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Emerging hemostatic materials for non-compressible hemorrhage control

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National Science Review 2022年第11期9卷 223-239页

作者： Ruonan Dong Hualei Zhang baolin guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University

Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield, causing a majority of deaths among all traumatic injury mortalities. Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment. Hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed. However, these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control. Different hemostatic strategies(physical, chemical and biological)have been proposed and different forms(sponges/foams, sealants/adhesives, microparticles/powders and platelet mimics) of hemostatic materials have been developed based on these strategies. A summary of the requirements, state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms, to give a clear understanding of the progress that has been made in this area and the promising directions for future generations.

关键词： non-compressible hemorrhage control commercialized hemorrhage-control strategies hemostatic sponge hydrogel microparticle platelet mimics

Synthetic biodegradable functional polymers for tissue engineering:a brief review

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Science China Chemistry 2014年第4期57卷 490-500页

作者： guo baolin MA Peter X Center for Biomedical Engineering and Regenerative Medicine Frontier Institute of Science and Technology Xi'an Jiaotong University Department of Biomedical Engineering University of Michigan Department of Biologic and Materials Sciences University of Michigan Macromolecular Science and Engineering Center University of Michigan Department of Materials Science and Engineering University of Michigan

Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly(glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix(ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.

关键词： synthetic biodegradable polymers functional polymers scaffolds tissue engineering

Antibacterial conductive self-healable supramolecular hydrogel dressing for infected motional wound healing

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Science China Chemistry 2022年第11期65卷 2238-2251页

作者： Rui Yu Zhenlong Li guoying Pan baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi'an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi'an710049China

Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin(GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel was crosslinked by monoaldehyde β-cyclodextrin via host-guest interaction and dynamic Schiff base and was free from permanent covalent bonds, heavy metals, and oxidants. Given its dynamic feature, the hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, the hydrogel was bioactive with conductivity, antioxidant property, hemostatic effect, antibacterial, and photothermal effect(the killing ratio for methicillinresistant Staphylococcus aureus(MRSA) was higher than 99.8% after 5 min of near-infrared irradiation) and exhibited ondemand removability. In the full-thickness MRSA-infected motional wound healing experiment, this novel hydrogel exhibited a significantly enhanced wound healing efficacy with a fast wound closure ratio(about 99.0% for 14 days), mild inflammatory response, high level of collagen deposition, and enhanced re-epithelialization by downregulating interleukin-6 and CD68 and upregulating vascular endothelial growth factor. The results indicated that this hydrogel has great potential in wound healing and skin tissue engineering and serves as an inspiration for the design of supramolecular biomaterials.

关键词： supramolecular hydrogel self-healing tissue adhesion joint wound

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Porous photothermal antibacterial antioxidant dual–crosslinked cryogel based on hyaluronic acid/polydopamine for non-compressible hemostasis and infectious wound repair

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Journal of Materials Science & Technology 2022年第26期121卷 207-219页

作者： Chunbo Wang Yuqing Liang Ying Huang Meng Li baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Cryogel dressings with good absorption ability and photothermal antibacterial properties for preventing wound infections and treating infected wounds have attracted widespread *** this work,a series of cryogels with macroporous structure,antioxidant and photothermal properties were prepared based on adipic dihydrazide modified hyaluronic acid(HA-ADH),and dopamine(DA).The antioxidant properties,hemostatic properties,near infrared(NIR)assisted photothermal antibacterial ability provided by polydopamine,recyclable compression mechanical properties,and cytocompatibility were *** results demonstrated that the HA-ADH/DA cryogels have stable mechanical properties,great antibacterial properties against ***(EC)and methicillin-resistant ***(MRSA).The high swelling ratio due to the high water retention of HA equipped the cryogels with the capability of absorbing exuded blood and excessive tissue fluid in the infected full-thickness skin defect model of *** cryogels demonstrated good cytocompatibility and antioxidant performance through cell tests and 1,1-diphenyl-2-methylbenzohydrazino(DPPH)scavenging efficiency *** cryogels showed enhanced blood-clotting index(BCI)and better hemostatic ability in the mouse liver trauma model and the rat deep noncompressible liver defect model compared with gauze and gelatin ***,compared with commercial TegadermTMdressing in vivo,the HA-ADH/DA cryogels could greatly promote infected skin wound healing in a full-thickness infected skin defect wound *** summary,the macroporous HAADH/DA cryogels with good antioxidant,high swelling ratio,photothermal antibacterial property,and biocompatibility are a promising hemostatic material and wound healing dressing.

