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Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1639-1660页

作者： Yanan Gao Qingwei Meng Jianwei Qin Qianqian Zhao baoming shi College of Animal Science and Technology Northeast Agricultural UniversityNo.600 Changjiang RoadXiangfang DistrictHarbinChina

Background Oxidized soybean oil(OSO)has been shown to impair growth and exacerbate inflammation,leading to intestinal barrier injury in *** evidence suggests important roles for resveratrol(RES)in the promoting growth performance,antioxidant capacity,anti-inflammatory,and regulate intestinal barriers in ***,The objectives of this study are to investigate the effects of dietary RES(purity 98%)supplementation on the growth performance,antioxidant capacity,inflammatory state,and intestinal function of weaned piglets challenged with *** A total of 28 castrated weaned male piglets with a similar body weight of 10.197 replications per treatment and±0.10 kg were randomly assigned to 4 dietary treatments for 28-d feeding trial with 1 piglet per *** were arranged as a 2×2 factorial with oil type[3%fresh soybean oil(FSO)vs.3%OSO]and dietary RES(0vs.300 mg/kg).Results The results showed that relative to the FSO group,OSO stress tended to decrease the average daily feed intake(ADFI),and decreased the activity levels of lipase,villus/crypt ratio(VCR),the mRNA expression of FABP1,SOD2,IL-10 and ZO-1 in the jejunum,and SOD2,GPX1,occludin and ZO-1 in the colon,the levels of acetic acid in the colonic digesta,whereas up-regulated the mRNA expression of IL-1βand TNF-αin the jejunum(P<0.05).Moreover,dietary supplementation with RES increased ether extract(EE),the activity levels of sucrase,lipase,α-amylase,villus height(VH)and VCR,the mRNA expression of FABP1,SOD2,IL-10 and occludin in the jejunum,and FABP1,PPAR-γ,GPX1,occludin and ZO-1 in the colon,and the abundance of Firmicutes,acetic and propionic acid,but decreased the levels of D-lactic acid in the plasma,the abundance of Bacteroidetes in the colonic digesta of weaned piglets compared to the non-RES group(P<0.05).Meanwhile,in the interaction effect analysis,relative to the OSO group,dietary RES supplementation in the diets supplemented with OSO increased the activity levels of tr

关键词： Inflammation Intestinal barrier Intestinal health Oxidative stress Oxidized soybean oil Piglets Resveratrol

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Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1669-1687页

作者： Wei He Xinyu Liu Ye Feng Hongwei Ding Haoyang Sun Zhongyu Li baoming shi College of Animal Science and Technology Northeast Agricultural University600 Changjiang StreetHarbin 150030PR China

Background Cold stress has negative effects on the growth and health of mammals, and has become a factor restricting livestock development at high latitudes and on plateaus. The gut-liver axis is central to energy metabolism, and the mechanisms by which it regulates host energy metabolism at cold temperatures have rarely been illustrated. In this study, we evaluated the status of glycolipid metabolism and oxidative stress in pigs based on the gut-liver axis and propose that AMP-activated protein kinase(AMPK) is a key target for alleviating energy stress at cold temperatures by dietary fat *** Dietary fat supplementation alleviated the negative effects of cold temperatures on growth performance and digestive enzymes, while hormonal homeostasis was also restored. Moreover, cold temperature exposure increased glucose transport in the jejunum. In contrast, we observed abnormalities in lipid metabolism, which was characterized by the accumulation of bile acids in the ileum and plasma. In addition, the results of the ileal metabolomic analysis were consistent with the energy metabolism measurements in the jejunum, and dietary fat supplementation increased the activity of the mitochondrial respiratory chain and lipid metabolism. As the central nexus of energy metabolism, the state of glycolipid metabolism and oxidative stress in the liver are inconsistent with that in the small intestine. Specifically, we found that cold temperature exposure increased glucose transport in the liver, which fully validates the idea that hormones can act on the liver to regulate glucose output. Additionally, dietary fat supplementation inhibited glucose transport and glycolysis, but increased gluconeogenesis, bile acid cycling, and lipid metabolism. Sustained activation of AMPK, which an energy receptor and regulator, leads to oxidative stress and apoptosis in the liver;dietary fat supplementation alleviates energy stress by reducing AMPK *** Cold s

