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Effects of ethanol extracts of scorpion on hippocampal apoptosis and caspase-3 expression in lithium chloride-pilocarpine-induced status epilepticus rats

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Neural Regeneration Research 2010年第2期5卷 118-125页

作者： Liang Yu Hongbin Sun Yi Liang Yan Xie baoming he Fei Xu Department of Neurology Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu 610072 Sichuan Province China

BACKGROUND： Previous studies have demonstrated that scorpion venom in the scorpion can inhibit epilepsy and apoptosis. However, it remains unclear whether ethanol extracts of scorpion （EES） exhibit similar effects. OBJECTIVE： To investigate the effects of EES on hippocampal apoptosis and caspase-3 expression, and to compare the effects on sodium valproate （positive control drug） in a rat model of status epilepticus induced by lithium chloride-pilocarpine. DESIGN, TIME AND SETTING： This randomized, controlled study was conducted at the Drug Research and Development Center, Kanghong Pharmaceuticals Group, and the Department of Pathology, Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital, China from May 2007 to April 2008. MATERIALS： EES were prepared by Huashen Pharmaceutical, China. Sodium valproate （Hunan Xiangzhong Pharmaceutical, China） and lithium chloride-pilocarpine （Sigma, USA） were also used in the present study. METHODS： From a total of 156 rats, six served as normal controls. The remaining rats were intraperitoneally injected with lithium chloride-pilocarpine to establish status epileptlcus models, and then assigned to five groups （n = 30, respectively）. Animals in each group were administered drugs at 15 minutes after epileptic seizure by gavage, i.e. in the normal control and model groups, rats were treated with 1 mL/0.1 kg saline. The sodium valproate group was administered 120 mg/kg/d sodium valproate. The low-, moderate-, and high-dose EES groups received treatments of 290, 580 and 1 160 mg/kg/d EES. The dispensed concentration was 1 mL/0.1 kg. Rat seizure behavior was observed. If status epilepticus did not terminated after 1 hour, the rats were intraperitoneally administered atropine （1 mg/kg） and diazepam （10 mg/kg） to terminate seizure. These rats were continuously observed for 6 hours to ensure seizure termination. Then rats were treated with the above-mentioned drugs at 8：00 am each day until sacrifice, which took place 4

关键词： ethanol extracts of scorpion apoptosis terminal dUTP nick-end labeling caspase-3 model of status epilepticus lithium chloride-pilocarpine brain injury neural regeneration

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Responses of runoff to changes in climate and human activities in the Liuhe River Basin, China

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Journal of Arid Land 2024年第8期16卷 1023-1043页

作者： LI Mingqian WANG he DU Wei GU Hongbiao ZHOU Fanchao CHI baoming School of Ecology and Environment Institute of Disaster PreventionLangfang 065201China hebei Key Laboratory of Resource and Environmental Disaster Mechanism and Risk Monitoring Sanhe 065201China Suzhou Qianxing Environmental Engineering Co. Ltd.Suzhou 215000China College of Transportation Engineering Nanjing Tech UniversityNanjing 210000China Tianjin North China Geological Exploration General Institute Tianjin 300000China

Since the 1950s,numerous soil and water conservation measures have been implemented to control severe soil erosion in the Liuhe River Basin(LRB),*** these measures have protected the upstream soil and water ecological environment,they have led to a sharp reduction in the downstream flow and the deterioration of the river ecological ***,it is important to evaluate the impact of soil and water conservation measures on hydrological processes to assess long-term runoff *** the Soil and Water Assessment Tool(SWAT)models and sensitivity analyses based on the Budyko hypothesis,this study quantitatively evaluated the effects of climate change,direct water withdrawal,and soil and water conservation measures on runoff in the LRB during different periods,including different responses to runoff discharge,hydrological regime,and flood *** runoff series were divided into a baseline period(1956-1969)and two altered periods,i.e.,period 1(1970-1999)and period 2(2000-2020).Human activities were the main cause of the decrease in runoff during the altered periods,contributing 86.03%(-29.61 mm),while the contribution of climate change was only 13.70%(-4.70 mm).The impact of climate change manifests as a decrease in flood volume caused by a reduction in precipitation during the flood *** of two flood cases indicated a 66.00%-84.00%reduction in basin runoff capacity due to soil and water conservation measures in the upstream *** and water conservation measures reduced the peak flow and total flood volume in the upstream runoff area by 77.98%and 55.16%,respectively,even with nearly double the *** runoff coefficient in the reservoir area without soil and water conservation measures was 4.0 times that in the conservation *** results contribute to the re-evaluation of soil and water conservation hydrological effects and provide important guidance for water resource planning and water conservation policy formu

