Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure

作     者：Teng Teng Guodong Sun Hongwei Ding Xin Song Guangdong Bai Baoming Shi Tingting Shang Teng Teng;Guodong Sun;Hongwei Ding;Xin Song;Guangdong Bai;Baoming Shi;Tingting Shang

作者机构：College of Animal Science and TechnologyNortheast Agricultural UniversityHarbin 150030China 

出 版 物：《畜牧与生物技术杂志:英文版》 (Journal of Animal Science and Biotechnology)

年 卷 期：2023年第14卷第5期

页      面：2158-2179页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 

基　　金：supported by the National Key R&D Program of China(2021YFD1300403) the Major Program of Heilongjiang Province of China(2021ZX12B08-02) 

主　　题：Cold exposure Colonic mucosal immunity Fatty acid oxidation Glucose and lipid metabolism Gut microbiota Pig model 

摘      要：Background Cold regions have long autumn and winter seasons and low ambient *** pigs are unable to adjust to the cold,oxidative damage and inflammation may ***,the differences between cold and non-cold adaptation regarding glucose and lipid metabolism,gut microbiota and colonic mucosal immunological features in pigs are *** study revealed the glucose and lipid metabolic responses and the dual role of gut microbiota in pigs during cold and non-cold ***,the regulatory effects of dietary glucose supplements on glucose and lipid metabolism and the colonic mucosal barrier were evaluated in cold-exposed *** Cold and non-cold-adapted models were established by Min and Yorkshire *** results exhibited that cold exposure induced glucose overconsumption in non-cold-adapted pig models(Yorkshire pigs),decreasing plasma glucose *** this case,cold exposure enhanced the ATGL and CPT-1αexpression to promote liver lipolysis and fatty acid ***,the two probiotics(Collinsella and Bifidobacterium)depletion and the enrichment of two pathogens(Sutterella and Escherichia-Shigella)in colonic microbiota are not conducive to colonic mucosal ***,glucagon-mediated hepatic glycogenolysis in cold-adapted pig models(Min pigs)maintained the stability of glucose homeostasis during cold *** contributed to the gut microbiota(including the enrichment of the Rikenellaceae RC9 gut group,[Eubacterium]coprostanoligenes group and WCHB1-41)that favored cold-adapted *** The results of both models indicate that the gut microbiota during cold adaptation contributes to the protection of the colonic *** non-cold adaptation,cold-induced glucose overconsumption promotes thermogenesis through lipolysis,but interferes with the gut microbiome and colonic mucosal ***,glucagon-mediated hepatic glycogenolysis contributes to glucose homeostasis during cold exposur