关键词： Apoptosis Cold temperature Energy stress Fat Glucolipid metabolism Mitochondrial homeostasis

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Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2158-2179页

作者： Teng Teng Guodong Sun Hongwei Ding Xin Song Guangdong Bai baoming shi Tingting Shang College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030China

Background Cold regions have long autumn and winter seasons and low ambient *** pigs are unable to adjust to the cold,oxidative damage and inflammation may ***,the differences between cold and non-cold adaptation regarding glucose and lipid metabolism,gut microbiota and colonic mucosal immunological features in pigs are *** study revealed the glucose and lipid metabolic responses and the dual role of gut microbiota in pigs during cold and non-cold ***,the regulatory effects of dietary glucose supplements on glucose and lipid metabolism and the colonic mucosal barrier were evaluated in cold-exposed *** Cold and non-cold-adapted models were established by Min and Yorkshire *** results exhibited that cold exposure induced glucose overconsumption in non-cold-adapted pig models(Yorkshire pigs),decreasing plasma glucose *** this case,cold exposure enhanced the ATGL and CPT-1αexpression to promote liver lipolysis and fatty acid ***,the two probiotics(Collinsella and Bifidobacterium)depletion and the enrichment of two pathogens(Sutterella and Escherichia-shigella)in colonic microbiota are not conducive to colonic mucosal ***,glucagon-mediated hepatic glycogenolysis in cold-adapted pig models(Min pigs)maintained the stability of glucose homeostasis during cold *** contributed to the gut microbiota(including the enrichment of the Rikenellaceae RC9 gut group,[Eubacterium]coprostanoligenes group and WCHB1-41)that favored cold-adapted *** The results of both models indicate that the gut microbiota during cold adaptation contributes to the protection of the colonic *** non-cold adaptation,cold-induced glucose overconsumption promotes thermogenesis through lipolysis,but interferes with the gut microbiome and colonic mucosal ***,glucagon-mediated hepatic glycogenolysis contributes to glucose homeostasis during cold exposur

关键词： Cold exposure Colonic mucosal immunity Fatty acid oxidation Glucose and lipid metabolism Gut microbiota Pig model

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Glucose supplementation improves intestinal amino acid transport and muscle amino acid pool in pigs during chronic cold exposure

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Animal Nutrition 2023年第1期12卷 360-374页

作者： Teng Teng Xin Song Guodong Sun Hongwei Ding Haoyang Sun Guangdong Bai baoming shi Institute of Animal Nutrition Northeast Agricultural UniversityHarbin 150030China

Mammals in northern regions chronically suffer from low temperatures during autumn-winter *** aim of this study was to investigate the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure via Min pig models(cold adaptation)and Yorkshire pig models(non-cold adaptation).Furthermore,this study explored the beneficial effects of glucose supplementation on small intestinal amino acid transport and amino acid pool in muscle of cold-exposed Yorkshire *** pigs(Exp.1)and Yorkshire pigs(Exp.2)were divided into a control group(17℃,n=6)and chronic cold exposure group(7℃,n=6),*** Yorkshire pigs(Exp.3)were divided into a cold control group and cold glucose supplementation group(8℃).The results showed that chronic cold exposure inhibited peptide transporter protein 1(PepT1)and excitatory amino acid transporter 3(EAAT3)expression in ileal mucosa and cationic amino acid transporter-1(CAT-1)in the jejunal mucosa of Yorkshire pigs(Pshire pigs were consumed by chronic cold exposure,accompanied by increased muscle RING-finger protein-1(MuRF1)and muscle atrophy F-box(atrogin-1)expression(Pshire pigs(Pshire pigs(P<0.05).It also improved BCAA and inhibited MuRF1 and atrogin-1 expression in muscle(P<0.05).Moreover,dystrophin concentration was improved by glucose supplementation(P<0.05).In summary,chronic cold exposure inhibits amino acid absorption in the small intestin

