy of Sciences Vienna Biccenter (VBC) Dr. Bohr-Gasse 3 1030 Vienna Austria Temasek Lifesciences Laboratory 1 Research Link Nationat University of Singapore 117604 Singapore Singapore Department of Biological Sciences National University of Singapore 14 Science Drive 4 117543 Singapore Singapore Institute for Molecules and Materials Radboud University Heyendaalseweg 135 6525 AJ Nijmegen the Netherlands

Heterochromatin Protein 1 （HP1） is a major regulator of chromatin structure and function. In animals, the network of proteins interacting with HP1 is mainly associated with constitutive heterochromatin marked by H3K9me3. HP1 physically interacts with the putative ortholog of the SNF2 chromatin remodeler ATRX, which controls deposition of histone variant H3.3 in mammals. In this study, we show that the Arabidopsis thaliana ortholog of ATRX participates in H3.3 deposition and possesses specific conserved domains in plants. We found that plant Like HP1 （LHP1） protein interacts with ATRX through domains that evolved specifically in land plant ancestors. Loss of ATRX function in Arabidopsis affects the expression of a limited subset of genes controlled by PRC2 （POLYCOMB REPRESSIVE COMPLEX 2）, including the flowering time regulator FLC. The function of ATRX in regulation of flowering time requires novel LHPl-interacting domain and ATPase activity of the ATRX SNF2 helicase domain. Taken together, these results suggest that distinct evolutionary pathways led to the interaction between ATRX and HP1 in mammals and its counterpart LHP1 in plants, resulting in distinct modes of transcriptional regulation.

关键词： ATRX LHPI1 H3 variants Chromatin Histone Evolution

miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus

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World journal of gastroenterology 2011年第8期17卷 1036-1044页

作者： Cameron M Smith David I Watson Mary P Leong george C Mayne Michael Z Michael bas PL Wijnhoven Damian j Hussey Department of Surgery Flinders University Bedford Park Department of gastroenterology and Hepatology Flinders University Bedford Park Department of Surgery Erasmus Medical Centre

AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P guish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P gulated in non-invasive epithelium adjacent to adenocarcinoma (P gh-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P ght contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.

关键词： miRNA Barrett’s esophagus Esophageal adenocarcinoma miR-200 Epithelial to mesenchymal transition Apoptosis Proliferation Epithelium