关键词： runoff soil and water conservation climate variability flood human activities Liuhe River Basin

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Retrospective case-analysis of the magnetic resonance imaging characteristics in the brain of patients with Wilson disease

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Neural Regeneration Research 2006年第6期1卷 529-532页

作者： Hong Li Kun You baoming he Jiagui Su Jian Hong Changbin Quan Min Zhao Department of Radiology Second Hospital Affiliated to the General Hospital of Chinese PLA. Beijing 100091 China

BACKGROUND： Wilson disease （WD） damages liver, brain, kidney, cornea and nervous system severely. It is manifested in four ways： brain, liver, kidney and bone muscle. Whether or not magnetic resonance imaging （MRI） can clearly display the diseased region and range in brain of patient with WD, which provides imageological evidence for clinical practice, is unclear. OBJECTIVE： To observe the characteristics of MRI of brain in patient with SD, and analyze the correlation of diseased region with clinical symptoms. DESIGN ： Retrospective case-analysis SETTING： Department of Radiology, Second Hospital Affiliated to the General Hospital of Chinese PLA. PARTICIPANTS： Thirty-one patients, including 18 males and 13 females, with WD admitted to the Department of Neurology, Second Hospital Affiliated to the General Hospital of Chinese PLA between January 1999 and December 2005 ware retrieved. The involved patients presented serum copper oxidase （sCP） activity decreasing and/or caruloplasmin level decreasing and /or udnary copper content increasing; typical extrapyramidal symptoms and/or physical sign; abnormality showed by slit-lamp examination, Kayser-Fleischer dog positive. METHODS ：（1） All the involved patients underwent MRI examination. AGE 1.5T imaging equipment was used. Spin-echo sequence was adopted to perform T2 and T1 -weighed image at transverse axis level. Partial cases subjected to head scanning at coronal and/or sagittal level. Gd-DTPA with dosage of 0.1 mmol/kg was the strongest in 4 cases. （2） MRI charactenstics of patients with different clinical symptoms were observed. MAIN OUTCOME MEASURES： MRI detection results of patients with WD and MRI characteristics of patients with different clinical symptoms. RESULTS： Thirty-one patients with WD participated in the result analysis. （1） Imageologicat examination results： WD involved many regions in the brain： dorsal caudate putamen （n =28）, thalamencephalon（n =25）, mesencephalon （n =25）, globus pallidus

关键词： Wilson disease cerebral cortex caudate putamen magnetic resonance clinical practice result analysis caudate nucleus nervous system copper content serum copper

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Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1669-1687页

作者： Wei he Xinyu Liu Ye Feng Hongwei Ding Haoyang Sun Zhongyu Li baoming Shi College of Animal Science and Technology Northeast Agricultural University600 Changjiang StreetHarbin 150030PR China