关键词： Chronic cold exposure Amino acid transporter Branched amino acid Protein deposition Glucose Pig

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Transcriptome analysis of the effect of pyrroloquinoline quinone disodium（PQQ·Na2） on reproductive performance in sows during gestation and lactation

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Journal of Animal Science and Biotechnology 2019年第4期10卷 1022-1036页

作者： Boru Zhang Chenxi Wang Wei Yang Hongyun Zhang Qingwei Meng baoming shi Anshan Shan Institute of Animal Nutrition Northeast Agricultural University

Background: Pyrroloquinoline quinone(PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium(PQQ·Na2) on reproductive performance in ***: Dietary supplementation with PQQ·Na2 significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk. The concentration of NO was significantly increased in the plasma and placenta. RNA-seq analysis showed that462 unigenes were differentially expressed between the control(Con) treatment and PQQ treatment *** these unigenes, 199 were upregulated, while 263 unigenes were downregulated. The assigned functions of the unigenes covered a broad range of GO categories. Reproduction(27, 7.03%) and the reproduction process(27, 7.03%) were assigned to the biological process category. By matching DEGs to the KEGG database, we identified 29 ***: In conclusion, dietary supplementation with PQQ·Na2 in gestating and lactating sows had positive effects on their reproductive performance.

关键词： Oxidative stress Pyrroloquinoline quinone Pyrroloquinoline quinone disodium Reproductive performance,RNA-seq Sow

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Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

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Journal of Animal Science and Biotechnology 2018年第3期9卷 639-651页

作者： Qingwei Meng Tao Guo Gaoqiang Li shishuai Sun shiqi He Baojing Cheng baoming shi Anshan Shan Institute of Animal Nutrition Northeast Agricultural University Harbin

Background: Resveratrol, a plant phenol, affords protection against inflammation and oxidative stress. The objective of this study was to investigate the effects of dietary resveratrol supplementation during pregnancy and lactation on the antioxidant status of sows and piglets and on antioxidant gene expression and pathway in ***: Forty sows were allotted to 2 dietary treatments 20 d after breeding. Sows were fed a control diet and a control diet with 300 mg/kg resveratrol. Oxidative stress biomarkers and antioxidant enzymes were measured in the placenta, milk, and plasma of sows and piglets. Antioxidant gene expression and protein expression of Kelch-like ECH-associated protein 1-Nuclear factor E2-related factor 2(Keap1-Nrf2), nuclear factor kappa B-p65(NFκB-p65) and sirtuin1(Sirt1) were quantified in the ***: Dietary resveratrol increased the litter and piglets weaning weights. Antioxidant status in the milk, placenta and plasma of sows and piglets was partially improved by dietary resveratrol. In placenta, Nrf2 protein expression was increased and Keap1 protein expression was decreased by dietary resveratrol. The m RNA expression of antioxidant genes including catalase(CAT), glutathione peroxidase 1(GPX1), GPX4, superoxide dismutase 1(SOD1)and heme oxygenase 1(HO1), and phase 2 detoxification genes, including glutamate-cysteine ligase modifier(GCLM), microsomal glutathione S-transferase 1(MGST1) and UDP glucuronosyltransferase family 1 member A1(UGT1 A1), was increased by dietary resveratrol. Dietary resveratrol also increased Sirt1 and phosphorylated NFκB-p65 protein expression in the placenta. We failed to observe any influences of dietary resveratrol on pro-inflammatory cytokine levels, including those of interleukin 1β(IL-1β), IL-6, IL-8 and tumor necrosis factor α(TNF-α). However, we observed that the m RNA expression of IL-8 in placenta was reduced by maternal resveratrol. In addition, dietary resveratrol showed interactive effects

关键词： Nrf2 Oxidative stress Piglet Placenta Resveratrol Sirt1 Sow

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Effects of Chinese herbs on lactation of rat and performance of offspring

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Journal of Northeast Agricultural University(English Edition) 2007年第1期14卷 22-26页

作者： shi baoming SHAN Anshan Institute of Animal Nutrition Northeast Agricultural University Harbin 150030 China

