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Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit:a propensity score matched study

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World Journal of Emergency Medicine 2024年第4期15卷 263-272页

作者： Yuhan sun baoqing sun Zhigang Ren Mingshan Xue Changju Zhu Qi Liu Translational Medicine Center Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Medical Key Laboratory of Emergency and Trauma Research Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:Patients with diabetes mellitus(DM)are vulnerable to community-acquired pneumonia(CAP),which have a high mortality *** aimed to investigate the value of heparin-binding protein(HBP)as a prognostic marker of mortality in patients with DM and ***:This retrospective study included CAP patients who were tested for HBP at intensive care unit(ICU)admission from January 2019 to April *** were allocated to the DM or non-DM group and paired with propensity score *** characteristics and clinical outcomes up to 90 days were *** primary outcome was the 10-day *** operating characteristic(ROC)curves,Kaplan-Meier analysis,and Cox regression were used for statistical ***:Among 152 enrolled patients,60 pairs were successfully *** was no significant difference in 10-day mortality,while more patients in the DM group died within 28 d(P=0.024)and 90 d(P=0.008).In the DM group,HBP levels at ICU admission were higher in 10-day non-survivors than in 10-day survivors(median 182.21[IQR:55.43-300]ng/ml *** 66.40[IQR:34.13-107.85]ng/mL,P=0.019),and HBP levels could predict the 10-day mortality with an area under the ROC curve of *** cut-off value,sensitivity,and specificity were 160.6 ng/mL,66.7%,and 90.2%,*** Cox regression analysis indicated that HBP was an independent prognostic factor for 10-day(HR 7.196,95%CI:1.596-32.455,P=0.01),28-day(HR 4.381,95%CI:1.449-13.245,P=0.009),and 90-day mortality(HR 4.581,95%CI:1.637-12.819,P=0.004)in patients with ***:Plasma HBP at ICU admission was associated with the 10-day,28-day,and 90-day mortality,and might be a prognostic factor in patients with DM and CAP.

关键词： Community-acquired pneumonia Diabetes mellitus Heparin-binding protein Propensity score match

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Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection

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Light(Science & Applications) 2024年第6期13卷 1112-1121页

作者： Heyan Meng Yuan Gao Xuhong Wang Xianye Li Lili Wang Xian Zhao baoqing sun School of Information Sciences and Engineering Shandong UniversityQingdaoChina Center for Optics Research and Engineering(CORE) Key Laboratory of Laser&Infrared System(Shandong University)Ministry of EducationShandong UniversityQingdaoChina School of Mechanical Electrical and Information EngineeringShandong UniversityWeihaiChina

Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of ***,the high cost associated with InGaAs focal plane array(FPA)has impeded the widespread adoption of NIR hyperspectral *** this challenge,in this study,we adopt an alternative approach—single-pixel detection for NIR hyperspectral *** investigation reveals that single-pixel detection outperforms conventional FPA,delivering a superior signal-to-noise ratio(SNR)for both spectral and imaging *** implement this strategy,we leverage self-assembled colloidal quantum dots(CQDs)and a digital micromirror device(DMD)for NIR spectral and spatial information multiplexing,complemented by single-pixel detection for simultaneous spectral and image *** experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128×*** resulting spectral and spatial data align well with reference instruments,which validates the effectiveness of our *** circumventing the need for expensive and bulky FPA and wavelength selection components,our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies,thereby expanding the range of potential applications.

关键词： spectral Quantum mirror

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2,000,000 fps 2D and 3D imaging of periodic or reproducible scenes with single-pixel detectors

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Photonics Research 2022年第9期10卷 2157-2164页

作者： WENJIE JIANG YONGKAI YIN JUNPENG JIAO XIAN ZHAO baoqing sun School of Information Science and Engineering Shandong UniversityQingdao 266237China Key Laboratory of Laser&Infrared System Ministry of EducationQingdao 266237China Center for Optics Research and Engineering Shandong UniversityQingdao 266237China

Single-pixel imaging(SPI)can capture 2D images of the target with only a nonpixelated detector,showing promising application potential in nonvisible spectral imaging,low-photon imaging,lidar,and other extreme imaging ***,the imaging mechanism of traditional SPI makes it difficult to achieve high imaging speed,which is a primary barrier for its widespread *** address this issue,in this work,we propose and demonstrate a novel high-speed 2D and 3D imaging scheme based on traditional SPI,termed time-resolved single-pixel imaging(TRSPI).Previous SPI works mainly utilize correlation between a stable target and iterative illumination masks to reconstruct a single *** TRSPI,by further exploiting correlation information between a dynamic scene and every static mask,we can reconstruct a series of time-varying images of the dynamic scene,given the dynamic scene is repetitive or ***,we conducted 2D and 3D imaging on a rotating chopper with a speed of 4800 revolutions per minute(rpm),and imaging speeds up to 2,000,000 *** is believed that this technology not only opens up a novel application direction for SPI,but also will provide a powerful solution for high-speed imaging.