Background Cold stress has negative effects on the growth and health of mammals, and has become a factor restricting livestock development at high latitudes and on plateaus. The gut-liver axis is central to energy metabolism, and the mechanisms by which it regulates host energy metabolism at cold temperatures have rarely been illustrated. In this study, we evaluated the status of glycolipid metabolism and oxidative stress in pigs based on the gut-liver axis and propose that AMP-activated protein kinase(AMPK) is a key target for alleviating energy stress at cold temperatures by dietary fat *** Dietary fat supplementation alleviated the negative effects of cold temperatures on growth performance and digestive enzymes, while hormonal homeostasis was also restored. Moreover, cold temperature exposure increased glucose transport in the jejunum. In contrast, we observed abnormalities in lipid metabolism, which was characterized by the accumulation of bile acids in the ileum and plasma. In addition, the results of the ileal metabolomic analysis were consistent with the energy metabolism measurements in the jejunum, and dietary fat supplementation increased the activity of the mitochondrial respiratory chain and lipid metabolism. As the central nexus of energy metabolism, the state of glycolipid metabolism and oxidative stress in the liver are inconsistent with that in the small intestine. Specifically, we found that cold temperature exposure increased glucose transport in the liver, which fully validates the idea that hormones can act on the liver to regulate glucose output. Additionally, dietary fat supplementation inhibited glucose transport and glycolysis, but increased gluconeogenesis, bile acid cycling, and lipid metabolism. Sustained activation of AMPK, which an energy receptor and regulator, leads to oxidative stress and apoptosis in the liver;dietary fat supplementation alleviates energy stress by reducing AMPK *** Cold s

关键词： Apoptosis Cold temperature Energy stress Fat Glucolipid metabolism Mitochondrial homeostasis

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发动机反推运动机构可靠性优化设计研究

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航空科学技术 2024年第4期35卷 52-59页

作者：常琦胡颖石周长聪何宝明冯奥博王元生西北工业大学陕西西安710072 中国航发商用航空发动机有限责任公司上海200241

反推装置作为现代民用飞机必不可少的减速系统,承担着飞机降落的重要任务,对飞机的安全飞行至关重要。根据叶栅式反推装置构型及其工作原理,本文建立了反推机构运动学理论模型。通过机构运动学仿真,验证了所建立模型的合理性与正确性。... 详细信息

反推装置作为现代民用飞机必不可少的减速系统,承担着飞机降落的重要任务,对飞机的安全飞行至关重要。根据叶栅式反推装置构型及其工作原理,本文建立了反推机构运动学理论模型。通过机构运动学仿真,验证了所建立模型的合理性与正确性。将阻流门在整个偏转过程中的最大角加速度作为优化目标,各部件满足几何运动关系作为约束条件,建立反推运动机构的确定性优化模型。与此同时,考虑反推运动机构的两种失效模式,将可靠性考虑到优化设计中,建立可靠性优化设计模型。在Matlab环境下对反推机构进行优化设计计算,结果表明,在满足可靠性约束的情况下,阻流门在整个运动过程中的角加速度得到了进一步的优化,且整个机构在运动中不出现干涉,整个反推力装置可以正常工作。本文建模流程与可靠性优化方法和结果可以为反推装置结构设计提供参考。

关键词：反推装置阻流门运动机构可靠性优化设计

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Scorpion ethanol extract and valproic acid effects on hippocampal glial fibrillary acidic protein expression in a rat model of chronic-kindling epilepsy induced by lithium chloride-pilocarpine

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Neural Regeneration Research 2012年第6期7卷 426-433页

作者： Yi Liang Hongbin Sun Liang Yu baoming he Yan Xie Department of Neurology Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital Chengdu 610072 SichuanProvince China

The present study analyzed the effects of ethanol extracts of scorpion on epilepsy prevention and hippocampal expression of glial fibrillary acidic protein in a lithium chloride-pilocarpine epileptic rat model. Results were subsequently compared with valproic acid. Results showed gradually- increased hippocampal glial fibrillary acidic protein expression following model establishment; glial fibrillary acidic protein mRNA expression was significantly increased at 3 days, reached a peak at 7 days, and then gradually decreased thereafter. Ethanol extracts of scorpion doses of 580 and 1 160 mg/kg, as well as 120 mg/kg valproic acid, led to a decreased number of glial fibrillary acidic protein-positive cells and glial fibrillary acidic protein mRNA expression, as well as decreased seizure grades and frequency of spontaneously recurrent seizures. The effects of 1 160 mg/kg ethanol extracts of scorpion were equal to those of 120 mg/kg valproic acid. These results suggested that the anti-epileptic effect of ethanol extracts of scorpion were associated with decreased hippocampal glial fibrillary acidic protein expression in a rat model of lithium chlofide-pilocarpine induced epilepsy.