关键词： Dopamine-hyaluronic acid-based cryogels Antioxidant Photothermal antibacterial Wound healing Hemostasis

Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

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Nano-Micro Letters 2022年第11期14卷 256-274页

作者： Yuqing Liang Huiru Xu Zhenlong Li Aodi Zhangji baolin guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Hydrogels with multifunctionalities,including sufficient bonding strength,injectability and self-healing capacity,responsive-adhesive ability,fault-tolerant and repeated tissue adhesion,are urgently demanded for invasive wound closure and wound *** by the adhesive mechanism of mussel and brown algae,bioinspired dynamic bonds cross-linked multifunctional hydrogel adhesive is designed based on sodium alginate(SA),gelatin(GT)and protocatechualdehyde,with ferric ions added,for sutureless *** dynamic hydrogel cross-linked through Schiff base bond,catechol-Fe coordinate bond and the strong interaction between GT with temperature-dependent phase transition and SA,endows the resulting hydrogel with sufficient mechanical and adhesive strength for efficient wound closure,injectability and self-healing capacity,and repeated closure of reopened ***,the temperature-dependent adhesive properties endowed mispositioning hydrogel to be removed/repositioned,which is conducive for the fault-tolerant adhesion of the hydrogel adhesives during ***,the hydrogels present good biocompatibility,near-infrared-assisted photothermal antibacterial activity,antioxidation and repeated thermo-responsive reversible adhesion and good hemostatic *** in vivo incision closure evaluation demonstrated their capability to promote the post-wound-closure and wound healing of the incisions,indicating that the developed reversible adhesive hydrogel dressing could serve as versatile tissue sealant.

关键词： Bioinspired injectable hydrogel Tissue sealant Temperature-dependent adhesion Reversible adhesion Wound healing

Antibacterial biomaterials for skin wound dressing

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 353-384页

作者： Yuqing Liang Yongping Liang Hualei Zhang baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human *** bacterial contamination could significantly menace the wound healing *** the sophisticated wound healing process,novel strategies for skin tissue engineering are focused on the integration of bioactive ingredients,antibacterial agents included,into biomaterials with different morphologies to improve cell behaviors and promote wound ***,a comprehensive review on antibacterial wound dressing to enhance wound healing has not been *** this review,various antibacterial biomaterials as wound dressings will be *** kinds of antibacterial agents,including antibiotics,nanoparticles(metal and metallic oxides,lightinduced antibacterial agents),cationic organic agents,and others,and their recent advances are *** selection and fabrication of biomaterials with different structures and forms,including films,hydrogel,electrospun nanofibers,sponge,foam and three-dimension(3D)printed scaffold for skin regeneration,are elaborated *** challenges and the future perspectives are presented in thismultidisciplinary *** envision that this review will provide a general insight to the elegant design and further refinement of wound dressing.

关键词： Antibacterial activity Wound healing Wound dressing Skin tissue engineering Biomaterials

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds

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Regenerative Biomaterials 2024年第5期3卷 119-131页

作者： Bowen Qiao Jiaxin Wang Lipeng Qiao Aziz Maleki Yongping Liang baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran Department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatment of MRSA-infected wounds,the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-amino phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected *** hydrophilic antibiotic moxifloxacin(M)was directly loaded in the *** hydrophobic curcumin(Cur)with anti-inflammatory function was first mixed with Pluronic F127(PF)to form Cur-encapsulated PF micelles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of moxifloxacin and Cur and their different existing forms in the HPA hydrogel,the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflammatory,antioxidant property,and biocompatibility of hydrogels were ***,in the MRSA-infected mouse skin wound,the hydrogel-treated group showed faster wound closure,less inflammation and more collagen *** experiments further confirmed that the hydrogel promoted better repair by reducing inflammation(TNF-a)and promoting vascular(VEGF)*** conclusion,this HPA/M&CurPF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.

关键词： MRSA-infected wounds spatiotemporally sequential delivery antibacterial anti-inflammatory

Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing

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Advanced Fiber Materials 2022年第5期4卷 1027-1057页

作者： Yutong Yang Yuzhang Du Jie Zhang Hualei Zhang baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Institute of Preventive Medicine Fourth Military Medical UniversityXi’an 710032China

Electrospun nanofibers have been extensively studied in the biomedical field,including the controlled release of drugs,bionics,cell scaffolds,hemostasis,wound healing,and tissue engineering because of their high porosity,large surface area-to-volume ratio,and programmable *** recent years researchers have continuously broadened the structural design of electrospun nanofibers,which have evolved from one-dimensional to three-dimensional structures,in order to diversify their *** properties enable nanofibers to structurally and functionally mimic natural extracellular matrix(ECM),thereby obtaining a favorable physiological microenvironment for both wound healing and hemostasis due to improved blood coagulation and concentration.A comprehensive review summarizing the recent research progress of the structural and functional design of electrospun nanofibers for hemostasis and wound healing,on the other hand,is *** review summarizes electrospun nanofibers used for hemostasis and wound healing,with a focus on structural design and modification *** wide application of electrospun nanofibers in hemostasis and wound healing is clarified using a special structural and innovative design for *** advantages and limitations of electrospun nanofibers with various structural forms are also discussed,as are the main challenges and future development directions for the development of structurally specific electrospun nanofibers for hemostasis and wound healing.

关键词： Electrospun nanofibers Structure Modification Hemostasis Wound healing

Hybrid polymer biomaterials for bone tissue regeneration

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Frontiers of Medicine 2019年第2期13卷 189-201页

作者： Bo Lei baolin guo Kunal J.Rambhia Peter X.Ma Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710054China Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Department of Biologic and Materials Sciences University of MichiganAnn ArborMI 48109USA Macromolecular Science and Engineering Center University of MichiganAnn ArborMI 48109USA Department of Material Science and Engineering University of MichiganAnn ArborMI 48109USA

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

关键词： hybrid polymer bone regeneration tissue engineering biomaterials