关键词： SPI utilize scene

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A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

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Chinese Science Bulletin 2012年第15期57卷 1824-1832页

作者： ZOU ZeHong HE Ying RUAN Lin sun baoqing CHEN HuiFang CHEN De LIU ShiMing YANG XiaoGuang TAO AiLin Guangzhou Municipal Key Laboratory of Allergy&Clinical Immunology Allergy Research Branch of the State Key Laboratory of Reapirator)Diseasethe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China Guangzhou Institute of Respiratory Diseases the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China National Institute for Nutrition and Food Safety Chinese Centre for Disease Control and PreventionBeijing 100050China

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much *** approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be ***,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal ***,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as *** biomedical journals listed in Highwire(http://***/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human *** EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in *** analysis pathway that we have developed can help guide the selection of genes to be used in genetic *** pathway also provides a paradigm for allergenicity analysis of transgene candidates.

关键词：转基因生物致敏性生物信息学候选基因评价 Web服务器基因蛋白过敏性

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High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2082-2094页

作者： Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao baoqing sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng Department of Clinical Immunology The Third Affiliated Hospital at Sun Yat-sen University510630 GuangzhouChina Department of Internal Medicine Ohio State University College of Medicine and Wexner Medical CenterColumbusOH 43210USA Department of Medicine Penn State College of MedicineHersheyPA 17033USA Laboratory of Human Diseases and Immunotherapy West China HospitalSichuan UniversityChengduChina Department of Internal Medicine The First Hospital of Harbin Medical UniversityHarbinChina Department of Allergy and Clinical Immunology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Pediatrics and Microbiology-Immunology Georgetown University Medical CenterWashingtonDCUSA

The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary *** sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including *** the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE *** used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient *** observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC *** treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in *** of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced *** mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal *** p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune *** together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of ***,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.

关键词： STAT1 lupus prevention

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时域鬼成像及其应用

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中国激光 2021年第12期48卷 337-354页

作者：孙宝清王玉鹏山东大学信息科学与工程学院山东青岛266237

鬼成像是一种具有双臂结构的新型成像技术,一路利用无空间分辨能力的探测器接收与物体相互作用的光束,另一路用于记录原始光场的空间分布。鬼成像通过多次测量对二者进行关联运算,即可重构出目标物体的空间强度信息,因此受到了研究人员... 详细信息

鬼成像是一种具有双臂结构的新型成像技术,一路利用无空间分辨能力的探测器接收与物体相互作用的光束,另一路用于记录原始光场的空间分布。鬼成像通过多次测量对二者进行关联运算,即可重构出目标物体的空间强度信息,因此受到了研究人员的广泛关注。最近,基于光的时空二元性,鬼成像从空域扩展到时域,时域鬼成像被提出并得以验证。由于使用低速探测器可以探测到高速信号,时域鬼成像逐步发展为一种高速光信号探测方法。此外,许多基于时域鬼成像的信息安全和传输方案也被相继提出。主要介绍时域鬼成像技术的基本原理及应用的发展历程,并着重介绍了其在长距离光纤探测、超快信号探测、信息安全以及提升相机帧率中的应用工作。

关键词：量子光学时域鬼成像光纤探测超快信号探测信息安全相机帧率

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Evolution of the newest diagnostic methods for COVID-19:a Chinese perspective

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 463-484页

作者： Mingtao LIU Jiali LYU Xianhui ZHENG Zhiman LIANG Baoying LEI Huihuang CHEN Yiyin MAI Huimin HUANG baoqing sun Department of Clinical Laboratory National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseaseState Key Laboratory of Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510140China National Center for Respiratory Medicine National Clinical Research Center of Respiratory DiseaseState Key Laboratory of Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510140China Guangzhou Medical University Guangzhou 511495China

Coronavirus disease 2019(COVID-19)has continued to spread globally since late 2019,representing a formidable challenge to the world's healthcare systems,wreaking havoc,and spreading rapidly through human *** fever,fatigue,and a persistent dry cough being the hallmark symptoms,this disease threatened to destabilize the delicate balance of our global *** and accurate diagnosis of COVID-19 is a prerequisite for understanding the number of confirmed cases in the world or a region,and an important factor in epidemic assessment and the development of control *** also plays a crucial role in ensuring that patients receive the appropriate medical treatment,leading to optimal patient *** transcription-polymerase chain reaction(RT-PCR)technology is currently the most mature method for detecting viral nucleic acids,but it has many ***,a variety of COVID-19 detection methods,including molecular biological diagnostic,immunodiagnostic,imaging,and artificial intelligence methods have been developed and applied in clinical practice to meet diverse scenarios and *** methods can help clinicians diagnose and treat COVID-19 *** review describes the variety of such methods used in China,providing an important reference in the field of the clinical diagnosis of COVID-19.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Diagnosis Polymerase chain reaction(PCR) Immunoassay Radiography