关键词： Chinese herbs epilepsy glial fibrillary acidic protein lithium chloride-pilocarpine scorpion ethanol extraction valproic acid

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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng Gu Haiyuan Li baoming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

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Application of ketogenic diet in the treatment of epilepsy patient with gut microbiota dysbiosis: a case study

Application of ketogenic diet in the treatment of epilepsy p...

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中国营养学会第十五届全国营养科学大会

作者： Tong Peng Yiran Guo baoming he 四川省医学科学院·四川省人民医院北京航空航天大学

In this case study, we report a 24-year-old male who initially presented with 14 days of fever, cephalalgia and paroxysmal limb convulsions, unconscious on admission. The patient was diagnosed with klebsiella pneumoniae pulmonary infection, mNGS ruled out viral encephalitis, suspected autoimmune encephalitis, ultra-refractory epileptic state, hypoproteinemia, and gut microbiota disorder. We evaluated the effects of ketogenic diet intervention on epileptic seizures and gut microbiota dysbiosis in this patient after 40 days of hospitalization and 6 months after discharge. Methods This patient s health and neurological status were regularly monitored by a neurologist during the diet intervention, which consisted of a modified liquid ketogenic diet(60% fat, 30% protein, 5% fiber, and 5% net carbohydrate by weight, comprised of vegetables, meats, eggs, nuts, and vegetable oils, administered by nasogastric tube). The patient was discharged from the hospital and given a 6-month ketogenic diet(60% fat, 30% protein, 5% fiber, and 5% net carbohydrate by weight, comprised of vegetables, meats, eggs, nuts, seeds, and oils) intervention under the supervision of a registered dietitian(RD). A return visit was scheduled by the neurologist after six months for MRI and EEG and a special evoked test. Feces were collected at admission in hospital(0 d), discharge from hospital(40 d), 3 months after discharge from hospital(130 d), and 6 months at return visit(220 d), and shortchain fatty acids(SCFAs) were analyzed by GC-MS and gut microbiota structure was analyzed using 16 S rDNA high-throughput sequencing. Results The patient was discharged from the hospital with the recovery of consciousness, occasional twitching, and normalization of blood protein levels, but the gut microbiota was disturbed, showing loss of microbiota diversity(α-diversity) and dysbiosis of microbiota structure(β-diversity). Moreover, slight trace SCFAs(he patient s feces at 0 d and 40 d. Afte

关键词： Ketogenic diet,Gut microbiota SCFAs,Metagenomics

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Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

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Bio-Design and Manufacturing 2024年第1期7卷 14-30页

作者： Xinshuo Huang baoming Liang Shantao Zheng Feifei Wu Mengyi he Shuang Huang Jingbo Yang Qiangqiang Ouyang Fanmao Liu Jing Liu Hui-jiuan Chen Xi Xie State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhou 510006China School of Biomedical Engineering Sun Yat-Sen UniversityShenzhen 518107China Pazhou Lab Guangzhou 510330China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510006China

Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

关键词： Microarrow sensor array Glucose sensing Reactive oxygen species sensing Integrated system Continuous monitoring

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Bacalin reduces HMGB1 expression and seizure activity in lithium-pilocarpine induced epilepsy model

Bacalin reduces HMGB1 expression and seizure activity in lit...

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中华医学会神经病学分会第十次全国脑电图与癫痫诊治进展高级讲授班及学术研讨会

作者： baoming he Bin Huang suping LI Liang YU Shu Yang Department of Neurology Sichuan Medical Science Academy and Sichuan Provincial People’s Hospital

Part 1To investigate the protein levels of HMGB1 and NF-kB in hippocampal homogenates of pilocarpine induced rat *** *** male SD rats were used for these experiments and were randomly divided into control group and epileptic *** epileptic group were injected with pilocarpine hydrochloride to induce the sustained seizures and killed at 1d、3d、1w,2w,1m,2m following the onset of SE.

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