An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Control rats were offered basal diets until the end of the weaning period. Rats in the other 8 groups were administered diets supplemented with 1% Medulla tetmpanacis （MT）, Astragalus membranacens （AM）, Vaccaria segetalis （VS）, Leonurus heterophyllus sweet （LHS）, Radix rehmarmiae preparata （RRP）, Squama man/t/s （SM）, Schisandra chinensis （SC）, Ligustrum lucidum （LL）, respectively. After parturition, the litter size was culled to 8 pups per dam. Pup weight and milk yield were significantly higher in the VS, LHS, AM and SM groups than these in the control group during middle and late lactation （P〈0.05 or P〈0.01）. The weight and feed intake were not different in the dams fed either diet.

关键词： rat lactation Chinese herbs

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Effects of temperature,moisture and choline chloride on vitamin A stability in broiler premix

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Journal of Northeast Agricultural University(English Edition) 2007年第2期14卷 115-119页

作者： SUN Haixia SHAN Anshan shi baoming Institute of Animal Nutrition Northeast Agricultural University Harbin 150030 China Northeast Institute of Geography and Agricultural Ecology Chinese Academy of Sciences Harbin 150040 China

A 2×2×2 factorial design was adopted to study the effects of temperature, moisture and choline chloride on vitamin A stability in premix. The results indicated that temperature, moisture and choline chloride damaged vitamin A significantly. The regression equations of vitamin A disappearance rate and storage time were as follows： in room temperature （18±3）℃, y=14.368Ln（x）＋ 4.1425, R^2=0.978; in high temperature （4 ℃ ）, y=22.24Ln （x）＋13.27, R^2=0.9918; in low moisture （2%-3%）, y= 10.408Ln （x）＋9.5418, R^2=-0.9322; in high moisture （8%-9%）, y=26.199Ln（x）＋7.8741, R^2=-0.9949; in the condition of choline chloride flee, y=9.5125Ln（x）＋ 8.9869, R^2=0.9826; supplemented with choline chloride, y=27.094Ln （x）＋8.4276, R^2=0.9984. Temperature had highly significant interaction with moisure and choline chloride on destruction of vitamin A, respectively from the periods of two months storage. However, from the period of the first month storage, the interaction of moisture and choline chloride, as well as the interaction of temperature, moisture and choline destroyed vitamin A remarkably.

关键词： vitamin A temperature moisture choline chloride stability

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Influence of Early Quantitative Feed Restriction on Performance and Carcass Characteristics of Broiler Chickens

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Journal of Northeast Agricultural University(English Edition) 2006年第2期13卷 140-144页

作者： shi baoming SHAN Anshan CHAN Long Institute of Animal Nutrition Northeast Agricultural University Harbin Heilongjiang 150030 PRC

An experiment was conducted to study the influence of eady quantitative feed restriction on the performance and carcass characteristics of broiler chickens. Two hundred 8-day-old commercial Avian male broiler chicks were assigned to four groups randomly, with 50 broilers each. At the age of 8 days the broilers were restricted to 90%, 80% or 70% of the ad libitum intake for 7 days. When the restricion was finished, all birds received feed ad libitum again. The results showed that diet restriction resulted in a reduction in body weight and daily gain during the restriction period （P 〈0.05）. The birds restricted to 90% of the ad libitum intake showed the occurring of growth compensation in the 3rd week. The birds restricted to 80% and 70% of the ad libitum intake had growth compensation in the 4th week. No significant differences between the effects of the restriction and the control on final body weight, growth rate, feed conversion efficiency and carcass characteristics （P 〈0.05）.

关键词： broiler, early feed restriction performance carcass characteristics

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胆碱在鸡饲料中的研究与应用

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饲料工业 2000年第6期21卷 37-39页

作者：石宝明东北农业大学动物营养研究所 150030

目前 ,胆碱在鸡饲料中的应用尚存很大争议。该文就胆碱的功能、鸡对胆碱的需要量、胆碱在鸡体内的合成、胆碱的饲料来源、饲料中胆碱可利用性评价、影响胆碱添加效果的因素。

关键词：胆碱鸡饲料可利用性添加量

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