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Quantum projection ghost imaging: a photon-numberselection method [Invited]

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Chinese Optics Letters 2024年第6期22卷 52-59页

作者： Dezhong Cao Suheng Zhang Yanan Zhao Cheng Ren Jun Zhang Baolai Liang baoqing sun Kaige Wang Department of Physics Yantai UniversityYantai 264005China College of Physics Science&Technology Hebei UniversityBaoding 071002China School of Information Science and Engineering Shandong UniversityQingdao 266237China Department of Physics Applied Optics Beijing Area Major LaboratoryBeijing Normal UniversityBeijing 100875China

We establish a quantum theory of computational ghost imaging and propose quantum projection imaging where object information can be reconstructed by quantum statistical correlation between a certain photon number of a bucket signal and digital micromirror device random patterns. The reconstructed image can be negative or positive, depending on the chosen photon number. In particular, the vacuum state (zero-number) projection produces a negative image with better visibility and contrast-to-noise ratio. The experimental results of quantum projection imaging agree well with theoretical simulations and show that, under the same measurement condition, vacuum projection imaging is superior to conventional and fast first-photon ghost imaging in low-light illumination.

关键词： ghost imaging quantum projection image reconstruction

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圆柱形金纳米线中表面等离激元的传输性质研究

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北京大学学报（自然科学版） 2011年第2期47卷 224-230页

作者：孙宝清古英龚旗煌北京大学物理学院现代光学研究所北京100871

从理论上研究了圆柱形金纳米线中,可见光波长下(λ=632.8 nm)表面等离激元模式的传输性质。通过求解麦克斯韦方程组,得到圆柱形金纳米线中表面等离激元波导的传播常数,进而得到表面等离激元模式的传输性质,包括其传播长度及有效半径等... 详细信息

从理论上研究了圆柱形金纳米线中,可见光波长下(λ=632.8 nm)表面等离激元模式的传输性质。通过求解麦克斯韦方程组,得到圆柱形金纳米线中表面等离激元波导的传播常数,进而得到表面等离激元模式的传输性质,包括其传播长度及有效半径等。还发现了表面等离激元模式的传输性质受到模式结构以及介质介电常数的影响,并且得到了表面等离激元传输距离和能量局域之间的普遍矛盾,即能量局域越好传播距离越短。通过计算,能够在特定的结构参数下获得较好的局域特性和传播长度,例如,当金属芯半径为40 nm,介质(SiO2)厚度为40 nm时,HE11模式的传播长度为103.6μm,有效半径642 nm。

关键词：圆柱形金纳米线表面等离激元传播距离有效半径

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A prospective cohort study of the presence of SARS-CoV-2 in clinical samples from multiple bodily sites:implications for transmission routes of COVID-19

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Journal of Bio-X Research 2022年第1期5卷 27-34页

作者： Meixian Liu Huimin Huang Xiqing Bian Zhiyuan Zheng Na Li baoqing sun Jian-Lin Wu State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyAvenida Wai LongTaipaMacao Special Administrative Region State Key Laboratory of Respiratory Disease National Clinical Center for Respiratory DiseasesGuangzhou Institute of Respiratory DiseasesFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Objective: The coronavirus disease 2019 (COVID-19) epidemic resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has still spread globally. The occurrence of the Delta variant, which is more infectious and spreads faster than earlier forms of the virus that causes COVID-19, makes infection prevention more challenging. Therefore, this study aimed to gain a comprehensive insight into the transmission routes of SARS-CoV-2 for curbing the propagation of SARS-CoV-2 in human ***: We studied a prospective cohort of 576 patients admitted consecutively to the First Affiliated Hospital of Guangzhou Medical University from January 21 to June 8, 2020. These patients were chosen based on their similar clinical phenotypes or imaging findings. There were 21 (3.6%) laboratory-confirmed COVID-19 patients (16 severe and 5 mild cases) and 555 non-COVID-19 patients. The antibody response and routes and duration of viral shedding were systematically evaluated in serial clinical specimens. Moreover, SARS-CoV-2 RNA was also detected in a mouth rinse, urine, and tear samples. This study was approved by the Medical Ethical Committee of The First Affiliated Hospital of Guangzhou Medical University (approval No. 2020-77).Results: SARS-CoV-2 mainly existed in sputum, nasal and throat swabs, and feces samples. Virus latency was longer in sputum and feces samples than in nasopharyngeal samples. IgG antibody response in respiratory samples was related to disease severity. Although droplets and aerosols are the major transmission routes for COVID-19, covert routes of transmission from asymptomatic patients, contaminated surfaces, and wastewater are also of ***: Our findings provide a solid foundation for developing prophylactic measures against SARS-CoV-2.

关键词： COVID-19 environment multiple bodily sites SARS-CoV-2 transmission route

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